Nature Communications - 04 February 2015

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Weekly Content Alert 04 February 2015  Featured image: Hakanpaa et al. show that angiopoietin-2 destabilizes integrity of the endothelium by promoting the activation of β1 integrin Latest content: Articles Corrigenda Errata Journal homepage Recommend to library Web feed     Latest Articles View all Articles     The sperm of aging male bustards retards their offspring’s development OPEN Brian T. Preston, Michel Saint Jalme, Yves Hingrat, Frederic Lacroix and Gabriele Sorci Sperm from aging males may decline in quality, but it is unclear how aging affects the ability of males to produce successful offspring. Here, the authors show that paternal aging of captive long-lived houbara bustards reduces both the likelihood that eggs hatch and the rate at which chicks grow. 03 February 2015 | doi: 10.1038/ncomms7146 Biological Sciences  Evolution  Zoology  Wave kinetics of random fibre lasers OPEN D V. Churkin, I V. Kolokolov, E V. Podivilov, I D. Vatnik, M A. Nikulin, S S. Vergeles, I S. Terekhov, V V. Lebedev, G. Falkovich, S A. Babin and S K. Turitsyn Kinetic theory is a mathematical framework that is used to describe non-linear systems with a large number of degrees of freedom. Here, the authors develop a concept of active wave kinetics of cyclic systems and describe the function of random fibre laser. 03 February 2015 | doi: 10.1038/ncomms7214 Physical Sciences  Optical physics  Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor OPEN Spencer A. Freeman, Valentin Jaumouillé, Kate Choi, Brian E. Hsu, Harikesh S. Wong, Libin Abraham, Marcia L. Graves, Daniel Coombs, Calvin D. Roskelley, Raibatak Das, Sergio Grinstein and Michael R. Gold Microbial pathogens can activate both innate and adaptive receptors, and integration of these signals may enhance the sensitivity of the immune response. Freeman et al. show that innate microbial cues sensitize B cells to antigen by increasing actin dynamics and reducing the actin-dependent confinement of the B-cell receptor. 03 February 2015 | doi: 10.1038/ncomms7168 Biological Sciences  Immunology  ZNF143 provides sequence specificity to secure chromatin interactions at gene promoters Swneke D. Bailey, Xiaoyang Zhang, Kinjal Desai, Malika Aid, Olivia Corradin, Richard Cowper-Sal·lari, Batool Akhtar-Zaidi, Peter C. Scacheri, Benjamin Haibe-Kains and Mathieu Lupien Chromatin interactions can connect distal regulatory elements to promoters via protein factors, but few such factors have been identified. Here, the authors show that zinc-finger protein ZNF143 is a sequence-specific chromatin-looping factor that connects promoters with distal regulatory elements. 03 February 2015 | doi: 10.1038/ncomms7186 Biological Sciences  Genetics  Molecular biology  Emergence of terpene cyclization in Artemisia annua OPEN Melissa Salmon, Caroline Laurendon, Maria Vardakou, Jitender Cheema, Marianne Defernez, Sol Green, Juan A. Faraldos and Paul E. O’Maille Terpene cyclases are ring-forming enzymes found in many biosynthetic pathways, but the evolutionary origins of the cyclization mechanism is not well understood. Here, the authors use structure-guided breeding to identify an epistatic network that controls the onset of cyclization activity in Artemisia annua. 03 February 2015 | doi: 10.1038/ncomms7143 Biological Sciences  Biochemistry  Evolution  Plant sciences  Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation Virginie Vives, Gaëlle Cres, Christian Richard, Muriel Busson, Yann Ferrandez, Anne-Gaelle Planson, Mahel Zeghouf, Jacqueline Cherfils, Luc Malaval and Anne Blangy Small-molecule C21 inhibits Rac GTPase activation by Dock5, which decreases osteoclast activity in vitro. Using three mouse models where bone loss is caused by hyperactive osteoclasts, Vives et al. show that C21 treatment safely and efficiently prevents osteoporosis while preserving bone formation. 03 February 2015 | doi: 10.1038/ncomms7218 Biological Sciences  Medical research  Growth dynamics and gas transport mechanism of nanobubbles in graphene liquid cells Dongha Shin, Jong Bo Park, Yong-Jin Kim, Sang Jin Kim, Jin Hyoun Kang, Bora Lee, Sung-Pyo Cho, Byung Hee Hong and Konstantin S Novoselov Nanobubbles in liquid phase are puzzling, because their internal pressure is estimated to be unphysically large. Here, Shin et al. visualize the dynamics of nanobubbles in water encapsulated by graphene membrane and show fast gas diffusion through ultrathin water layer between two coalescing bubbles. 02 February 2015 | doi: 10.1038/ncomms7068 Physical Sciences  Applied physics  Fluids and plasma physics  Methylome sequencing in triple-negative breast cancer reveals distinct methylation clusters with prognostic value Clare Stirzaker, Elena Zotenko, Jenny Z. Song, Wenjia Qu, Shalima S. Nair, Warwick J. Locke, Andrew Stone, Nicola J. Armstong, Mark D. Robinson, Alexander Dobrovic, Kelly A. Avery-Kiejda, Kate M. Peters, Juliet D. French, Sandra Stein, Darren J. Korbie, Matt Trau, John F. Forbes, Rodney J. Scott, Melissa A. Brown, Glenn D. Francis et al. Triple-negative breast cancers (TNBCs) are a heterogeneous group of cancers with varying prognoses. Here, the authors carry out whole-genome methylation capture sequencing from TNBC samples and matched normal samples, and identify differentially methylated regions that define a potentially novel TNBC signature. 02 February 2015 | doi: 10.1038/ncomms6899 Biological Sciences  Cancer  Genetics  Sorting of small infectious virus particles by flow virometry reveals distinct infectivity profiles Raphaël Gaudin and Natasha S Barteneva Individual viral particles can display heterogeneity in their composition of lipids, proteins or nucleic acids. Here, the authors apply advanced flow cytometry techniques to sort Junin virus particles and show that particle size and envelope glycoprotein concentration correlate with infectivity. 02 February 2015 | doi: 10.1038/ncomms7022 Biological Sciences  Virology  Hierarchical densification and negative thermal expansion in Ce-based metallic glass under high pressure Qiang Luo, Gaston Garbarino, Baoan Sun, Dawei Fan, Yue Zhang, Zhi Wang, Yajuan Sun, Jin Jiao, Xiaodong Li, Pengshan Li, Norbert Mattern, Jürgen Eckert and Jun Shen Metallic glasses show polyamorphous features, while the nature of the transformation between those amorphous structures is still unclear. Here, Luo et al. propose a pressure-induced hierarchical densification to explain a transformation in Ce-based metallic glass near glass transition temperature. 02 February 2015 | doi: 10.1038/ncomms6703 Physical Sciences  Condensed matter  Materials science  Targeting protein tyrosine phosphatase σ after myocardial infarction restores cardiac sympathetic innervation and prevents arrhythmias OPEN R. T. Gardner, L. Wang, B. T. Lang, J. M. Cregg, C. L. Dunbar, W. R. Woodward, J. Silver, C. M. Ripplinger and B. A. Habecker Chondroitin sulfate proteoglycans (CSP) in the myocardial scar inhibit the tissue’s reinnervation, rendering it prone to arrhythmia. Here the authors show that blocking the activity of the CSP receptor, protein tyrosine phosphatase receptor σ, promotes scar reinnervation and prevents arrhythmia in mice. 02 February 2015 | doi: 10.1038/ncomms7235 Biological Sciences  Medical research  Ultrasensitive and label-free molecular-level detection enabled by light phase control in magnetoplasmonic nanoantennas Nicolò Maccaferri, Keith E. Gregorczyk, Thales V. A. G. de Oliveira, Mikko Kataja, Sebastiaan van Dijken, Zhaleh Pirzadeh, Alexandre Dmitriev, Johan Åkerman, Mato Knez and Paolo Vavassori Ferromagnetic nanoantennas support plasmons and exhibit magneto-optical activity under external magnetic fields. Maccaferri et al. show how designed phase compensation in the electric response of these nanostructures enables them to act as ultrasensitive label-free molecular sensors with high figures of merit. 02 February 2015 | doi: 10.1038/ncomms7150 Physical Sciences  Analytical chemistry  Applied physics  Nanotechnology  Tumour suppressor TRIM33 targets nuclear β-catenin degradation Jianfei Xue, Yaohui Chen, Yamei Wu, Zhongyong Wang, Aidong Zhou, Sicong Zhang, Kangyu Lin, Kenneth Aldape, Sadhan Majumder, Zhimin Lu and Suyun Huang Aberrant activation of β-catenin in the nucleus has been implicated in several cancers, but the mechanisms regulating nuclear β-catenin are not well understood. Here the authors identify Trim33 as new E3 ligase targeting nuclear β-catenin independently of Wnt signal. 02 February 2015 | doi: 10.1038/ncomms7156 Biological Sciences  Cancer  Molecular biology  A high-throughput optomechanical retrieval method for sequence-verified clonal DNA from the NGS platform OPEN Howon Lee, Hyoki Kim, Sungsik Kim, Taehoon Ryu, Hwangbeom Kim, Duhee Bang and Sunghoon Kwon One of the biggest bottlenecks in large-scale DNA synthesis is the retrieval of target clonal DNA from high-density sequencing platforms. Here, the authors present a method called ‘Sniper Cloning’ that allows for precise mapping of target clone features and rapid retrieval of targets for full utilization of DNA clones. 02 February 2015 | doi: 10.1038/ncomms7073 Biological Sciences  Genetics  Molecular biology  Complete architecture of the archaeal RNA polymerase open complex from single-molecule FRET and NPS Julia Nagy, Dina Grohmann, Alan C.M. Cheung, Sarah Schulz, Katherine Smollett, Finn Werner and Jens Michaelis The archaeal RNA transcription machinery does not have a dedicated helicase factor. Here, the authors report the three-dimensional architecture of the open complex of DNA, RNA polymerase and its associated factors from M. jannaschii, providing a possible mechanism for promoter DNA melting. 30 January 2015 | doi: 10.1038/ncomms7161 Biological Sciences  Biochemistry  Biophysics  Dietary restriction protects against experimental cerebral malaria via leptin modulation and T-cell mTORC1 suppression Pedro Mejia, J. Humberto Treviño-Villarreal, Christopher Hine, Eylul Harputlugil, Samantha Lang, Ediz Calay, Rick Rogers, Dyann Wirth, Manoj T. Duraisingh and James R. Mitchell Nutrition can affect the outcome of infectious diseases through its effects on pathogens and/or host immunity. Here, Mejia et al. show that dietary restriction protects from experimental cerebral malaria in mice through its effects on leptin and mTORC1 in T cells. 30 January 2015 | doi: 10.1038/ncomms7050 Biological Sciences  Immunology  Medical research  Microbiology  Ultimately short ballistic vertical graphene Josephson junctions OPEN Gil-Ho Lee, Sol Kim, Seung-Hoon Jhi and Hu-Jong Lee The functionality of Josephson junctions—a thin insulating layer between two superconducting regions—is greatly enhanced by using hybrid material systems. Here, the authors incorporate graphene into a Josephson junction and demonstrate ballistic transport through the atom-thick layer. 30 January 2015 | doi: 10.1038/ncomms7181 Physical Sciences  Applied physics  Nanotechnology  Endothelial destabilization by angiopoietin-2 via integrin β1 activation OPEN Laura Hakanpaa, Tuomas Sipila, Veli-Matti Leppanen, Prson Gautam, Harri Nurmi, Guillaume Jacquemet, Lauri Eklund, Johanna Ivaska, Kari Alitalo and Pipsa Saharinen Angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) have opposing effects on vascular stability through their receptor Tie2, but there is evidence for Tie2-independent functions of Ang2. Here, Hakanpaa et al. show that Ang2 directly activates β1-integrin, leading to rearrangement of the actin cytoskeleton and decreased VE-cadherin in cell–cell junctions. 30 January 2015 | doi: 10.1038/ncomms6962 Biological Sciences  Cell biology  NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes Maria Soledad Sosa, Falguni Parikh, Alexandre Gaspar Maia, Yeriel Estrada, Almudena Bosch, Paloma Bragado, Esther Ekpin, Ajish George, Yang Zheng, Hung-Ming Lam, Colm Morrissey, Chi-Yeh Chung, Eduardo F. Farias, Emily Bernstein and Julio A. Aguirre-Ghiso Tumour cells disseminated from the primary tumour can remain dormant for years before initiating metastases. Here Sosa et al. show that the orphan nuclear receptor NR2F1 can be induced by bone marrow cues and by epigenetic drugs to promote quiescence and tumour cell dormancy in several cancer types. 30 January 2015 | doi: 10.1038/ncomms7170 Biological Sciences  Cancer  Ultrasmooth organic–inorganic perovskite thin-film formation and crystallization for efficient planar heterojunction solar cells Wei Zhang, Michael Saliba, David T. Moore, Sandeep K. Pathak, Maximilian T. Hörantner, Thomas Stergiopoulos, Samuel D. Stranks, Giles E. Eperon, Jack A. Alexander-Webber, Antonio Abate, Aditya Sadhanala, Shuhua Yao, Yulin Chen, Richard H. Friend, Lara A. Estroff, Ulrich Wiesner and Henry J. Snaith Organic-inorganic metal halide perovskites are of considerable promise for efficient, easy to manufacture solar cells. Here, the authors show that the choice of anions in the perovskite solution can considerably affect the crystal growth and performance of these solar cells. 30 January 2015 | doi: 10.1038/ncomms7142 Physical Sciences  Applied physics  Materials science  Optical physics  Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan OPEN Markus Schosserer, Nadege Minois, Tina B. Angerer, Manuela Amring, Hanna Dellago, Eva Harreither, Alfonso Calle-Perez, Andreas Pircher, Matthias Peter Gerstl, Sigrid Pfeifenberger, Clemens Brandl, Markus Sonntagbauer, Albert Kriegner, Angela Linder, Andreas Weinhäusel, Thomas Mohr, Matthias Steiger, Diethard Mattanovich, Mark Rinnerthaler, Thomas Karl et al. Cellular pathways modulating longevity and stress resistance are known to affect protein translation. Here the authors show that the RNA methyltransferase, Nsun5, or its yeast homologue Rcm1, regulates lifespan of three different model organisms by modifying ribosomal RNA at a specific cytosine residue. 30 January 2015 | doi: 10.1038/ncomms7158 Biological Sciences  Medical research  Molecular biology  Ambient seafloor noise excited by earthquakes in the Nankai subduction zone OPEN Takashi Tonegawa, Yoshio Fukao, Tsutomu Takahashi, Koichiro Obana, Shuichi Kodaira and Yoshiyuki Kaneda Excitations of seismic background noise are mostly related to fluid disturbances, and earthquakes have not been considered as a source due to their intermittent nature. Here, the authors use a seabed hydrophone array and show that background noise offshore Japan is mainly due to small earthquakes. 30 January 2015 | doi: 10.1038/ncomms7132 Earth Sciences  Prospective errors determine motor learning OPEN Ken Takiyama, Masaya Hirashima and Daichi Nozaki Motor learning is characterized by diverse cognitive processes, which lack a unified theoretical framework. Here, Takiyama et al. present a model demonstrating that motor learning is determined by prospective errors, which they test in a specially designed visuomotor adaptation task. 30 January 2015 | doi: 10.1038/ncomms6925 Biological Sciences  Neuroscience  Macrotene chromosomes provide insights to a new mechanism of high-order gene amplification in eukaryotes OPEN Agnès Thierry, Varun Khanna, Sophie Créno, Ingrid Lafontaine, Laurence Ma, Christiane Bouchier and Bernard Dujon Copy number variation is an important source of genetic variation in natural populations and may have a role in human disease. Here, the authors identify high-order amplification structures that form large extended chromosomes and suggest that these may occur due to accidental template switching in stress conditions. 30 January 2015 | doi: 10.1038/ncomms7154 Biological Sciences  Genetics  Molecular biology  Massive band gap variation in layered oxides through cation ordering Prasanna V. Balachandran and James M. Rondinelli Understanding and controlling the electronic band gap of a material is vital for many electronic and optoelectronic applications. Towards this aim, this study shows how huge band gap variations can arise by manipulating the electrostatic interactions via cation ordering in correlated oxide materials. 30 January 2015 | doi: 10.1038/ncomms7191 Physical Sciences  Condensed matter  Materials science  Theoretical physics  Augmented AMPK activity inhibits cell migration by phosphorylating the novel substrate Pdlim5 OPEN Yi Yan, Osamu Tsukamoto, Atsushi Nakano, Hisakazu Kato, Hidetaka Kioka, Noriaki Ito, Shuichiro Higo, Satoru Yamazaki, Yasunori Shintani, Ken Matsuoka, Yulin Liao, Hiroshi Asanuma, Masanori Asakura, Kazuaki Takafuji, Tetsuo Minamino, Yoshihiro Asano, Masafumi Kitakaze and Seiji Takashima Augmented AMP-activated protein kinase (AMPK) activity inhibits cell migration through an unknown mechanism. Here, Yan et al. show that AMPK phosphorylates the novel substrate PDZ and LIM domain 5 (Pdlim5), and that phosphomimetic Pdlim5 impairs cell migration by disrupting the Rac1-Arp2/3 signalling pathway. 30 January 2015 | doi: 10.1038/ncomms7137 Biological Sciences  Cell biology  Emergence of coherence via transverse condensation in a uniform quasi-two-dimensional Bose gas Lauriane Chomaz, Laura Corman, Tom Bienaimé, Rémi Desbuquois, Christof Weitenberg, Sylvain Nascimbène, Jérôme Beugnon and Jean Dalibard Interacting quantum many-body systems in low dimensions is an active research area in ultra-cold gases. Here, Chomaz et al. study the dimensional crossover of Bose–Einstein condensation and observe the emergence of phase coherence in an ultra-cold quasi-2D Bose gas confined to a flat-bottom trapping potential. 30 January 2015 | doi: 10.1038/ncomms7162 Physical Sciences  Atomic and molecular physics  Condensed matter  Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity Akihiro Fujimoto, Mayuko Furuta, Yuichi Shiraishi, Kunihito Gotoh, Yoshiiku Kawakami, Koji Arihiro, Toru Nakamura, Masaki Ueno, Shun-ichi Ariizumi, Ha Hai Nguyen, Daichi Shigemizu, Tetsuo Abe, Keith A. Boroevich, Kaoru Nakano, Aya Sasaki, Rina Kitada, Kazihiro Maejima, Yujiro Yamamoto, Hiroko Tanaka, Tetsuo Shibuya et al. Intrahepatic cholangiocarcinoma and combined hepatocellular cholangiocarcinoma displaying biliary phenotypes are aggressive cancers. Fujimoto et al. characterize the mutational profile of chronic hepatitis and identify mutations in KRAS and IDH associated with poor survival. 30 January 2015 | doi: 10.1038/ncomms7120 Biological Sciences  Cancer  Hydrophobic mismatch sorts SNARE proteins into distinct membrane domains OPEN Dragomir Milovanovic, Alf Honigmann, Seiichi Koike, Fabian Göttfert, Gesa Pähler, Meike Junius, Stefan Müllar, Ulf Diederichsen, Andreas Janshoff, Helmut Grubmüller, Herre J. Risselada, Christian Eggeling, Stefan W. Hell, Geert van den Bogaart and Reinhard Jahn Clustering of proteins in the plasma membrane plays an important role in the regulation of both cellular signalling and membrane remodelling. Milovanovic et al. demonstrate that mismatch between transmembrane domain length and the lipid bilayer thickness is sufficient to drive clustering of SNARE proteins. 30 January 2015 | doi: 10.1038/ncomms6984 Biological Sciences  Biophysics  Cell biology  De novo design of an RNA tile that self-assembles into a homo-octameric nanoprism Jinwen Yu, Zhiyu Liu, Wen Jiang, Guansong Wang and Chengde Mao The rational design of nucleic acid nanostructures requires building blocks that can be predictably combined into a uniform structure. Here, the authors present a designed RNA building block able to self-assemble into a homo-octameric cube. 30 January 2015 | doi: 10.1038/ncomms6724 Chemical Sciences  Nanotechnology  Generalization of word meanings during infant sleep OPEN Manuela Friedrich, Ines Wilhelm, Jan Born and Angela D. Friederici In adults, oscillatory brain activity during sleep is related to memory consolidation. Here, the authors measure brain activity from infants who are exposed to novel word meanings, and show that infant sleep results in the retention and reorganization of recently encoded memories. 29 January 2015 | doi: 10.1038/ncomms7004 Biological Sciences  Neuroscience  Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques Carlo Condello, Peng Yuan, Aaron Schain and Jaime Grutzendler In Alzheimer’s disease (AD), β-amyloid plaques are tightly enveloped by microglia but the significance of this phenomenon is unknown. Here the authors used confocal and in vivo two-photon imaging in AD mouse models and revealed that microglia constitute a barrier that seems to prevent the formation of neurotoxic hotspots of protofibrillar β-amyloid. 29 January 2015 | doi: 10.1038/ncomms7176 Biological Sciences  Neuroscience  An oncogenic role of Agrin in regulating focal adhesion integrity in hepatocellular carcinoma OPEN Sayan Chakraborty, Manikandan Lakshmanan, Hannah L.F. Swa, Jianxiang Chen, Xiaoqian Zhang, Yan Shan Ong, Li Shen Loo, Semih Can Akıncılar, Jayantha Gunaratne, Vinay Tergaonkar, Kam M. Hui and Wanjin Hong The proteoglycan Agrin is known to be expressed in neurons and muscle and to bind ECM protein laminin. Here the authors report that Agrin promotes hepatocellular carcinoma by stimulating proliferation, decreasing focal adhesion, increasing invasiveness and promoting an epithelial-to-mesenchymal transition. 29 January 2015 | doi: 10.1038/ncomms7184 Biological Sciences  Cancer  Molecular biology  The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity Quan Li, Moe Yokoshi, Hitomi Okada and Yukio Kawahara TAR DNA-binding protein of 43 kDa (TDP-43) and its C-terminal fragment of 25 kDa (CTF25) play critical roles in several neurodegenerative diseases but the cleavage site that generates CTF25 remains undetermined. Here the authors show that caspase-4 cleaves TDP-43 after Aps174 generating CTF25, and this leads to TDP-43 clearance and increased cell viability. 29 January 2015 | doi: 10.1038/ncomms7183 Biological Sciences  Cell biology  Neuroscience  Turnover time of fluorescent dissolved organic matter in the dark global ocean Teresa S. Catalá, Isabel Reche, Antonio Fuentes-Lema, Cristina Romera-Castillo, Mar Nieto-Cid, Eva Ortega-Retuerta, Eva Calvo, Marta Álvarez, Cèlia Marrasé, Colin A. Stedmon and X. Antón Álvarez-Salgado The microbial carbon pump may play an important role in carbon sequestration in the deep ocean, but quantifying organic matter in this dark realm is difficult. Here, the authors use fluorescence spectroscopy to investigate the turnover time of fluorescent dissolved organic matter. 29 January 2015 | doi: 10.1038/ncomms6986 Earth Sciences  Biogeochemistry  Oceanography  Probing electric field control of magnetism using ferromagnetic resonance Ziyao Zhou, Morgan Trassin, Ya Gao, Yuan Gao, Diana Qiu, Khalid Ashraf, Tianxiang Nan, Xi Yang, S. R. Bowden, D. T. Pierce, M. D. Stiles, J. Unguris, Ming Liu, Brandon M. Howe, Gail J. Brown, S. Salahuddin, R. Ramesh and Nian X. Sun Multiferroic BiFeO3 is promising for applications where electric and magnetic fields need to be coupled, for example, in magnetic data storage. Here, combining theory and experiment the authors provide a microscopic insight into the switching of magnetization by electric fields in BiFeO3. 29 January 2015 | doi: 10.1038/ncomms7082 Physical Sciences  Condensed matter  Materials science  ROW1 maintains quiescent centre identity by confining WOX5 expression to specific cells OPEN Yuzhou Zhang, Yue Jiao, Zhaohui Liu and Yu-Xian Zhu The quiescent centre controls stem cell differentiation at the root apical meristem. Here Zhang et al. propose that ROW1 maintains meristem cell identity by repressing expression of the WOX5 transcription factor in the proximal meristem zone, thus confining its activity to the quiescent centre. 29 January 2015 | doi: 10.1038/ncomms7003 Biological Sciences  Plant sciences  Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility OPEN Jennifer Wessel, Audrey Y Chu, Sara M Willems, Shuai Wang, Hanieh Yaghootkar, Jennifer A Brody, Marco Dauriz, Marie-France Hivert, Sridharan Raghavan, Leonard Lipovich, Bertha Hidalgo, Keolu Fox, Jennifer E Huffman, Ping An, Yingchang Lu, Laura J Rasmussen-Torvik, Niels Grarup, Margaret G Ehm, Li Li, Abigail S Baldridge et al. Both rare and common variants contribute to the aetiology of complex traits such as type 2 diabetes (T2D). Here, the authors examine the effect of coding variation on glycaemic traits and T2D, and identify low-frequency variation in GLP1R significantly associated with these traits. 29 January 2015 | doi: 10.1038/ncomms6897 Biological Sciences  Genetics  Purely hydrodynamic ordering of rotating disks at a finite Reynolds number Yusuke Goto and Hajime Tanaka A theoretical description of hydrodynamic interaction between particles is challenging due to its long-rang nature and many-body effect. Here, the authors numerically show rich phase ordering caused by the hydrodynamic interaction in a model system of rotating disks immersed in a two-dimensional fluid. 28 January 2015 | doi: 10.1038/ncomms6994 Physical Sciences  Applied physics  Fluids and plasma physics  Theoretical physics  New loci and coding variants confer risk for age-related macular degeneration in East Asians OPEN Ching-Yu Cheng, Kenji Yamashiro, Li Jia Chen, Jeeyun Ahn, Lulin Huang, Lvzhen Huang, Chui Ming G. Cheung, Masahiro Miyake, Peter D. Cackett, Ian Y. Yeo, Augustinus Laude, Ranjana Mathur, Junxiong Pang, Kar Seng Sim, Adrian H. Koh, Peng Chen, Shu Yen Lee, Doric Wong, Choi Mun Chan, Boon Kwang Loh et al. Age-related macular degeneration (AMD) is a major cause of blindness worldwide. Here, the authors carry out a two-stage genome-wide association study for AMD and identify three new AMD risk loci, highlighting the shared and distinct genetic basis of the disease in East Asians and Europeans. 28 January 2015 | doi: 10.1038/ncomms7063 Biological Sciences  Genetics  ADAM8 as a drug target in pancreatic cancer Uwe Schlomann, Garrit Koller, Catharina Conrad, Taheera Ferdous, Panagiota Golfi, Adolfo Molejon Garcia, Sabrina Höfling, Maddy Parsons, Patricia Costa, Robin Soper, Maud Bossard, Thorsten Hagemann, Rozita Roshani, Norbert Sewald, Randal R. Ketchem, Marcia L. Moss, Fred H. Rasmussen, Miles A. Miller, Douglas A. Lauffenburger, David A. Tuveson et al. Expression of ADAM8, a metalloprotease disintegrin, correlates with worse prognosis in pancreatic adenocarcinoma (PDAC). Here Schlomann et al. show that ADAM8 promotes PDAC invasiveness, and develop a peptide inhibitor that blocks ADAM8 function and impedes PDAC progression in mouse models. 28 January 2015 | doi: 10.1038/ncomms7175 Biological Sciences  Cancer  Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence Régis Joulia, Nicolas Gaudenzio, Magda Rodrigues, Jodie Lopez, Nicolas Blanchard, Salvatore Valitutti and Eric Espinosa Mast cells are tissue-resident immune cells important for clearance of parasitic worms but also mediating allergic reactions. Here Joulia et al. show that human mast cells form degranulatory synapses with antibody-targeted cells and pathogens to increase efficiency and minimize off-target effects. 28 January 2015 | doi: 10.1038/ncomms7174 Biological Sciences  Immunology  Seeded growth of highly crystalline molybdenum disulphide monolayers at controlled locations Gang Hee Han, Nicholas J. Kybert, Carl H. Naylor, Bum Su Lee, Jinglei Ping, Joo Hee Park, Jisoo Kang, Si Young Lee, Young Hee Lee, Ritesh Agarwal and A. T. Charlie Johnson Although synthesis of high-quality MoS2 has been demonstrated, growth of monolayer MoS2 at controlled locations is highly desirable for applications. Here, the authors introduce a method where patterned seeds of molybdenum source material are used to grow isolated flakes at predetermined locations. 28 January 2015 | doi: 10.1038/ncomms7128 Physical Sciences  Materials science  Nanotechnology  Topological superconductivity and unconventional pairing in oxide interfaces Mathias S. Scheurer and Jörg Schmalian When the insulators SrTiO3 and LaAlO3 are brought together, a two-dimensional electron gas forms that exhibits both superconductivity and magnetic behaviour. Mathias Scheurer and Jörg Schmalian propose a link between the topological nature of the superconducting state and its microscopic mechanism. 28 January 2015 | doi: 10.1038/ncomms7005 Physical Sciences  Condensed matter  Coherent spin control of a nanocavity-enhanced qubit in diamond Luozhou Li, Tim Schröder, Edward H. Chen, Michael Walsh, Igal Bayn, Jordan Goldstein, Ophir Gaathon, Matthew E. Trusheim, Ming Lu, Jacob Mower, Mircea Cotlet, Matthew L. Markham, Daniel J. Twitchen and Dirk Englund Nitrogen-vacancy centres in diamond have established themselves as excellent candidates for solid-state quantum memories due to their optical addressability and long coherence times. Here, the authors report on a diamond-nanocavity system with improved spin-photon interface performances. 28 January 2015 | doi: 10.1038/ncomms7173 Physical Sciences  Applied physics  Nanotechnology  Temporal and spatial regulation of translation in the mammalian oocyte via the mTOR–eIF4F pathway OPEN Andrej Susor, Denisa Jansova, Renata Cerna, Anna Danylevska, Martin Anger, Tereza Toralova, Radek Malik, Jaroslava Supolikova, Matthew S. Cook, Jeong Su Oh and Michal Kubelka Meiotic maturation of oocytes and early development of mammalian embryos is largely dependent on the translation of mRNAs stored in the oocyte. Here the authors uncover a population of mRNA retained in the oocyte nucleus whose translation is spatially and temporally regulated by the mTOR–eIF4F pathway during meiosis. 28 January 2015 | doi: 10.1038/ncomms7078 Biological Sciences  Cell biology  Developmental biology    Nature Communications JOBS of the week Post doctoral fellow Icahn School of Medicine at Mount Sinai Research Assistant / Associate University of Cambridge - Sainsbury Laboratory Research Associate (Fixed Term) University of Cambridge Pre-doctoral researcher University of Vienna (Universitaet Wien) Postdoctoral Fellow Medical University of South Carolina postdoctoral fellow University of Kentucky College of Medicine Postdoctoral Researcher John Innes Centre (JIC) Ph.D. Studentship University of St Andrews Research Assistant University of Bristol More Science jobs from Nature Communications EVENT Evolution 2015 26.06.15 Guarujá, Brazil More science events from       Latest Corrigenda     Corrigendum: Growth and modelling of spherical crystalline morphologies of molecular materials O Shalev, S Biswas, Y Yang, T Eddir, O Ahanotu, W Lu, R Clarke and M Shtein 03 February 2015 | doi: 10.1038/ncomms7038 Physical Sciences  Applied physics  Materials science      Corrigendum: Photoinitiated charge separation in a hybrid titanium dioxide metalloporphyrin peptide material H. Christopher Fry, Yuzi Liu, Nada M Dimitrijevic and Tijana Rajh 02 February 2015 | doi: 10.1038/ncomms6109 Chemical Sciences  Inorganic chemistry  Nanotechnology      Corrigendum: PICALM modulates autophagy activity and tau accumulation Kevin Moreau, Angeleen Fleming, Sara Imarisio, Ana Lopez Ramirez, Jacob L. Mercer, Maria Jimenez-Sanchez, Carla F. Bento, Claudia Puri, Eszter Zavodszky, Farah Siddiqi, Catherine P. Lavau, Maureen Betton, Cahir J. O'Kane, Daniel S. Wechsler and David C. Rubinsztein 28 January 2015 | doi: 10.1038/ncomms7110 Biological Sciences  Cell biology  Neuroscience      Corrigendum: Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline Violette Da Cunha, Mark R. Davies, Pierre-Emmanuel Douarre, Isabelle Rosinski-Chupin, Immaculada Margarit, Sebastien Spinali, Tim Perkins, Pierre Lechat, Nicolas Dmytruk, Elisabeth Sauvage, Laurence Ma, Benedetta Romi, Magali Tichit, Maria-José Lopez-Sanchez, Stéphane Descorps-Declere, Erika Souche, Carmen Buchrieser, Patrick Trieu-Cuot, Ivan Moszer, Dominique Clermont et al. 28 January 2015 | doi: 10.1038/ncomms7108 Biological Sciences  Evolution  Genetics  Microbiology      Corrigendum: A pan-cancer proteomic perspective on The Cancer Genome Atlas Rehan Akbani, Patrick Kwok Shing Ng, Henrica M.J. Werner, Maria Shahmoradgoli, Fan Zhang, Zhenlin Ju, Wenbin Liu, Ji-Yeon Yang, Kosuke Yoshihara, Jun Li, Shiyun Ling, Elena G. Seviour, Prahlad T. Ram, John D. Minna, Lixia Diao, Pan Tong, John V. Heymach, Steven M. Hill, Frank Dondelinger, Nicolas Städler et al. 28 January 2015 | doi: 10.1038/ncomms5852 Biological Sciences  Bioinformatics  Cancer        Latest Errata     Erratum: Hydrogen bond rotations as a uniform structural tool for analyzing protein architecture Robert C. Penner, Ebbe S. Andersen, Jens L. Jensen, Adriana K. Kantcheva, Maike Bublitz, Poul Nissen, Anton M.H. Rasmussen, Katrine L. Svane, Bjørk Hammer, Reza Rezazadegan, Niels Chr Nielsen, Jakob T. Nielsen and Jørgen E. Andersen 03 February 2015 | doi: 10.1038/ncomms7209 Biological Sciences  Biochemistry  Biophysics      Erratum: Slow-light-enhanced gain in active photonic crystal waveguides Sara Ek, Per Lunnemann, Yaohui Chen, Elizaveta Semenova, Kresten Yvind and Jesper Mork 30 January 2015 | doi: 10.1038/ncomms6596 Physical Sciences  Applied physics  Nanotechnology  Optical physics      Erratum: Camelid genomes reveal evolution and adaptation to desert environments Huiguang Wu, Xuanmin Guang, Mohamed B. Al-Fageeh, Junwei Cao, Shengkai Pan, Huanmin Zhou, Li Zhang, Mohammed H. Abutarboush, Yanping Xing, Zhiyuan Xie, Ali S. Alshanqeeti, Yanru Zhang, Qiulin Yao, Badr M. Al-Shomrani, Dong Zhang, Jiang Li, Manee M. Manee, Zili Yang, Linfeng Yang, Yiyi Liu et al. 28 January 2015 | doi: 10.1038/ncomms7107 Biological Sciences  Evolution  Genetics      Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com  More Nature Events You have been sent this Table of Contents Alert because you have opted in to receive it. 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