Molecular Systems Biology - New articles published - 1 Jul 2014

June 2014 | Volume 10, Number 6 Submit Table of Contents Articles Volume 10, Number 6 Articles Cell cycle population effects in perturbation studies Genetic, stress or nutrient perturbation of yeast resulting in slower growth yields a common expression signature, previously known as the environmental stress response. This is largely due to a cell cycle population shift and is relevant to many perturbation‐based studies. Eoghan O'Duibhir, Philip Lijnzaad, Joris J Benschop, Tineke L Lenstra, Dik van Leenen, Marian JA Groot Koerkamp, Thanasis Margaritis, Mariel O Brok, Patrick Kemmeren, and Frank CP Holstege Published online 21.06.2014 Efficient search, mapping, and optimization of multi‐protein genetic systems in diverse bacteria A computational approach for designing multi‐enzyme pathways is presented that combines sequence optimization, kinetic modeling, and accurate expression prediction. The method is illustrated for the direct forward engineering of robust circuits with targeted activities. Iman Farasat, Manish Kushwaha, Jason Collens, Michael Easterbrook, Matthew Guido, and Howard M Salis Published online 21.06.2014 Screen for mitochondrial DNA copy number maintenance genes reveals essential role for ATP synthase An RNAi screen for genes needed in mtDNA copy number maintenance in Drosophila yielded 97 positives, including previously characterized mtDNA maintenance proteins, subunits of the cytoribosome, proteasome, and ATP synthase. Atsushi Fukuoh, Giuseppe Cannino, Mike Gerards, Suzanne Buckley, Selena Kazancioglu, Filippo Scialo, Eero Lihavainen, Andre Ribeiro, Eric Dufour, and Howard T Jacobs Published online 21.06.2014   Unsubscribe from or edit your subscription for this service. Or by mail: Customer Service * 425 Broadway St * Redwood City, CA 94063 * U.S.A. Copyright © 2014 by the European Molecular Biology Organisation.