Scientific Reports Biology Table of Contents e-alert: 3 February 2015

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03 February 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports         Don't let your data go to waste...  Scientific Data helps researchers make the most of their data, offering publication in a peer reviewed open access journal. We welcome data of all sizes, from all areas of science.   What's unique? A new type of article providing detailed descriptions of scientifically valuable datasets, maximising data discoverability and reuse.   Discover what we can do for your data           Biological Sciences               Social priming enhances interpersonal synchronization and feeling of connectedness towards schizophrenia patients ▶     Stéphane Raffard, Robin N. Salesse, Ludovic Marin et al.     What leads healthy individuals to abnormal feelings of contact with schizophrenia patients remains obscure. Despite recent findings that human bonding is an interactive process …             Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure ▶     Corinna Glasner, Mirjan M. van Timmeren, Tim Stobernack et al.     Chronic nasal carriage of the bacterium Staphylococcus aureus in patients with the autoimmune disease granulomatosis with polyangiitis (GPA) is a risk factor for disease relapse. …             Annexin A2 as a target endothelial cell membrane autoantigen in Behçet's disease ▶     Peng Chen, Hai Yan, Yaping Tian et al.     Cell membrane proteins are believed to play a critical role in the pathogenesis of autoimmune diseases. However, few membrane autoantigens have been linked with Behçet's disease. …             Ranking species in mutualistic networks ▶     Virginia Domínguez-García, Miguel A. Muñoz     Understanding the architectural subtleties of ecological networks, believed to confer them enhanced stability and robustness, is a subject of outmost relevance. Mutualistic …             Identifying anti-growth factors for human cancer cell lines through genome-scale metabolic modeling ▶     Pouyan Ghaffari, Adil Mardinoglu, Anna Asplund et al.     Human cancer cell lines are used as important model systems to study molecular mechanisms associated with tumor growth, hereunder how genomic and biological heterogeneity found …             A concurrent excitation and inhibition of dopaminergic subpopulations in response to nicotine ▶     Raphaël Eddine, Sebastien Valverde, Stefania Tolu et al.     Midbrain dopamine (DA) neurons are key players in motivation and reward processing. Increased DA release is thought to be central in the initiation of drug addiction. Whereas …             The Endoparasitoid, Cotesia vestalis, Regulates Host Physiology by Reprogramming the Neuropeptide Transcriptional Network ▶     Min Shi, Shuai Dong, Ming-tian Li et al.     Endoparasitoids develop inside another insect by regulating host immunity and development via maternal factors injected into hosts during oviposition. Prior results have provided …             The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese heroin-dependent patients ▶     Shiou-Lan Chen, Sheng-Yu Lee, Yun-Hsuan Chang et al.     BDNF and its gene polymorphism may be important in synaptic plasticity and neuron survival, and may become a key target in the physiopathology of long-term heroin use. Thus, we …             SMK-17, a MEK1/2-specific inhibitor, selectively induces apoptosis in β-catenin-mutated tumors ▶     Masaki Kiga, Ayako Nakayama, Yuki Shikata et al.     Although clinical studies have evaluated several MEK1/2 inhibitors, it is unlikely that MEK1/2 inhibitors will be studied clinically. BRAF mutations have been proposed as a …             Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease ▶     Nana Jin, Xiaomin Yin, Dian Yu et al.     Abnormal hyperphosphorylation of tau is pivotally involved in the pathogenesis of Alzheimer's disease (AD) and related tauopathies. Glycogen synthase kinase 3β (GSK-3β) is a …             An HDAC-dependent epigenetic mechanism that enhances the efficacy of the antidepressant drug fluoxetine ▶     C. Schmauss     Depression is a prevalent and debilitating psychiatric illnesses. However, currently prescribed antidepressant drugs are only efficacious in a limited group of patients. Studies …             Elabela-Apelin Receptor Signaling Pathway is Functional in Mammalian Systems ▶     Zhi Wang, Daozhan Yu, Mengqiao Wang et al.     Elabela (ELA) or Toddler is a recently discovered hormone which is required for normal development of heart and vasculature through activation of apelin receptor (APJ), a G …             Multiple invasions of an infectious retrovirus in cat genomes ▶     Sayumi Shimode, So Nakagawa, Takayuki Miyazawa     Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections of host germ-line cells. While most ERVs are defective, some are active and express viral proteins. …             Integrative analysis of differentially expressed microRNAs of pulmonary alveolar macrophages from piglets during H1N1 swine influenza A virus infection ▶     Pengfei Jiang, Na Zhou, Xinyu Chen et al.     H1N1 swine influenza A virus (H1N1 SwIV) is one key subtype of influenza viruses with pandemic potential. MicroRNAs (miRNAs) are endogenous small RNA molecules that regulate gene …             Adjudin protects rodent cochlear hair cells against gentamicin ototoxicity via the SIRT3-ROS pathway ▶     Yizhou Quan, Li Xia, Jiaxiang Shao et al.     Hearing loss resulting from hair cell degeneration is a common disease that affects millions of people worldwide. Strategies to overcome the apparent irreversible hair cell loss …             Molecular evolution of the VP1, VP2, and VP3 genes in human rhinovirus species C ▶     Makoto Kuroda, Shoichi Niwa, Tsuyoshi Sekizuka et al.     Human rhinovirus species C (HRV-C) was recently discovered, and this virus has been associated with various acute respiratory illnesses (ARI). However, the molecular evolution of …             Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Involved in Inflammation by Negatively Regulating the NF-κB Pathway ▶     Lijian Chen, Lijie Feng, Xia Wang et al.     Inflammation can cause endoplasmic reticulum (ER) stress and therefore activates the unfolded protein response (UPR). ER stress and the consequent UPR have the potential to …             Cigarette smoke alters primary human bronchial epithelial cell differentiation at the air-liquid interface ▶     Andrea C. Schamberger, Claudia A. Staab-Weijnitz, Nikica Mise-Racek et al.     The differentiated human airway epithelium consists of different cell types forming a polarized and pseudostratified epithelium. This is dramatically altered in chronic …             A simple rule for quadrupedal gait generation determined by leg loading feedback: a modeling study ▶     Yasuhiro Fukuoka, Yasushi Habu, Takahiro Fukui     We discovered a specific rule for generating typical quadrupedal gaits (the order of the movement of four legs) through a simulated quadrupedal locomotion, in which unprogrammed …             Exploring the microbiota dynamics related to vegetable biomasses degradation and study of lignocellulose-degrading bacteria for industrial biotechnological application ▶     Valeria Ventorino, Alberto Aliberti, Vincenza Faraco et al.     The aims of this study were to evaluate the microbial diversity of different lignocellulosic biomasses during degradation under natural conditions and to isolate, select, …             Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway ▶     Kumsun Cho, Jae Yong Chung, Sung Kweon Cho et al.     Metformin is a first-line drug for treating type 2 diabetes. Although metformin is known to phosphorylate AMP-activated protein kinase (AMPK), it is unclear how the …             Fractionation of human spermatogenic cells using STA-PUT gravity sedimentation and their miRNA profiling ▶     Yun Liu, Minghui Niu, Chencheng Yao et al.     Human spermatogenic cells have not yet been isolated, and notably, their global miRNA profiles remain unknown. Here we have effectively isolated human spermatogonia, pachytene …             Identification and application of keto acids transporters in Yarrowia lipolytica ▶     Hongwei Guo, Peiran Liu, Catherine Madzak et al.     Production of organic acids by microorganisms is of great importance for obtaining building-block chemicals from sustainable biomass. Extracellular accumulation of organic acids …             Highlighting nonlinear patterns in population genetics datasets ▶     Gregorio Alanis-Lobato, Carlo Vittorio Cannistraci, Anders Eriksson et al.     Detecting structure in population genetics and case-control studies is important, as it exposes phenomena such as ecoclines, admixture and stratification. Principal Component …             Synechococcus elongatus UTEX 2973, a fast growing cyanobacterial chassis for biosynthesis using light and CO2 ▶     Jingjie Yu, Michelle Liberton, Paul F. Cliften et al.     Photosynthetic microbes are of emerging interest as production organisms in biotechnology because they can grow autotrophically using sunlight, an abundant energy source, and CO2…             Optimized tuning of TALEN specificity using non-conventional RVDs ▶     Alexandre Juillerat, Coline Pessereau, Gwendoline Dubois et al.     A key feature when designing DNA targeting tools and especially nucleases is specificity. The ability to control and tune this important parameter represents an invaluable …             Transcriptome Analysis of Sexually Dimorphic Chinese White Wax Scale Insects Reveals Key Differences in Developmental Programs and Transcription Factor Expression ▶     Pu Yang, Xiao-Ming Chen, Wei-Wei Liu et al.     The Chinese white wax scale insect, Ericerus pela, represents one of the most dramatic examples of sexual dimorphism in any insect species. In this study, we showed that although …             The world's second largest population of humpback dolphins in the waters of Zhanjiang deserves the highest conservation priority ▶     Xinrong Xu, Jinyuan Song, Zhenhua Zhang et al.     Chinese white dolphins (Sousa chinensis) inhabiting shallow coastal waters are vulnerable to impacts from human activities in the near shore waters. This study examined the …             The short-chain fatty acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes ▶     Zhiwei Ang, Jun Zhi Er, Jeak Ling Ding     G-protein coupled receptor 43 (GPR43) recognizes short chain fatty acids and is implicated in obesity, colitis, asthma and arthritis. Here, we present the first full …             Global-scale computational analysis of genomic sequences reveals the recombination pattern and coevolution dynamics of cereal-infecting geminiviruses ▶     Beilei Wu, Xiaonan Shang, Jörg Schubert et al.     Genetic diversity and recombination patterns were evaluated for 229 isolates of Wheat dwarf virus (WDV), which are important cereal-infecting geminiviruses. Recombination hot …             Microcontroller-Assisted Compensation of Adenosine Triphosphate Levels: Instrument and Method Development ▶     Jie-Bi Hu, Ting-Ru Chen, Yu-Chie Chen et al.     In order to ascertain optimum conditions for biocatalytic processes carried out in vitro, we have designed a bio-opto-electronic system which ensures real-time compensation for …             Dental plaque development on a hydroxyapatite disk in young adults observed by using a barcoded pyrosequencing approach ▶     Toru Takeshita, Masaki Yasui, Yukie Shibata et al.     Dental plaque is a dynamic microbial biofilm ecosystem that comprises hundreds of species including difficult-to-cultivate bacteria. We observed the assembly of a plaque …             ZnO Nanorod Array Grown on Ag Layer: A Highly Efficient Fluorescence Enhancement Platform ▶     Yongqi Yin, Ye Sun, Miao Yu et al.     ZnO nanorods (NRs) are known for ultra-sensitive biomolecule detection through fluorescence enhancement. In this work, we demonstrate that ZnO NR arrays grown on Ag layers can …             Oxygen-18 isotope of breath CO2 linking to erythrocytes carbonic anhydrase activity: a biomarker for pre-diabetes and type 2 diabetes ▶     Chiranjit Ghosh, Gourab D. Banik, Abhijit Maity et al.     Carbonic anhydrase (CA), a well-characterized metalloenzyme, is associated with oxygen-18 ( 18O)-isotopic fractionations of CO2. To investigate how CA activity links the 18O of …             Field resistance of transgenic plantain to nematodes has potential for future African food security ▶     Leena Tripathi, Annet Babirye, Hugh Roderick et al.     Plant parasitic nematodes impose losses of up to 70% on plantains and cooking bananas in Africa. Application of nematicides is inappropriate and resistant cultivars are …             The secreted factor Ag1 missing in higher vertebrates regulates fins regeneration in Danio rerio ▶     Anastasiya S. Ivanova, Igor N. Shandarin, Galina V. Ermakova et al.     Agr family includes three groups of genes, Ag1, Agr2 and Agr3, which encode the thioredoxin domain-containing secreted proteins and have been shown recently to participate in …             Suppression of adrenal βarrestin1-dependent aldosterone production by ARBs: head-to-head comparison ▶     Samalia Dabul, Ashley Bathgate-Siryk, Thairy Reyes Valero et al.     The known angiotensin II (AngII) physiological effect of aldosterone synthesis and secretion is mediated by either Gq/11 proteins or βarrestin1 (βarr1), both of which can couple …             Properties of ecosystems that are vulnerable during eco-fusion ▶     Katsuhiko Yoshida, Kei Tokita     When two ecosystems with separate evolutionary histories come into contact (eco-fusion), reciprocal invasions occur during their fusion. Asymmetries in the migration direction or …             Benefits of rice seed priming are offset permanently by prolonged storage and the storage conditions ▶     Saddam Hussain, Manman Zheng, Fahad Khan et al.     Seed priming is a commercially successful practice, but reduced longevity of primed seeds during storage may limit its application. We established a series of experiments on rice …             Acorn cotyledons are larger than their seedlings' need: evidence from artificial cutting experiments ▶     Xianfeng Yi, Zhenyu Wang, Changqu Liu et al.     Although the consequences of cotyledon removal have been widely studied in oaks producing large acorns, we have little knowledge of at what level cotyledons can be removed …             Automated Analysis of Cell-Matrix Adhesions in 2D and 3D Environments ▶     Joshua A. Broussard, Nicole L. Diggins, Stephen Hummel et al.     Cell-matrix adhesions are of great interest because of their contribution to numerous biological processes, including cell migration, differentiation, proliferation, survival, …             Association between cytochrome P450 1A1 (CYP1A1) gene polymorphisms and the risk of renal cell carcinoma: a meta-analysis ▶     Fan-dong Meng, Ping Ma, Cheng-guang Sui et al.     Cytochrome P450 1A1 (CYP1A1) usually metabolizes carcinogens to their inactive derivatives but occasionally converts the chemicals to more potent carcinogens. To date, many …             Glycerol-3-phosphate O-acyltransferase is required for PBAN-induced sex pheromone biosynthesis in Bombyx mori ▶     Mengfang Du, Xiaoguang Liu, Xiaoming Liu et al.     Female moths employ their own pheromone blends as a communicational medium in mating behavior. The biosynthesis and release of sex pheromone in female moths are regulated by …             Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes ▶     Chao Liu, Jia Hu, Chunxiang Qu et al.     Cryptochromes function in animal circadian regulation. Zebrafish are known to have six cryptochrome (cry) genes but their evolutionary relationships are not yet fully resolved. …             PhenomeExpress: A refined network analysis of expression datasets by inclusion of known disease phenotypes ▶     Jamie Soul, Timothy E. Hardingham, Raymond P. Boot-Handford et al.     We describe a new method, PhenomeExpress, for the analysis of transcriptomic datasets to identify pathogenic disease mechanisms. Our analysis method includes input from both …             FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach ▶     Weiqiang Lu, Feixiong Cheng, Jing Jiang et al.     Non-steroidal anti-inflammatory drugs (NSAIDs) are worldwide used drugs for analgesic, antipyretic, and anti-inflammatory therapeutics. However, NSAIDs often cause several …             A nutritionally-enhanced oil from transgenic Camelina sativa effectively replaces fish oil as a source of eicosapentaenoic acid for fish ▶     M. B. Betancor, M. Sprague, S. Usher et al.     For humans a daily intake of up to 500 mg omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA) is recommended, amounting to an annual requirement of 1.25 million metric …             Enhancement of faba bean competitive ability by arbuscular mycorrhizal fungi is highly correlated with dynamic nutrient acquisition by competing wheat ▶     Xu Qiao, Shuikuan Bei, Chunjie Li et al.     The mechanistic understanding of the dynamic processes linking nutrient acquisition and biomass production of competing individuals can be instructive in optimizing intercropping …             Serotonin Deficiency Exacerbates Acetaminophen-Induced Liver Toxicity In Mice ▶     Jingyao Zhang, Sidong Song, Qing Pang et al.     Acetaminophen (APAP) overdose is a major cause of acute liver failure. Peripheral 5-hydroxytryptamine (serotonin, 5-HT) is a cytoprotective neurotransmitter which is also …             An injectable acoustic transmitter for juvenile salmon ▶     Z. D. Deng, T. J. Carlson, H. Li et al.     Salmon recovery and the potential detrimental effects of dams on fish have been attracting national attention due to the environmental and economic implications. In recent years …             Subperiosteal Transmission Of Intra-Articular Pressure Between Articulated And Stationary Joints ▶     Mark Pitkin, Raghuveer Muppavarapu, Charles Cassidy et al.     Hydrostatic pressures can be transmitted between synovial capsules. In each of ten rabbits, we simultaneously measured pressure in two joints, one of which was passively ranged, …             The impact of resveratrol and hydrogen peroxide on muscle cell plasticity shows a dose-dependent interaction ▶     Alessandra Bosutti, Hans Degens     While reactive oxygen species (ROS) play a role in muscle repair, excessive amounts of ROS for extended periods may lead to oxidative stress. Antioxidants, as resveratrol (RS), …             SynBioLGDB: a resource for experimentally validated logic gates in synthetic biology ▶     Liqiang Wang, Kun Qian, Yan Huang et al.     Synthetic biologists have developed DNA/molecular modules that perform genetic logic operations in living cells to track key moments in a cell's life or change the fate of a …             Unbalanced Activation of Glutathione Metabolic Pathways Suggests Potential Involvement in Plant Defense against the Gall Midge Mayetiola destructor in Wheat ▶     Xuming Liu, Shize Zhang, R. Jeff Whitworth et al.     Glutathione, γ-glutamylcysteinylglycine, exists abundantly in nearly all organisms. Glutathione participates in various physiological processes involved in redox reactions by …             Novel codon-optimized mini-intronic plasmid for efficient, inexpensive, and xeno-free induction of pluripotency ▶     Sebastian Diecke, Jiamiao Lu, Jaecheol Lee et al.     The development of human induced pluripotent stem cell (iPSC) technology has revolutionized the regenerative medicine field. This technology provides a powerful tool for disease …             MiR-148b suppresses cell proliferation and invasion in hepatocellular carcinoma by targeting WNT1/β-catenin pathway ▶     Jun-gang Zhang, Ying Shi, De-fei Hong et al.     Accumulating evidences indicate that microRNAs play a vital role in regulating tumor progression. However, the roles of miR-148b in hepatocellular carcinoma (HCC) are still …             Differential mechanisms of asparaginase resistance in B-type acute lymphoblastic leukemia and malignant natural killer cell lines ▶     Wei-Wen Chien, Céline Le Beux, Nicolas Rachinel et al.     Bacterial L-asparaginase (ASNase), hydrolyzing L-asparagine (Asn), is an important drug for treating patients with acute lymphoblastic leukaemia (ALL) and natural killer (NK) …             Signal enhancement and Patterson-search phasing for high-spatial-resolution coherent X-ray diffraction imaging of biological objects ▶     Yuki Takayama, Saori Maki-Yonekura, Tomotaka Oroguchi et al.     In this decade coherent X-ray diffraction imaging has been demonstrated to reveal internal structures of whole biological cells and organelles. However, the spatial resolution is …             Draft genome sequence of adzuki bean, Vigna angularis ▶     Yang Jae Kang, Dani Satyawan, Sangrea Shim et al.     Adzuki bean (Vigna angularis var. angularis) is a dietary legume crop in East Asia. The presumed progenitor (Vigna angularis var. nipponensis) is widely found in East Asia, …             Reference gene selection for cross-species and cross-ploidy level comparisons in Chrysanthemum spp. ▶     Haibin Wang, Sumei Chen, Jiafu Jiang et al.     The establishment of a (set of) stably expressed reference gene(s) is required to normalize transcription data. Polyploidy is very common in the plant kingdom, but it is not …             Chemosensillum immunolocalization and ligand specificity of chemosensory proteins in the alfalfa plant bug Adelphocoris lineolatus (Goeze) ▶     Liang Sun, Jing-Jiang Zhou, Shao-Hua Gu et al.     Insect chemosensory proteins (CSPs) are a family of small soluble proteins. To date, their physiological functions in insect olfaction remain largely controversial in comparison …             A transcription blocker isolated from a designed repeat protein combinatorial library by in vivo functional screen ▶     Elena B. Tikhonova, Abdul S. Ethayathulla, Yue Su et al.     A highly diverse DNA library coding for ankyrin seven-repeat proteins (ANK-N5C) was designed and constructed by a PCR-based combinatorial assembly strategy. A bacterial melibiose …             Dysregulated Ca2+ Homeostasis in Fanconi anemia cells ▶     Cesare Usai, Silvia Ravera, Paola Cuccarolo et al.     Fanconi Anemia (FA) is a rare and complex inherited blood disorder associated with bone marrow failure and malignancies. Many alterations in FA physiology appear linked to red-ox …             Residues remote from the binding pocket control the antagonist selectivity towards the corticotropin-releasing factor receptor-1 ▶     Xianqiang Sun, Jianxin Cheng, Xu Wang et al.     The corticotropin releasing factors receptor-1 and receptor-2 (CRF1R and CRF2R) are therapeutic targets for treating neurological diseases. Antagonists targeting CRF1R have been …             Integrated miRNA and mRNA expression profiling to identify mRNA targets of dysregulated miRNAs in non-obstructive azoospermia ▶     Xuan Zhuang, Zhiming Li, Huinuan Lin et al.     The aim of this study was to identify mRNA targets of dysregulated miRNAs through the integrated analysis of miRNA and mRNA expression profiling in men with normal versus …             Simulated microgravity inhibits L-type calcium channel currents partially by the up-regulation of miR-103 in MC3T3-E1 osteoblasts ▶     Zhongyang Sun, Xinsheng Cao, Zhuo Zhang et al.     L-type voltage-sensitive calcium channels (LTCCs), particularly Cav1.2 LTCCs, play fundamental roles in cellular responses to mechanical stimuli in osteoblasts. Numerous studies …             Resveratrol Prevents Age-Related Memory and Mood Dysfunction with Increased Hippocampal Neurogenesis and Microvasculature, and Reduced Glial Activation ▶     Maheedhar Kodali, Vipan K. Parihar, Bharathi Hattiangady et al.     Greatly waned neurogenesis, diminished microvasculature, astrocyte hypertrophy and activated microglia are among the most conspicuous structural changes in the aged hippocampus. …             Apoptosis Signal-regulating Kinase 1 promotes Ochratoxin A-induced renal cytotoxicity ▶     Rui Liang, Xiao Li Shen, Boyang Zhang et al.     Oxidative stress and apoptosis are involved in Ochratoxin A (OTA)-induced renal cytotoxicity. Apoptosis signal-regulating kinase 1 (ASK1) is a Mitogen-Activated Protein Kinase …             Treatment of urodelans based on temperature dependent infection dynamics of Batrachochytrium salamandrivorans ▶     M. Blooi, A. Martel, F. Haesebrouck et al.     The recently emerged chytrid fungus Batrachochytrium salamandrivorans currently causes amphibian population declines. We hypothesized that temperature dictates infection dynamics …             Effect of the enzyme and PCR conditions on the quality of high-throughput DNA sequencing results ▶     Claudia Brandariz-Fontes, Miguel Camacho-Sanchez, Carles Vilà et al.     Library preparation protocols for high-throughput DNA sequencing (HTS) include amplification steps in which errors can build up. In order to have confidence in the sequencing …             Transgenic mouse model expressing P53R172H, luciferase, EGFP, and KRASG12D in a single open reading frame for live imaging of tumor ▶     Hye-Lim Ju, Diego F. Calvisi, Hyuk Moon et al.     Genetically engineered mouse cancer models allow tumors to be imaged in vivo via co-expression of a reporter gene with a tumor-initiating gene. However, differential …             Multi-trait mimicry of ants by a parasitoid wasp ▶     Miriama Malcicka, T. Martijn Bezemer, Bertanne Visser et al.     Many animals avoid attack from predators through toxicity or the emission of repellent chemicals. Defensive mimicry has evolved in many species to deceive shared predators, for …             Effects of fictive reward on rat's choice behavior ▶     Ko-Un Kim, Namjung Huh, Yunsil Jang et al.     Choices of humans and non-human primates are influenced by both actually experienced and fictive outcomes. To test whether this is also the case in rodents, we examined rat's …             Functional characterization of a vanillin dehydrogenase in Corynebacterium glutamicum ▶     Wei Ding, Meiru Si, Weipeng Zhang et al.     Vanillin dehydrogenase (VDH) is a crucial enzyme involved in the degradation of lignin-derived aromatic compounds. Herein, the VDH from Corynebacterium glutamicum was …             Translationally Controlled Tumor Protein induces epithelial to mesenchymal transition and promotes cell migration, invasion and metastasis ▶     Seong-Yeon Bae, Hyun Jung Kim, Kong-Joo Lee et al.     Translationally controlled tumor protein (TCTP), is a highly conserved protein involved in fundamental processes, such as cell proliferation and growth, tumorigenesis, apoptosis, …             Systems approach for the selection of micro-RNAs as therapeutic biomarkers of anti-EGFR monoclonal antibody treatment in colorectal cancer ▶     Avisek Deyati, Shweta Bagewadi, Philipp Senger et al.     miRNA plays an important role in tumourgenesis by regulating expression of oncogenes and tumour suppressors. Thus affects cell proliferation and differentiation, apoptosis, …             Luciferase Reporter Gene Assay on Human 5-HT Receptor: Which Response Element Should Be Chosen? ▶     Yiming Chen, Zhongyu Xu, Dang Wu et al.     Serotonin (5-HT) receptors are valuable molecular targets for antipsychotic drug discovery. Current reported methods for detecting 5-HT receptors, such as cAMP accumulation and …             In vitro reconstruction of branched tubular structures from lung epithelial cells in high cell concentration gradient environment ▶     Masaya Hagiwara, Fei Peng, Chih-Ming Ho     We have succeeded in developing hollow branching structure in vitro commonly observed in lung airway using primary lung airway epithelial cells. Cell concentration gradient is …             Amino acids substitutions in the PB2 protein of H7N9 influenza A viruses are important for virulence in mammalian hosts ▶     Seiya Yamayoshi, Satoshi Fukuyama, Shinya Yamada et al.     We tested the biological significance of two amino acid mutations in the PB2 protein (glutamic acid to lysine at position 627 and aspartic acid to asparagine at position 701) of …             Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles ▶     HaJeung Park, Sarah Iqbal, Pamela Hernandez et al.     Three JNK isoforms, JNK1, JNK2, and JNK3 have been reported and unique biological function has been ascribed to each. It is unknown if selective inhibition of these isoforms …             CORRIGENDUM: Separable Bilayer Microfiltration Device for Viable Label-free Enrichment of Circulating Tumour Cells ▶     Ming-Da Zhou, Sijie Hao, Anthony J. Williams et al.                 CORRIGENDUM: Different Inhibitory Effect and Mechanism of Hydroxyapatite Nanoparticles on Normal Cells and Cancer Cells In Vitro and In Vivo ▶     Yingchao Han, Shipu Li, Xianying Cao et al.                 Evidence for high dispersal ability and mito-nuclear discordance in the small brown planthopper, Laodelphax striatellus ▶     Jing-Tao Sun, Man-Man Wang, Yan-Kai Zhang et al.     Understanding dispersal ability in pest species is critical for both theoretical aspects of evolutionary and population biology and from a practical standpoint, such as …             Octopamine and tyramine respectively regulate attractive and repulsive behavior in locust phase changes ▶     Zongyuan Ma, Xiaojiao Guo, Hong Lei et al.     Aggregative and solitary behaviors are universal phenomena in animals. Interestingly, locusts (Locusta migratoria) can reversibly transit their behavior between gregarious and …             Wnt5a promotes cancer cell invasion and proliferation by receptor-mediated endocytosis-dependent and -independent mechanisms, respectively ▶     Kensaku Shojima, Akira Sato, Hideaki Hanaki et al.     Wnt5a activates the Wnt/β-catenin-independent pathway and its overexpression is associated with tumor aggressiveness enhancing invasive activity. For this action, Wnt5a-induced …             Correlation of circular RNA abundance with proliferation – exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues ▶     Anna Bachmayr-Heyda, Agnes T. Reiner, Katharina Auer et al.     Circular RNAs are a recently (re-)discovered abundant RNA species with presumed function as miRNA sponges, thus part of the competing endogenous RNA network. We analysed the …             Hydro-Responsive Curling of the Resurrection Plant Selaginella lepidophylla ▶     Ahmad Rafsanjani, Véronique Brulé, Tamara L. Western et al.     The spirally arranged stems of the spikemoss Selaginella lepidophylla, an ancient resurrection plant, compactly curl into a nest-ball shape upon dehydration. Due to its spiral …             The Evidence of Glioblastoma Heterogeneity ▶     Akio Soeda, Akira Hara, Takahiro Kunisada et al.     Cancers are composed of heterogeneous combinations of cells that exhibit distinct phenotypic characteristics and proliferative potentials. 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