Nature Communications - 11 February 2015

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Advertisement Avoid accidental plagiarism with this free white paper by an AJE editor & PhD. Make sure you're citing correctly and thoroughly. Avoid common pitfalls (and the resulting embarrassment when a journal notices). Download "In Your Own Words: Best Practices for Avoiding Plagiarism." AJE© provides publication services and resources for researchers. A division of Research Square©.     Weekly Content Alert 11 February 2015  Featured image: Vericella et al. use polymer microcapsules composed of liquid carbonate cores and highly permeable silicone shells for carbon dioxide capture. Latest content: Articles Corrigenda Errata Advertisement Nature Communications is now fully open access All new submissions to Nature Communications, if accepted, will be published open access and an article processing charge will apply. For more information visit the website. Many research funders and institutions make funds available to pay open access APCs: please consult our open access funding page to check if your funder or institution has funding available. For advice on whether you are eligible for APC funding and help in approaching funders and institutions please contact us at openaccess@nature.com. Journal homepage Recommend to library Web feed   Advertisement Scientific Editing:  MSC Scientific Editing gives your research article a high-quality scientific edit that can help you make an impact on your intended audience.  Nature-standard editing - English language edit included - Specialist editors in your subject area. Find out more today.      Latest Articles View all Articles     Structural characterization of a protective epitope spanning A(H1N1)pdm09 influenza virus neuraminidase monomers OPEN Hongquan Wan, Hua Yang, David A. Shore, Rebecca J. Garten, Laura Couzens, Jin Gao, Lianlian Jiang, Paul J. Carney, Julie Villanueva, James Stevens and Maryna C. Eichelberger Neuraminidase inhibitors offer a line of defence against flu infections, but resistance can occur even in the absence of prior exposure. Here Wan et al. describe the mode of action of CD6, a monoclonal antibody that protects against a common influenza strain, as a new therapeutic intervention model. 10 February 2015 | doi: 10.1038/ncomms7114 Biological Sciences  Medical research  Virology  Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation Ping-xia Zhang, Jijun Cheng, Siying Zou, Anthony D. D'Souza, Jonathan L. Koff, Jun Lu, Patty J. Lee, Diane S. Krause, Marie E. Egan and Emanuela M. Bruscia Hyperinflammation in cystic fibrosis has been linked to decreased levels of caveolin-1, resulting in higher LPS responsiveness of TLR4. Here the authors show that in a mouse model of cystic fibrosis decreased Akt results in accumulation of miR-199a-5p directly targeting caveolin-1 in macrophages. 10 February 2015 | doi: 10.1038/ncomms7221 Biological Sciences  Immunology  Off-target-free gene delivery by affinity-purified receptor-targeted viral vectors Robert C. Münch, Anke Muth, Alexander Muik, Thorsten Friedel, Julia Schmatz, Birgit Dreier, Alexandra Trkola, Andreas Plückthun, Hildegard Büning and Christian J. Buchholz The clinical use of adeno-associated virus vectors (AAVs) has been limited by the lack of transduction specificity. Here the authors show that receptor-targeted, affinity-tagged, and purified AVVs reach tumours in mouse models with high selectivity and efficiency, outperforming therapeutic antibodies. 10 February 2015 | doi: 10.1038/ncomms7246 Biological Sciences  Biotechnology  Cancer  Improving image contrast and material discrimination with nonlinear response in bimodal atomic force microscopy OPEN Daniel Forchheimer, Robert Forchheimer and David B. Haviland Bimodal atomic force microscopy is a promising approach in obtaining high-quality image contrast and material property mapping. Here, the authors show that by considering nonlinear response in bimodal atomic force microscopy, significant improvements in image contrast and material discrimination can be achieved. 10 February 2015 | doi: 10.1038/ncomms7270 Physical Sciences  Applied physics  Materials science  Nanotechnology  A rapid bioluminescence assay for measuring myeloperoxidase activity in human plasma OPEN Reece J. Goiffon, Sara C. Martinez and David Piwnica-Worms Levels of the enzyme myeloperoxidase in the blood are considered a biomarker for the severity of cardiovascular disease. Here the authors report a rapid and inexpensive method for measuring myeloperoxidase activity in human plasma by luminescence, after adsorption of the enzyme to a polymer surface. 10 February 2015 | doi: 10.1038/ncomms7271 Biological Sciences  Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis Bingning Dong, Ju-Seog Lee, Yun-Yong Park, Feng Yang, Ganyu Xu, Wendong Huang, Milton J. Finegold and David D. Moore Activation of the liver receptor CAR and β-catenin are both involved in hepatocellular carcinoma. Here, the authors show that combined activation of both CAR and β-catenin in mice can drive uncontrolled liver growth and is sufficient for hepatocarcinogenesis. 09 February 2015 | doi: 10.1038/ncomms6944 Biological Sciences  Cancer  Molecular biology  Electron paramagnetic resonance imaging for real-time monitoring of Li-ion batteries OPEN M. Sathiya, J.-B. Leriche, E. Salager, D. Gourier, J.-M. Tarascon and H. Vezin It is important as well as challenging to in situ probe redox mechanisms occurring at battery electrodes. Here, the authors develop an in situ electron paramagnetic resonance imaging technique and provide measurements on the nucleation growth of the anionic and cationic redox species at a battery electrode. 09 February 2015 | doi: 10.1038/ncomms7276 Chemical Sciences  Analytical chemistry  Materials science  Thermogenesis-triggered seed dispersal in dwarf mistletoe OPEN Rolena A.J. deBruyn, Mark Paetkau, Kelly A. Ross, David V. Godfrey and Cynthia Ross Friedman Lodgepole pine dwarf mistletoe is a parasitic forest pathogen that disperses its seeds via an explosive discharge. Here, deBruyn et al. show that ripened mistletoe fruits generate heat less than two minutes before this discharge, suggesting a role for thermogenesis in seed dispersal. 09 February 2015 | doi: 10.1038/ncomms7262 Biological Sciences  Plant sciences  A leak pathway for luminal protons in endosomes drives oncogenic signalling in glioblastoma Kalyan C. Kondapalli, Jose P. Llongueras, Vivian Capilla-González, Hari Prasad, Anniesha Hack, Christopher Smith, Hugo Guerrero-Cázares, Alfredo Quiñones-Hinojosa and Rajini Rao Glioblastoma multiforme is the most common and aggressive form of primary brain tumour, and in 50% of cases EFGR is mutated, amplified or upregulated. Here the authors show that NHE9 controls the amount of EGFR at the membrane surface of brain tumour-initiating stem cells by affecting the luminal pH of sorting endosomes. 09 February 2015 | doi: 10.1038/ncomms7289 Biological Sciences  Cancer  Molecular biology  A real-time study of the benefits of co-solvents in polymer solar cell processing Jacobus J. van Franeker, Mathieu Turbiez, Weiwei Li, Martijn M Wienk and René A.J. Janssen Controlling the mix of electron-donating and electron-accepting organic semiconductors is crucial for improving solar cell efficiency. Here, the authors show how the addition of small amounts of co-solvents prevents the formation of fullerene-rich domains that reduce the performance of these devices 06 February 2015 | doi: 10.1038/ncomms7229 Physical Sciences  Applied physics  Materials science  Small heterodimer partner interacts with NLRP3 and negatively regulates activation of the NLRP3 inflammasome OPEN Chul-Su Yang, Jwa-Jin Kim, Tae Sung Kim, Phil Young Lee, Soo Yeon Kim, Hye-Mi Lee, Dong-Min Shin, Loi T. Nguyen, Moo-Seung Lee, Hyo Sun Jin, Kwang-Kyu Kim, Chul-Ho Lee, Myung Hee Kim, Sung Goo Park, Jin-Man Kim, Hueng-Sik Choi and Eun-Kyeong Jo Excessive NLRP3 inflammasome activation underlies inflammatory diseases such as gout. Here the authors show that orphan nuclear receptor small heterodimer partner protein (SHP) negatively regulates NLRP3, and its loss leads to accumulation of damaged mitochondria and gout-like immunopathology. 06 February 2015 | doi: 10.1038/ncomms7115 Biological Sciences  Immunology  The pervasive role of biological cohesion in bedform development OPEN Jonathan Malarkey, Jaco H. Baas, Julie A. Hope, Rebecca J. Aspden, Daniel R. Parsons, Jeff Peakall, David M. Paterson, Robert J. Schindler, Leiping Ye, Ian D. Lichtman, Sarah J. Bass, Alan G. Davies, Andrew J. Manning and Peter D. Thorne The role of cohesion is vital to our understanding of how sedimentary bedforms evolve. Here, the authors show that microorganisms within the sediment affect cohesion and demonstrate that ripples can take up to one hundred times as long to develop when extracellular polymeric substances are present. 06 February 2015 | doi: 10.1038/ncomms7257 Earth Sciences  Geology and geophysics  Room-temperature-concerted switch made of a binary atom cluster Eiichi Inami, Ikutaro Hamada, Keiichi Ueda, Masayuki Abe, Seizo Morita and Yoshiaki Sugimoto Switches made from just a few atoms are the ultimate limit for reducing the size of electronic devices. Inami et al. now demonstrate a room-temperature switch in which the formation of a binary atom cluster on a semiconductor surface is altered using a scanning probe microscopy tip. 06 February 2015 | doi: 10.1038/ncomms7231 Physical Sciences  Applied physics  The transcriptional regulator BBX24 impairs DELLA activity to promote shade avoidance in Arabidopsis thaliana Carlos D. Crocco, Antonella Locascio, Cristian M. Escudero, David Alabadí, Miguel A. Blázquez and Javier F. Botto Plants respond to shade by elongating their stems to grow toward the light. Here, Crocco et al. show that the BBX24 transcriptional regulator promotes the shade avoidance response by activating gibberellin signalling and the PIF4 transcription factor under low light conditions. 06 February 2015 | doi: 10.1038/ncomms7202 Biological Sciences  Plant sciences  Design concept for α-hydrogen-substituted nitroxides Michal Amar, Sukanta Bar, Mark A. Iron, Hila Toledo, Boris Tumanskii, Linda J.W. Shimon, Mark Botoshansky, Natalia Fridman and Alex M. Szpilman Nitroxyl radicals have many important applications but are generally stabilized through steric bulk on the adjacent carbon centres. Here, the authors design a simple, modular preparation of nitroxyl radicals with α-hydrogens that are stable for extended periods and are catalytically active. 06 February 2015 | doi: 10.1038/ncomms7070 Chemical Sciences  Organic chemistry  Physical chemistry  Structural mechanism of ergosterol regulation by fungal sterol transcription factor Upc2 Huiseon Yang, Junsen Tong, Chul Won Lee, Subin Ha, Soo Hyun Eom and Young Jun Im In yeast, the transcription factor Upc2 regulates genes involved in ergosterol biosynthesis, but how its activity is regulated is unknown. Here Yang et al. present the structure of the Upc2 C-terminal domain and discover that it functions as a sensor of the ergosterol level, regulating the transcriptional activity and cellular localization of Upc2. 06 February 2015 | doi: 10.1038/ncomms7129 Biological Sciences  Biochemistry  Ultrasensitive quantification of TAP-dependent antigen compartmentalization in scarce primary immune cell subsets OPEN Hanna Fischbach, Marius Döring, Daphne Nikles, Elisa Lehnert, Christoph Baldauf, Ulrich Kalinke and Robert Tampé Antigenic peptides are loaded into major histocompatibility complex class I (MHC I) molecules after entering the ER via the TAP transporter. Here, Fischbach et al. develop a flow cytometry assay to monitor TAP-dependent peptide translocation that is sensitive enough to use on scarce primary cell subsets. 06 February 2015 | doi: 10.1038/ncomms7199 Biological Sciences  Cell biology  Imaging regulatory T cell dynamics and CTLA4-mediated suppression of T cell priming Melanie P. Matheu, Shivashankar Othy, Milton L. Greenberg, Tobias X. Dong, Martijn Schuijs, Kim Deswarte, Hamida Hammad, Bart N. Lambrecht, Ian Parker and Michael D. Cahalan T regulatory cells (Tregs) prevent immunopathology by inhibiting excessive T-cell activation. Here the authors show interactions between dendritic cells, Tregs and antigen-specific T cells in the lymph node during initiation of the immune response in real time by two-photon microscopy. 05 February 2015 | doi: 10.1038/ncomms7219 Biological Sciences  Immunology  Wide-angle planar microtracking for quasi-static microcell concentrating photovoltaics Jared S. Price, Xing Sheng, Bram M. Meulblok, John A. Rogers and Noel C. Giebink Concentrating photovoltaics (PVs) offer a route to lower the cost of solar power, but their scale has been incompatible with roof top installation. Here, Price et al. demonstrate quasi-static concentrating PVs that achieve >200 × flux concentration over a full day in the form factor of a standard PV panel. 05 February 2015 | doi: 10.1038/ncomms7223 Physical Sciences  Materials science  Optical physics  Genomic analysis of hybrid rice varieties reveals numerous superior alleles that contribute to heterosis OPEN Xuehui Huang, Shihua Yang, Junyi Gong, Yan Zhao, Qi Feng, Hao Gong, Wenjun Li, Qilin Zhan, Benyi Cheng, Junhui Xia, Neng Chen, Zhongna Hao, Kunyan Liu, Chuanrang Zhu, Tao Huang, Qiang Zhao, Lei Zhang, Danlin Fan, Congcong Zhou, Yiqi Lu et al. The principle of heterosis, whereby a hybrid variety outperforms both parents, is commonly exploited in agriculture to maximize crop yield. Here Huang et al. show that the accumulation of multiple superior alleles in hybrid varieties contributes to hybrid vigour and increased yield in rice. 05 February 2015 | doi: 10.1038/ncomms7258 Biological Sciences  Genetics  Plant sciences  Anoctamin 6 mediates effects essential for innate immunity downstream of P2X7 receptors in macrophages Jiraporn Ousingsawat, Podchanart Wanitchakool, Arthur Kmit, Ana M. Romao, Walailak Jantarajit, Rainer Schreiber and Karl Kunzelmann Activation of purinergic P2X7 receptors is important for phagocytosis and bacterial killing. Here the authors show that a phospholipid scramblase, Anoctamin 6, is activated downstream of P2X7R and is a critical mediator of bacterial internalization and killing by macrophages. 05 February 2015 | doi: 10.1038/ncomms7245 Biological Sciences  Biophysics  Cell biology  Immunology  Quantitative high throughput screening using a primary human three-dimensional organotypic culture predicts in vivo efficacy Hilary A. Kenny, Madhu Lal-Nag, Erin A. White, Min Shen, Chun-Yi Chiang, Anirban K. Mitra, Yilin Zhang, Marion Curtis, Elizabeth M. Schryver, Sam Bettis, Ajit Jadhav, Matthew B. Boxer, Zhuyin Li, Marc Ferrer and Ernst Lengyel Tumour microenvironment affects the outcome of pharmacological anticancer treatments. Here, Kenny et al. show that organotypic cultures of ovarian cancer cells can recapitulate metastasis. They identify several new compounds that block cancer invasion and metastasis and improve survival in mouse models. 05 February 2015 | doi: 10.1038/ncomms7220 Biological Sciences  Cancer  Synthetic lateral inhibition governs cell-type bifurcation with robust ratios Mitsuhiro Matsuda, Makito Koga, Knut Woltjen, Eisuke Nishida and Miki Ebisuya Cell-type diversity results from a series of binary cell fate decisions. Here, Matsuda et al. find that cells engineered with a Notch/Delta lateral inhibition circuit spontaneously bifurcate into Notch-active and Delta-positive subpopulations that are robust at the individual and population levels. 05 February 2015 | doi: 10.1038/ncomms7195 Biological Sciences  Bioengineering  Cell biology  The assembly dynamics of the cytolytic pore toxin ClyA OPEN Stephan Benke, Daniel Roderer, Bengt Wunderlich, Daniel Nettels, Rudi Glockshuber and Benjamin Schuler Pore-forming toxins are expressed as monomers and assemble into multimeric pores. Here, Benke et al. follow the kinetics of pore formation for the bacterial toxin ClyA with single-molecule methods and show that pore formation progresses through the assembly of oligomeric intermediates, rather than by the addition of monomers to a nascent pore. 05 February 2015 | doi: 10.1038/ncomms7198 Biological Sciences  Biochemistry  Biophysics  Carbon–carbon bond activation of cyclobutenones enabled by the addition of chiral organocatalyst to ketone OPEN Bao-Sheng Li, Yuhuang Wang, Zhichao Jin, Pengcheng Zheng, Rakesh Ganguly and Yonggui Robin Chi Activation of C–C bonds is a powerful method for directly functionalizing organic molecules, but is still a challenging task. Here, the authors show that N-heterocyclic carbenes can activate the C–C bonds in cyclic ketones, allowing the enantioselective formation of lactams. 05 February 2015 | doi: 10.1038/ncomms7207 Chemical Sciences  Catalysis  Organic chemistry  Observation of directly interacting coherent two-level systems in an amorphous material OPEN Jürgen Lisenfeld, Grigorij J. Grabovskij, Clemens Müller, Jared H. Cole, Georg Weiss and Alexey V. Ustinov Material defects create spurious two-level systems that are a source of noise in nanostructured devices. Lisenfeld et al. use a superconducting qubit to perform high-resolution defect spectroscopy, providing direct evidence of quantum coherent interaction between two defects. 05 February 2015 | doi: 10.1038/ncomms7182 Physical Sciences  Applied physics  Materials science  The dual role of coherent twin boundaries in hydrogen embrittlement Matteo Seita, John P. Hanson, Silvija Gradečak and Michael J. Demkowicz When exposed to hydrogen, alloys may lose their ductility and fracture unexpectedly, a phenomenon known as hydrogen embrittlement. Here, the authors investigate hydrogen embrittlement in a Ni-based superalloy and find that coherent twin boundaries are susceptible to crack initiation. 05 February 2015 | doi: 10.1038/ncomms7164 Physical Sciences  Materials science  Antibody potency relates to the ability to recognize the closed, pre-fusion form of HIV Env Miklos Guttman, Albert Cupo, Jean-Philippe Julien, Rogier W. Sanders, Ian A. Wilson, John P. Moore and Kelly K. Lee Broadly neutralizing antibodies targeting the Env protein of HIV-1 are being used to guide vaccine design. Here, Guttman et al. show that highly potent antibodies bind to the ‘closed’, prefusion form of Env, whereas less potent antibodies bind only to the ‘open’ form (typical of receptor-bound virus). 05 February 2015 | doi: 10.1038/ncomms7144 Biological Sciences  Biochemistry  Biophysics  Virology  Encapsulated liquid sorbents for carbon dioxide capture John J. Vericella, Sarah E. Baker, Joshuah K. Stolaroff, Eric B. Duoss, James O. Hardin, James Lewicki, Elizabeth Glogowski, William C. Floyd, Carlos A. Valdez, William L. Smith, Joe H. Satcher, William L. Bourcier, Christopher M. Spadaccini, Jennifer A. Lewis and Roger D. Aines Most carbon capture technologies rely on corrosive amine solutions, or high surface area materials. Here, the authors fabricate polymer microcapsules with liquid carbonate cores and permeable silicone shells combining the capacity of liquid sorbents with the surface area and low volatility of solid materials. 05 February 2015 | doi: 10.1038/ncomms7124 Chemical Sciences  Materials science  Conductance oscillations induced by ballistic snake states in a graphene heterojunction Thiti Taychatanapat, Jun You Tan, Yuting Yeo, Kenji Watanabe, Takashi Taniguchi and Barbaros Özyilmaz Exotic electron dynamics called snake states are predicted along a p–n junction in graphene. Taychatanapat et al. now demonstrate that such snake states can manifest themselves through oscillatory conductance across the junction, revealing their twisting nature. 05 February 2015 | doi: 10.1038/ncomms7093 Physical Sciences  Applied physics  Materials science  MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer Peter C. Hart, Mao Mao, Andre Luelsdorf P. de Abreu, Kristine Ansenberger-Fricano, Dede N. Ekoue, Douglas Ganini, Andre Kajdacsy-Balla, Alan M. Diamond, Richard D. Minshall, Marcia E. L. Consolaro, Janine H. Santos and Marcelo G. Bonini Tumour cells sustain high levels of glycolysis even in presence of oxygen, which is known as the Warburg effect. Here the authors show that MnSOD contributes to the Warburg effect by increasing the levels of H2O2 released from mitochondria, which sustains glycolysis by activating AMPK. 05 February 2015 | doi: 10.1038/ncomms7053 Biological Sciences  Cancer  Molecular biology  Interference and holography with femtosecond laser pulses of different colours Serguey Odoulov, Alexandr Shumelyuk, Holger Badorreck, Stefan Nolte, Kay-Michael Voit and Mirco Imlau High-contrast fringes and holographic grating imprinting rely on the coherence of the superimposing beams, and thus, it typically requires the interference of beams originating from a single laser. Here, Odoulov et al. demonstrate that holographic grating recording is possible using pulses of different colour. 05 February 2015 | doi: 10.1038/ncomms6866 Physical Sciences  Optical physics  Dense genotyping of immune-related susceptibility loci reveals new insights into the genetics of psoriatic arthritis OPEN John Bowes, Ashley Budu-Aggrey, Ulrike Huffmeier, Steffen Uebe, Kathryn Steel, Harry L. Hebert, Chris Wallace, Jonathan Massey, Ian N. Bruce, James Bluett, Marie Feletar, Ann W. Morgan, Helena Marzo-Ortega, Gary Donohoe, Derek W. Morris, Philip Helliwell, Anthony W. Ryan, David Kane, Richard B. Warren, Eleanor Korendowych et al. Psoriatic arthritis (PsA) is a chronic inflammatory arthritis with a significant genetic component. Here, the authors analyse immune-related genetic markers in 1,962 PsA patients and 8,923 controls to identify novel PsA risk loci and highlight distinct genetic differences between psoriasis and PsA. 05 February 2015 | doi: 10.1038/ncomms7046 Biological Sciences  Genetics  Immunology  The 3D-architecture of individual free silver nanoparticles captured by X-ray scattering OPEN Ingo Barke, Hannes Hartmann, Daniela Rupp, Leonie Flückiger, Mario Sauppe, Marcus Adolph, Sebastian Schorb, Christoph Bostedt, Rolf Treusch, Christian Peltz, Stephan Bartling, Thomas Fennel, Karl-Heinz Meiwes-Broer and Thomas Möller The occurrence of thermodynamically metastable nanoparticles determines the particle growth in nature, but capturing them is experimentally challenging. Barke et al. identify the three-dimensional shape of metastable silver nanoparticles in gas phase, characterized by X-ray free-electron laser. 04 February 2015 | doi: 10.1038/ncomms7187 Physical Sciences  Materials science  Optical physics  Single-pixel imaging by means of Fourier spectrum acquisition Zibang Zhang, Xiao Ma and Jingang Zhong Single-pixel imaging can capture a scene without a direct line of sight to the object but high-quality imaging has proven challenging. Here, by acquiring their Fourier spectrum, Zhang et al. demonstrate indirect, high-quality single-pixel imaging in the presence of noisy environmental illumination. 04 February 2015 | doi: 10.1038/ncomms7225 Physical Sciences  Applied physics  Optical physics  PYK2 sustains endosomal-derived receptor signalling and enhances epithelial-to-mesenchymal transition Nandini Verma, Omer Keinan, Michael Selitrennik, Thomas Karn, Martin Filipits and Sima Lev Proline-rich tyrosine kinase 2 (PYK2) has been previously involved in the positive regulation of epithelial-to-mesenchymal transition (EMT); however, the mechanisms were not known. Here the authors uncover key roles of PYK2 during EGF-induced EMT in human mammary cell lines involving STAT3 and c-MET. 04 February 2015 | doi: 10.1038/ncomms7064 Biological Sciences  Cancer  Molecular biology  Genetic blueprint of the zoonotic pathogen Toxocara canis OPEN Xing-Quan Zhu, Pasi K. Korhonen, Huimin Cai, Neil D. Young, Peter Nejsum, Georg von Samson-Himmelstjerna, Peter R. Boag, Patrick Tan, Qiye Li, Jiumeng Min, Yulan Yang, Xiuhua Wang, Xiaodong Fang, Ross S. Hall, Andreas Hofmann, Paul W. Sternberg, Aaron R. Jex and Robin B. Gasser Toxocara canis is a zoonotic parasite of major worldwide socioeconomic importance. Here, the authors sequence the genome and transcriptome of T. canis, and highlight potential mechanisms involved in development and host–parasite interactions that could support the pursuit of new drug interventions. 04 February 2015 | doi: 10.1038/ncomms7145 Biological Sciences  Genetics  KCNQ5 K+ channels control hippocampal synaptic inhibition and fast network oscillations Pawel Fidzinski, Tatiana Korotkova, Matthias Heidenreich, Nikolaus Maier, Sebastian Schuetze, Oliver Kobler, Werner Zuschratter, Dietmar Schmitz, Alexey Ponomarenko and Thomas J. Jentsch Several K+ channels control neuronal excitability, but the function of KCNQ5 (Kv7.5), which displays wide expression in the brain, is not known. Here the authors show that KCNQ5 controls excitability and function of hippocampal networks through modulation of synaptic inhibition. 04 February 2015 | doi: 10.1038/ncomms7254 Biological Sciences  Neuroscience  Multi-localization transport behaviour in bulk thermoelectric materials OPEN Wenyu Zhao, Ping Wei, Qingjie Zhang, Hua Peng, Wanting Zhu, Dingguo Tang, Jian Yu, Hongyu Zhou, Zhiyuan Liu, Xin Mu, Danqi He, Jichao Li, Chunlei Wang, Xinfeng Tang and Jihui Yang An ideal thermoelectric material has a large Seebeck coefficient, and a high electrical but low thermal conductivity; however, optimizing all three is difficult. Zhao et al. discover three types of coexisting multi-localization transport behaviours in filled skutterudite materials that aid this optimization. 04 February 2015 | doi: 10.1038/ncomms7197 Physical Sciences  Materials science  Spatiotemporal noise characterization for chirped-pulse amplification systems OPEN Jingui Ma, Peng Yuan, Jing Wang, Yongzhi Wang, Guoqiang Xie, Heyuan Zhu and Liejia Qian High-field physics experiments are often plagued by noise in the driving laser, which remains poorly characterized. Ma et al. study the noise in a pulse stretcher and compressor system in the spatiotemporal domain and find that noise from the stretcher elements governs the pulse contrast at the laser focus. 04 February 2015 | doi: 10.1038/ncomms7192 Physical Sciences  Optical physics  Mitochondrial Ca2+-dependent NLRP3 activation exacerbates the Pseudomonas aeruginosa-driven inflammatory response in cystic fibrosis Alessandro Rimessi, Valentino Bezzerri, Simone Patergnani, Saverio Marchi, Giulio Cabrini and Paolo Pinton Airway epithelia from cystic fibrosis patients show an exaggerated inflammatory response to P. aeruginosa. Here, Rimessi et al. show that P. aeruginosa exposure causes augmented Ca2+ signalling in the absence of functional CFTR, leading to mitochondrial damage and activation of the NLRP3 inflammasome. 04 February 2015 | doi: 10.1038/ncomms7201 Biological Sciences  Cell biology  Immunology  Microbiology  Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases Atsuo Kanno, Natsuko Tanimura, Masayuki Ishizaki, Kentaro Ohko, Yuji Motoi, Masahiro Onji, Ryutaro Fukui, Takaichi Shimozato, Kazuhide Yamamoto, Takuma Shibata, Shigetoshi Sano, Akiko Sugahara-Tobinai, Toshiyuki Takai, Umeharu Ohto, Toshiyuki Shimizu, Shin-ichiroh Saitoh and Kensuke Miyake TLR7 triggers immune responses upon sensing microbial RNA, and its endosomal localization is thought to prevent TLR7 activation by host RNA. Here, Kanno et al. show that TLR7 is also present on the surface of immune cells, and that anti-TLR7 antibody can prevent TLR7-mediated autoimmunity. 04 February 2015 | doi: 10.1038/ncomms7119 Biological Sciences  Immunology  HIV-1 Tat inhibits phagocytosis by preventing the recruitment of Cdc42 to the phagocytic cup Solène Debaisieux, Simon Lachambre, Antoine Gross, Clément Mettling, Sébastien Besteiro, Hocine Yezid, Daniel Henaff, Christophe Chopard, Jean-Michel Mesnard and Bruno Beaumelle Phagocytic activity of macrophages is reduced in HIV-1-infected patients, but the reason for this is unknown. Here, the authors report that secreted Tat protein inhibits phagocytosis by binding to the phospholipid PI(4,5)P2 and impairing the recruitment of small GTPase Cdc42 to the phagocytic cup. 04 February 2015 | doi: 10.1038/ncomms7211 Biological Sciences  Cell biology  Immunology  Virology  Sensory integration dynamics in a hierarchical network explains choice probabilities in cortical area MT OPEN Klaus Wimmer, Albert Compte, Alex Roxin, Diogo Peixoto, Alfonso Renart and Jaime de la Rocha The activity of sensory neurons can be correlated with perceptual decisions and this effect may provide insights into how sensory information is processed during perceptual tasks. Here the authors develop a network model of sensory and decision-making areas and propose that the dynamics across the network hierarchy explains the choice probabilities. 04 February 2015 | doi: 10.1038/ncomms7177 Biological Sciences  Neuroscience  The jasmonate-responsive GTR1 transporter is required for gibberellin-mediated stamen development in Arabidopsis OPEN Hikaru Saito, Takaya Oikawa, Shin Hamamoto, Yasuhiro Ishimaru, Miyu Kanamori-Sato, Yuko Sasaki-Sekimoto, Tomoya Utsumi, Jing Chen, Yuri Kanno, Shinji Masuda, Yuji Kamiya, Mitsunori Seo, Nobuyuki Uozumi, Minoru Ueda and Hiroyuki Ohta GTR1 is known to transport glucosinolates in Arabidopsis. Here, Saito et al. show that GTR1 also transports the plant hormones jasmonate and gibberellin when heterologously expressed in Xenopus oocytes, and that gtr1 mutant plants show a gibberellin-related fertility phenotype. 04 February 2015 | doi: 10.1038/ncomms7095 Biological Sciences  Plant sciences  Brillouin-scattering-induced transparency and non-reciprocal light storage OPEN Chun-Hua Dong, Zhen Shen, Chang-Ling Zou, Yan-Lei Zhang, Wei Fu and Guang-Can Guo Stimulated Brillouin scattering is a non-linear interaction that allows light to be stored as coherent acoustic waves. Here, the authors report on Brillouin scattering-induced transparency in an optical microresonator whose high quality allows for long-lifetime non-reciprocal light storage. 04 February 2015 | doi: 10.1038/ncomms7193 Physical Sciences  Optical physics  Collaborative rewiring of the pluripotency network by chromatin and signalling modulating pathways OPEN Khoa A. Tran, Steven A. Jackson, Zachariah P.G. Olufs, Nur Zafirah Zaidan, Ning Leng, Christina Kendziorski, Sushmita Roy and Rupa Sridharan Improving the efficiency of reprogramming of somatic cells to induced pluripotent stem cells is of major interest. Here, the authors combine ascorbic acid and 2i (MAP kinase and GSK inhibitors) conditions and show increased efficiency and synchronicity in the reprogramming of fibroblasts and partially reprogrammed cells, and study epigenetic effectors and signalling pathways responsible for this effect. 04 February 2015 | doi: 10.1038/ncomms7188 Biological Sciences  Cell biology  Developmental biology  Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1 Cong Guo, Anton E. Ludvik, Michelle E. Arlotto, M. Geoffrey Hayes, Loren L. Armstrong, Denise M. Scholtens, Christopher D. Brown, Christopher B. Newgard, Thomas C. Becker, Brian T. Layden, William L. Lowe and Timothy E. Reddy Maternal glucose levels during pregnancy can affect the metabolic health of a developing fetus, both early on and later in life. Here, the authors reveal that genetic variants in several regulatory elements alter glucose homeostasis during pregnancy by reducing the expression of a novel hexokinase gene, HKDC1. 04 February 2015 | doi: 10.1038/ncomms7069 Biological Sciences  Genetics  Molecular biology  TH2 cells and their cytokines regulate formation and function of lymphatic vessels Kihyuk Shin, Raghu P. Kataru, Hyeung Ju Park, Bo-In Kwon, Tae Woo Kim, Young Kwon Hong and Seung-Hyo Lee Lymphatic vessels remodel in response to inflammatory conditions and T-cell-secreted cytokines. Here, the authors show that T helper type 2 cells inhibit lymphangiogenesis by secreting IL-4 and IL-13, and that blockade of these cytokines can alleviate allergic asthma symptoms by improving the lymphatic function in mice. 04 February 2015 | doi: 10.1038/ncomms7196 Biological Sciences  Immunology  Medical research  Entropic cages for trapping DNA near a nanopore Xu Liu, Mirna Mihovilovic Skanata and Derek Stein Nanopore sensors provide a useful way of analysing single molecules, such as DNA. Here, the authors present a nanopore-based single-molecule reactor, into which DNA can be fed and removed, and which also acts as an entropic cage allowing for DNA chemical modifications. 04 February 2015 | doi: 10.1038/ncomms7222 Physical Sciences  Nanotechnology  Total synthesis and antiviral activity of indolosesquiterpenoids from the xiamycin and oridamycin families OPEN Zhanchao Meng, Haixin Yu, Li Li, Wanyin Tao, Hao Chen, Ming Wan, Peng Yang, David J. Edmonds, Jin Zhong and Ang Li Using a single strategy to make a number of related intermediates is a useful strategy in the total synthesis. Here, the authors report the synthesis of a number of natural products, employing two diastereomerically complementary metal-catalyzed cyclizations as the key step to access a number of frameworks. 04 February 2015 | doi: 10.1038/ncomms7096 Chemical Sciences  Organic chemistry  A laboratory study of asymmetric magnetic reconnection in strongly driven plasmas M.J. Rosenberg, C.K. Li, W. Fox, I. Igumenshchev, F.H. Séguin, R.P.J. Town, J.A. Frenje, C. Stoeckl, V. Glebov and R.D. Petrasso Magnetic reconnection occurs close to the surface of the sun, in the Earth’s magnetosphere and in astronomical plasmas. Here, the authors investigate magnetic reconnection in a laboratory-based experiments with an asymmetric configuration similar to those found in real astrophysical situations. 04 February 2015 | doi: 10.1038/ncomms7190 Physical Sciences  Fluids and plasma physics  Visualization of a ferromagnetic metallic edge state in manganite strips Kai Du, Kai Zhang, Shuai Dong, Wengang Wei, Jian Shao, Jiebin Niu, Jinjie Chen, Yinyan Zhu, Hanxuan Lin, Xiaolu Yin, Sy-Hwang Liou, Lifeng Yin and Jian Shen Boundary effects play a strong role in the electronic properties of structured manganites. Here, Du et al. demonstrate the existence of ferromagnetic metallic edge states and an enhanced metal–insulator transition temperature in patterned strips of manganite which emerge because of broken symmetry effects. 04 February 2015 | doi: 10.1038/ncomms7179 Physical Sciences  Condensed matter  Materials science  Nanoarchitectured materials composed of fullerene-like spheroids and disordered graphene layers with tunable mechanical properties Zhisheng Zhao, Erik F. Wang, Hongping Yan, Yoshio Kono, Bin Wen, Ligang Bai, Feng Shi, Junfeng Zhang, Curtis Kenney-Benson, Changyong Park, Yanbin Wang and Guoyin Shen Type-II glass-like carbon is a widely used material with desirable physical properties for industrial applications. Here, the authors investigate its structure-property performance under compression, and propose a model to explain its unusual, and pressure-tunable, elastic and mechanical properties. 04 February 2015 | doi: 10.1038/ncomms7212 Chemical Sciences  Materials science  Towards enabling femtosecond helicity-dependent spectroscopy with high-harmonic sources G. Lambert, B. Vodungbo, J. Gautier, B. Mahieu, V. Malka, S. Sebban, P. Zeitoun, J. Luning, J. Perron, A. Andreev, S. Stremoukhov, F. Ardana-Lamas, A. Dax, C. P. Hauri, A. Sardinha and M. Fajardo High-harmonic generation is now capable of delivering high-energy X-ray pulses with short duration, but achieving elliptical polarization remains challenging. Here, Lambert et al. use a cross-polarized two-colour laser field to produce elliptically polarized X-rays and measure magnetic circular dichroism in nickel. 04 February 2015 | doi: 10.1038/ncomms7167 Physical Sciences  Materials science  Optical physics  Formation of lunar swirls by magnetic field standoff of the solar wind Timothy D. Glotch, Joshua L. Bandfield, Paul G. Lucey, Paul O. Hayne, Benjamin T. Greenhagen, Jessica A. Arnold, Rebecca R. Ghent and David A. Paige Lunar swirls are high-albedo features on the Moon whose origins are widely debated. Using observations from the Diviner Lunar Radiometer, Glotch et al. present evidence supporting the idea that the swirls arise from abnormal space weathering caused by local magnetic field deflection of solar wind. 04 February 2015 | doi: 10.1038/ncomms7189 Earth Sciences  Astronomy  Geology and geophysics  Planetary sciences  Emerging magnetic order in platinum atomic contacts and chains OPEN Florian Strigl, Christopher Espy, Maximilian Bückle, Elke Scheer and Torsten Pietsch The development of magnetism in metallic atomic chains is a widely debated phenomenon, of relevance to atomic-scale spintronics. Here, Strigl et al. measure the magneto-conductance of platinum break junctions stretched over sub-atomic distances, evidencing the evolution of distinct magnetic order. 04 February 2015 | doi: 10.1038/ncomms7172 Physical Sciences  Condensed matter  Materials science  Nanotechnology  Sulphur shuttling across a chaperone during molybdenum cofactor maturation Pascal Arnoux, Christian Ruppelt, Flore Oudouhou, Jérôme Lavergne, Marina I. Siponen, René Toci, Ralf R. Mendel, Florian Bittner, David Pignol, Axel Magalon and Anne Walburger Microbial formate dehydrogenases (FDH) are molybdenum-containing enzymes that can catalyse the reduction of CO2 into formate. Here, the authors suggest a structural and functional basis for sulphuration of the molybdenum cofactor in E. coli FDH, a key step in the production of active formate dehydrogenase. 04 February 2015 | doi: 10.1038/ncomms7148 Biological Sciences  Biochemistry  Biophysics  Chemical biology  Long-term nitrogen deposition depletes grassland seed banks Sofía Basto, Ken Thompson, Gareth Phoenix, Victoria Sloan, Jonathan Leake and Mark Rees Rising levels of nitrogen deposition represents a major threat to the biodiversity and plant communities worldwide. Here Basto et al. show that increased nitrogen deposition results in reductions in the size and species richness of the seed bank in acid grassland soils. 04 February 2015 | doi: 10.1038/ncomms7185 Biological Sciences  Ecology  Plant sciences    Nature Communications JOBS of the week Postdoctoral Fellow Karolinska Institutet (KI) Research Assistant Queen Mary University of London Postdoctoral Research Scientist The Babraham Institute Research Associate The Sainsbury Laboratory (TSL) Postdoctoral Fellow UT Southwestern Medical Center at Dallas Bioinformatics Scientist II Children's Hospital of Philadelphia PhD Position Available University of Miami Ph.D. position University of Antwerp - Belgium Junior Group Leaders Université de Lyon 2 Junior Research Group Leader Positions Center for Chronic Immunodeficiency at the University Medical Center Freiburg More Science jobs from Nature Communications EVENT Evolution 2015 26.06.15 Guarujá, Brazil More science events from       Latest Corrigenda     Corrigendum: Inclusion flotation-driven channel segregation in solidifying steels Dianzhong Li, Xing-Qiu Chen, Paixian Fu, Xiaoping Ma, Hongwei Liu, Yun Chen, Yanfei Cao, Yikun Luan and Yiyi Li 09 February 2015 | doi: 10.1038/ncomms7291 Physical Sciences  Materials science      Corrigendum: Genotyping with CRISPR-Cas-derived RNA-guided endonucleases Jong Min Kim, Daesik Kim, Seokjoong Kim and Jin-Soo Kim 06 February 2015 | doi: 10.1038/ncomms5292 Biological Sciences  Biotechnology  Molecular biology      Corrigendum: Kinetically tuned dimensional augmentation as a versatile synthetic route towards robust metal–organic frameworks Dawei Feng, Kecheng Wang, Zhangwen Wei, Ying-Pin Chen, Cory M. Simon, Ravi K. Arvapally, Richard L. Martin, Mathieu Bosch, Tian-Fu Liu, Stephen Fordham, Daqiang Yuan, Mohammad A. Omary, Maciej Haranczyk, Berend Smit and Hong-Cai Zhou 05 February 2015 | doi: 10.1038/ncomms7106 Chemical Sciences  Inorganic chemistry  Materials science        Latest Errata     Erratum: Ferroelectrically driven spatial carrier density modulation in graphene Christoph Baeumer, Diomedes Saldana-Greco, John Mark P. Martirez, Andrew M. Rappe, Moonsub Shim and Lane W. Martin 10 February 2015 | doi: 10.1038/ncomms7371 Physical Sciences  Applied physics  Nanotechnology      Erratum: An RNA polymerase II-coupled function for histone H3K36 methylation in checkpoint activation and DSB repair Deepak Kumar Jha and Brian D. Strahl 06 February 2015 | doi: 10.1038/ncomms7015 Biological Sciences  Molecular biology      Advertisement Nature Reviews Clinical Oncology  FREE POSTER: BREAST CANCER INTRINSIC SUBTYPES This special Poster highlights recent achievements and development of our genetic understanding of the intrinsic subtypes of molecular breast cancer subtypes. Produced with support from:  NanoString® Technologies, Inc     Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com  More Nature Events You have been sent this Table of Contents Alert because you have opted in to receive it. 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