Nature Reviews Immunology Contents July 2014 Volume 14 Number 7 pp 429-514

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TABLE OF CONTENTS
July 2014 Volume 14 Number 7
Impact Factor 33.129 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Ectopic lymphoid-like structures in infection, cancer and autoimmunity Costantino Pitzalis, Gareth W. Jones, Michele Bombardieri & Simon A. Jones
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RESEARCH HIGHLIGHTS Top Pattern recognition receptors: Sensing tinkering toxins p429 | doi:10.1038/nri3711 Activation of the pyrin inflammasome is induced by bacterial modification of RHO GTPases. PDF Neutrophils: Bugging transplantation p430 | doi:10.1038/nri3703 Bacteria-induced recruitment of neutrophils could have a role in the pathogenesis of graft-versus-host disease. PDF Microbiota: The liver debugs the system p430 | doi:10.1038/nri3704 The liver clears commensal bacteria that have breached intestinal defences. PDF Immunotherapy: Two hits are better than one p431 | doi:10.1038/nri3710 Combining CXCR2 blockade with PD1 blockade overcomes multiple mechanisms of tumour immune evasion. PDF Signalling: A new master to rival NF-κB? p432 | doi:10.1038/nri3708 TFEB is an evolutionarily ancient transcription factor that regulates the host response to bacterial infections. PDF T cells: IL-9 breaks down barriers p432 | doi:10.1038/nri3709 Interleukin-9 secreted by T helper 9 cells impairs intestinal barrier function and exacerbates ulcerative colitis. PDF Immunometabolism: A beige immune response p433 | doi:10.1038/nri3706 The type 2 cytokines IL-4 and IL-13 induce beige fat thermogenesis through catecholamine secretion by alternatively activated macrophages. PDF Immunology JOBS of the week Postdoctoral Research Fellow in Immunology & Hemostaseology University Medical Center - Mainz Immune synapse and intracellular signalling Universidad Autonoma de Madrid Postdoctoral Training Opportunity Studying B Cell Immune Tolerance University of Chicago Postdoctoral Position, Signaling and Gene Expression in Immune Cells Universitat Pompeu Fabra (UPF) Postdoctoral Fellow Position - Inflammatory Bowel Disease Immunologist National Institute of Allergy and Infectious Disease/National Institutes of Health (NIH) More Science jobs from Immunology EVENT Conference on Cell and Gene Therapy for HIV Cure 2014 26.08.14 Seattle, USA More science events from
REVIEWS		Top
Integrating canonical and metabolic signalling programmes in the regulation of T cell responses Kristen N. Pollizzi & Jonathan D. Powell p435 | doi:10.1038/nri3701 T cell subsets have unique metabolic needs. In this Review, the authors explain how metabolic pathways are interconnected with signalling pathways that mediate the activation and differentiation of discrete T cell subsets. They suggest that a better understanding of this complexity will lead to more targeted therapies for immune regulation. Abstract | Full Text | PDF
Ectopic lymphoid-like structures in infection, cancer and autoimmunity Costantino Pitzalis, Gareth W. Jones, Michele Bombardieri & Simon A. Jones p447 | doi:10.1038/nri3700 Inflammation can promote the development of lymphoid structures in tissue sites at which they do not normally occur. Here, the authors discuss how these ectopic lymphoid-like structures arise and, furthermore, how they affect immune responses in the setting of infection and disease. Abstract | Full Text | PDF
Innate immune activation in neurodegenerative disease Michael T. Heneka, Markus P. Kummer & Eicke Latz p463 | doi:10.1038/nri3705 In this Review, the authors discuss how innate immune mechanisms can contribute to the development of neurodegenerative disease. They suggest that both local and systemic inflammation can drive pathological microglial cell activity, thereby leading to neuronal cell dysfunction and disease. Abstract | Full Text | PDF
Mast cell secretory granules: armed for battle Sara Wernersson & Gunnar Pejler p478 | doi:10.1038/nri3690 Mast cell granules contain numerous immunomodulatory compounds that are rapidly released in various inflammatory settings. Here, the authors describe the composition, biogenesis and maturation of mast cell granules, and they focus on the biological effects of the mast cell proteases that are released. Abstract | Full Text | PDF
Follicular dendritic cells: dynamic antigen libraries Balthasar A. Heesters, Riley C. Myers & Michael C. Carroll p495 | doi:10.1038/nri3689 Follicular dendritic cells (FDCs) in lymph nodes support the development of high-affinity antibody responses by retaining antigens at their cell surface for long periods of time. Although FDCs are generally regarded as 'accessory cells' in the germinal centre, recent data suggest that they have more active roles in the development of humoral immune responses. This Review focuses on our current understanding of FDCs. Abstract | Full Text | PDF
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The life and fate of mesenchymal stem cells (open access) In this review article, Martin J. Hoogduijn and colleagues discuss current knowledge on the migratory properties of endogenous and exogenous MSC and confer on how culture-induced modifications of MSC may affect these properties. Finally, we will discuss how, despite their limited survival, administered MSC can bring about their therapeutic effects. Read more high-quality articles from Frontiers in Immunology
PERSPECTIVES		Top
TIMELINE From empiricism to rational design: a personal perspective of the evolution of vaccine development Ennio De Gregorio & Rino Rappuoli Published online: 13 June 2014 p505 | doi:10.1038/nri3694 The technological revolution in vaccination — from the empirical approach pioneered by Jenner and Pasteur to the recent developments in structural and reverse vaccinology, combined with synthetic biology — promises great hope for the development of safer and more effective vaccines against all infectious diseases. Abstract | Full Text | PDF
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*2012 Journal Citation Report (Thomson Reuters, 2013)

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