Nature Reviews Rheumatology - Table of Contents alert Volume 10 Issue 4

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TABLE OF CONTENTS
April 2014 Volume 10 Number 4
Impact Factor 9.745 *	In this issue Research Highlights News and Views Reviews Perspectives Also this month  Featured article: Pathogenesis and prevention of rheumatic disease: focus on preclinical RA and SLE Kevin D. Deane & Hani El-Gabalawy
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RESEARCH HIGHLIGHTS Top Connective tissue diseases: A NET of peril for endothelial cells in SLE? Published online: 11 March 2014 p195 | doi:10.1038/nrrheum.2014.41 PDF Osteoarthritis: Zinc linked with osteoarthritis Published online: 04 March 2014 p196 | doi:10.1038/nrrheum.2014.35 PDF Osteoarthritis: Circulating miRNAs—early osteoarthritis biomarkers? Published online: 25 February 2014 p197 | doi:10.1038/nrrheum.2014.25 PDF Rheumatoid arthritis: Where there's smoke, there's altered transcription Published online: 11 March 2014 p197 | doi:10.1038/nrrheum.2014.40 PDF Osteoarthritis: Blocking cartilage damage in a rat model of OA by intra-articular injection of an amniotic membrane allograft Published online: 25 February 2014 p198 | doi:10.1038/nrrheum.2014.26 PDF Vasculitis syndromes: Phase III trial of infliximab in Kawasaki disease Published online: 11 March 2014 p198 | doi:10.1038/nrrheum.2014.42 PDF IN BRIEF Osteoarthritis: Overnight custom splinting reduces OA finger pain | Connective tissue diseases: Vitamin D replacement improves cutaneous lupus | Inflammation: Tocilizumab effective for refractory Still's disease | Rheumatoid arthritis: Mortality rates in RA have not improved over past 20 years PDF Rheumatology JOBS of the week Endowed Research Faculty Position in Immunology / Rheumatology Mayo Clinic Scientist / Manager in Immunology / Rheumatology Shanghai Institute of Rheumatology, Jiaotong University More Science jobs from
NEWS AND VIEWS		Top
Genetics: A new interpretation of genetic studies in RA Michel Neidhart & Emmanuel Karouzakis Published online: 25 February 2014 p199 | doi:10.1038/nrrheum.2014.21 Understanding the genetics of rheumatoid arthritis (RA) is complex, multiple genes and environmental factors are involved. A new multicentre genetic study summarizes the fundamental gene polymorphisms, pathways and cell types that are related to RA and, based on this analysis, proposes new targets for RA drug treatments. Full Text | PDF
Connective tissue diseases: Systemic sclerosis: beyond limited and diffuse subsets? John Varga & Monique Hinchcliff Published online: 18 February 2014 p200 | doi:10.1038/nrrheum.2014.22 Patients with systemic sclerosis present with varying clinical features, have different responses to therapy, and end up with different outcomes. Categorizing patients improves disease management. A new study now proposes that patients with systemic sclerosis and overlapping features of another connective tissue disease might form a distinct disease subset. Full Text | PDF
Rheumatoid arthritis: Treating cardiovascular risk in RA requires multidisciplinary care Rekha Mankad & Sherine E. Gabriel Published online: 18 March 2014 p202 | doi:10.1038/nrrheum.2014.37 Rheumatoid arthritis is associated with an excess risk of cardiovascular disease, but current cardiovascular risk models might not be adequate to fully predict individual risk in a patient with this disease. Does the solution lie in closer collaboration between rheumatologists and cardiologists? Full Text | PDF
REVIEWS		Top
Neural mechanisms underlying the pain of juvenile idiopathic arthritis Luke La Hausse de Lalouvière, Yiannis Ioannou & Maria Fitzgerald Published online: 04 February 2014 p205 | doi:10.1038/nrrheum.2014.4 Pain is a debilitating symptom of juvenile idiopathic arthritis (JIA) that can persist despite effective disease control. Insights into the underlying mechanisms of pain in JIA could highlight new treatment approaches and improve management. Here, the neurobiological basis of pain in JIA is described, using findings from animal models to inform the situation in humans. Abstract | Full Text | PDF
Pathogenesis and prevention of rheumatic disease: focus on preclinical RA and SLE Kevin D. Deane & Hani El-Gabalawy Published online: 11 February 2014 p212 | doi:10.1038/nrrheum.2014.6 That many autoimmune rheumatic diseases have an extended preclinical period, during which autoimmunity develops and evolves, is becoming apparent. In this Review, the authors discuss the current knowledge of the preclinical pathogenesis of rheumatoid arthritis and systemic lupus erythematosus, and use these diseases as models to highlight how such understanding could, in the future, improve therapeutic intervention and even lead to preventative approaches in autoimmune rheumatic diseases. Abstract | Full Text | PDF | Supplementary information
Persisting eicosanoid pathways in rheumatic diseases Marina Korotkova & Per-Johan Jakobsson Published online: 11 February 2014 p229 | doi:10.1038/nrrheum.2014.1 Eicosanoids are major regulators of inflammation and are thought to be involved in the pathogenesis of rheumatic diseases. Here, the authors provide an overview of eicosanoid pathways in a variety of rheumatic diseases (including rheumatoid arthritis, osteoarthritis and gout, among others) and describe how targeting this pathway might lead to novel anti-inflammatory treatment strategies. Abstract | Full Text | PDF | Supplementary information
Hand osteoarthritis—nonpharmacological and pharmacological treatments Margreet Kloppenburg Published online: 28 January 2014 p242 | doi:10.1038/nrrheum.2013.214 Hand osteoarthritis (OA) is a common disease and the prevalence is expected to increase further with ageing of the general population. In this comprehensive Review, Margreet Kloppenburg describes the nonpharmacological and pharmacological management strategies currently available to alleviate the symptoms of hand OA. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Multimorbidity and rheumatic conditions—enhancing the concept of comorbidity Helga Radner, Kazuki Yoshida, Josef S. Smolen & Daniel H. Solomon Published online: 14 January 2014 p252 | doi:10.1038/nrrheum.2013.212 The concepts of comorbidity and multimorbidity consider a patient with multiple diseases from different perspectives, which affects how a clinician approaches treatment. In this Perspectives article, Radner and colleagues discuss the concept of multimorbidity and how its integration into daily clinical practice can improve the care of patients with rheumatic conditions. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2012. Nature Reviews Rheumatology was previously published as Nature Clinical Practice Rheumatology.

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