Nature Reviews Gastroenterology & Hepatology - Table of Contents alert Volume 12 Issue 2

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TABLE OF CONTENTS
February 2015 Volume 12 Number 2
Impact Factor 10.807 *	In this issue Research Highlights Year in Review Reviews Also this month  Featured article: Mycobiota in gastrointestinal diseases Pranab K. Mukherjee, Boualem Sendid, Gautier Hoarau, Jean-Frédéric Colombel, Daniel Poulain & Mahmoud A. Ghannoum
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RESEARCH HIGHLIGHTS Top Pancreatic cancer: From normal to metastases—a whole gamut of pancreatic organoids Published online: 20 January 2015 p61 | doi:10.1038/nrgastro.2015.1 PDF Colorectal cancer: On the origin of colonic tumours—outside the niche Published online: 16 December 2014 p62 | doi:10.1038/nrgastro.2014.228 PDF Gut microbiota: The difference diet makes to metabolites and microbiota Published online: 16 December 2014 p63 | doi:10.1038/nrgastro.2014.227 PDF Liver: Does angiogenesis have a role in the resolution of liver fibrosis? Published online: 23 December 2014 p63 | doi:10.1038/nrgastro.2014.230 PDF Liver: Sussing out statins in cirrhosis—KLF2 is the key Published online: 06 January 2015 p64 | doi:10.1038/nrgastro.2014.233 PDF IBD: Strategic management of postoperative Crohn's disease Published online: 20 January 2015 p64 | doi:10.1038/nrgastro.2015.2 PDF IN BRIEF Liver: PPIs associated with mortality in patients with cirrhosis | Helicobacter pylori : New model for Helicobacter pylori infection developed | Therapy: Obeticholic acid safe and effective in primary biliary cirrhosis | Transplantation: Variable outcomes for liver transplantation PDF Gastroenterology & Hepatology JOBS of the week Assistant / Associate Professor, Gastroenterology, (Las Vegas) University of Nevada School of Medicine (Las Vegas campus) More Science jobs from Gastroenterology & Hepatology EVENT International Workshop on Gastroenterology 21.07.15 istanbul, Turkey More science events from
YEAR IN REVIEW		Top
NAFLD in 2014: Genetics, diagnostics and therapeutic advances in NAFLD Mary E. Rinella & Arun J. Sanyal Published online: 06 January 2015 p65 | doi:10.1038/nrgastro.2014.232 In 2014, NAFLD was confirmed as the fastest growing aetiology for hepatocellular cancer in the USA. However, 2014 also saw progress in our understanding of the heritability and pathogenesis of NAFLD, and an important clinical trial targeting the farnesoid X receptor pathway has illustrated advances in developing a pharmacological therapy. Full Text | PDF
IBD pathogenesis in 2014: Molecular pathways controlling barrier function in IBD Raja Atreya & Markus F. Neurath Published online: 02 December 2014 p67 | doi:10.1038/nrgastro.2014.201 Several key studies published in 2014 have shed light on the pathogenesis of IBD by investigating the molecular mechanisms controlling mucosal homeostasis and intestinal barrier function. These studies revealed that alterations of intestinal homeostasis drive chronic intestinal inflammation. Here, we describe these findings and discuss future directions for translational research in IBD. Full Text | PDF
Pancreatic disease in 2014: Pancreatic fibrosis and standard diagnostics Güralp O. Ceyhan & Helmut Friess Published online: 06 January 2015 p68 | doi:10.1038/nrgastro.2014.234 In 2014, pancreatic fibrosis has increasingly been recognized as a key determinant of the pathogenesis, therapy response and disease progression of chronic pancreatitis and pancreatic cancer. In addition, secretin-stimulated magnetic resonance cholangiopancreatography has gained increasing importance, especially in visualizing pancreatic duct abnormalities. However, the true imaging capacity has not been fully analysed. Full Text | PDF
Hepatitis B in 2014: HBV research moves forward—receptors and reactivation Man-Fung Yuen & Ching-Lung Lai Published online: 16 December 2014 p70 | doi:10.1038/nrgastro.2014.226 Since the discovery of HBV in the 1960s, its life cycle and the natural history of infection have been delineated by many studies. In 2014, new findings concerning the host-virus interaction and new studies of HBV reactivation from occult HBV infection are of considerable interest. Full Text | PDF
IBS in 2014: Developments in pathophysiology, diagnosis and management Peter J. Whorwell Published online: 23 December 2014 p72 | doi:10.1038/nrgastro.2014.225 IBS affects up to 15% of the population and continues to provide the medical profession with diagnostic and therapeutic challenges. The pathophysiology is complex and until it is better understood management strategies will necessarily remain rather empirical. Full Text | PDF
Oesophageal cancer in 2014: Advances in curatively intended treatment Jesper Lagergren Published online: 02 December 2014 p74 | doi:10.1038/nrgastro.2014.213 Oesophageal cancer is characterized by poor prognosis, and curatively intended treatment is extensive and demanding. In 2014, well-designed clinical studies have advanced our knowledge of how to improve the treatment of oesophageal cancer at various tumour stages. Full Text | PDF
REVIEWS		Top
Mycobiota in gastrointestinal diseases Pranab K. Mukherjee, Boualem Sendid, Gautier Hoarau, Jean-Frédéric Colombel, Daniel Poulain & Mahmoud A. Ghannoum Published online: 11 November 2014 p77 | doi:10.1038/nrgastro.2014.188 The association that the mycobiome has with gastrointestinal health and disease is gradually being revealed using state-of-the-art sequencing technologies. This Review presents the latest research on the interaction between fungi, bacteria and the host in relation to gastrointestinal disease, in particular IBD and graft-versus-host disease. The authors point out that further research is needed in this developing area of science and highlight areas of future endeavour. Abstract | Full Text | PDF
Clinical management of hereditary colorectal cancer syndromes Hans F. A. Vasen, Ian Tomlinson & Antoni Castells Published online: 13 January 2015 p88 | doi:10.1038/nrgastro.2014.229 For patients to take part in detection programmes and therefore reduce premature mortality due to cancer, it is vital for hereditary colorectal cancer syndromes to be identified early. Implementation of high-throughput techniques and genetic profiling of all new cases of colorectal cancer has improved early identification of affected families. As cancer risk and surveillance recommendations vary depending on gene defect, this Review argues that it is advantageous to include the gene defect in disease terminology to help facilitate the appropriate clinical management. Abstract | Full Text | PDF
Stress-related mucosal disease in the critically ill patient Marc Bardou, Jean-Pierre Quenot & Alan Barkun Published online: 06 January 2015 p98 | doi:10.1038/nrgastro.2014.235 Stress-related mucosal bleeding (SRMD) is an important issue owing to its severity, and its management in critically ill patients is especially difficult. In this Review, the latest information on the epidemiology, risk factors and management of SRMD are outlined to help guide clinicians of the most appropriate treatment strategies for patients in intensive care units. Abstract | Full Text | PDF
The concept of gut rehabilitation and the future of visceral transplantation Kareem Abu-Elmagd Published online: 20 January 2015 p108 | doi:10.1038/nrgastro.2014.216 This Review provides an in-depth and up-to-date overview of the major achievements in the evolving field of gut rehabilitation, with special emphasis on visceral transplantation. New insights into current challenges are highlighted, including future strategies to optimize the management of gut failure and enhance the long-term therapeutic efficacy of transplantation. Abstract | Full Text | PDF | Supplementary information
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*Journal Citation Reports, Thomson, 2013. Nature Reviews Gastroenterology & Hepatology was previously published as Nature Clinical Practice Gastroenterology & Hepatology.

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