Nature Communications - 14 January 2015

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Advertisement Avoid accidental plagiarism with this free white paper by an AJE editor & PhD. Make sure you're citing correctly and thoroughly. Avoid common pitfalls (and the resulting embarrassment when a journal notices). Download "In Your Own Words: Best Practices for Avoiding Plagiarism." AJE© provides publication services and resources for researchers. A division of Research Square©.     Weekly Content Alert 14 January 2015  Featured image: Schiffbauer et al. study geochemical mechanisms of soft tissue preservation in Ediacaran tubular fossils. Latest content: Articles Corrigenda Journal homepage Recommend to library Web feed     Latest Articles View all Articles     Experimental evidence for the co-evolution of hominin tool-making teaching and language T. J. H. Morgan, N. T. Uomini, L. E. Rendell, L. Chouinard-Thuly, S. E. Street, H. M. Lewis, C. P. Cross, C. Evans, R. Kearney, I. de la Torre, A. Whiten and K. N. Laland Oldowan stone tool-making might have influenced the evolution of human language and teaching. Here the authors show that transmission of Oldowan tool-making skills improves with teaching and language, suggesting that hominin reliance on stone tool-making generated selection for teaching and language. 13 January 2015 | doi: 10.1038/ncomms7029 Biological Sciences  Evolution  Reciprocal inhibition between sensory ASH and ASI neurons modulates nociception and avoidance in Caenorhabditis elegans Min Guo, Tai-Hong Wu, Yan-Xue Song, Ming-Hai Ge, Chun-Ming Su, Wei-Pin Niu, Lan-Lan Li, Zi-Jing Xu, Chang-Li Ge, Maha T. H. Al-Mhanawi, Shi-Ping Wu and Zheng-Xing Wu In Caenorhabditis elegans, nociception and avoidance behaviour are crucial for survival, but their modulation is poorly understood. Here, the authors describe a cross-inhibitory neural circuit between ASH and ASI sensory neurons that fine-tunes nociception and mediates adaptive avoidance behaviour. 13 January 2015 | doi: 10.1038/ncomms6655 Biological Sciences  Neuroscience  Profiling lymphocyte interactions at the single-cell level by microfluidic cell pairing Burak Dura, Stephanie K. Dougan, Marta Barisa, Melanie M. Hoehl, Catherine T. Lo, Hidde L. Ploegh and Joel Voldman Direct cell–cell interactions form the basis of the adaptive immune response. Here, Dura et al. present an advanced microfluidic platform that enables highly parallel pairing of primary immune cells and multiparametric and dynamic measurements of lymphocyte interactions and activation processes. 13 January 2015 | doi: 10.1038/ncomms6940 Biological Sciences  Bioengineering  Immunology  Phosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization Juan Peng, Aline Awad, Sokhavuth Sar, Ola Hamze Komaiha, Romina Moyano, Amel Rayal, Didier Samuel, Annette Shewan, Bart Vanhaesebroeck, Keith Mostov and Ama Gassama-Diagne Kidney epithelial cells grown in 3D culture form polarized cysts in which basal membranes surround a lumen. Peng et al. show that the p110δ subunit of phosphoinositide 3-kinase contributes to the formation of these structures by influencing focal adhesion at the basal membrane. 13 January 2015 | doi: 10.1038/ncomms6937 Biological Sciences  Cell biology  Amino acid coevolution reveals three-dimensional structure and functional domains of insect odorant receptors Thomas A. Hopf, Satoshi Morinaga, Sayoko Ihara, Kazushige Touhara, Debora S. Marks and Richard Benton The structure of insect odorant receptors (ORs) has remained elusive due to their lack of homology to other proteins and the inability to obtain OR crystals. Here, the authors use amino acid evolutionary covariation patterns to fold these proteins de novo and generate the first three-dimensional models of insect ORs. 13 January 2015 | doi: 10.1038/ncomms7077 Biological Sciences  Bioinformatics  Neuroscience  Recoverable plasticity in penta-twinned metallic nanowires governed by dislocation nucleation and retraction OPEN Qingquan Qin, Sheng Yin, Guangming Cheng, Xiaoyan Li, Tzu-Hsuan Chang, Gunther Richter, Yong Zhu and Huajian Gao 1D nanostructures are widely regarded as important building blocks for a broad range of applications. Here, the authors study dislocation-mediated plastic deformation in penta-twinned silver nanowires, finding that in situ deformation at small to moderate strains can be entirely reversible. 13 January 2015 | doi: 10.1038/ncomms6983 Physical Sciences  Materials science  Enhanced transcriptome maps from multiple mouse tissues reveal evolutionary constraint in gene expression OPEN Dmitri D. Pervouchine, Sarah Djebali, Alessandra Breschi, Carrie A. Davis, Pablo Prieto Barja, Alex Dobin, Andrea Tanzer, Julien Lagarde, Chris Zaleski, Lei-Hoon See, Meagan Fastuca, Jorg Drenkow, Huaien Wang, Giovanni Bussotti, Baikang Pei, Suganthi Balasubramanian, Jean Monlong, Arif Harmanci, Mark Gerstein, Michael A. Beer et al. The analysis of mammalian transcriptomes could provide new insights into human biology. Here the authors carry out RNA sequencing in a large collection of mouse tissues and compare these data to human transcriptome profiles, identifying a set of constrained genes that carry out basic cellular functions with remarkably constant expression levels across tissues and species. 13 January 2015 | doi: 10.1038/ncomms6903 Biological Sciences  Evolution  Genetics  Engineering two-dimensional superconductivity and Rashba spin–orbit coupling in LaAlO3/SrTiO3 quantum wells by selective orbital occupancy OPEN Gervasi Herranz, Gyanendra Singh, Nicolas Bergeal, Alexis Jouan, Jérôme Lesueur, Jaume Gázquez, María Varela, Mateusz Scigaj, Nico Dix, Florencio Sánchez and Josep Fontcuberta Two-dimensional electron gases at oxide interfaces induce exotic behaviours. By studying samples with different crystal orientation, Herranz et al. show that the extension and anisotropy of the oxide quantum well properties can be controlled through selective sub-band filling via orientational tuning. 13 January 2015 | doi: 10.1038/ncomms7028 Physical Sciences  Condensed matter  Materials science  Observation of strong electron pairing on bands without Fermi surfaces in LiFe1−xCoxAs H. Miao, T. Qian, X. Shi, P. Richard, T. K. Kim, M. Hoesch, L. Y. Xing, X.-C. Wang, C.-Q. Jin, J.-P. Hu and H. Ding It remains to be seen if high-T c superconductors rely on similar Fermi-surface instabilities as their BCS counterparts. Miao et al. study the high-T c compound LiFe1−x Co x As with high-resolution ARPES and find a robust gap with Co doping that suggests the order parameter is not tied to such instabilities. 13 January 2015 | doi: 10.1038/ncomms7056 Physical Sciences  Condensed matter  A borane laser Luis Cerdán, Jakub Braborec, Inmaculada Garcia-Moreno, Angel Costela and Michael G. S. Londesborough Solution-processed blue lasers are used in many applications such as spectroscopy or material processing. Here, the authors demonstrate a borane solution-based blue laser that offers a high efficiency and a photostability that is superior to commercial laser dyes. 13 January 2015 | doi: 10.1038/ncomms6958 Physical Sciences  Optical physics  Physical chemistry  Coherent coupling of molecular resonators with a microcavity mode OPEN A. Shalabney, J. George, J. Hutchison, G. Pupillo, C. Genet and T. W. Ebbesen Coherent coupling of light with electronic transitions has led to phenomena such as polariton lasing and superfluidity. Shalabney et al. now couple the optical modes of micro-cavity to the vibrational modes of a molecule at room temperature and thereby alter the chemical behaviour of the molecule. 13 January 2015 | doi: 10.1038/ncomms6981 Physical Sciences  Optical physics  Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability OPEN Anna-Claire Devlin, Karen Burr, Shyamanga Borooah, Joshua D. Foster, Elaine M. Cleary, Imbisaat Geti, Ludovic Vallier, Christopher E. Shaw, Siddharthan Chandran and Gareth B. Miles Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that affects spinal cord motor neurons. Here the authors use induced pluripotent stem cell-derived motor neurons obtained from patients with ALS-linked mutations, and find functional deficits resulting from a progressive decrease in voltage-activated Na+ and K+ currents that occur in the absence of cell death. 12 January 2015 | doi: 10.1038/ncomms6999 Biological Sciences  Cell biology  Neuroscience  The Hippo pathway effector YAP is a critical regulator of skeletal muscle fibre size K. I. Watt, B. J. Turner, A. Hagg, X. Zhang, J. R. Davey, H. Qian, C. Beyer, C. E. Winbanks, K. F. Harvey and P. Gregorevic The Yes-associated protein (YAP) is a core effector of the Hippo pathway, which regulates proliferation and apoptosis in organ development, but its function in adult skeletal muscle remains poorly defined. Here the authors show that YAP is an essential regulator of myofibre size in adult skeletal muscle, via interaction with TEAD transcription factors. 12 January 2015 | doi: 10.1038/ncomms7048 Biological Sciences  Cell biology  Developmental biology  A subcutaneous adipose tissue–liver signalling axis controls hepatic gluconeogenesis OPEN Shannon M. Reilly, Maryam Ahmadian, Brian F. Zamarron, Louise Chang, Maeran Uhm, BreAnne Poirier, Xiaoling Peng, Danielle M. Krause, Evgenia Korytnaya, Adam Neidert, Christopher Liddle, Ruth T. Yu, Carey N. Lumeng, Elif A. Oral, Michael Downes, Ronald M. Evans and Alan R. Saltiel The drug amlexanox is known to improve obesity-related metabolic dysfunction in mice. Here the authors show that this effect is mediated by interleukin-6 secreted from subcutaneous adipocytes, which then inhibits gluconeogenesis in the liver by phosphorylating the hepatic transcription factor Stat3. 12 January 2015 | doi: 10.1038/ncomms7047 Biological Sciences  Medical research  Hidden topological order and its correlation with glass-forming ability in metallic glasses Z. W. Wu, M. Z. Li, W. H. Wang and K. X. Liu Metallic glasses are amorphous in the absence of long-range atomic packing orders, but their medium-range order may not be completely lost. Here, Wu et al. identify a number of crystalline units that are entangled in medium range and their influence on the glass-forming ability in binary glasses. 12 January 2015 | doi: 10.1038/ncomms7035 Physical Sciences  Condensed matter  Materials science  A fatty acid-dependent hypothalamic–DVC neurocircuitry that regulates hepatic secretion of triglyceride-rich lipoproteins Jessica T. Y. Yue, Mona A. Abraham, Mary P. LaPierre, Patricia I. Mighiu, Peter E. Light, Beatrice M. Filippi and Tony K. T. Lam The brain has a central role in the regulation of organismal energy homeostasis. Here the authors show that neurons in the mediobasal hypothalamus respond to fatty acids by generating neuronal signals, relayed to the liver via vagal nerves that mediate secretion of very-low-density lipoproteins. 12 January 2015 | doi: 10.1038/ncomms6970 Biological Sciences  Medical research  Large interdomain rearrangement triggered by suppression of micro- to millisecond dynamics in bacterial Enzyme I Vincenzo Venditti, Vitali Tugarinov, Charles D. Schwieters, Alexander Grishaev and G. Marius Clore Enzyme I (EI)—a component of the bacterial phosphotransferase signal transduction system—undergoes large conformational rearrangements upon substrate binding. Here the authors show that the EI open-to-closed conformational switch occurs through suppression of micro- to millisecond dynamics of C-terminal domain. 12 January 2015 | doi: 10.1038/ncomms6960 Biological Sciences  Biochemistry  Biophysics  Reconfigurable radio-frequency arbitrary waveforms synthesized in a silicon photonic chip OPEN Jian Wang, Hao Shen, Li Fan, Rui Wu, Ben Niu, Leo T. Varghese, Yi Xuan, Daniel E. Leaird, Xi Wang, Fuwan Gan, Andrew M. Weiner and Minghao Qi Performing radio-frequency arbitrary waveform generation in the optical domain offers advantages over electronic-based methods but suffers from lack of integration and slow speed. Here, Wang et al. propose a fast-reconfigurable, radio-frequency arbitrary waveform generator fully integrated in a silicon chip. 12 January 2015 | doi: 10.1038/ncomms6957 Physical Sciences  Applied physics  Nanotechnology  Optical physics  Single-crystal field-effect transistors of new Cl2-NDI polymorph processed by sublimation in air Tao He, Matthias Stolte, Christian Burschka, Nis Hauke Hansen, Thomas Musiol, Daniel Kälblein, Jens Pflaum, Xutang Tao, Jochen Brill and Frank Würthner Charge transport in organic semiconductors is highly sensitive to crystalline polymorphs. Here, He et al. manufacture the first n-channel single-crystal transistor via sublimation at ambient conditions and identify a new polymorphous phase that does not exist in its solution-processed counterpart. 12 January 2015 | doi: 10.1038/ncomms6954 Chemical Sciences  Materials science  Physical chemistry  Exciton dynamics reveal aggregates with intermolecular order at hidden interfaces in solution-cast organic semiconducting films Cathy Y. Wong, Benjamin L. Cotts, Hao Wu and Naomi S. Ginsberg Grain boundaries between crystalline domains in solution-processed organic semiconductor thin films are believed to inhibit charge transport, but their structure is invisible to conventional characterization techniques. Wong et al. show the existence of nano-crystalline aggregates at domain interfaces. 12 January 2015 | doi: 10.1038/ncomms6946 Physical Sciences  Materials science  Physical chemistry  Late-stage C–H functionalization of complex alkaloids and drug molecules via intermolecular rhodium-carbenoid insertion Jing He, Lawrence G. Hamann, Huw M. L. Davies and Rohan E. J. Beckwith The ability to functionalize a C–H bond is useful in complex organic syntheses, but the scope of this approach is sometimes limited by its sensitivity to basic amines. Here, the authors achieve functionalization of amine-containing natural products by site-selective rhodium-carbene-mediated C–H insertion. 12 January 2015 | doi: 10.1038/ncomms6943 Chemical Sciences  Medicinal chemistry  Organic chemistry  Multi-body coalescence in Pickering emulsions Tong Wu, Haitao Wang, Benxin Jing, Fang Liu, Peter C. Burns and Chongzheng Na Pickering emulsions are particle-stabilized droplets suspended in an immiscible liquid, and the study of individual droplet coalescence has yielded many interesting findings. Here, Wu et al. move towards larger droplet numbers to investigate the influence of population on coalescence. 12 January 2015 | doi: 10.1038/ncomms6929 Physical Sciences  Materials science  Nanotechnology  Physical chemistry  MARQUIS: A multiplex method for absolute quantification of peptides and posttranslational modifications Timothy G. Curran, Yi Zhang, Daniel J. Ma, Jann N. Sarkaria and Forest M. White The absolute quantification of proteins and level of modifications between biological samples remain fraught with technical difficulties. Here, the authors present MARQUIS, a new mass spectrometry method that allows for precise absolute quantification of posttranslational modifications in complex protein samples. 12 January 2015 | doi: 10.1038/ncomms6924 Biological Sciences  Biochemistry  Biotechnology  Nanoscale sub-100 picosecond all-optical magnetization switching in GdFeCo microstructures L. Le Guyader, M. Savoini, S. El Moussaoui, M. Buzzi, A. Tsukamoto, A. Itoh, A. Kirilyuk, T. Rasing, A. V. Kimel and F. Nolting All-optical magnetization switching holds significant potential for future ultrafast high-density recording applications. Here, Le Guyader et al. demonstrate sub-100 ps sub-wavelength magnetization reversal by passive focussing of a single femtosecond laser pulse in micro-patterned GdFeCo thin films. 12 January 2015 | doi: 10.1038/ncomms6839 Physical Sciences  Condensed matter  Nanotechnology  Optical physics  The DNA-binding network of Mycobacterium tuberculosis OPEN Kyle J. Minch, Tige R. Rustad, Eliza J. R. Peterson, Jessica Winkler, David J. Reiss, Shuyi Ma, Mark Hickey, William Brabant, Bob Morrison, Serdar Turkarslan, Chris Mawhinney, James E. Galagan, Nathan D. Price, Nitin S. Baliga and David R. Sherman Adaptation of Mycobacterium tuberculosis to the host environment is principally mediated through its transcription factors. Here, the authors report the DNA binding and transcriptional profile of ~80% of all predicted M. tuberculosis transcription factors, and find wide-spread dormant DNA binding. 12 January 2015 | doi: 10.1038/ncomms6829 Biological Sciences  Genetics  Molecular biology  Vortex flows impart chirality-specific lift forces Thomas M. Hermans, Kyle J. M. Bishop, Peter S. Stewart, Stephen H. Davis and Bartosz A. Grzybowski The separation of enantiomers by flows holds promise in food and pharmaceutical industries, but the feasibility remains uncertain. Here, Hermans et al. separate macroscopic particles of opposite chirality at a liquid interface using shear flows, which provides insights into the mechanism at nanoscale. 12 January 2015 | doi: 10.1038/ncomms6640 Physical Sciences  Fluids and plasma physics  Physical chemistry  MED26 regulates the transcription of snRNA genes through the recruitment of little elongation complex Hidehisa Takahashi, Ichigaku Takigawa, Masashi Watanabe, Delnur Anwar, Mio Shibata, Chieri Tomomori-Sato, Shigeo Sato, Amol Ranjan, Chris W. Seidel, Tadasuke Tsukiyama, Wataru Mizushima, Masayasu Hayashi, Yasuyuki Ohkawa, Joan W. Conaway, Ronald C. Conaway and Shigetsugu Hatakeyama The little elongation complex (LEC) has been implicated in the regulation of Pol II-transcribed snRNA genes. Here, the authors show that MED26 recruits the LEC to a subset of Pol II-transcribed snRNA genes through its N terminus, entailing a TAF7 to LEC switch that facilitates the transition from initiation to elongation. 09 January 2015 | doi: 10.1038/ncomms6941 Biological Sciences  Biochemistry  Molecular biology  Mutations in PNPLA6 are linked to photoreceptor degeneration and various forms of childhood blindness S. Kmoch, J. Majewski, V. Ramamurthy, S. Cao, S. Fahiminiya, H. Ren, I. M. MacDonald, I. Lopez, V. Sun, V. Keser, A. Khan, V. Stránecký, H. Hartmannová, A. Přistoupilová, K. Hodaňová, L. Piherová, L. Kuchař, A. Baxová, R. Chen, O. G. P. Barsottini et al. Blindness due to retinal degeneration affects millions of people worldwide, but many disease-causing mutations remain unknown. Here the authors link mutations in the gene PNPLA6 with childhood blindness in seven families with retinal degeneration and show that the gene plays a role in photoreceptor survival in Drosophila. 09 January 2015 | doi: 10.1038/ncomms6614 Biological Sciences  Genetics  Neuroscience  Enhanced Moran effect by spatial variation in environmental autocorrelation Thomas M. Massie, Guntram Weithoff, Nina Kuckländer, Ursula Gaedke and Bernd Blasius Spatially separate populations may exhibit synchronised dynamics as a result of correlated environmental influences. Here, Massie et al. show that this phenomenon, known as the Moran effect, can be enhanced if the environmental signals experienced by two populations differ in their noise colour. 09 January 2015 | doi: 10.1038/ncomms6993 Biological Sciences  Ecology  Tropomodulin3 is a novel Akt2 effector regulating insulin-stimulated GLUT4 exocytosis through cortical actin remodeling OPEN Chun-Yan Lim, Xuezhi Bi, Donghai Wu, Jae Bum Kim, Peter W. Gunning, Wanjin Hong and Weiping Han Insulin-stimulated GLUT4-storage vesicle fusion with the plasma membrane depends on activity of Akt2 and its downstream effectors. Here Lim et al. identify the actin-capping protein tropomodulin 3 as a novel Akt2 effector that remodels cortical actin to help facilitate GLUT4 membrane insertion. 09 January 2015 | doi: 10.1038/ncomms6951 Biological Sciences  Cell biology  BCL11A is a triple-negative breast cancer gene with critical functions in stem and progenitor cells OPEN Walid T. Khaled, Song Choon Lee, John Stingl, Xiongfeng Chen, H. Raza Ali, Oscar M. Rueda, Fazal Hadi, Juexuan Wang, Yong Yu, Suet-Feung Chin, Mike Stratton, Andy Futreal, Nancy A. Jenkins, Sam Aparicio, Neal G. Copeland, Christine J. Watson, Carlos Caldas and Pentao Liu Triple-negative breast cancers (TNBCs) tend to have poor prognosis; however, the mechanisms underlying TNBC pathology are not well understood. Here the authors utilize epidemiologic data and animal models to demonstrate an important role for BCL11A in the genesis and propagation of TNBCs. 09 January 2015 | doi: 10.1038/ncomms6987 Biological Sciences  Cancer  Molecular biology  The evolution of cyclopropenium ions into functional polyelectrolytes OPEN Yivan Jiang, Jessica L. Freyer, Pepa Cotanda, Spencer D. Brucks, Kato L. Killops, Jeffrey S. Bandar, Christopher Torsitano, Nitash P. Balsara, Tristan H. Lambert and Luis M. Campos Cationic polyelectrolytes have a broad range of applications, including membranes for fuel cells. Here, the authors report a family of cationic polyelectrolytes based on the highly modular cyclopropenium ion building block, which show high ionic conductivity and tunable physical properties. 09 January 2015 | doi: 10.1038/ncomms6950 Chemical Sciences  Materials science  Organic chemistry  Innate sensing of microbial products promotes wound-induced skin cancer OPEN Esther Hoste, Esther N. Arwert, Rohit Lal, Andrew P. South, Julio C. Salas-Alanis, Dedee F. Murrell, Giacomo Donati and Fiona M. Watt Inflammation and wounding can promote cancer development, but the underlying mechanisms are unclear. Here Hoste et al. show that leukocytes sensing flagellin, a component of bacteria, play a key role in inducing skin cancer in the context of wounding and chronic inflammation. 09 January 2015 | doi: 10.1038/ncomms6932 Biological Sciences  Cancer  Immunology  Global pattern for the effect of climate and land cover on water yield Guoyi Zhou, Xiaohua Wei, Xiuzhi Chen, Ping Zhou, Xiaodong Liu, Yin Xiao, Ge Sun, David F. Scott, Shuyidan Zhou, Liusheng Han and Yongxian Su The effects of forests on water yield are uncertain, with some studies indicating that increased evapotranspiration reduces water yield and other showing that forests increase it. Here, the authors analyse published data to settle this debate, finding that afforestation has a positive effect on water yield. 09 January 2015 | doi: 10.1038/ncomms6918 Earth Sciences  Climate science  Vasculopathy-associated hyperangiotensinemia mobilizes haematopoietic stem cells/progenitors through endothelial AT2R and cytoskeletal dysregulation Kyung Hee Chang, Ramesh C Nayak, Swarnava Roy, Ajay Perumbeti, Ashley M Wellendorf, Katie Y Bezold, Megan Pirman, Sarah E Hill, Joseph Starnes, Anastacia Loberg, Xuan Zhou, Tadashi Inagami, Yi Zheng, Punam Malik and Jose A Cancelas Increased levels of haematopoietic stem and progenitor cells in the blood have been linked to some forms of organ failure. Here, the authors show that the hormone angiotensin II increases mobilization of haematopoietic stem and progenitor cells by inducing cytoskeletal changes in bone marrow cells. 09 January 2015 | doi: 10.1038/ncomms6914 Biological Sciences  Cell biology  Medical research  Combining gene mutation with gene expression data improves outcome prediction in myelodysplastic syndromes OPEN Moritz Gerstung, Andrea Pellagatti, Luca Malcovati, Aristoteles Giagounidis, Matteo G Della Porta, Martin Jädersten, Hamid Dolatshad, Amit Verma, Nicholas C. P. Cross, Paresh Vyas, Sally Killick, Eva Hellström-Lindberg, Mario Cazzola, Elli Papaemmanuil, Peter J. Campbell and Jacqueline Boultwood The myelodysplastic syndromes (MDS) are a heterogeneous group of chronic blood cancers. Here, the authors analyse genomic and gene expression data from MDS patients to investigate how driver mutations alter gene expression, diagnostic clinical variables and survival. 09 January 2015 | doi: 10.1038/ncomms6901 Biological Sciences  Cancer  Genetics  Magnetic control of transverse electric polarization in BiFeO3 M. Tokunaga, M. Akaki, T. Ito, S. Miyahara, A. Miyake, H. Kuwahara and N. Furukawa BiFeO3 is one of the most widely studied multiferroic materials, as it offers a strong coupling between magnetism and electric polarization up to room temperature. Here, studying monodomain crystals, the authors find an additional electric polarization component orthogonal to the widely studied one. 09 January 2015 | doi: 10.1038/ncomms6878 Physical Sciences  Condensed matter  On-chip detection of non-classical light by scalable integration of single-photon detectors OPEN Faraz Najafi, Jacob Mower, Nicholas C. Harris, Francesco Bellei, Andrew Dane, Catherine Lee, Xiaolong Hu, Prashanta Kharel, Francesco Marsili, Solomon Assefa, Karl K. Berggren and Dirk Englund The integration of single-photon detectors, as superconducting nanowire single-photon detectors, in photonic-integrated circuits is a goal of quantum information science. Here, Najafi et al. introduce a micrometer-scale flip-chip process enabling such a integration in a scalable way. 09 January 2015 | doi: 10.1038/ncomms6873 Physical Sciences  Applied physics  Nanotechnology  Optical physics  CCR7-dependent trafficking of RORγ+ ILCs creates a unique microenvironment within mucosal draining lymph nodes OPEN Emma C. Mackley, Stephanie Houston, Clare L. Marriott, Emily E. Halford, Beth Lucas, Vuk Cerovic, Kara J. Filbey, Rick M. Maizels, Matthew R. Hepworth, Gregory F. Sonnenberg, Simon Milling and David R. Withers Innate lymphoid cells have an important role in mucosal immunity and present peptide:MHCII to CD4 T cells. Here the authors show that innate lymphoid cell subsets migrate from the gut mucosa to the draining lymph nodes via different mechanisms, where they form distinct microenvironments. 09 January 2015 | doi: 10.1038/ncomms6862 Biological Sciences  Immunology  Tandem intercalation strategy for single-layer nanosheets as an effective alternative to conventional exfoliation processes Sohee Jeong, Dongwon Yoo, Minji Ahn, Pere Miró, Thomas Heine and Jinwoo Cheon The synthesis of single-layer transition metal chalcogenides (TMCs) is desirable, but challenging. Here, the authors propose a new exfoliation method, wherein single-layer TMCs are produced via a one-pot tandem molecular intercalation approach. 09 January 2015 | doi: 10.1038/ncomms6763 Chemical Sciences  Inorganic chemistry  Materials science  Nanotechnology  Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus Min Wang, Wei Zhang, Jianxun Qi, Fei Wang, Jianfang Zhou, Yuhai Bi, Ying Wu, Honglei Sun, Jinhua Liu, Chaobin Huang, Xiangdong Li, Jinghua Yan, Yuelong Shu, Yi Shi and George F. Gao Avian strains of the influenza virus sometimes infect human hosts with severe consequences. Here, Wang et al. report that the H10N8 avian influenza virus, for which two lethal human infections have been reported, possesses restricted affinity towards the human receptor and suggest a structural basis for H10N8’s limited virulence. 09 January 2015 | doi: 10.1038/ncomms6600 Biological Sciences  Medical research  Virology  Glucocorticoids mediate induction of microRNA-708 to suppress ovarian cancer metastasis through targeting Rap1B OPEN Kai-Ti Lin, Yu-Ming Yeh, Chi-Mu Chuang, Scarlett Y. Yang, Jer-Wei Chang, Shu-Pin Sun, Yi-Shiang Wang, Kuan-Chong Chao and Lu-Hai Wang Glucocorticoids show promise for the treatment of ovarian cancer. Here the authors show that glucocorticoids transcriptionally induce the tumour suppressor miR-708, which is downregulated in ovarian cancer, especially in late stages and metastatic tumours. 08 January 2015 | doi: 10.1038/ncomms6917 Biological Sciences  Cancer  Molecular biology  Conversion of the LIMA1 tumour suppressor into an oncogenic LMO-like protein by API2–MALT1 in MALT lymphoma Zilin Nie, Ming-Qing Du, Linda M. McAllister-Lucas, Peter C. Lucas, Nathanael G. Bailey, Cory M. Hogaboam, Megan S. Lim and Kojo S. J. Elenitoba-Johnson Protein fusions between the paracaspase MALT1 and API2 (inhibitor of apoptosis 2) are found in B-cell lymphoma. Here the authors identify the tumour suppressor LIMA1 as a new target of API2–MALT1 chimeric protein and show that API2–MALT1-mediated proteolysis generates a LIM domain-only (LMO)-containing fragment with oncogenic properties in vitro and in vivo. 08 January 2015 | doi: 10.1038/ncomms6908 Biological Sciences  Cancer  Molecular biology  Correlating hydrogen oxidation and evolution activity on platinum at different pH with measured hydrogen binding energy Wenchao Sheng, Zhongbin Zhuang, Minrui Gao, Jie Zheng, Jingguang G. Chen and Yushan Yan Hydrogen oxidation and evolution are two of the key reactions in renewable energy conversion and storage devices. Here, the authors report the correlation between reaction rate and measured hydrogen binding energy for polycrystalline platinum in buffer solutions ranging from pH 0 to 13. 08 January 2015 | doi: 10.1038/ncomms6848 Chemical Sciences  Materials science  Physical chemistry  Flow damping due to stochastization of the magnetic field OPEN K. Ida, M. Yoshinuma, H. Tsuchiya, T. Kobayashi, C. Suzuki, M. Yokoyama, A. Shimizu, K. Nagaoka, S. Inagaki, K. Itoh, null null, T. Akiyama, M. Emoto, T. Evans, A. Dinklage, X. Du, K. Fujii, M. Goto, T. Goto, M. Hasuo et al. Understanding the transport of ions, electrons and heat in magnetized plasmas is important to the development of fusion power as well as our understanding of the behaviour of astrophysical objects. Ida et al. find that stochastization of magnetic field lines in a plasma damps plasma flow more strongly than expected. 08 January 2015 | doi: 10.1038/ncomms6816 Physical Sciences  Fluids and plasma physics  Maturation of the HIV-1 core by a non-diffusional phase transition OPEN Gabriel A. Frank, Kedar Narayan, Julian W. Bess, Gregory Q. Del Prete, Xiongwu Wu, Amy Moran, Lisa M. Hartnell, Lesley A. Earl, Jeffrey D. Lifson and Sriram Subramaniam Current models of HIV maturation involve the diffusion of the cleaved capsid protein into the viral core. Here, Frank et al. use cryo-electron tomography to characterize HIV assembly intermediates, and propose a novel maturation mechanism involving a non-diffusional phase transition. 08 January 2015 | doi: 10.1038/ncomms6854 Biological Sciences  Biochemistry  Virology  Membrane tension and peripheral protein density mediate membrane shape transitions Zheng Shi and Tobias Baumgart An ultrafast mechanism of endocytosis was recently discovered, and proposed to be dependent on local reduction in membrane tension. Shi and Baumgart provide experimental support for this hypothesis by quantifying the impact of membrane tension on membrane tubulation by endocytic proteins, such as endophilin A1. 08 January 2015 | doi: 10.1038/ncomms6974 Biological Sciences  Biophysics  Generation of spin currents by surface plasmon resonance OPEN K. Uchida, H. Adachi, D. Kikuchi, S. Ito, Z. Qiu, S. Maekawa and E. Saitoh Optical methods allow for the excitation of diverse magnetic phenomena in nanostructured materials. Here, Uchida et al. demonstrate how pure spin current may be generated across a Pt/BiY2Fe5O12 thin film interface by optically exciting surface plasmon resonance in embedded gold nanoparticles. 08 January 2015 | doi: 10.1038/ncomms6910 Physical Sciences  Condensed matter  Nanotechnology  Optical physics  Co-infection alters population dynamics of infectious disease OPEN Hanna Susi, Benoit Barrès, Pedro F. Vale and Anna-Liisa Laine Co-infection of plants with multiple pathogen strains is predicted to alter disease dynamics. Here, Susi et al. use experimental and natural population data to show that co-infected host plants spread more disease and cause more devastating epidemics than singly infected hosts. 08 January 2015 | doi: 10.1038/ncomms6975 Biological Sciences  Ecology  Plant sciences  A genome-wide association study of marginal zone lymphoma shows association to the HLA region OPEN Joseph Vijai, Zhaoming Wang, Sonja I. Berndt, Christine F. Skibola, Susan L. Slager, Silvia de Sanjose, Mads Melbye, Bengt Glimelius, Paige M. Bracci, Lucia Conde, Brenda M. Birmann, Sophia S. Wang, Angela R. Brooks-Wilson, Qing Lan, Paul I. W. de Bakker, Roel C. H. Vermeulen, Carol Portlock, Stephen M. Ansell, Brian K. Link, Jacques Riby et al. Marginal zone lymphoma (MZL) is a common subtype of B-cell non-Hodgkin lymphoma. Here the authors carry out a two-stage genome-wide association study in over 8,000 Europeans and identify two new MZL risk loci at chromosome 6p, implicating the major histocompatibility complex in the disease for the first time. 08 January 2015 | doi: 10.1038/ncomms6751 Biological Sciences  Cancer  Genetics  Visualizing cellular imaging data using PhenoPlot OPEN Heba Z. Sailem, Julia E. Sero and Chris Bakal Cellular imaging studies can generate large volumes of complex phenotypic data; however, presenting this information in a form that quickly conveys trends in the data set remains a challenge. Sailem et al. present a tool which translates such data into easily interpretable cell-like glyphs. 08 January 2015 | doi: 10.1038/ncomms6825 Biological Sciences  Bioinformatics  Camera-based three-dimensional real-time particle tracking at kHz rates and Ångström accuracy Alexander Huhle, Daniel Klaue, Hergen Brutzer, Peter Daldrop, Sihwa Joo, Oliver Otto, Ulrich F. Keyser and Ralf Seidel Particle tracking with ultra-high resolution in optical and magnetic tweezers has so far relied on laser detection through photodiodes. Here, Huhle et al. demonstrate three-dimensional particle tracking with Ångström accuracy and real-time GPU-accelerated data processing at kHz rates using camera-based imaging. 07 January 2015 | doi: 10.1038/ncomms6885 Physical Sciences  Biophysics  Nanotechnology  Experimental measurement-device-independent verification of quantum steering Sacha Kocsis, Michael J. W. Hall, Adam J. Bennet, Dylan J. Saunders and Geoff J. Pryde Quantum steering is a form of quantum non-locality that can be verified for arbitrarily low detection efficiencies and high losses at the price of requiring complete trust in one of the parties. Here, Kocsis et al. present measurement-device-independent steering protocols that remove this need for trust. 07 January 2015 | doi: 10.1038/ncomms6886 Physical Sciences  Optical physics  Theoretical physics  Volume and porosity thermal regulation in lipid mesophases by coupling mobile ligands to soft membranes OPEN Lucia Parolini, Bortolo M. Mognetti, Jurij Kotar, Erika Eiser, Pietro Cicuta and Lorenzo Di Michele DNA-functionalized particles can aggregate into materials with programmable morphology, but the response of these materials to external stimuli is limited. Here, the authors demonstrate how the structure of DNA-liposome aggregates can be controlled by changing temperature. 07 January 2015 | doi: 10.1038/ncomms6948 Physical Sciences  Condensed matter  Materials science  Phase steps and resonator detuning measurements in microresonator frequency combs Pascal Del’Haye, Aurélien Coillet, William Loh, Katja Beha, Scott B. Papp and Scott A. Diddams The nonlinear dynamic interaction between optical comb frequencies and microresonator modes are not yet fully understood. Here, the authors demonstrate a method to characterize microcomb states and observe discrete phase steps that have not been observed in conventional frequency combs. 07 January 2015 | doi: 10.1038/ncomms6668 Physical Sciences  Optical physics  Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice OPEN Linkang Zhou, Shi-Young Park, Li Xu, Xiayu Xia, Jing Ye, Lu Su, Kyeong-Hoon Jeong, Jang Ho Hur, Hyunhee Oh, Yoshikazu Tamori, Cristina M. Zingaretti, Saverio Cinti, Jesús Argente, Miao Yu, Lizhen Wu, Shenghong Ju, Feifei Guan, Hongyuan Yang, Cheol Soo Choi, David B. Savage et al. Fsp27 mediates ‘fusion’ of lipid droplets in mouse adipose tissue. Here, the authors investigate the physiological consequences of loss of Fsp27 in three different mouse models of ‘energetic overload’, and observe hepatic steatosis and insulin resistance but reduced adipose tissue inflammation. 07 January 2015 | doi: 10.1038/ncomms6949 Biological Sciences  Medical research  Crystallographic and spectroscopic snapshots reveal a dehydrogenase in action OPEN Lu Huo, Ian Davis, Fange Liu, Babak Andi, Shingo Esaki, Hiroaki Iwaki, Yoshie Hasegawa, Allen M. Orville and Aimin Liu Aldehydes are common intermediates in enzymatic pathways, but their high reactivity can make them difficult to observe. Here, the authors study the mechanism of aldehyde deactivation in a dehydrogenase, showing a key E/Z isomerization and observing a thiohemiacetal intermediate by crystal structure analysis. 07 January 2015 | doi: 10.1038/ncomms6935 Chemical Sciences  Biochemistry  Chemical biology  Physical chemistry  Sulphur-impregnated flow cathode to enable high-energy-density lithium flow batteries Hongning Chen, Qingli Zou, Zhuojian Liang, Hao Liu, Quan Li and Yi-Chun Lu Redox flow batteries are a promising technique for large-scale electricity storage, but suffer from low energy density and volumetric capacity. Here, the authors present a lithium redox flow battery with a sulphur-impregnated carbon composite as the catholyte, which leads to substantial performance improvement. 07 January 2015 | doi: 10.1038/ncomms6877 Chemical Sciences  Materials science  Physical chemistry  Proinflammatory TLR signalling is regulated by a TRAF2-dependent proteolysis mechanism in macrophages Jin Jin, Yichuan Xiao, Hongbo Hu, Qiang Zou, Yanchuan Li, Yanpan Gao, Wei Ge, Xuhong Cheng and Shao-Cong Sun Activation of Toll-like receptors induces inflammation, which is critical for defence against infection but can cause autoimmunity, and thus needs tight regulation. Here, the authors show that TRAF2 limits inflammatory responses downstream of these receptors by inducing degradation of IRF5 and c-Rel. 07 January 2015 | doi: 10.1038/ncomms6930 Biological Sciences  Immunology  ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling OPEN Steven Goossens, Enrico Radaelli, Odile Blanchet, Kaat Durinck, Joni Van der Meulen, Sofie Peirs, Tom Taghon, Cedric S. Tremblay, Magdaline Costa, Morvarid Farhang Ghahremani, Jelle De Medts, Sonia Bartunkova, Katharina Haigh, Claire Schwab, Natalie Farla, Tim Pieters, Filip Matthijssens, Nadine Van Roy, J. Adam Best, Kim Deswarte et al. Driver mutations in early T-cell precursor leukaemia (ETP-ALL) are poorly characterized. Here the authors show that Zeb2 overexpression is often found in ETP-ALL, can recapitulate the disease in transgenic mice and confers survival advantage by upregulating IL-7 signalling. 07 January 2015 | doi: 10.1038/ncomms6794 Biological Sciences  Cancer  Immunology  Medical research  Large resistivity modulation in mixed-phase metallic systems Yeonbae Lee, Z. Q. Liu, J. T. Heron, J. D. Clarkson, J. Hong, C. Ko, M. D. Biegalski, U. Aschauer, S. L. Hsu, M. E. Nowakowski, J. Wu, H. M. Christen, S. Salahuddin, J. B. Bokor, N. A. Spaldin, D. G. Schlom and R. Ramesh The control of magnetization by an electric field can offer new magnetic data devices. Here, controlling magnetic phases in FeRh, the authors achieve a large electroresistance response in FeRh/PMN-PT heterostructures by applying an electric field, which could be used for non-volatile memory applications. 07 January 2015 | doi: 10.1038/ncomms6959 Physical Sciences  Condensed matter  Materials science  A lysine-rich motif in the phosphatidylserine receptorPSR-1 mediates recognition and removal of apoptotic cells Hengwen Yang, Yu-Zen Chen, Yi Zhang, Xiaohui Wang, Xiang Zhao, James I. Godfroy, Qian Liang, Man Zhang, Tianying Zhang, Quan Yuan, Mary Ann Royal, Monica Driscoll, Ning-Shao Xia, Hang Yin and Ding Xue The phosphatidylserine receptor PSR-1 has been proposed to mediate recognition of apoptotic cells by phagocytes; however, this function has been contested. Yang et al. identify a lysine-rich motif in C. elegans PSR-1 that binds phosphatidylserine, and show that this motif is required for its phagocytic function. 07 January 2015 | doi: 10.1038/ncomms6717 Biological Sciences  Biochemistry  Cell biology    Nature Communications JOBS of the week Postdoctoral Research Assistant University of Bristol Research Advisor British Heart Foundation Postdoctoral Associate University of Florida PhD students ETH Zurich Research Associate University of Cambridge PhD Position Ulm University Faculty Position in Neuroscience North Carolina State University (NCSU) Research fellow Duke NUS Graduate Medical School Research Associate McGill University Research Fellow The University of Warwick More Science jobs from Nature Communications EVENT Nutritional Immunology: Role in Health and Disease 31.07.15 Lisbon, Portugal More science events from       Latest Corrigenda     Corrigendum: Protruding knob-like proteins violate local symmetries in an icosahedral marine virus Preeti Gipson, Matthew L. Baker, Desislava Raytcheva, Cameron Haase-Pettingell, Jacqueline Piret, Jonathan A. King and Wah Chiu 12 January 2015 | doi: 10.1038/ncomms7040 Biological Sciences  Bioinformatics  Biophysics  Virology      Corrigendum: IL-37 protects against obesity-induced inflammation and insulin resistance Dov B. Ballak, Janna A. van Diepen, Alexander R. Moschen, Henry J. Jansen, Anneke Hijmans, Gert-Jan Groenhof, Floris Leenders, Philip Bufler, Mark V. Boekschoten, Michael Müller, Sander Kersten, Suzhao Li, SooHyun Kim, Hadar Eini, Eli C. Lewis, Leo A. B. Joosten, Herbert Tilg, Mihai G. Netea, Cees J. Tack, Charles A. Dinarello et al. 12 January 2015 | doi: 10.1038/ncomms7039 Biological Sciences  Medical research      Corrigendum: The tumour suppressor LKB1 regulates myelination through mitochondrial metabolism Shabnam Pooya, Xiaona Liu, V. B. Sameer Kumar, Jane Anderson, Fumiyasu Imai, Wujuan Zhang, Georgianne Ciraolo, Nancy Ratner, Kenneth D. R. Setchell, Yutaka Yoshida, Michael P. Jankowski and Biplab Dasgupta 09 January 2015 | doi: 10.1038/ncomms7075 Biological Sciences  Neuroscience      Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com  More Nature Events You have been sent this Table of Contents Alert because you have opted in to receive it. 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