Nature Reviews Nephrology - Table of Contents alert Volume 10 Issue 7

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TABLE OF CONTENTS
July 2014 Volume 10 Number 7
Impact Factor 7.943 *	In this issue Research Highlights News and Views Addendum Reviews Perspectives Also this month  Featured article: B cells with immune-regulating function in transplantation Jessica Stolp, Laurence A. Turka & Kathryn J. Wood
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RESEARCH HIGHLIGHTS Top Acute kidney injury: Time to get personal with fluid administration and keep contrast-induced injury at bay Published online: 10 June 2014 p359 | doi:10.1038/nrneph.2014.99 PDF Imaging: Stepping towards real-time assessment of donor organs Published online: 06 May 2014 p360 | doi:10.1038/nrneph.2014.81 PDF Clinical trials: Human antibody-mediated T-cell suppression for kidney transplantation Published online: 20 May 2014 p361 | doi:10.1038/nrneph.2014.82 PDF Dialysis: Socioeconomic differences in dialysis modality uptake Published online: 13 May 2014 p361 | doi:10.1038/nrneph.2014.89 PDF Development: Fetal growth and renal outcomes Published online: 27 May 2014 p361 | doi:10.1038/nrneph.2014.97 PDF Chronic kidney disease: Paradoxical association between serum IL-10 levels and risk of cardiovascular events Published online: 20 May 2014 p362 | doi:10.1038/nrneph.2014.93 PDF Glomerular disease: KLF4 promotes podocyte differentiation Published online: 27 May 2014 p362 | doi:10.1038/nrneph.2014.96 PDF IN BRIEF Renal fibrosis: Protective effects of AT1 receptor activation | Surgery: Preoperative aspirin benefits patients with CKD | Renal fibrosis: Sonic hedgehog promotes fibroblast proliferation | Chronic kidney disease: Age modifies risk of coronary events PDF Nephrology JOBS of the week Pediatric Research Associate Cleveland Clinic Lerner Research Institute More Science jobs from Nephrology EVENT ISN World Congress of Nephrology 2015 13.03.15 Cape Town, South Africa More science events from
NEWS AND VIEWS		Top
Chronic kidney disease: Should sodium intake be restricted in patients with CKD? Michel Burnier & Gregoire Wuerzner Published online: 20 May 2014 p363 | doi:10.1038/nrneph.2014.88 A reduction of salt intake to <5 g sodium chloride per day is generally advised for patients with chronic kidney disease. However, hard evidence to support this recommendation is lacking. New data from Fan et al. suggest that very strict sodium limits might be harmful in patients with renal disease. Full Text | PDF
End-stage renal disease: Dual transplantation—the immunological role of the liver Marc Martinez-Llordella & Alberto Sanchez-Fueyo Published online: 13 May 2014 p364 | doi:10.1038/nrneph.2014.78 Kidney transplant recipients who also receive a partial liver allograft have better long-term outcomes than those who receive a kidney alone, despite the more-complex surgery. Understanding how the liver exerts these beneficial effects might enable their exploitation in the future. Full Text | PDF
Transplantation: The relevance of the FAVORIT blood pressure associations Krista L. Lentine & Daniel C. Brennan Published online: 06 May 2014 p366 | doi:10.1038/nrneph.2014.79 Secondary analysis of the FAVORIT data in kidney transplant recipients showed that systolic blood pressure ≥140 mmHg and diastolic blood pressure <70 mmHg at trial entry were associated with increased risks of cardiovascular disease over a mean of 4 years. Whether these blood pressure values are associated with mortality is unclear. Full Text | PDF
ADDENDUM		Top
Addendum: The gut–renal axis: do incretin-based agents confer renoprotection in diabetes? Marcel H. A. Muskiet, Mark M. Smits, Linde M. Morsink & Michaela Diamant Published online: 02 May 2014 p362 | doi:10.1038/nrneph.2014.90 Full Text | PDF
REVIEWS		Top
Proteostasis in endoplasmic reticulum—new mechanisms in kidney disease Reiko Inagi, Yu Ishimoto & Masaomi Nangaku Published online: 22 April 2014 p369 | doi:10.1038/nrneph.2014.67 In the endoplasmic reticulum (ER), networks of protein homeostasis—proteostasis—regulate protein synthesis, folding and degradation via the unfolded protein response (UPR) pathway. A defective UPR is deleterious to renal cell function and viability and is implicated in the pathophysiology of various kidney pathologies. Here, the authors discuss the role of oxidative, glycative and hypoxic stress and how optimizing ER proteostasis might prevent and treat kidney diseases. Abstract | Full Text | PDF
Lipid biology of the podocyte—new perspectives offer new opportunities Alessia Fornoni, Sandra Merscher & Jeffrey B. Kopp Published online: 27 May 2014 p379 | doi:10.1038/nrneph.2014.87 Fornoni et al. discuss the role of lipid biology in podocytes in the pathogenesis of glomerulopathies focusing on diabetic kidney disease and focal segmental glomerulosclerosis. They outline recent findings from genetic disorders that highlight the function of apolipoproteins in the podocyte and discuss the therapeutic implications. Abstract | Full Text | PDF
B cells with immune-regulating function in transplantation Jessica Stolp, Laurence A. Turka & Kathryn J. Wood Published online: 20 May 2014 p389 | doi:10.1038/nrneph.2014.80 Data from studies in humans and rodents suggest that B cells have the capacity to control or regulate the immune response to a transplanted organ. Here, the authors describe the phenotypes and mechanisms that have been associated with regulatory B cell function and discuss the evidence for a role of these cells in transplant tolerance. Abstract | Full Text | PDF
Pattern recognition receptors and the inflammasome in kidney disease Jaklien C. Leemans, Lotte Kors, Hans-Joachim Anders & Sandrine Florquin Published online: 03 June 2014 p398 | doi:10.1038/nrneph.2014.91 In this Review, the authors discuss the pathological mechanisms related to Toll-like receptors, nucleotide-binding oligomerization domain receptors and the NACHT, LRR and PYD domains-containing protein 3 inflammasome in various kidney diseases. Although these receptors are protective in the host defence against urinary tract infection, they can perpetuate tissue damage in sterile inflammatory and immune-mediated kidney diseases—making them promising drug targets. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Hyperosmolarity drives hypertension and CKD—water and salt revisited Richard J. Johnson, Bernardo Rodriguez-Iturbe, Carlos Roncal-Jimenez, Miguel A. Lanaspa, Takuji Ishimoto, Takahiko Nakagawa, Ricardo Correa-Rotter, Catharina Wesseling, Lise Bankir & Laura G. Sanchez-Lozada Published online: 06 May 2014 p415 | doi:10.1038/nrneph.2014.76 Recurrent dehydration and salt loss might be a mechanism that causes chronic kidney disease, whereby increased plasma osmolarity activates both intrarenal (polyol-fructokinase) and extrarenal (vasopressin) pathways to drive injury. The authors propose that water and salt influence blood pressure through the timing and combination of their intake, affecting plasma osmolarity and intrarenal and extrarenal mechanisms of renal injury. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2012. Nature Reviews Nephrology was previously published as Nature Clinical Practice Nephrology.

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