Nature Reviews Drug Discovery contents March 2015 Volume 14 Number 3 pp 149-221

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TABLE OF CONTENTS
March 2015 Volume 14 Number 3
Impact Factor 37.231 *	In this issue Comment News and Analysis Research Highlights Reviews Correspondence Addendum Also this month  Featured article: Advances in the development of influenza virus vaccines Florian Krammer & Peter Palese
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Comment: Preclinical target validation using patient-derived cells Aled M. Edwards, Cheryl H. Arrowsmith, Chas Bountra, Mark E. Bunnage, Marc Feldmann, Julian C. Knight, Dhavalkumar D. Patel, Panagiotis Prinos, Michael D. Taylor, Michael Sundström on behalf of the SGC Open Source Target-Discovery Partnership p149 | doi:10.1038/nrd4565 The Structural Genomics Consortium (SGC) and its clinical, industry and disease-foundation partners are launching open-source preclinical translational medicine studies. Abstract | Full Text | PDF
NEWS AND ANALYSIS		Top
Fragile X disappointments upset autism ambitions Asher Mullard p151 | doi:10.1038/nrd4555 The clinical failure of two large mGluR5-antagonist programmes in Fragile X syndrome has forced drug developers to rethink trial design and target selection for neurodevelopmental indications. PDF
New twist on antibiotic hunt hits pay dirt Alla Katsnelson p153 | doi:10.1038/nrd4556 Platform probes microbial dark matter, boosting natural-product discovery efforts. PDF
NEWS IN BRIEF Charting the decline of US biomedical research funding Asher Mullard p155 | doi:10.1038/nrd4567 PDF
Roche buys $1 billion majority stake in Foundation Asher Mullard p155 | doi:10.1038/nrd4568 PDF
$215 million precision-medicine initiative takes shape Asher Mullard p155 | doi:10.1038/nrd4569 PDF
BIOBUSINESS BRIEFS Regulatory watch: Efficiency indicators for new drugs approved by the FDA from 2003 to 2013 Rossella Belleli, Roland Fisch & Thomas D. Szucs p156 | doi:10.1038/nrd4563 PDF
BIOBUSINESS BRIEFS Patent watch: US Supreme Court revises patent claim construction standards Kevin Noonan p157 | doi:10.1038/nrd4564 PDF
AN AUDIENCE WITH Mike Varney p158 | doi:10.1038/nrd4566 Mike Varney, the new Head of Genentech Research and Early Development (gRED), discusses the culture of science at Genentech under Roche. PDF
FROM THE ANALYST'S COUCH What does it take to produce a breakthrough drug? Dirk Calcoen, Laura Elias & Xiaomeng Yu p161 | doi:10.1038/nrd4570 Several breakthrough drugs have recently been approved to treat hepatitis C virus (HCV) infection. To understand what it takes to achieve such success, Calcoen and colleagues analysed attrition rates for HCV drug projects over the last 20 years compared with other indications. PDF
RESEARCH HIGHLIGHTS Top Fibrotic disease: Fixing a feedback loop in fibrosis p163 | doi:10.1038/nrd4559 PDF Cardiovascular disease: MYDGF promotes heart repair after myocardial infarction p164 | doi:10.1038/nrd4557 PDF Anticancer agents: An alternative route to targeting telomere elongation p164 | doi:10.1038/nrd4558 PDF Cancer stem cells: Targeting the root of cancer relapse p165 | doi:10.1038/nrd4560 PDF Stroke: Meddling with the mind p166 | doi:10.1038/nrd4561 PDF IN BRIEF Infectious diseases: Towards a new class of tuberculosis drugs | Antibody design: Hormone–CDR fusions enhance hormone efficacy | Endometriosis: Suppressing the oestrogen-inflammatory axis | Natural products: Enhancing production PDF Drug Discovery JOBS of the week Postdoc in Drug Delivery University of North Texas Health Science Center at Fort Worth Postdoctoral Fellowship-Drug Discover Moffitt Cancer Center & Research Institute PhD in Cancer and Genetics: New Drug Therapies Cardiff University Postdoctoral Scholar Position in Bioengineering, Biosensors and Drug Delivery University of California - Irvine Research Scientists Cancer Research UK - MedImmune Alliance More Science jobs from Drug Discovery EVENT RICT 2015: Drug Discovery and Selection - Understanding Targets and Mechanisms 01.07.15 Avignon, France More science events from
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REVIEWS		Top
Advances in the development of influenza virus vaccines Florian Krammer & Peter Palese p167 | doi:10.1038/nrd4529 Current influenza vaccines are effective but require reformulation each year and do not protect against pandemic influenza strains. Here, Krammer and Palese discuss the advances in the design and production of seasonal and pandemic influenza virus vaccines, including novel vaccine constructs and adjuvants. Advances in the design of universal influenza vaccines are also presented. Abstract | Full Text | PDF
Unleashing the therapeutic potential of human kallikrein-related serine proteases Ioannis Prassas, Azza Eissa, Gennadiy Poda & Eleftherios P. Diamandis p183 | doi:10.1038/nrd4534 Members of the family of kallikrein (KLK)-related proteases are found in various tissues — including the airway, prostate and brain — and have a wide range of functions. The authors describe the roles of KLKs in health and disease, and highlight the small-molecule, peptide-based, protein-based, antibody-based and immunotherapeutic strategies that are being used to target KLKs in certain diseases. Abstract | Full Text | PDF | Supplementary information
Principles in the design of ligand-targeted cancer therapeutics and imaging agents Madduri Srinivasarao, Chris V. Galliford & Philip S. Low p203 | doi:10.1038/nrd4519 One strategy for treating cancer while limiting off-target effects on healthy cells is to conjugate cytotoxic agents to small-molecule ligands for receptors that are upregulated in tumours. Low and colleagues explain the key aspects to be considered when designing ligand–drug conjugates, and summarize the ligand–drug and ligand–imaging agent conjugates that are currently in clinical trials. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Correspondence: Progression-seeking bias and rational optimism in research and development Dennis W. Lendrem, B. Clare Lendrem, Richard W. Peck, Stephen C. Senn, Simon Day & John D. Isaacs p219 | doi:10.1038/nrd4320-c1 Full Text | PDF | Supplementary information
ADDENDUM		Top
Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders Katrina J. Falkenberg & Ricky W. Johnstone p219 | doi:10.1038/nrd4579 Full Text | PDF
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