Nature Reviews Rheumatology - Table of Contents alert Volume 10 Issue 10

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TABLE OF CONTENTS
October 2014 Volume 10 Number 10
Impact Factor 10.252 *	In this issue Research Highlights News and Views Reviews Perspectives Also this month  Web Collections: Imaging in rheumatology
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RESEARCH HIGHLIGHTS Top Connective tissue diseases: Depleting plasmacytoid dendritic cells: a new therapeutic approach in SLE? Published online: 16 September 2014 p573 | doi:10.1038/nrrheum.2014.160 PDF Osteoarthritis: mRNA decay in OA Published online: 09 September 2014 p574 | doi:10.1038/nrrheum.2014.155 PDF Osteoimmunology: Dual role for Wnt4: bone formation and bone resorption Published online: 26 August 2014 p575 | doi:10.1038/nrrheum.2014.146 PDF Spondyloarthropathies: Is the UPR key to removing misfolded HLA-B27 heavy chain dimers? Published online: 26 August 2014 p575 | doi:10.1038/nrrheum.2014.147 PDF Osteoarthritis: A role for CXCR2 signalling in cartilage homeostasis Published online: 02 September 2014 p576 | doi:10.1038/nrrheum.2014.148 PDF Experimental arthritis: Link between IL-10 and activation of the NLRP3 inflammasome in the synovium Published online: 16 September 2014 p576 | doi:10.1038/nrrheum.2014.161 PDF IN BRIEF Spondyloarthropathies: DMARD treatment changes common in patients with PsA | Bone: Use of proton-pump inhibitors not linked to bone loss | Clinical trials: Publication bias for publicly registered RCTs | Rheumatoid arthritis: Using DAS28 thresholds overestimates RA remission rates PDF
NEWS AND VIEWS		Top
Osteoarthritis: Does post-injury ACL reconstruction prevent future OA? Chunyi Wen & L. Stefan Lohmander Published online: 22 July 2014 p577 | doi:10.1038/nrrheum.2014.120 Young adults with an acute rupture of the anterior cruciate ligament of the knee are faced with the decision of whether or not to undergo early reconstructive surgery. However, a lack of high-quality evidence means questions remain about whether this surgical strategy protects against the development of osteoarthritis in the future. Full Text | PDF
Therapy: Oral or subcutaneous methotrexate for rheumatoid arthritis? Sabri Alsaeedi & Edward C. Keystone Published online: 05 August 2014 p578 | doi:10.1038/nrrheum.2014.129 Although methotrexate is the main therapy for rheumatoid arthritis, surprisingly little is known about the optimal route of administration; bioavailability of methotrexate has been shown to vary accordingly. In terms of delaying a switch to biologic therapy, is the subcutaneous route superior to oral methotrexate therapy? Full Text | PDF
REVIEWS		Top
Mechanisms, impact and management of pain in rheumatoid arthritis David A. Walsh & Daniel F. McWilliams Published online: 27 May 2014 p581 | doi:10.1038/nrrheum.2014.64 The pain associated with rheumatoid arthritis (RA) is complex, both in its manifestations and its underlying mechanisms. In this Review, the authors summarize what is known about the qualities of RA pain, the contributions of inflammation, peripheral and central pain processing and other factors, and discuss the range of therapeutic options available for the treatment of to this important symptom. Abstract | Full Text | PDF
The multifactorial role of neutrophils in rheumatoid arthritis Helen L. Wright, Robert J. Moots & Steven W. Edwards Published online: 10 June 2014 p593 | doi:10.1038/nrrheum.2014.80 In addition to their cytotoxic, inflammatory and immunoregulatory functions, neutrophils are implicated in the pathogenesis of several autoimmune diseases, including rheumatoid arthritis. This article highlights the contributions of neutrophils to the pathophysiology of rheumatoid arthritis, focusing on the generation of autoantigens resulting from the release of neutrophil extracellular traps. Abstract | Full Text | PDF
PTPN22: the archetypal non-HLA autoimmunity gene Stephanie M. Stanford & Nunzio Bottini Published online: 08 July 2014 p602 | doi:10.1038/nrrheum.2014.109 SNPs of PTPN22, a 'shared autoimmunity gene', are important risk factors for rheumatoid arthritis, juvenile idiopathic arthritis and other autoimmune diseases. In this article, Stanford and Bottini review the function of mouse and human PTPN22 in Toll-like receptor and lymphocyte antigen-receptor signalling pathways, and suggest functional models for the involvement of PTPN22 variants in the pathogenesis of autoimmune diseases. Abstract | Full Text | PDF
Adverse reactions to biologic agents and their medical management Onur Boyman, Denis Comte & François Spertini Published online: 12 August 2014 p612 | doi:10.1038/nrrheum.2014.123 Despite being associated with a high rate of adverse events, biologic agents are now commonly used to treat patients with rheumatic diseases. In this comprehensive Review, the authors describe these adverse events and how rheumatologists should manage patients to treat and avoid such complications. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
TIMELINE Progress in imaging in rheumatology Emilio Filippucci, Luca Di Geso & Walter Grassi Published online: 09 September 2014 p628 | doi:10.1038/nrrheum.2014.145 Diagnostic imaging in rheumatology has become an important feature of the management of a variety of rheumatic diseases. This Timeline Perspectives charts the progress in the field of imaging in rheumatology over the past few decades, with particular emphasis on developments in radiography, MRI and ultrasonography. Abstract | Full Text | PDF
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Nature Reviews Rheumatology  FOCUS ON VASCULITIS  Specially commissioned articles outline the latest research in the field of vasculitis, covering topics including vasculature development, and vasculitis pathogenesis and treatment. Produced with support from  Genentech, a member of the Roche group
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*Journal Citation Reports, Thomson, 2013. Nature Reviews Rheumatology was previously published as Nature Clinical Practice Rheumatology.

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