Nature Reviews Neurology - Table of Contents alert Volume 10 Issue 7

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TABLE OF CONTENTS
July 2014 Volume 10 Number 7
Impact Factor 15.518 *	In this issue Research Highlights News and Views Reviews Perspectives Also this month  Featured article: MGMT testing—the challenges for biomarker-based glioma treatment Wolfgang Wick, Michael Weller, Martin van den Bent, Marc Sanson, Markus Weiler, Andreas von Deimling, Christoph Plass, Monika Hegi, Michael Platten & Guido Reifenberger
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Nature Reviews Neurology  Focus on Epilepsy  In this special focus issue, cutting-edge investigators from around the world highlight the important challenges and progress in epilepsy research and clinical practice. Produced with financial support from UCB
RESEARCH HIGHLIGHTS Top Epilepsy: Electrophysiology elucidates epileptiform activity Published online: 17 June 2014 p363 | doi:10.1038/nrneurol.2014.106 PDF Neurosurgery: Directional electrodes widen the therapeutic window for deep brain stimulation in movement disorders Published online: 17 June 2014 p364 | doi:10.1038/nrneurol.2014.101 PDF Cerebral aneurysms: Genetic risk factors are associated with the site of intracranial aneurysm development Published online: 17 June 2014 p364 | doi:10.1038/nrneurol.2014.105 PDF Epilepsy: Chemical-genetic seizure silencing—unlocking the potential Published online: 17 June 2014 p365 | doi:10.1038/nrneurol.2014.104 PDF Neurodevelopmental disorders: Elevated fetal sex steroids might confer risk for autism Published online: 17 June 2014 p366 | doi:10.1038/nrneurol.2014.107 PDF IN BRIEF Neuro-oncology: High blood perfusion in gliomas predicts poor prognosis | Spinal cord injury: Levels of circulating microRNAs predict severity of spinal cord contusion in mice | Stroke: Selective serotonin reuptake inhibitors increase severity and mortality of haemorrhagic stroke | Multiple sclerosis: Reactivation of Epstein-Barr or herpes viruses not associated with MS relapse | Parkinson disease: Impulsivity in PD alleviated by noradrenergic enhancement | Traumatic brain injury: Benefits of resuming anticoagulant therapy after traumatic brain injury outweigh the risks | Alzheimer disease: Infection burden could contribute to AD | Neuromuscular disease: Caspase-4 is a potential therapeutic target for Duchenne muscular dystrophy PDF Neurology JOBS of the week Post Doctoral Position National Institute of Neuroscience, National Center of Neurology and Psychiatry More Science jobs from
NEWS AND VIEWS		Top
Stroke: Comparable care, worse outcomes for women with stroke Louise D. McCullough & Judith H. Lichtman Published online: 17 June 2014 p367 | doi:10.1038/nrneurol.2014.103 Sex differences are increasingly recognized in many areas of medicine, and stroke is no exception. Women tend to be more adversely affected by stroke than men and, as a new study illustrates, this discrepancy cannot be attributed solely to sex-related differences in acute stroke care. Full Text | PDF
Multiple sclerosis: Does aggressive MS warrant aggressive treatment? Mark S. Freedman Published online: 03 June 2014 p368 | doi:10.1038/nrneurol.2014.98 Aggressive, refractory multiple sclerosis warrants unconventional therapy. A retrospective multicentre study assessed the effects of ablating the immune system, then reconstituting it using bone marrow derived stem cells. Though this particular regimen improved disability in some patients, others continued to relapse, perhaps indicating the treatment did not go far enough. Full Text | PDF
Disorders of consciousness: Diagnostic accuracy of brain imaging in the vegetative state Adrian M. Owen Published online: 17 June 2014 p370 | doi:10.1038/nrneurol.2014.102 Differential diagnosis in the vegetative and minimally conscious states is notoriously difficult. A new report compares the diagnostic accuracy of two neuroimaging methods, using bedside behavioural assessment as a reference. The results highlight the many theoretical and methodological challenges in studying this patient group. Full Text | PDF
REVIEWS		Top
MGMT testing—the challenges for biomarker-based glioma treatment Wolfgang Wick, Michael Weller, Martin van den Bent, Marc Sanson, Markus Weiler, Andreas von Deimling, Christoph Plass, Monika Hegi, Michael Platten & Guido Reifenberger Published online: 10 June 2014 p372 | doi:10.1038/nrneurol.2014.100 The DNA repair protein O 6-methylguanine-DNA methyltransferase (MGMT) might interfere with alkylating agent chemotherapy in patients with glioma or glioblastoma. In this Review, Wick and colleagues discuss how epigenetic silencing of the MGMT gene via promotor methylation is associated with improved response to chemotherapy, and with improved survival, in patients with glioblastoma and other gliomas. The authors also highlight the usefulness of MGMT promotor methylation as a biomarker for both clinical practice and the design of treatment trials. Abstract | Full Text | PDF
Cataplexy—clinical aspects, pathophysiology and management strategy Yves Dauvilliers, Jerry M. Siegel, Regis Lopez, Zoltan A. Torontali & John H. Peever Published online: 03 June 2014 p386 | doi:10.1038/nrneurol.2014.97 Cataplexy is the pathognomonic symptom of narcolepsy, a condition that is caused by depletion of orexin neurons. Cataplectic attacks are characterized by sudden involuntary muscle weakness or paralysis, often triggered by strong emotions. In this article, Dauvilliers et al. review the latest understanding of potential mechanisms underlying narcolepsy and cataplexy, the utility of experimental models, and the need for early diagnosis and therapy. Abstract | Full Text | PDF | Supplementary information
The clinical approach to autonomic failure in neurological disorders Eduardo E. Benarroch Published online: 27 May 2014 p396 | doi:10.1038/nrneurol.2014.88 Central and peripheral neurological disorders can present with autonomic failure or hyperactivity, which can affect the sympathetic, parasympathetic and/or enteric nervous systems. This Review outlines the clinical approach to patients with generalized autonomic failure, focusing predominantly on classification and diagnosis, but also touching briefly on treatment and management. A systematic approach to diagnosis is essential to enable detection of treatable, potentially disabling or life-threatening conditions. Abstract | Full Text | PDF
Neuropathic pruritus Laurent Misery, Emilie Brenaut, Raphaële Le Garrec, Claire Abasq, Steeve Genestet, Pascale Marcorelles & Fabien Zagnoli Published online: 10 June 2014 p408 | doi:10.1038/nrneurol.2014.99 Pruritus is a very common condition, with almost one-third of the global population experiencing itch in a given week. Its origin is not always in the skin: damage to neurons or glia can induce neuropathic pruritus, which is often associated with neuropathic pain. Neuropathic pruritus is often difficult to treat and—if chronic—can severely impair quality of life. Here, Laurent Misery and colleagues review the role of the nervous system and neuropathic syndromes in pruritus, summarize the currently available therapeutic options, and propose therapeutic strategies for managing neuropathic pruritus. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Preimplantation genetic diagnosis for inherited neurological disorders Ilan Tur-Kaspa, Roohi Jeelani & P. Murali Doraiswamy Published online: 27 May 2014 p417 | doi:10.1038/nrneurol.2014.84 Preimplantation genetic diagnosis (PGD) facilitates conception of a healthy child by couples at risk of having offspring with an inherited debilitating or fatal neurological disorder. PGD has been carried out for various conditions, including spinal muscular atrophy, Huntington disease, fragile X syndrome, and chromosomal and mitochondrial disorders. This article aims to assist neurologists in counselling and treatment of individuals who wish to explore the option of PGD, and advocates the formulation of guidelines for the responsible integration of PGD into preventative neurology. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2012. Nature Reviews Neurology was previously published as Nature Clinical Practice Neurology.

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