Scientific Reports Table of Contents e-alert: 3 February 2015

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03 February 2015      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports         Don't let your data go to waste... Scientific Data helps researchers make the most of their data, offering publication in a peer reviewed open access journal. We welcome data of all sizes, from all areas of science.   What's unique? A new type of article providing detailed descriptions of scientifically valuable datasets, maximising data discoverability and reuse.   Discover what we can do for your data          Jump to the content that matters to you ▼ Biological Sciences   ▼ Chemical Sciences   ▼ Physical Sciences   ▼ Earth & Environmental Sciences   ▼ Health Sciences               Biological Sciences ▲ top               Social priming enhances interpersonal synchronization and feeling of connectedness towards schizophrenia patients ▶     Stéphane Raffard, Robin N. Salesse, Ludovic Marin et al.     What leads healthy individuals to abnormal feelings of contact with schizophrenia patients remains obscure. Despite recent findings that human bonding is an interactive process …             Low anti-staphylococcal IgG responses in granulomatosis with polyangiitis patients despite long-term Staphylococcus aureus exposure ▶     Corinna Glasner, Mirjan M. van Timmeren, Tim Stobernack et al.     Chronic nasal carriage of the bacterium Staphylococcus aureus in patients with the autoimmune disease granulomatosis with polyangiitis (GPA) is a risk factor for disease relapse. …             Annexin A2 as a target endothelial cell membrane autoantigen in Behçet's disease ▶     Peng Chen, Hai Yan, Yaping Tian et al.     Cell membrane proteins are believed to play a critical role in the pathogenesis of autoimmune diseases. However, few membrane autoantigens have been linked with Behçet's disease. …             Ranking species in mutualistic networks ▶     Virginia Domínguez-García, Miguel A. Muñoz     Understanding the architectural subtleties of ecological networks, believed to confer them enhanced stability and robustness, is a subject of outmost relevance. Mutualistic …             Identifying anti-growth factors for human cancer cell lines through genome-scale metabolic modeling ▶     Pouyan Ghaffari, Adil Mardinoglu, Anna Asplund et al.     Human cancer cell lines are used as important model systems to study molecular mechanisms associated with tumor growth, hereunder how genomic and biological heterogeneity found …             A concurrent excitation and inhibition of dopaminergic subpopulations in response to nicotine ▶     Raphaël Eddine, Sebastien Valverde, Stefania Tolu et al.     Midbrain dopamine (DA) neurons are key players in motivation and reward processing. Increased DA release is thought to be central in the initiation of drug addiction. Whereas …             The Endoparasitoid, Cotesia vestalis, Regulates Host Physiology by Reprogramming the Neuropeptide Transcriptional Network ▶     Min Shi, Shuai Dong, Ming-tian Li et al.     Endoparasitoids develop inside another insect by regulating host immunity and development via maternal factors injected into hosts during oviposition. Prior results have provided …             The BDNF Val66Met polymorphism and plasma brain-derived neurotrophic factor levels in Han Chinese heroin-dependent patients ▶     Shiou-Lan Chen, Sheng-Yu Lee, Yun-Hsuan Chang et al.     BDNF and its gene polymorphism may be important in synaptic plasticity and neuron survival, and may become a key target in the physiopathology of long-term heroin use. Thus, we …             SMK-17, a MEK1/2-specific inhibitor, selectively induces apoptosis in β-catenin-mutated tumors ▶     Masaki Kiga, Ayako Nakayama, Yuki Shikata et al.     Although clinical studies have evaluated several MEK1/2 inhibitors, it is unlikely that MEK1/2 inhibitors will be studied clinically. BRAF mutations have been proposed as a …             Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease ▶     Nana Jin, Xiaomin Yin, Dian Yu et al.     Abnormal hyperphosphorylation of tau is pivotally involved in the pathogenesis of Alzheimer's disease (AD) and related tauopathies. Glycogen synthase kinase 3β (GSK-3β) is a …             An HDAC-dependent epigenetic mechanism that enhances the efficacy of the antidepressant drug fluoxetine ▶     C. Schmauss     Depression is a prevalent and debilitating psychiatric illnesses. However, currently prescribed antidepressant drugs are only efficacious in a limited group of patients. Studies …             Elabela-Apelin Receptor Signaling Pathway is Functional in Mammalian Systems ▶     Zhi Wang, Daozhan Yu, Mengqiao Wang et al.     Elabela (ELA) or Toddler is a recently discovered hormone which is required for normal development of heart and vasculature through activation of apelin receptor (APJ), a G …             Multiple invasions of an infectious retrovirus in cat genomes ▶     Sayumi Shimode, So Nakagawa, Takayuki Miyazawa     Endogenous retroviruses (ERVs) are remnants of ancient retroviral infections of host germ-line cells. While most ERVs are defective, some are active and express viral proteins. …             Integrative analysis of differentially expressed microRNAs of pulmonary alveolar macrophages from piglets during H1N1 swine influenza A virus infection ▶     Pengfei Jiang, Na Zhou, Xinyu Chen et al.     H1N1 swine influenza A virus (H1N1 SwIV) is one key subtype of influenza viruses with pandemic potential. MicroRNAs (miRNAs) are endogenous small RNA molecules that regulate gene …             Adjudin protects rodent cochlear hair cells against gentamicin ototoxicity via the SIRT3-ROS pathway ▶     Yizhou Quan, Li Xia, Jiaxiang Shao et al.     Hearing loss resulting from hair cell degeneration is a common disease that affects millions of people worldwide. Strategies to overcome the apparent irreversible hair cell loss …             Molecular evolution of the VP1, VP2, and VP3 genes in human rhinovirus species C ▶     Makoto Kuroda, Shoichi Niwa, Tsuyoshi Sekizuka et al.     Human rhinovirus species C (HRV-C) was recently discovered, and this virus has been associated with various acute respiratory illnesses (ARI). However, the molecular evolution of …             Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Involved in Inflammation by Negatively Regulating the NF-κB Pathway ▶     Lijian Chen, Lijie Feng, Xia Wang et al.     Inflammation can cause endoplasmic reticulum (ER) stress and therefore activates the unfolded protein response (UPR). ER stress and the consequent UPR have the potential to …             Cigarette smoke alters primary human bronchial epithelial cell differentiation at the air-liquid interface ▶     Andrea C. Schamberger, Claudia A. Staab-Weijnitz, Nikica Mise-Racek et al.     The differentiated human airway epithelium consists of different cell types forming a polarized and pseudostratified epithelium. This is dramatically altered in chronic …             A simple rule for quadrupedal gait generation determined by leg loading feedback: a modeling study ▶     Yasuhiro Fukuoka, Yasushi Habu, Takahiro Fukui     We discovered a specific rule for generating typical quadrupedal gaits (the order of the movement of four legs) through a simulated quadrupedal locomotion, in which unprogrammed …             Exploring the microbiota dynamics related to vegetable biomasses degradation and study of lignocellulose-degrading bacteria for industrial biotechnological application ▶     Valeria Ventorino, Alberto Aliberti, Vincenza Faraco et al.     The aims of this study were to evaluate the microbial diversity of different lignocellulosic biomasses during degradation under natural conditions and to isolate, select, …             Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway ▶     Kumsun Cho, Jae Yong Chung, Sung Kweon Cho et al.     Metformin is a first-line drug for treating type 2 diabetes. Although metformin is known to phosphorylate AMP-activated protein kinase (AMPK), it is unclear how the …             Fractionation of human spermatogenic cells using STA-PUT gravity sedimentation and their miRNA profiling ▶     Yun Liu, Minghui Niu, Chencheng Yao et al.     Human spermatogenic cells have not yet been isolated, and notably, their global miRNA profiles remain unknown. Here we have effectively isolated human spermatogonia, pachytene …             Identification and application of keto acids transporters in Yarrowia lipolytica ▶     Hongwei Guo, Peiran Liu, Catherine Madzak et al.     Production of organic acids by microorganisms is of great importance for obtaining building-block chemicals from sustainable biomass. Extracellular accumulation of organic acids …             Highlighting nonlinear patterns in population genetics datasets ▶     Gregorio Alanis-Lobato, Carlo Vittorio Cannistraci, Anders Eriksson et al.     Detecting structure in population genetics and case-control studies is important, as it exposes phenomena such as ecoclines, admixture and stratification. Principal Component …             Synechococcus elongatus UTEX 2973, a fast growing cyanobacterial chassis for biosynthesis using light and CO2 ▶     Jingjie Yu, Michelle Liberton, Paul F. Cliften et al.     Photosynthetic microbes are of emerging interest as production organisms in biotechnology because they can grow autotrophically using sunlight, an abundant energy source, and CO2…             Optimized tuning of TALEN specificity using non-conventional RVDs ▶     Alexandre Juillerat, Coline Pessereau, Gwendoline Dubois et al.     A key feature when designing DNA targeting tools and especially nucleases is specificity. The ability to control and tune this important parameter represents an invaluable …             Transcriptome Analysis of Sexually Dimorphic Chinese White Wax Scale Insects Reveals Key Differences in Developmental Programs and Transcription Factor Expression ▶     Pu Yang, Xiao-Ming Chen, Wei-Wei Liu et al.     The Chinese white wax scale insect, Ericerus pela, represents one of the most dramatic examples of sexual dimorphism in any insect species. In this study, we showed that although …             The world's second largest population of humpback dolphins in the waters of Zhanjiang deserves the highest conservation priority ▶     Xinrong Xu, Jinyuan Song, Zhenhua Zhang et al.     Chinese white dolphins (Sousa chinensis) inhabiting shallow coastal waters are vulnerable to impacts from human activities in the near shore waters. This study examined the …             The short-chain fatty acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes ▶     Zhiwei Ang, Jun Zhi Er, Jeak Ling Ding     G-protein coupled receptor 43 (GPR43) recognizes short chain fatty acids and is implicated in obesity, colitis, asthma and arthritis. Here, we present the first full …             Global-scale computational analysis of genomic sequences reveals the recombination pattern and coevolution dynamics of cereal-infecting geminiviruses ▶     Beilei Wu, Xiaonan Shang, Jörg Schubert et al.     Genetic diversity and recombination patterns were evaluated for 229 isolates of Wheat dwarf virus (WDV), which are important cereal-infecting geminiviruses. Recombination hot …             Microcontroller-Assisted Compensation of Adenosine Triphosphate Levels: Instrument and Method Development ▶     Jie-Bi Hu, Ting-Ru Chen, Yu-Chie Chen et al.     In order to ascertain optimum conditions for biocatalytic processes carried out in vitro, we have designed a bio-opto-electronic system which ensures real-time compensation for …             Dental plaque development on a hydroxyapatite disk in young adults observed by using a barcoded pyrosequencing approach ▶     Toru Takeshita, Masaki Yasui, Yukie Shibata et al.     Dental plaque is a dynamic microbial biofilm ecosystem that comprises hundreds of species including difficult-to-cultivate bacteria. We observed the assembly of a plaque …             ZnO Nanorod Array Grown on Ag Layer: A Highly Efficient Fluorescence Enhancement Platform ▶     Yongqi Yin, Ye Sun, Miao Yu et al.     ZnO nanorods (NRs) are known for ultra-sensitive biomolecule detection through fluorescence enhancement. In this work, we demonstrate that ZnO NR arrays grown on Ag layers can …             Oxygen-18 isotope of breath CO2 linking to erythrocytes carbonic anhydrase activity: a biomarker for pre-diabetes and type 2 diabetes ▶     Chiranjit Ghosh, Gourab D. Banik, Abhijit Maity et al.     Carbonic anhydrase (CA), a well-characterized metalloenzyme, is associated with oxygen-18 ( 18O)-isotopic fractionations of CO2. To investigate how CA activity links the 18O of …             Field resistance of transgenic plantain to nematodes has potential for future African food security ▶     Leena Tripathi, Annet Babirye, Hugh Roderick et al.     Plant parasitic nematodes impose losses of up to 70% on plantains and cooking bananas in Africa. Application of nematicides is inappropriate and resistant cultivars are …             The secreted factor Ag1 missing in higher vertebrates regulates fins regeneration in Danio rerio ▶     Anastasiya S. Ivanova, Igor N. Shandarin, Galina V. Ermakova et al.     Agr family includes three groups of genes, Ag1, Agr2 and Agr3, which encode the thioredoxin domain-containing secreted proteins and have been shown recently to participate in …             Suppression of adrenal βarrestin1-dependent aldosterone production by ARBs: head-to-head comparison ▶     Samalia Dabul, Ashley Bathgate-Siryk, Thairy Reyes Valero et al.     The known angiotensin II (AngII) physiological effect of aldosterone synthesis and secretion is mediated by either Gq/11 proteins or βarrestin1 (βarr1), both of which can couple …             Properties of ecosystems that are vulnerable during eco-fusion ▶     Katsuhiko Yoshida, Kei Tokita     When two ecosystems with separate evolutionary histories come into contact (eco-fusion), reciprocal invasions occur during their fusion. Asymmetries in the migration direction or …             Benefits of rice seed priming are offset permanently by prolonged storage and the storage conditions ▶     Saddam Hussain, Manman Zheng, Fahad Khan et al.     Seed priming is a commercially successful practice, but reduced longevity of primed seeds during storage may limit its application. We established a series of experiments on rice …             Acorn cotyledons are larger than their seedlings' need: evidence from artificial cutting experiments ▶     Xianfeng Yi, Zhenyu Wang, Changqu Liu et al.     Although the consequences of cotyledon removal have been widely studied in oaks producing large acorns, we have little knowledge of at what level cotyledons can be removed …             Automated Analysis of Cell-Matrix Adhesions in 2D and 3D Environments ▶     Joshua A. Broussard, Nicole L. Diggins, Stephen Hummel et al.     Cell-matrix adhesions are of great interest because of their contribution to numerous biological processes, including cell migration, differentiation, proliferation, survival, …             Association between cytochrome P450 1A1 (CYP1A1) gene polymorphisms and the risk of renal cell carcinoma: a meta-analysis ▶     Fan-dong Meng, Ping Ma, Cheng-guang Sui et al.     Cytochrome P450 1A1 (CYP1A1) usually metabolizes carcinogens to their inactive derivatives but occasionally converts the chemicals to more potent carcinogens. To date, many …             Glycerol-3-phosphate O-acyltransferase is required for PBAN-induced sex pheromone biosynthesis in Bombyx mori ▶     Mengfang Du, Xiaoguang Liu, Xiaoming Liu et al.     Female moths employ their own pheromone blends as a communicational medium in mating behavior. The biosynthesis and release of sex pheromone in female moths are regulated by …             Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes ▶     Chao Liu, Jia Hu, Chunxiang Qu et al.     Cryptochromes function in animal circadian regulation. Zebrafish are known to have six cryptochrome (cry) genes but their evolutionary relationships are not yet fully resolved. …             PhenomeExpress: A refined network analysis of expression datasets by inclusion of known disease phenotypes ▶     Jamie Soul, Timothy E. Hardingham, Raymond P. Boot-Handford et al.     We describe a new method, PhenomeExpress, for the analysis of transcriptomic datasets to identify pathogenic disease mechanisms. Our analysis method includes input from both …             FXR antagonism of NSAIDs contributes to drug-induced liver injury identified by systems pharmacology approach ▶     Weiqiang Lu, Feixiong Cheng, Jing Jiang et al.     Non-steroidal anti-inflammatory drugs (NSAIDs) are worldwide used drugs for analgesic, antipyretic, and anti-inflammatory therapeutics. However, NSAIDs often cause several …             A nutritionally-enhanced oil from transgenic Camelina sativa effectively replaces fish oil as a source of eicosapentaenoic acid for fish ▶     M. B. Betancor, M. Sprague, S. Usher et al.     For humans a daily intake of up to 500 mg omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA) is recommended, amounting to an annual requirement of 1.25 million metric …             Enhancement of faba bean competitive ability by arbuscular mycorrhizal fungi is highly correlated with dynamic nutrient acquisition by competing wheat ▶     Xu Qiao, Shuikuan Bei, Chunjie Li et al.     The mechanistic understanding of the dynamic processes linking nutrient acquisition and biomass production of competing individuals can be instructive in optimizing intercropping …             Serotonin Deficiency Exacerbates Acetaminophen-Induced Liver Toxicity In Mice ▶     Jingyao Zhang, Sidong Song, Qing Pang et al.     Acetaminophen (APAP) overdose is a major cause of acute liver failure. Peripheral 5-hydroxytryptamine (serotonin, 5-HT) is a cytoprotective neurotransmitter which is also …             An injectable acoustic transmitter for juvenile salmon ▶     Z. D. Deng, T. J. Carlson, H. Li et al.     Salmon recovery and the potential detrimental effects of dams on fish have been attracting national attention due to the environmental and economic implications. In recent years …             Subperiosteal Transmission Of Intra-Articular Pressure Between Articulated And Stationary Joints ▶     Mark Pitkin, Raghuveer Muppavarapu, Charles Cassidy et al.     Hydrostatic pressures can be transmitted between synovial capsules. In each of ten rabbits, we simultaneously measured pressure in two joints, one of which was passively ranged, …             The impact of resveratrol and hydrogen peroxide on muscle cell plasticity shows a dose-dependent interaction ▶     Alessandra Bosutti, Hans Degens     While reactive oxygen species (ROS) play a role in muscle repair, excessive amounts of ROS for extended periods may lead to oxidative stress. Antioxidants, as resveratrol (RS), …             SynBioLGDB: a resource for experimentally validated logic gates in synthetic biology ▶     Liqiang Wang, Kun Qian, Yan Huang et al.     Synthetic biologists have developed DNA/molecular modules that perform genetic logic operations in living cells to track key moments in a cell's life or change the fate of a …             Unbalanced Activation of Glutathione Metabolic Pathways Suggests Potential Involvement in Plant Defense against the Gall Midge Mayetiola destructor in Wheat ▶     Xuming Liu, Shize Zhang, R. Jeff Whitworth et al.     Glutathione, γ-glutamylcysteinylglycine, exists abundantly in nearly all organisms. Glutathione participates in various physiological processes involved in redox reactions by …             Novel codon-optimized mini-intronic plasmid for efficient, inexpensive, and xeno-free induction of pluripotency ▶     Sebastian Diecke, Jiamiao Lu, Jaecheol Lee et al.     The development of human induced pluripotent stem cell (iPSC) technology has revolutionized the regenerative medicine field. This technology provides a powerful tool for disease …             MiR-148b suppresses cell proliferation and invasion in hepatocellular carcinoma by targeting WNT1/β-catenin pathway ▶     Jun-gang Zhang, Ying Shi, De-fei Hong et al.     Accumulating evidences indicate that microRNAs play a vital role in regulating tumor progression. However, the roles of miR-148b in hepatocellular carcinoma (HCC) are still …             Differential mechanisms of asparaginase resistance in B-type acute lymphoblastic leukemia and malignant natural killer cell lines ▶     Wei-Wen Chien, Céline Le Beux, Nicolas Rachinel et al.     Bacterial L-asparaginase (ASNase), hydrolyzing L-asparagine (Asn), is an important drug for treating patients with acute lymphoblastic leukaemia (ALL) and natural killer (NK) …             Signal enhancement and Patterson-search phasing for high-spatial-resolution coherent X-ray diffraction imaging of biological objects ▶     Yuki Takayama, Saori Maki-Yonekura, Tomotaka Oroguchi et al.     In this decade coherent X-ray diffraction imaging has been demonstrated to reveal internal structures of whole biological cells and organelles. However, the spatial resolution is …             Draft genome sequence of adzuki bean, Vigna angularis ▶     Yang Jae Kang, Dani Satyawan, Sangrea Shim et al.     Adzuki bean (Vigna angularis var. angularis) is a dietary legume crop in East Asia. The presumed progenitor (Vigna angularis var. nipponensis) is widely found in East Asia, …             Reference gene selection for cross-species and cross-ploidy level comparisons in Chrysanthemum spp. ▶     Haibin Wang, Sumei Chen, Jiafu Jiang et al.     The establishment of a (set of) stably expressed reference gene(s) is required to normalize transcription data. Polyploidy is very common in the plant kingdom, but it is not …             Chemosensillum immunolocalization and ligand specificity of chemosensory proteins in the alfalfa plant bug Adelphocoris lineolatus (Goeze) ▶     Liang Sun, Jing-Jiang Zhou, Shao-Hua Gu et al.     Insect chemosensory proteins (CSPs) are a family of small soluble proteins. To date, their physiological functions in insect olfaction remain largely controversial in comparison …             A transcription blocker isolated from a designed repeat protein combinatorial library by in vivo functional screen ▶     Elena B. Tikhonova, Abdul S. Ethayathulla, Yue Su et al.     A highly diverse DNA library coding for ankyrin seven-repeat proteins (ANK-N5C) was designed and constructed by a PCR-based combinatorial assembly strategy. A bacterial melibiose …             Dysregulated Ca2+ Homeostasis in Fanconi anemia cells ▶     Cesare Usai, Silvia Ravera, Paola Cuccarolo et al.     Fanconi Anemia (FA) is a rare and complex inherited blood disorder associated with bone marrow failure and malignancies. Many alterations in FA physiology appear linked to red-ox …             Residues remote from the binding pocket control the antagonist selectivity towards the corticotropin-releasing factor receptor-1 ▶     Xianqiang Sun, Jianxin Cheng, Xu Wang et al.     The corticotropin releasing factors receptor-1 and receptor-2 (CRF1R and CRF2R) are therapeutic targets for treating neurological diseases. Antagonists targeting CRF1R have been …             Integrated miRNA and mRNA expression profiling to identify mRNA targets of dysregulated miRNAs in non-obstructive azoospermia ▶     Xuan Zhuang, Zhiming Li, Huinuan Lin et al.     The aim of this study was to identify mRNA targets of dysregulated miRNAs through the integrated analysis of miRNA and mRNA expression profiling in men with normal versus …             Simulated microgravity inhibits L-type calcium channel currents partially by the up-regulation of miR-103 in MC3T3-E1 osteoblasts ▶     Zhongyang Sun, Xinsheng Cao, Zhuo Zhang et al.     L-type voltage-sensitive calcium channels (LTCCs), particularly Cav1.2 LTCCs, play fundamental roles in cellular responses to mechanical stimuli in osteoblasts. Numerous studies …             Resveratrol Prevents Age-Related Memory and Mood Dysfunction with Increased Hippocampal Neurogenesis and Microvasculature, and Reduced Glial Activation ▶     Maheedhar Kodali, Vipan K. Parihar, Bharathi Hattiangady et al.     Greatly waned neurogenesis, diminished microvasculature, astrocyte hypertrophy and activated microglia are among the most conspicuous structural changes in the aged hippocampus. …             Apoptosis Signal-regulating Kinase 1 promotes Ochratoxin A-induced renal cytotoxicity ▶     Rui Liang, Xiao Li Shen, Boyang Zhang et al.     Oxidative stress and apoptosis are involved in Ochratoxin A (OTA)-induced renal cytotoxicity. Apoptosis signal-regulating kinase 1 (ASK1) is a Mitogen-Activated Protein Kinase …             Treatment of urodelans based on temperature dependent infection dynamics of Batrachochytrium salamandrivorans ▶     M. Blooi, A. Martel, F. Haesebrouck et al.     The recently emerged chytrid fungus Batrachochytrium salamandrivorans currently causes amphibian population declines. We hypothesized that temperature dictates infection dynamics …             Effect of the enzyme and PCR conditions on the quality of high-throughput DNA sequencing results ▶     Claudia Brandariz-Fontes, Miguel Camacho-Sanchez, Carles Vilà et al.     Library preparation protocols for high-throughput DNA sequencing (HTS) include amplification steps in which errors can build up. In order to have confidence in the sequencing …             Transgenic mouse model expressing P53R172H, luciferase, EGFP, and KRASG12D in a single open reading frame for live imaging of tumor ▶     Hye-Lim Ju, Diego F. Calvisi, Hyuk Moon et al.     Genetically engineered mouse cancer models allow tumors to be imaged in vivo via co-expression of a reporter gene with a tumor-initiating gene. However, differential …             Multi-trait mimicry of ants by a parasitoid wasp ▶     Miriama Malcicka, T. Martijn Bezemer, Bertanne Visser et al.     Many animals avoid attack from predators through toxicity or the emission of repellent chemicals. Defensive mimicry has evolved in many species to deceive shared predators, for …             Effects of fictive reward on rat's choice behavior ▶     Ko-Un Kim, Namjung Huh, Yunsil Jang et al.     Choices of humans and non-human primates are influenced by both actually experienced and fictive outcomes. To test whether this is also the case in rodents, we examined rat's …             Functional characterization of a vanillin dehydrogenase in Corynebacterium glutamicum ▶     Wei Ding, Meiru Si, Weipeng Zhang et al.     Vanillin dehydrogenase (VDH) is a crucial enzyme involved in the degradation of lignin-derived aromatic compounds. Herein, the VDH from Corynebacterium glutamicum was …             Translationally Controlled Tumor Protein induces epithelial to mesenchymal transition and promotes cell migration, invasion and metastasis ▶     Seong-Yeon Bae, Hyun Jung Kim, Kong-Joo Lee et al.     Translationally controlled tumor protein (TCTP), is a highly conserved protein involved in fundamental processes, such as cell proliferation and growth, tumorigenesis, apoptosis, …             Systems approach for the selection of micro-RNAs as therapeutic biomarkers of anti-EGFR monoclonal antibody treatment in colorectal cancer ▶     Avisek Deyati, Shweta Bagewadi, Philipp Senger et al.     miRNA plays an important role in tumourgenesis by regulating expression of oncogenes and tumour suppressors. Thus affects cell proliferation and differentiation, apoptosis, …             Luciferase Reporter Gene Assay on Human 5-HT Receptor: Which Response Element Should Be Chosen? ▶     Yiming Chen, Zhongyu Xu, Dang Wu et al.     Serotonin (5-HT) receptors are valuable molecular targets for antipsychotic drug discovery. Current reported methods for detecting 5-HT receptors, such as cAMP accumulation and …             In vitro reconstruction of branched tubular structures from lung epithelial cells in high cell concentration gradient environment ▶     Masaya Hagiwara, Fei Peng, Chih-Ming Ho     We have succeeded in developing hollow branching structure in vitro commonly observed in lung airway using primary lung airway epithelial cells. Cell concentration gradient is …             Amino acids substitutions in the PB2 protein of H7N9 influenza A viruses are important for virulence in mammalian hosts ▶     Seiya Yamayoshi, Satoshi Fukuyama, Shinya Yamada et al.     We tested the biological significance of two amino acid mutations in the PB2 protein (glutamic acid to lysine at position 627 and aspartic acid to asparagine at position 701) of …             Structural Basis and Biological Consequences for JNK2/3 Isoform Selective Aminopyrazoles ▶     HaJeung Park, Sarah Iqbal, Pamela Hernandez et al.     Three JNK isoforms, JNK1, JNK2, and JNK3 have been reported and unique biological function has been ascribed to each. It is unknown if selective inhibition of these isoforms …             CORRIGENDUM: Separable Bilayer Microfiltration Device for Viable Label-free Enrichment of Circulating Tumour Cells ▶     Ming-Da Zhou, Sijie Hao, Anthony J. Williams et al.                 CORRIGENDUM: Different Inhibitory Effect and Mechanism of Hydroxyapatite Nanoparticles on Normal Cells and Cancer Cells In Vitro and In Vivo ▶     Yingchao Han, Shipu Li, Xianying Cao et al.                 Evidence for high dispersal ability and mito-nuclear discordance in the small brown planthopper, Laodelphax striatellus ▶     Jing-Tao Sun, Man-Man Wang, Yan-Kai Zhang et al.     Understanding dispersal ability in pest species is critical for both theoretical aspects of evolutionary and population biology and from a practical standpoint, such as …             Octopamine and tyramine respectively regulate attractive and repulsive behavior in locust phase changes ▶     Zongyuan Ma, Xiaojiao Guo, Hong Lei et al.     Aggregative and solitary behaviors are universal phenomena in animals. Interestingly, locusts (Locusta migratoria) can reversibly transit their behavior between gregarious and …             Wnt5a promotes cancer cell invasion and proliferation by receptor-mediated endocytosis-dependent and -independent mechanisms, respectively ▶     Kensaku Shojima, Akira Sato, Hideaki Hanaki et al.     Wnt5a activates the Wnt/β-catenin-independent pathway and its overexpression is associated with tumor aggressiveness enhancing invasive activity. For this action, Wnt5a-induced …             Correlation of circular RNA abundance with proliferation – exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues ▶     Anna Bachmayr-Heyda, Agnes T. Reiner, Katharina Auer et al.     Circular RNAs are a recently (re-)discovered abundant RNA species with presumed function as miRNA sponges, thus part of the competing endogenous RNA network. We analysed the …             Hydro-Responsive Curling of the Resurrection Plant Selaginella lepidophylla ▶     Ahmad Rafsanjani, Véronique Brulé, Tamara L. Western et al.     The spirally arranged stems of the spikemoss Selaginella lepidophylla, an ancient resurrection plant, compactly curl into a nest-ball shape upon dehydration. Due to its spiral …             The Evidence of Glioblastoma Heterogeneity ▶     Akio Soeda, Akira Hara, Takahiro Kunisada et al.     Cancers are composed of heterogeneous combinations of cells that exhibit distinct phenotypic characteristics and proliferative potentials. Because most cancers have a clonal …                     Chemical Sciences ▲ top               A ruthenium(II) complex as turn-on Cu(II) luminescent sensor based on oxidative cyclization mechanism and its application in vivo ▶     Yunfei Zhang, Zonglun Liu, Kui Yang et al.     Copper ions play a vital role in a variety of fundamental physiological processes not only in human beings and plants, but also for extensive insects and microorganisms. In this …             The transition from single molecule to ensemble revealed by fluorescence polarization. ▶     Toby D. M. Bell, Andrew H. A. Clayton     Fluorescence polarization measurements in the condensed phase provide rich information on rotational dynamics and interactions between macromolecules. An important parameter in …             Rationally Designed Peptidomimetic Modulators of Aβ Toxicity in Alzheimer's Disease ▶     K. Rajasekhar, S. N. Suresh, Ravi Manjithaya et al.     Alzheimer's disease is one of the devastating illnesses mankind is facing in the 21st century. The main pathogenic event in Alzheimer's disease is believed to be the aggregation …             One-step hydrothermal synthesis of graphene decorated V2O5 nanobelts for enhanced electrochemical energy storage ▶     Minoh Lee, Suresh Kannan Balasingam, Hu Young Jeong et al.     Graphene-decorated V2O5 nanobelts (GVNBs) were synthesized via a low-temperature hydrothermal method in a single step. V2O5 nanobelts (VNBs) were formed in the presence of …             Label-free detection of kanamycin based on a G-quadruplex DNA aptamer-based fluorescent intercalator displacement assay ▶     Yun-Peng Xing, Chun Liu, Xiao-Hong Zhou et al.     This work was the first to report that the kanamycin-binding DNA aptamer (5′-TGG GGG TTG AGG CTA AGC CGA-3′) can form stable parallel G-quadruplex DNA (G4-DNA) structures by …             Microcontroller-Assisted Compensation of Adenosine Triphosphate Levels: Instrument and Method Development ▶     Jie-Bi Hu, Ting-Ru Chen, Yu-Chie Chen et al.     In order to ascertain optimum conditions for biocatalytic processes carried out in vitro, we have designed a bio-opto-electronic system which ensures real-time compensation for …             Li-Rich Li-Si Alloy As A Lithium-Containing Negative Electrode Material Towards High Energy Lithium-Ion Batteries ▶     Shinichiroh Iwamura, Hirotomo Nishihara, Yoshitaka Ono et al.     Lithium-ion batteries (LIBs) are generally constructed by lithium-including positive electrode materials, such as LiCoO2, and lithium-free negative electrode materials, such as …             Residues remote from the binding pocket control the antagonist selectivity towards the corticotropin-releasing factor receptor-1 ▶     Xianqiang Sun, Jianxin Cheng, Xu Wang et al.     The corticotropin releasing factors receptor-1 and receptor-2 (CRF1R and CRF2R) are therapeutic targets for treating neurological diseases. Antagonists targeting CRF1R have been …             Modeling the metastable dynamics of correlated structures ▶     Alexey M. Shakirov, Sergey V. Tsibulsky, Andrey E. Antipov et al.     Metastable quantum dynamics of an asymmetric triangular cluster that is coupled to a reservoir is investigated. The dynamics is governed by bath-mediated transitions, which in …             In vitro reconstruction of branched tubular structures from lung epithelial cells in high cell concentration gradient environment ▶     Masaya Hagiwara, Fei Peng, Chih-Ming Ho     We have succeeded in developing hollow branching structure in vitro commonly observed in lung airway using primary lung airway epithelial cells. Cell concentration gradient is …             Nanoscale Lubrication of Ionic Surfaces Controlled via a Strong Electric Field ▶     Evgheni Strelcov, Rajeev Kumar, Vera Bocharova et al.     Frictional forces arise whenever objects around us are set in motion. Controlling them in a rational manner means gaining leverage over mechanical energy losses and wear. This …             Charge-transfer-based Gas Sensing Using Atomic-layer MoS2 ▶     Byungjin Cho, Myung Gwan Hahm, Minseok Choi et al.     Two-dimensional (2D) molybdenum disulphide (MoS2) atomic layers have a strong potential to be used as 2D electronic sensor components. However, intrinsic synthesis challenges …                 Scientific Editing: MSC Scientific Editing gives your research article a high-quality scientific edit that can help you make an impact on your intended audience.   Nature-standard editing - English language edit included - Specialist editors in your subject area. Find out more today.         Physical Sciences ▲ top               Emergent photovoltage on SmB6 surface upon bulk-gap evolution revealed by pump-and-probe photoemission spectroscopy ▶     Y. Ishida, T. Otsu, T. Shimada et al.     Recent studies suggest that an exemplary Kondo insulator SmB6 belongs to a new class of topological insulators (TIs), in which non-trivial spin-polarized metallic states emerge …             A ruthenium(II) complex as turn-on Cu(II) luminescent sensor based on oxidative cyclization mechanism and its application in vivo ▶     Yunfei Zhang, Zonglun Liu, Kui Yang et al.     Copper ions play a vital role in a variety of fundamental physiological processes not only in human beings and plants, but also for extensive insects and microorganisms. In this …             The transition from single molecule to ensemble revealed by fluorescence polarization. ▶     Toby D. M. Bell, Andrew H. A. Clayton     Fluorescence polarization measurements in the condensed phase provide rich information on rotational dynamics and interactions between macromolecules. An important parameter in …             High performance anode-supported tubular solid oxide fuel cells fabricated by a novel slurry-casting method ▶     Nan-Qi Duan, Dong Yan, Bo Chi et al.     Tubular solid oxide fuel cells were fabricated and evaluated for their microstructure and electrochemical performance. The tubular substrate was prepared by casting NiO-Y2O3 …             Reduced near-infrared absorption using ultra-thin lossy metals in Fabry-Perot cavities ▶     Hasan Kocer, Serkan Butun, Zhongyang Li et al.     We show that a triple-layer metal-insulator-metal (MIM) structure has spectrally selective IR absorption, while an ultra-thin metal film has non-selective absorption in the near …             Enhancement of polarizabilities of cylinders with cylinder-slab resonances ▶     Meng Xiao, Xueqin Huang, H. Liu et al.     If an object is very small in size compared with the wavelength of light, it does not scatter light efficiently. It is hence difficult to detect a very small object with light. …             The Emergence of Dirac points in Photonic Crystals with Mirror Symmetry ▶     Wen-Yu He, C. T. Chan     We show that Dirac points can emerge in photonic crystals possessing mirror symmetry when band gap closes. The mechanism of generating Dirac points is discussed in a …             Broadband Frequency-Selective Spoof Surface Plasmon Polaritons on Ultrathin Metallic Structure ▶     Jia Yuan Yin, Jian Ren, Hao Chi Zhang et al.     We propose an ultrathin metallic structure to produce frequency-selective spoof surface plasmon polaritons (SPPs) in the microwave and terahertz frequencies. Designed on a thin …             Scalar model for frictional precursors dynamics ▶     Alessandro Taloni, Andrea Benassi, Stefan Sandfeld et al.     Recent experiments indicate that frictional sliding occurs by nucleation of detachment fronts at the contact interface that may appear well before the onset of global sliding. …             A simple rule for quadrupedal gait generation determined by leg loading feedback: a modeling study ▶     Yasuhiro Fukuoka, Yasushi Habu, Takahiro Fukui     We discovered a specific rule for generating typical quadrupedal gaits (the order of the movement of four legs) through a simulated quadrupedal locomotion, in which unprogrammed …             Fabrication of heterogeneous nanomaterial array by programmable heating and chemical supply within microfluidic platform towards multiplexed gas sensing application ▶     Daejong Yang, Kyungnam Kang, Donghwan Kim et al.     A facile top-down/bottom-up hybrid nanofabrication process based on programmable temperature control and parallel chemical supply within microfluidic platform has been developed …             Dual-band-enhanced Transmission through a Subwavelength Aperture by Coupled Metamaterial Resonators ▶     Yunsheng Guo, Ji Zhou     In classical mechanics, it is well known that a system consisting of two identical pendulums connected by a spring will steadily oscillate with two modes: one at the fundamental …             Femtosecond Laser Pulse Driven Melting in Gold Nanorod Aqueous Colloidal Suspension: Identification of a Transition from Stretched to Exponential Kinetics ▶     Yuelin Li, Zhang Jiang, Xiao-Min Lin et al.     Many potential industrial, medical, and environmental applications of metal nanorods rely on the physics and resultant kinetics and dynamics of the interaction of these particles …             One-step hydrothermal synthesis of graphene decorated V2O5 nanobelts for enhanced electrochemical energy storage ▶     Minoh Lee, Suresh Kannan Balasingam, Hu Young Jeong et al.     Graphene-decorated V2O5 nanobelts (GVNBs) were synthesized via a low-temperature hydrothermal method in a single step. V2O5 nanobelts (VNBs) were formed in the presence of …             ZnO Nanorod Array Grown on Ag Layer: A Highly Efficient Fluorescence Enhancement Platform ▶     Yongqi Yin, Ye Sun, Miao Yu et al.     ZnO nanorods (NRs) are known for ultra-sensitive biomolecule detection through fluorescence enhancement. In this work, we demonstrate that ZnO NR arrays grown on Ag layers can …             Structural transition and enhanced phase transition properties of Se doped Ge2Sb2Te5 alloys ▶     E. M. Vinod, K. Ramesh, K. S. Sangunni     Amorphous Ge2Sb2Te5 (GST) alloy, upon heating crystallize to a metastable NaCl structure around 150°C and then to a stable hexagonal structure at high temperatures (≥250°C). It …             Suspending Effect on Low-Frequency Charge Noise in Graphene Quantum Dot ▶     Xiang-Xiang Song, Hai-Ou Li, Jie You et al.     Charge noise is critical in the performance of gate-controlled quantum dots (QDs). Such information is not yet available for QDs made out of the new material graphene, where both …             A facile approach to synthesize stable CNTs@MnO electrocatalyst for high energy lithium oxygen batteries ▶     Wen-Bin Luo, Shu-Lei Chou, Jia-Zhao Wang et al.     A composite of manganese monoxide loaded onto carbon nanotubes (CNTs@MnO) has been synthesized by a facile approach, in which the CNTs form a continuous conductive network …             Confined-space synthesis of single crystal TiO2 nanowires in atmospheric vessel at low temperature: a generalized approach ▶     Xiaoyue Wang, Hai Wang, Yu Zhou et al.     Extensive efforts have been devoted to develop innovative synthesis strategies for nanomaterials in order to exploit the true potential of nanotechnology. However, most …             Strong enhancement of photoresponsivity with shrinking the electrodes spacing in few layer GaSe photodetectors ▶     Yufei Cao, Kaiming Cai, Pingan Hu et al.     A critical challenge for the integration of optoelectronics is that photodetectors have relatively poor sensitivities at the nanometer scale. Generally, a large electrodes …             Detrended Partial-Cross-Correlation Analysis: A New Method for Analyzing Correlations in Complex System ▶     Naiming Yuan, Zuntao Fu, Huan Zhang et al.     In this paper, a new method, detrended partial-cross-correlation analysis (DPCCA), is proposed. Based on detrended cross-correlation analysis (DCCA), this method is improved by …             Spatiotemporal chaotic unjamming and jamming in granular avalanches ▶     Ziwei Wang, Jie Zhang     We have investigated the spatiotemporal chaotic dynamics of unjamming and jamming of particles in a model experiment – a rotating drum partially filled with bidisperse disks to …             Rationally Designed Peptidomimetic Modulators of Aβ Toxicity in Alzheimer's Disease ▶     K. Rajasekhar, S. N. Suresh, Ravi Manjithaya et al.     Alzheimer's disease is one of the devastating illnesses mankind is facing in the 21st century. The main pathogenic event in Alzheimer's disease is believed to be the aggregation …             Label-free detection of kanamycin based on a G-quadruplex DNA aptamer-based fluorescent intercalator displacement assay ▶     Yun-Peng Xing, Chun Liu, Xiao-Hong Zhou et al.     This work was the first to report that the kanamycin-binding DNA aptamer (5′-TGG GGG TTG AGG CTA AGC CGA-3′) can form stable parallel G-quadruplex DNA (G4-DNA) structures by …             Microcontroller-Assisted Compensation of Adenosine Triphosphate Levels: Instrument and Method Development ▶     Jie-Bi Hu, Ting-Ru Chen, Yu-Chie Chen et al.     In order to ascertain optimum conditions for biocatalytic processes carried out in vitro, we have designed a bio-opto-electronic system which ensures real-time compensation for …             Few-quintuple Bi2Te3 nanofilms as potential thermoelectric materials ▶     Gang Zhou, Dong Wang     The thermoelectric transport properties of p-type Bi2Te3 nanofilms with various quintuple layers (QL) were systematically investigated based on ab initio electronic structure …             Decoherence imaging of spin ensembles using a scanning single-electron spin in diamond ▶     Lan Luan, Michael S. Grinolds, Sungkun Hong et al.     The nitrogen-vacancy (NV) defect center in diamond has demonstrated great capability for nanoscale magnetic sensing and imaging for both static and periodically modulated target …             Thermally induced magnetization switching in Fe/MnAs/GaAs(001): selectable magnetic configurations by temperature and field control ▶     Carlo Spezzani, Franck Vidal, Renaud Delaunay et al.     Spintronic devices currently rely on magnetization control by external magnetic fields or spin-polarized currents. Developing temperature-driven magnetization control has …             Three-Dimensional Optical Trapping of a Plasmonic Nanoparticle using Low Numerical Aperture Optical Tweezers ▶     Oto Brzobohatý, Martin Šiler, Jan Trojek et al.     It was previously believed that larger metal nanoparticles behave as tiny mirrors that are pushed by the light beam radiative force along the direction of beam propagation, …             Observation of Wave Packet Distortion during a Negative-Group-Velocity Transmission ▶     Dexin Ye, Yannick Salamin, Jiangtao Huangfu et al.     In Physics, causality is a fundamental postulation arising from the second law of thermodynamics. It states that, the cause of an event precedes its effect. In the context of …             More about the doubling degeneracy operators associated with Majorana fermions and Yang-Baxter equation ▶     Li-Wei Yu, Mo-Lin Ge     A new realization of doubling degeneracy based on emergent Majorana operator Γ presented by Lee-Wilczek has been made. The Hamiltonian can be obtained through the new type of …             Fully printed flexible and disposable wireless cyclic voltammetry tag ▶     Younsu Jung, Hyejin Park, Jin-Ah Park et al.     A disposable cyclic voltammetry (CV) tag is printed on a plastic film by integrating wireless power transmitter, polarized triangle wave generator, electrochemical cell and …             An injectable acoustic transmitter for juvenile salmon ▶     Z. D. Deng, T. J. Carlson, H. Li et al.     Salmon recovery and the potential detrimental effects of dams on fish have been attracting national attention due to the environmental and economic implications. In recent years …             Li-Rich Li-Si Alloy As A Lithium-Containing Negative Electrode Material Towards High Energy Lithium-Ion Batteries ▶     Shinichiroh Iwamura, Hirotomo Nishihara, Yoshitaka Ono et al.     Lithium-ion batteries (LIBs) are generally constructed by lithium-including positive electrode materials, such as LiCoO2, and lithium-free negative electrode materials, such as …             Fabrication of high-Q lithium niobate microresonators using femtosecond laser micromachining ▶     Jintian Lin, Yingxin Xu, Zhiwei Fang et al.     We report on fabrication of high-Q lithium niobate (LN) whispering-gallery-mode (WGM) microresonators suspended on silica pedestals by femtosecond laser direct writing followed …             Direct evidence for kinetic effects associated with solar wind reconnection ▶     Xiaojun Xu, Yi Wang, Fengsi Wei et al.     Kinetic effects resulting from the two-fluid physics play a crucial role in the fast collisionless reconnection, which is a process to explosively release massive energy stored …             Revealing the flexoelectricity in the mixed-phase regions of epitaxial BiFeO3 thin films ▶     Cheng-En Cheng, Heng-Jui Liu, Franco Dinelli et al.     Understanding the elastic response on the nanoscale phase boundaries of multiferroics is an essential issue in order to explain their exotic behaviour. Mixed-phase BiFeO3 films, …             Highly Efficient Electronic Sensitization of Non-oxidized Graphene Flakes on Controlled Pore-loaded WO3 Nanofibers for Selective Detection of H2S Molecules ▶     Seon–Jin Choi, Chanyong Choi, Sang-Joon Kim et al.     Tailoring of semiconducting metal oxide nanostructures, which possess controlled pore size and concentration, is of great value to accurately detect various volatile organic …             Nanoscale simulation of shale transport properties using the lattice Boltzmann method: permeability and diffusivity ▶     Li Chen, Lei Zhang, Qinjun Kang et al.     Porous structures of shales are reconstructed using the markov chain monte carlo (MCMC) method based on scanning electron microscopy (SEM) images of shale samples from Sichuan …             A size-dependent constitutive model of bulk metallic glasses in the supercooled liquid region ▶     Di Yao, Lei Deng, Mao Zhang et al.     Size effect is of great importance in micro forming processes. In this paper, micro cylinder compression was conducted to investigate the deformation behavior of bulk metallic …             Residues remote from the binding pocket control the antagonist selectivity towards the corticotropin-releasing factor receptor-1 ▶     Xianqiang Sun, Jianxin Cheng, Xu Wang et al.     The corticotropin releasing factors receptor-1 and receptor-2 (CRF1R and CRF2R) are therapeutic targets for treating neurological diseases. Antagonists targeting CRF1R have been …             Modeling the metastable dynamics of correlated structures ▶     Alexey M. Shakirov, Sergey V. Tsibulsky, Andrey E. Antipov et al.     Metastable quantum dynamics of an asymmetric triangular cluster that is coupled to a reservoir is investigated. The dynamics is governed by bath-mediated transitions, which in …             Giant Electric Field Enhancement in Split Ring Resonators Featuring Nanometer-Sized Gaps ▶     S. Bagiante, F. Enderli, J. Fabiańska et al.     Today's pulsed THz sources enable us to excite, probe, and coherently control the vibrational or rotational dynamics of organic and inorganic materials on ultrafast time scales. …             Longitudinal wave function control in single quantum dots with an applied magnetic field ▶     Shuo Cao, Jing Tang, Yunan Gao et al.     Controlling single-particle wave functions in single semiconductor quantum dots is in demand to implement solid-state quantum information processing and spintronics. Normally, …             Spectrally intense terahertz source based on triangular Selenium ▶     Mostafa Shalaby, Christoph P. Hauri     The intensity of a nonlinear terahertz (THz) source is primarily given by its spectral density. In this letter, we introduce triangular Selinium (Se) as a novel THz emitter and …             Dynamics of microdroplets over the surface of hot water ▶     Takahiro Umeki, Masahiko Ohata, Hiizu Nakanishi et al.     When drinking a cup of coffee under the morning sunshine, you may notice white membranes of steam floating on the surface of the hot water. They stay notably close to the surface …             Effect of Gd doping and O deficiency on the Curie temperature of EuO ▶     Nuttachai Jutong, Ulrich Eckern, Thomas Mairoser et al.     The effect of Gd doping and O deficiency on the electronic structure, exchange interaction, and Curie temperature of EuO in the cubic and tetragonal phases is studied by means of …             On the Existence of Low-Mass Dark Matter and its Direct Detection ▶     James Bateman, Ian McHardy, Alexander Merle et al.     Dark Matter (DM) is an elusive form of matter which has been postulated to explain astronomical observations through its gravitational effects on stars and galaxies, …             Nanoscale Lubrication of Ionic Surfaces Controlled via a Strong Electric Field ▶     Evgheni Strelcov, Rajeev Kumar, Vera Bocharova et al.     Frictional forces arise whenever objects around us are set in motion. Controlling them in a rational manner means gaining leverage over mechanical energy losses and wear. This …             Gate-tuned quantum oscillations of topological surface states in β-Ag2Te ▶     Azat Sulaev, Weiguang Zhu, Kie Leong Teo et al.     We report the strong experimental evidence of the existence of topological surface states with large electric field tunability and mobility in β-Ag2Te. Pronounced 2D Shubnikov-de …             Optimum periodicity of repeated contractile actions applied in mass transport ▶     Sungsook Ahn, Sang Joon Lee     Dynamically repeated periodic patterns are abundant in natural and artificial systems, such as tides, heart beats, stock prices, and the like. The characteristic repeatability …             Charge-transfer-based Gas Sensing Using Atomic-layer MoS2 ▶     Byungjin Cho, Myung Gwan Hahm, Minseok Choi et al.     Two-dimensional (2D) molybdenum disulphide (MoS2) atomic layers have a strong potential to be used as 2D electronic sensor components. However, intrinsic synthesis challenges …             CORRIGENDUM: Different Inhibitory Effect and Mechanism of Hydroxyapatite Nanoparticles on Normal Cells and Cancer Cells In Vitro and In Vivo ▶     Yingchao Han, Shipu Li, Xianying Cao et al.                 CORRIGENDUM: Separable Bilayer Microfiltration Device for Viable Label-free Enrichment of Circulating Tumour Cells ▶     Ming-Da Zhou, Sijie Hao, Anthony J. Williams et al.                 In vitro reconstruction of branched tubular structures from lung epithelial cells in high cell concentration gradient environment ▶     Masaya Hagiwara, Fei Peng, Chih-Ming Ho     We have succeeded in developing hollow branching structure in vitro commonly observed in lung airway using primary lung airway epithelial cells. Cell concentration gradient is …             Hydro-Responsive Curling of the Resurrection Plant Selaginella lepidophylla ▶     Ahmad Rafsanjani, Véronique Brulé, Tamara L. Western et al.     The spirally arranged stems of the spikemoss Selaginella lepidophylla, an ancient resurrection plant, compactly curl into a nest-ball shape upon dehydration. Due to its spiral …               Earth & Environmental Sciences ▲ top               Disentangling the relative effects of bushmeat availability on human nutrition in central Africa ▶     John E. Fa, Jesús Olivero, Raimundo Real et al.     We studied links between human malnutrition and wild meat availability within the Rainforest Biotic Zone in central Africa. We distinguished two distinct hunted mammalian …             Red coralline algae assessed as marine pH proxies using 11B MAS NMR ▶     M. Cusack, N. A. Kamenos, C. Rollion-Bard et al.     Reconstructing pH from biogenic carbonates using boron isotopic compositions relies on the assumption that only borate, and no boric acid, is present. Red coralline algae are …             Ranking species in mutualistic networks ▶     Virginia Domínguez-García, Miguel A. Muñoz     Understanding the architectural subtleties of ecological networks, believed to confer them enhanced stability and robustness, is a subject of outmost relevance. Mutualistic …             Exploring the microbiota dynamics related to vegetable biomasses degradation and study of lignocellulose-degrading bacteria for industrial biotechnological application ▶     Valeria Ventorino, Alberto Aliberti, Vincenza Faraco et al.     The aims of this study were to evaluate the microbial diversity of different lignocellulosic biomasses during degradation under natural conditions and to isolate, select, …             Label-free detection of kanamycin based on a G-quadruplex DNA aptamer-based fluorescent intercalator displacement assay ▶     Yun-Peng Xing, Chun Liu, Xiao-Hong Zhou et al.     This work was the first to report that the kanamycin-binding DNA aptamer (5′-TGG GGG TTG AGG CTA AGC CGA-3′) can form stable parallel G-quadruplex DNA (G4-DNA) structures by …             Detrended Partial-Cross-Correlation Analysis: A New Method for Analyzing Correlations in Complex System ▶     Naiming Yuan, Zuntao Fu, Huan Zhang et al.     In this paper, a new method, detrended partial-cross-correlation analysis (DPCCA), is proposed. Based on detrended cross-correlation analysis (DCCA), this method is improved by …             Responses of plant nutrient resorption to phosphorus addition in freshwater marsh of Northeast China ▶     Rong Mao, De-Hui Zeng, Xin-Hou Zhang et al.     Anthropogenic activities have increased phosphorus (P) inputs to most aquatic and terrestrial ecosystems. However, the relationship between plant nutrient resorption and P …             Impacts of reactive nitrogen on climate change in China ▶     Yalan Shi, Shenghui Cui, Xiaotang Ju et al.     China is mobilizing the largest anthropogenic reactive nitrogen (Nr) in the world due to agricultural, industrial and urban development. However, the climate effects related to …             Crustal thickness control on Sr/Y signatures of recent arc magmas: an Earth scale perspective ▶     Massimo Chiaradia     Arc magmas originate in subduction zones as partial melts of the mantle, induced by aqueous fluids/melts liberated by the subducted slab. Subsequently, they rise through and …             Indo-China Monsoon Indices ▶     ChinLeong Tsai, Swadhin K. Behera, Takuji Waseda     Myanmar and Thailand often experience severe droughts and floods that cause irreparable damage to the socio-economy condition of both countries. In this study, the Southeastern …             An injectable acoustic transmitter for juvenile salmon ▶     Z. D. Deng, T. J. Carlson, H. Li et al.     Salmon recovery and the potential detrimental effects of dams on fish have been attracting national attention due to the environmental and economic implications. In recent years …             Fully printed flexible and disposable wireless cyclic voltammetry tag ▶     Younsu Jung, Hyejin Park, Jin-Ah Park et al.     A disposable cyclic voltammetry (CV) tag is printed on a plastic film by integrating wireless power transmitter, polarized triangle wave generator, electrochemical cell and …             Temporal constraints on future accumulation-area loss of a major Arctic ice cap due to climate change (Vestfonna, Svalbard) ▶     Marco Möller, Christoph Schneider     Arctic glaciers and ice caps are major contributors to past, present and future sea-level fluctuations. Continued global warming may eventually lead to the equilibrium line …             The relevance of nanoscale biological fragments for ice nucleation in clouds ▶     D. O′Sullivan, B. J. Murray, J. F. Ross et al.     Most studies of the role of biological entities as atmospheric ice-nucleating particles have focused on relatively rare supermicron particles such as bacterial cells, fungal …             Moderate drop in water table increases peatland vulnerability to post-fire regime shift ▶     N. Kettridge, M. R. Turetsky, J. H. Sherwood et al.     Northern and tropical peatlands represent a globally significant carbon reserve accumulated over thousands of years of waterlogged conditions. It is unclear whether moderate …               Health Sciences ▲ top               Cigarette smoke alters primary human bronchial epithelial cell differentiation at the air-liquid interface ▶     Andrea C. Schamberger, Claudia A. Staab-Weijnitz, Nikica Mise-Racek et al.     The differentiated human airway epithelium consists of different cell types forming a polarized and pseudostratified epithelium. This is dramatically altered in chronic …             Concordant analysis of KRAS, BRAF, PIK3CA mutations, and PTEN expression between primary colorectal cancer and matched metastases ▶     Chen Mao, Xin-Yin Wu, Zu-Yao Yang et al.     Current data on the concordance of KRAS, BRAF, PIK3CA mutation status or PTEN expression status between primary tumors and metastases in colorectal cancer (CRC) are conflicting. …             Truncation and activation of GSK-3β by calpain I: a molecular mechanism links to tau hyperphosphorylation in Alzheimer's disease ▶     Nana Jin, Xiaomin Yin, Dian Yu et al.     Abnormal hyperphosphorylation of tau is pivotally involved in the pathogenesis of Alzheimer's disease (AD) and related tauopathies. Glycogen synthase kinase 3β (GSK-3β) is a …             Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Involved in Inflammation by Negatively Regulating the NF-κB Pathway ▶     Lijian Chen, Lijie Feng, Xia Wang et al.     Inflammation can cause endoplasmic reticulum (ER) stress and therefore activates the unfolded protein response (UPR). ER stress and the consequent UPR have the potential to …             Comparative risk assessment of alcohol, tobacco, cannabis and other illicit drugs using the margin of exposure approach ▶     Dirk W. Lachenmeier, Jürgen Rehm     A comparative risk assessment of drugs including alcohol and tobacco using the margin of exposure (MOE) approach was conducted. The MOE is defined as ratio between toxicological …             Dental plaque development on a hydroxyapatite disk in young adults observed by using a barcoded pyrosequencing approach ▶     Toru Takeshita, Masaki Yasui, Yukie Shibata et al.     Dental plaque is a dynamic microbial biofilm ecosystem that comprises hundreds of species including difficult-to-cultivate bacteria. We observed the assembly of a plaque …             Oxygen-18 isotope of breath CO2 linking to erythrocytes carbonic anhydrase activity: a biomarker for pre-diabetes and type 2 diabetes ▶     Chiranjit Ghosh, Gourab D. Banik, Abhijit Maity et al.     Carbonic anhydrase (CA), a well-characterized metalloenzyme, is associated with oxygen-18 ( 18O)-isotopic fractionations of CO2. To investigate how CA activity links the 18O of …             Correlation of serum KL-6 and CC16 levels with neurodevelopmental outcome in premature infants at 12 months corrected age ▶     Zhiqun Zhang, Hui Lu, Yunxia Zhu et al.     The aim of this study was to evaluate KL-6 and CC16 levels and their correlation with neurodevelopmental outcome among very low birth weight pre-term infants at 12 months …             Using Networks to Combine “Big Data” and Traditional Surveillance to Improve Influenza Predictions ▶     Michael W. Davidson, Dotan A. Haim, Jennifer M. Radin     Seasonal influenza infects approximately 5–20% of the U.S. population every year, resulting in over 200,000 hospitalizations. The ability to more accurately assess infection …             PhenomeExpress: A refined network analysis of expression datasets by inclusion of known disease phenotypes ▶     Jamie Soul, Timothy E. Hardingham, Raymond P. Boot-Handford et al.     We describe a new method, PhenomeExpress, for the analysis of transcriptomic datasets to identify pathogenic disease mechanisms. Our analysis method includes input from both …             Suppression of adrenal βarrestin1-dependent aldosterone production by ARBs: head-to-head comparison ▶     Samalia Dabul, Ashley Bathgate-Siryk, Thairy Reyes Valero et al.     The known angiotensin II (AngII) physiological effect of aldosterone synthesis and secretion is mediated by either Gq/11 proteins or βarrestin1 (βarr1), both of which can couple …             Subperiosteal Transmission Of Intra-Articular Pressure Between Articulated And Stationary Joints ▶     Mark Pitkin, Raghuveer Muppavarapu, Charles Cassidy et al.     Hydrostatic pressures can be transmitted between synovial capsules. In each of ten rabbits, we simultaneously measured pressure in two joints, one of which was passively ranged, …             Serotonin Deficiency Exacerbates Acetaminophen-Induced Liver Toxicity In Mice ▶     Jingyao Zhang, Sidong Song, Qing Pang et al.     Acetaminophen (APAP) overdose is a major cause of acute liver failure. Peripheral 5-hydroxytryptamine (serotonin, 5-HT) is a cytoprotective neurotransmitter which is also …             A nutritionally-enhanced oil from transgenic Camelina sativa effectively replaces fish oil as a source of eicosapentaenoic acid for fish ▶     M. B. Betancor, M. Sprague, S. Usher et al.     For humans a daily intake of up to 500 mg omega-3 (n-3) long-chain polyunsaturated fatty acids (LC-PUFA) is recommended, amounting to an annual requirement of 1.25 million metric …             Concurrent radiotherapy and weekly chemotherapy of 5-fluorouracil and platinum agents for postoperative locoregional recurrence of oesophageal squamous cell carcinoma ▶     Wen-Wen Zhang, Yu-Jia Zhu, Han Yang et al.     The most optimal management for postoperative locoregional recurrence of oesophageal squamous cell carcinoma is still controversial. Several studies have reported the feasibility …             Effect of Menopausal Status on Carotid Intima-Media Thickness and Presence of Carotid Plaque in Chinese Women Generation Population ▶     Yong Zhou, Dandan Wang, Xin Yang et al.     Menopause is an important physiological stage in women's life. The potential association of menopause with carotid intima-media thickness as well as with occurrence and stability …             Highly Efficient Electronic Sensitization of Non-oxidized Graphene Flakes on Controlled Pore-loaded WO3 Nanofibers for Selective Detection of H2S Molecules ▶     Seon–Jin Choi, Chanyong Choi, Sang-Joon Kim et al.     Tailoring of semiconducting metal oxide nanostructures, which possess controlled pore size and concentration, is of great value to accurately detect various volatile organic …             Simulated microgravity inhibits L-type calcium channel currents partially by the up-regulation of miR-103 in MC3T3-E1 osteoblasts ▶     Zhongyang Sun, Xinsheng Cao, Zhuo Zhang et al.     L-type voltage-sensitive calcium channels (LTCCs), particularly Cav1.2 LTCCs, play fundamental roles in cellular responses to mechanical stimuli in osteoblasts. Numerous studies …             Dysregulated Ca2+ Homeostasis in Fanconi anemia cells ▶     Cesare Usai, Silvia Ravera, Paola Cuccarolo et al.     Fanconi Anemia (FA) is a rare and complex inherited blood disorder associated with bone marrow failure and malignancies. Many alterations in FA physiology appear linked to red-ox …             Integrated miRNA and mRNA expression profiling to identify mRNA targets of dysregulated miRNAs in non-obstructive azoospermia ▶     Xuan Zhuang, Zhiming Li, Huinuan Lin et al.     The aim of this study was to identify mRNA targets of dysregulated miRNAs through the integrated analysis of miRNA and mRNA expression profiling in men with normal versus …             Resveratrol Prevents Age-Related Memory and Mood Dysfunction with Increased Hippocampal Neurogenesis and Microvasculature, and Reduced Glial Activation ▶     Maheedhar Kodali, Vipan K. Parihar, Bharathi Hattiangady et al.     Greatly waned neurogenesis, diminished microvasculature, astrocyte hypertrophy and activated microglia are among the most conspicuous structural changes in the aged hippocampus. …             Apoptosis Signal-regulating Kinase 1 promotes Ochratoxin A-induced renal cytotoxicity ▶     Rui Liang, Xiao Li Shen, Boyang Zhang et al.     Oxidative stress and apoptosis are involved in Ochratoxin A (OTA)-induced renal cytotoxicity. Apoptosis signal-regulating kinase 1 (ASK1) is a Mitogen-Activated Protein Kinase …             Sensitivity and dose dependency of radiation-induced injury in hematopoietic stem/progenitor cells in mice ▶     Chang-Ying Guo, Lan Luo, Yoshishige Urata et al.     We evaluated the sensitivity and dose dependency of radiation-induced injury in hematopoietic stem/progenitor cells. Adult C57BL/6 mice were daily exposed to 0, 2, 10, 50, and …             The Evidence of Glioblastoma Heterogeneity ▶     Akio Soeda, Akira Hara, Takahiro Kunisada et al.     Cancers are composed of heterogeneous combinations of cells that exhibit distinct phenotypic characteristics and proliferative potentials. Because most cancers have a clonal …             Treatment of urodelans based on temperature dependent infection dynamics of Batrachochytrium salamandrivorans ▶     M. Blooi, A. Martel, F. Haesebrouck et al.     The recently emerged chytrid fungus Batrachochytrium salamandrivorans currently causes amphibian population declines. 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