Nature Communications - 17 February 2016

Advertisement Sputtered Metal Deep-UV Interference Filters Manufactured using single substrates of UV-grade fused silica and backed by warranty, these filters are available in 11 different passbands in a wide range of sizes, from 2mm-200mm. Laser damage thresholds >0.15 J/cm2 using a 355nm laser (10 ns pulse, 10 Hz), and suffer no degradation after 2 hours @ 300ºC. www.chroma.com     Weekly Content Alert Nature Communications is now fully open access. Read more. 17 February 2016  Featured image: Van Giesen et al. find that individual sensory neurons in fly larvae can respond to multiple taste sensations. Latest content: Review Articles Corrigenda Erratum Journal homepage Recommend to library Web feed       Nature Communications - now fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Review View all Reviews     Integrating geological archives and climate models for the mid-Pliocene warm period OPEN Alan M. Haywood, Harry J. Dowsett and Aisling M. Dolan The mid-Pliocene Warm Period (mPWP), analogous to future climate conditions, is considered a test-bed for the predictive capability of climate models. Here, Dowsett et al. review our understanding of the mPWP and discuss recent and future advances in the context of proxy data/model integration. 16 February 2016 | doi: 10.1038/ncomms10646 Earth Sciences  Climate science        Latest Articles View all Articles     Negative global phosphorus budgets challenge sustainable intensification of grasslands OPEN S. Z. Sattari, A. F. Bouwman, R. Martinez Rodríguez, A. H. W. Beusen and M. K. van Ittersum Grasslands lose soil fertility when manure from grazing livestock is spread on croplands. Here, Sattari et al. show that in order to achieve production increases that will meet global milk and meat demands for 2050, grassland phosphorus inputs must increase four-fold relative to inputs from 2005. 16 February 2016 | doi: 10.1038/ncomms10696 Biological Sciences  Biogeochemistry  Ecology  A potential hidden layer of meteorites below the ice surface of Antarctica OPEN G. W. Evatt, M. J. Coughlan, K. H. Joy, A. R. D. Smedley, P. J. Connolly and I. D. Abrahams Collection data suggest the proportion of iron-based meteorites recovered from Antarctica is significantly lower than the rest of the world. Here, the authors propose a mechanism to explain this discrepancy, showing that iron meteorites heated by solar energy can move down through the ice, not to re-emerge. 16 February 2016 | doi: 10.1038/ncomms10679 Earth Sciences  Geology and geophysics  Planetary sciences  Near-island biological hotspots in barren ocean basins OPEN Jamison M. Gove, Margaret A. McManus, Anna B. Neuheimer, Jeffrey J. Polovina, Jeffrey C. Drazen, Craig R. Smith, Mark A. Merrifield, Alan M. Friedlander, Julia S. Ehses, Charles W. Young, Amanda K. Dillon and Gareth J. Williams The Island Mass Effect (IME), where island proximity enhances phytoplankton biomass, remains a poorly understood phenomenon. Here, the authors show the IME is a common feature among Pacific reefs, driving increased production that creates biological hotspots in otherwise barren ocean basins. 16 February 2016 | doi: 10.1038/ncomms10581 Earth Sciences  Ecology  Oceanography  Arbitrary cross-section SEM-cathodoluminescence imaging of growth sectors and local carrier concentrations within micro-sampled semiconductor nanorods OPEN Kentaro Watanabe, Takahiro Nagata, Seungjun Oh, Yutaka Wakayama, Takashi Sekiguchi, János Volk and Yoshiaki Nakamura Semiconductor nanocrystals are potential nanoelectronic materials but often display nonuniform electric properties due to their anisotropic growths. Here, the authors report cross-sectional cathodoluminescence imaging of a single-crystalline ZnO nanowire to resolve its growth sectors with different carrier concentrations. 16 February 2016 | doi: 10.1038/ncomms10609 Chemical Sciences  Applied physics  Materials science  Nanotechnology  Precision multidimensional assay for high-throughput microRNA drug discovery OPEN Benjamin Haefliger, Laura Prochazka, Bartolomeo Angelici and Yaakov Benenson Progress in drug discovery can be hampered by a limited exploration of chemical space and the difficulty in assessing the full range of drug candidates’ effects on living cells. Here the authors describe a cell-based assay to distinguish between off-target and specific effects of candidate compounds targeting micro RNAs. 16 February 2016 | doi: 10.1038/ncomms10709 Biological Sciences  Biotechnology  Systems biology  Discovery of cahuitamycins as biofilm inhibitors derived from a convergent biosynthetic pathway OPEN Sung Ryeol Park, Ashootosh Tripathi, Jianfeng Wu, Pamela J. Schultz, Isaiah Yim, Thomas J. McQuade, Fengan Yu, Carl-Johan Arevang, Abraham Y. Mensah, Giselle Tamayo-Castillo, Chuanwu Xi and David H. Sherman Pathogenic microbes can often attach to surfaces and form biofilms that display increased antibiotic resistance. Here, the authors characterize the biosynthesis of a new class of natural products, the cahuitamycins, that inhibit formation of biofilms by the pathogenic bacterium Acinetobacter baumannii. 16 February 2016 | doi: 10.1038/ncomms10710 Biological Sciences  Biochemistry  Chemical biology  Microbiology  Tenomodulin promotes human adipocyte differentiation and beneficial visceral adipose tissue expansion OPEN Ozlem Senol-Cosar, Rachel J. Roth Flach, Marina DiStefano, Anil Chawla, Sarah Nicoloro, Juerg Straubhaar, Olga T. Hardy, Hye Lim Noh, Jason K. Kim, Martin Wabitsch, Philipp E. Scherer and Michael P. Czech Expansion of visceral adipose tissue is usually associated with insulin resistance and metabolic disease. Here, the authors show that the membrane protein TNMD is upregulated in visceral fat of insulin resistant obese individuals and promotes healthy adipose tissue expansion through increasing adipogenesis. 16 February 2016 | doi: 10.1038/ncomms10686 Biological Sciences  Medical research  Athermal domain-wall creep near a ferroelectric quantum critical point OPEN Fumitaka Kagawa, Nao Minami, Sachio Horiuchi and Yoshinori Tokura At very low temperature, particle-like objects such as atoms and material phase boundaries become less able to move due to thermally inactivity. Here, Kagawa et al. show that ferroelectric domain walls gain energy for creep motion due to quantum fluctuations at low temperature. 16 February 2016 | doi: 10.1038/ncomms10675 Physical Sciences  Condensed matter  Materials science  Earth's oldest mantle fabrics indicate Eoarchaean subduction OPEN Mary-Alix Kaczmarek, Steven M. Reddy, Allen P. Nutman, Clark R. L. Friend and Vickie C. Bennett Subduction is a main component of Phanerozoic plate tectonics, although the timing of initiation is controversial. Here, the authors present microstructural data from two 3.72 billion year old dunite lenses of Isua in Greenland, which suggest that subduction was already in operation during the Eoarchaean. 16 February 2016 | doi: 10.1038/ncomms10665 Earth Sciences  Geology and geophysics  Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain OPEN Zachary Freyberg, Mark S. Sonders, Jenny I. Aguilar, Takato Hiranita, Caline S. Karam, Jorge Flores, Andrea B. Pizzo, Yuchao Zhang, Zachary J. Farino, Audrey Chen, Ciara A. Martin, Theresa A. Kopajtic, Hao Fei, Gang Hu, Yi-Ying Lin, Eugene V. Mosharov, Brian D. McCabe, Robin Freyberg, Kandatege Wimalasena, Ling-Wei Hsin et al. Amphetamines are known to enhance extracellular dopamine levels, but the underlying mechanisms are unclear. Utilising a new pH biosensor for synaptic vesicles, the authors show that amphetamines diminish vesicle pH gradients, disrupting dopamine packaging and leading to increased neurotransmitter release. 16 February 2016 | doi: 10.1038/ncomms10652 Biological Sciences  Neuroscience  Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway OPEN Yuta Hatori, Ye Yan, Katharina Schmidt, Eri Furukawa, Nesrin M. Hasan, Nan Yang, Chin-Nung Liu, Shanthini Sockanathan and Svetlana Lutsenko Differentiating neurons have an increased requirement for copper than their precursors, but the mechanism of altered copper homoeostasis is not known. Here, Hatori et al. show that neuronal differentiation is accompanied by an increased flux of copper through the secretory pathway, increasing supply to copper-dependent enzymes. 16 February 2016 | doi: 10.1038/ncomms10640 Biological Sciences  Cell biology  Neuroscience  Visualizing the orientational dependence of an intermolecular potential OPEN Adam Sweetman, Mohammad A. Rashid, Samuel P. Jarvis, Janette L. Dunn, Philipp Rahe and Philip Moriarty Intermolecular interactions underpin an array of physical and chemical phenomena. Here, the authors probe the three dimensional potential between fullerene molecules in different orientations showing that the positional variation in the intermolecular binding energy is dominated repulsive interactions. 16 February 2016 | doi: 10.1038/ncomms10621 Chemical Sciences  Condensed matter  Nanotechnology  Physical chemistry  Thermal and quantum depletion of superconductivity in narrow junctions created by controlled electromigration OPEN Xavier D. A. Baumans, Dorin Cerbu, Obaïd-Allah Adami, Vyacheslav S. Zharinov, Niels Verellen, Gianpaolo Papari, Jeroen E. Scheerder, Gufei Zhang, Victor V. Moshchalkov, Alejandro V. Silhanek and Joris Van de Vondel Nanostructured superconductors allow dissipationless electrical transport to be exploited in technologically relevant devices. Here, the authors follow how detrimental fluctuations of the superconducting order parameter evolve in Al atomic contacts as their width is controlled by electromigration. 16 February 2016 | doi: 10.1038/ncomms10560 Physical Sciences  Condensed matter  The presence of extra chromosomes leads to genomic instability OPEN Verena Passerini, Efrat Ozeri-Galai, Mirjam S. de Pagter, Neysan Donnelly, Sarah Schmalbrock, Wigard P. Kloosterman, Batsheva Kerem and Zuzana Storchová One of the hallmarks of cancer cells is aneuploidy, however the molecular effects are poorly understood. Here the authors show that trisomic and tetrasomic cells display increased genomic instability and reduced levels of the helicase MCM2-7. 15 February 2016 | doi: 10.1038/ncomms10754 Biological Sciences  Molecular biology  Directed block copolymer self-assembly implemented via surface-embedded electrets OPEN Mei-Ling Wu, Dong Wang and Li-Jun Wan The controlled orientation of block copolymers promises to deliver high resolution patterning for implementation in future nanoscale technologies. Here, the authors use the electric field from charged electrets to induce extremely localised perpendicularly oriented microdomains in polymer thin films. 15 February 2016 | doi: 10.1038/ncomms10752 Chemical Sciences  Materials science  Nanotechnology  Physical chemistry  Observations of narrow bipolar events reveal how lightning is initiated in thunderstorms OPEN William Rison, Paul R. Krehbiel, Michael G. Stock, Harald E. Edens, Xuan-Min Shao, Ronald J. Thomas, Mark A. Stanley and Yang Zhang How lightning is initiated inside storms has been a long-standing and fundamental question. Here, the authors report observations of a previously unrecognized type of discharge, called fast positive breakdown, that is found to initiate many and potentially all lightning discharges in storms. 15 February 2016 | doi: 10.1038/ncomms10721 Earth Sciences  Atmospheric science  The histone variant H2A.X is a regulator of the epithelial–mesenchymal transition OPEN Urbain Weyemi, Christophe E. Redon, Rohini Choudhuri, Towqir Aziz, Daisuke Maeda, Myriem Boufraqech, Palak R. Parekh, Taresh K. Sethi, Manjula Kasoji, Natalie Abrams, Anand Merchant, Vinodh N. Rajapakse and William M. Bonner The histone H2A variants are involved in DNA repair, gene regulation and cancer development. In this study, the authors unravel an additional role for H2A.X in the regulation of mesenchymal-like traits and activation of the EMT transcription factors, Slug and ZEB1, in colon cancer cells. 15 February 2016 | doi: 10.1038/ncomms10711 Biological Sciences  Cancer  Cell biology  A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells OPEN Akshay K. Ahuja, Karolina Jodkowska, Federico Teloni, Anna H. Bizard, Ralph Zellweger, Raquel Herrador, Sagrario Ortega, Ian D. Hickson, Matthias Altmeyer, Juan Mendez and Massimo Lopes In fast proliferating embryonic stem cells (ESC) the DNA damage response is activated by mechanisms that are as yet elusive. Here, Ahuja et al. link the DNA damage response to replication stress in mouse ESCs, caused by a short G1 phase, and propose fork remodelling as maintaining genome stability in embryos. 15 February 2016 | doi: 10.1038/ncomms10660 Biological Sciences  Cell biology  Developmental biology  Molecular biology  Non-equilibrium behaviour in coacervate-based protocells under electric-field-induced excitation OPEN Yudan Yin, Lin Niu, Xiaocui Zhu, Meiping Zhao, Zexin Zhang, Stephen Mann and Dehai Liang Synthetic cells are designed to mimic basic life processes, but it is challenging to prepare cells that can persist and operate at non-equilibrium conditions. Here, Yin et al. show complex dynamical behaviors of protocells made by exposing polylysine and single-stranded DNA droplets to an electric field. 15 February 2016 | doi: 10.1038/ncomms10658 Chemical Sciences  Bioengineering  Materials science  Physical chemistry  GAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway OPEN Pablo D. Cárdenas, Prashant D. Sonawane, Jacob Pollier, Robin Vanden Bossche, Veena Dewangan, Efrat Weithorn, Lior Tal, Sagit Meir, Ilana Rogachev, Sergey Malitsky, Ashok P. Giri, Alain Goossens, Saul Burdman and Asaph Aharoni Steroidal glycoalkaloids (SGAs) accumulate in solanaceous plants and contribute to plant defence but are toxic to humans. Here the authors show that the GAME9 transcription factor is a regulator of the SGA biosynthetic pathways providing a potential way to manipulate SGA levels in crops. 15 February 2016 | doi: 10.1038/ncomms10654 Biological Sciences  Plant sciences  Prediction of an arc-tunable Weyl Fermion metallic state in MoxW1−xTe2 OPEN Tay-Rong Chang, Su-Yang Xu, Guoqing Chang, Chi-Cheng Lee, Shin-Ming Huang, BaoKai Wang, Guang Bian, Hao Zheng, Daniel S. Sanchez, Ilya Belopolski, Nasser Alidoust, Madhab Neupane, Arun Bansil, Horng-Tay Jeng, Hsin Lin and M. Zahid Hasan Two-dimensional materials provide possible platforms to map exotic phenomena from particle physics to condensed matter physics. Here, the authors predict doping dependent electronic behaviour in MoxW1−xTe2, in resemblance of a phenomenon which is believed to exist only in particle physics. 15 February 2016 | doi: 10.1038/ncomms10639 Physical Sciences  Condensed matter  Materials science  Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria OPEN Larry J. Dishaw, Brittany Leigh, John P. Cannon, Assunta Liberti, M. Gail Mueller, Diana P. Skapura, Charlotte R. Karrer, Maria R. Pinto, Rosaria De Santis and Gary W. Litman Protochordates, including Ciona intestinalis, lack an adaptive immune system but possess innate immune receptors, including the secreted immunoglobulin V-region-containing VCBPs. Here the authors show that VCBP-C of Ciona binds gut bacteria and chitin-rich gut mucosa, influences biofilm formation and likely plays a role in gut homeostasis. 15 February 2016 | doi: 10.1038/ncomms10617 Biological Sciences  Immunology  Atypical natural killer T-cell receptor recognition of CD1d–lipid antigens OPEN Jérôme Le Nours, T. Praveena, Daniel G. Pellicci, Nicholas A. Gherardin, Fiona J. Ross, Ricky T. Lim, Gurdyal S. Besra, Santosh Keshipeddy, Stewart K. Richardson, Amy R. Howell, Stephanie Gras, Dale I. Godfrey, Jamie Rossjohn and Adam P. Uldrich The invariant αβTCR of type I NKT cells recognizes a lipid α-GalCer presented by CD1d. Here the authors describe atypical α-GalCer-reactive NKT cells with diverse TCRs, which bind to CD1d-α-GalCer in a manner distinct from type I NKT cells, thus unveiling greater diversity in lipid antigen recognition. 15 February 2016 | doi: 10.1038/ncomms10570 Biological Sciences  Immunology  Molecular biology  Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP OPEN Mausita Karmakar, Michael A. Katsnelson, George R. Dubyak and Eric Pearlman Neutrophils are a major source of IL-1 β in a number of inflammatory settings. Here the authors show that mouse and human neutrophils express functional P2X7 receptors, which mediate ATP-triggered NLRP3 inflammasome activation and IL-1 ß secretion. 15 February 2016 | doi: 10.1038/ncomms10555 Biological Sciences  Immunology  ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types OPEN Waltraut Lehmann, Dirk Mossmann, Julia Kleemann, Kerstin Mock, Chris Meisinger, Tilman Brummer, Ricarda Herr, Simone Brabletz, Marc P. Stemmler and Thomas Brabletz The transcription factors ZEB1 and YAP function in different pathways yet both activate aggressive behaviour in cancer cells. Here, the authors describe that the proteins physically interact and that this changes the transcriptional activity of ZEB1 from a repressor to an activator. 15 February 2016 | doi: 10.1038/ncomms10498 Biological Sciences  Cancer  Cell biology  Periodic patterning of the Drosophila eye is stabilized by the diffusible activator Scabrous OPEN Avishai Gavish, Arkadi Shwartz, Abraham Weizman, Eyal Schejter, Ben-Zion Shilo and Naama Barkai Patterning in the Drosophila eye is achieved by a series of signalling cascades over several cell distances. Here Gavish et al. model lateral inhibition in the developing eye to understand how developmental noise refines such patterning, identifying a novel activator required for buffering spatial variability. 15 February 2016 | doi: 10.1038/ncomms10461 Biological Sciences  Cell biology  Developmental biology  Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods OPEN Zhen Xu, Fumio Takizawa, David Parra, Daniela Gómez, Louise von Gersdorff Jørgensen, Scott E. LaPatra and J. Oriol Sunyer In teleost fish the gills perform—in addition to respiration—functions such as immune defence. Here the authors show that IgT, a teleost specific Ig previously shown to be involved in gut and skin mucosal immunity, is locally induced in the gill, where it plays a key role in immunity in rainbow trout. 12 February 2016 | doi: 10.1038/ncomms10728 Biological Sciences  Immunology  Deformation-induced trace element redistribution in zircon revealed using atom probe tomography OPEN Sandra Piazolo, Alexandre La Fontaine, Patrick Trimby, Simon Harley, Limei Yang, Richard Armstrong and Julie M. Cairney Pb/U ratios and trace element distributions within zircon grains are used to determine a rock's age and geological processes, but the degree of element immobility and diffusion is uncertain. Here, the authors use atom probe tomography to reveal sub-micron scale mechanisms of trace element mobility. 12 February 2016 | doi: 10.1038/ncomms10490 Earth Sciences  Geology and geophysics  Loss of UBE3A from TH-expressing neurons suppresses GABA co-release and enhances VTA-NAc optical self-stimulation OPEN Janet Berrios, Alice M. Stamatakis, Pranish A. Kantak, Zoe A. McElligott, Matthew C. Judson, Megumi Aita, Marie Rougie, Garret D. Stuber and Benjamin D. Philpot Mesoaccumbal terminals within the VTA are known to co-release both GABA and dopamine, although the functional role of the former has yet to be determined. Here, the authors find that non-canonical GABA release is regulated by the E3-ubiquitin ligase, UBE3A, and enhances optogenetic self-stimulation. 12 February 2016 | doi: 10.1038/ncomms10702 Biological Sciences  Neuroscience  The mRNA-edited form of GABRA3 suppresses GABRA3-mediated Akt activation and breast cancer metastasis OPEN Kiranmai Gumireddy, Anping Li, Andrew V. Kossenkov, Masayuki Sakurai, Jinchun Yan, Yan Li, Hua Xu, Jian Wang, Paul J. Zhang, Lin Zhang, Louise C. Showe, Kazuko Nishikura and Qihong Huang GABRA3, a subunit of the GABA receptor, is often highly expressed in brain metastasis and breast cancers. Here, the authors demonstrated that GABRA3 activates AKT to promote breast cancer cell invasion and that the A-to-I edited form of GABRA3, specifically expressed in noninvasive breast cancers, can suppress the function of wild type GABRA3. 12 February 2016 | doi: 10.1038/ncomms10715 Biological Sciences  Cancer  Cell biology  Structural semiconductor-to-semimetal phase transition in two-dimensional materials induced by electrostatic gating OPEN Yao Li, Karel-Alexander N. Duerloo, Kerry Wauson and Evan J. Reed Control of conductivity and optical properties via atomic structure changes is of technological importance in information storage. Here, Li et al. show that electrostatic gating has the potential to drive structural semiconductor-to-semimetal phase transitions in some monolayer transition metal dichalcogenides. 12 February 2016 | doi: 10.1038/ncomms10671 Physical Sciences  Materials science  Nanotechnology  Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging OPEN Jeremy Roy, Bongki Kim, Eric Hill, Pablo Visconti, Dario Krapf, Claudio Vinegoni, Ralph Weissleder, Dennis Brown and Sylvie Breton It was recently shown that basal cells in pseudostratified epithelia extend a long cytoplasmic process across the tight junction barrier into the lumen. Here Roy & Kim et al. show that these projections, which they call axiopodia, extend and retract over time in a c-Src and MEK-ERK-dependent manner. 12 February 2016 | doi: 10.1038/ncomms10666 Biological Sciences  Cell biology  Approaching a universal scaling relationship between fracture stiffness and fluid flow OPEN Laura J. Pyrak-Nolte and David D. Nolte Fractures in rock can be altered geochemically and deformed under stress, affecting fluid flow rates across many orders of magnitude. Here, the authors present a universal scaling relationship between fluid flow and fracture specific stiffness, which will aid the interpretation of subsurface sites. 12 February 2016 | doi: 10.1038/ncomms10663 Earth Sciences  Geology and geophysics  Interferon-inducible protein SCOTIN interferes with HCV replication through the autolysosomal degradation of NS5A OPEN Nari Kim, Min-Jung Kim, Pil Soo Sung, Yong Chul Bae, Eui-Cheol Shin and Joo-Yeon Yoo Hepatitis C virus (HCV) nonstructural 5A (NS5A) protein is a critical factor for HCV RNA replication. Here the authors show that SCOTIN, an interferon beta-inducible host protein, functions to limit HCV replication by targeting viral protein NS5A for autophagosomal degradation. 12 February 2016 | doi: 10.1038/ncomms10631 Biological Sciences  Cell biology  Virology  Anthropogenic effects are associated with a lower persistence of marine food webs OPEN Luis J. Gilarranz, Camilo Mora and Jordi Bascompte Human activity is affecting the diversity and abundance of marine organisms. Here, Gilarranz et al. show that the persistence of marine food webs is reduced by the effects of fishing pressure, human density, and thermal stress. 12 February 2016 | doi: 10.1038/ncomms10737 Biological Sciences  Ecology  Oceanography  Land use imperils plant and animal community stability through changes in asynchrony rather than diversity OPEN Nico Blüthgen, Nadja K. Simons, Kirsten Jung, Daniel Prati, Swen C. Renner, Steffen Boch, Markus Fischer, Norbert Hölzel, Valentin H. Klaus, Till Kleinebecker, Marco Tschapka, Wolfgang W. Weisser and Martin M. Gossner Long-term stability of ecological communities is vital for maintaining ecosystem functioning. Here, Blüthgen et al. show that greater land-use intensity in grasslands and forests can have negative impacts on the stability of plant and animal communities, driven primarily by variation in asynchrony between species. 12 February 2016 | doi: 10.1038/ncomms10697 Biological Sciences  Ecology  Lysosomal recruitment of TSC2 is a universal response to cellular stress OPEN Constantinos Demetriades, Monika Plescher and Aurelio A. Teleman In response to amino acid and growth factor removal the TSC1/2 complex translocates to the lysosome to inactivate mTOR and inhibit cell growth. Here, the authors have shown that other cellular stresses also trigger this translocation to the lysosome suggesting that this is a universal mechanism in the stress response. 12 February 2016 | doi: 10.1038/ncomms10662 Biological Sciences  Cell biology  SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing OPEN Sifan Chen, Maximilian Felix Blank, Aishwarya Iyer, Bingding Huang, Lin Wang, Ingrid Grummt and Renate Voit SIRT7 is a protein deacetylase with important roles in rRNA synthesis, ribosome biogenesis and cell proliferation. Here the authors show a role of SIRT7 in rRNA maturation via deacetylation of U3-55k, a core component of the U3 snoRNP complex. 12 February 2016 | doi: 10.1038/ncomms10734 Biological Sciences  Molecular biology  PTEN modulates EGFR late endocytic trafficking and degradation by dephosphorylating Rab7 OPEN Swapnil Rohidas Shinde and Subbareddy Maddika Rab7 is a critical GTPase for endosome maturation and it is implicated in the endocytic traffic of several receptors, including EGFR. In this study, the authors reveal the potential role of PTEN in the endocytic trafficking pathway of EGFR, which is dependent on its phosphatase activity through the direct post-translational modification of Rab7. 12 February 2016 | doi: 10.1038/ncomms10689 Biological Sciences  Cancer  Cell biology  Tripartite assembly of RND multidrug efflux pumps OPEN Laetitia Daury, François Orange, Jean-Christophe Taveau, Alice Verchère, Laura Monlezun, Céline Gounou, Ravi K. R. Marreddy, Martin Picard, Isabelle Broutin, Klaas M. Pos and Olivier Lambert Tripartite efflux systems consist of inner membrane, outer membrane and periplasmic components. Here, Daury et al. reconstitute native versions of RND transporters in nanodiscs and present projection structures emphasizing the role of the periplasmic adaptor in linking the inner and outer membrane proteins. 12 February 2016 | doi: 10.1038/ncomms10731 Biological Sciences  Biophysics  A variant at 9p21.3 functionally implicates CDKN2B in paediatric B-cell precursor acute lymphoblastic leukaemia aetiology OPEN Eric A. Hungate, Sapana R. Vora, Eric R. Gamazon, Takaya Moriyama, Timothy Best, Imge Hulur, Younghee Lee, Tiffany-Jane Evans, Eva Ellinghaus, Martin Stanulla, Jéremie Rudant, Laurent Orsi, Jacqueline Clavel, Elizabeth Milne, Rodney J. Scott, Ching-Hon Pui, Nancy J. Cox, Mignon L. Loh, Jun J. Yang, Andrew D. Skol et al. A risk variant located at 9p21.3 is associated with cancer risk in pediatric B-cell precursor acute lymphoblastic leukaemia. Here, the authors show that this variant affects the gene expression of the tumour suppressor gene Cdkn2b. 12 February 2016 | doi: 10.1038/ncomms10635 Biological Sciences  Cancer  Genetics  SCFFbxo22-KDM4A targets methylated p53 for degradation and regulates senescence OPEN Yoshikazu Johmura, Jia Sun, Kyoko Kitagawa, Keiko Nakanishi, Toshiya Kuno, Aya Naiki-Ito, Yumi Sawada, Tomomi Miyamoto, Atsushi Okabe, Hiroyuki Aburatani, ShengFan Li, Ichiro Miyoshi, Satoru Takahashi, Masatoshi Kitagawa and Makoto Nakanishi Cellular senescence—the permanent cessation of cell proliferation—is a process that can be deregulated in cancer and other aging-related diseases. Here the authors demonstrate that the SCFFbxo22-KDM4A complex plays an essential role during senescence as an E3 ligase that targets methylated p53 for degradation. 12 February 2016 | doi: 10.1038/ncomms10574 Biological Sciences  Cancer  Cell biology  Discovery and enantiocontrol of axially chiral urazoles via organocatalytic tyrosine click reaction OPEN Ji-Wei Zhang, Jin-Hui Xu, Dao-Juan Cheng, Chuan Shi, Xin-Yuan Liu and Bin Tan Axially chiral compounds play an important role in areas such as asymmetric catalysis. Here, the authors report an organocatalytic asymmetric tyrosine click-like reaction, giving access to enantio enriched urazoles with restricted rotation around an N-C bond. 11 February 2016 | doi: 10.1038/ncomms10677 Chemical Sciences  Catalysis  Organic chemistry  Hexadecapolar colloids OPEN Bohdan Senyuk, Owen Puls, Oleh M. Tovkach, Stanislav B. Chernyshuk and Ivan I. Smalyukh Colloidal systems can form bulk phases such as liquid and crystals, but they also exhibit interesting behaviours that have no atomic analogues. Here, by dispersing solid polymer microspheres in a nematic liquid crystal, Senyuk et al. demonstrate spontaneous formation of hexadecapolar nematic colloids. 11 February 2016 | doi: 10.1038/ncomms10659 Physical Sciences  Condensed matter  Materials science  Advanced intermediate temperature sodium–nickel chloride batteries with ultra-high energy density OPEN Guosheng Li, Xiaochuan Lu, Jin Y. Kim, Kerry D. Meinhardt, Hee Jung Chang, Nathan L. Canfield and Vincent L. Sprenkle Sodium metal halide batteries are attractive technologies for stationary electrical energy storage. Here, the authors report that planar sodium-nickel chloride batteries operated at an intermediate temperature of 190 °C display larger energy densities than tubular batteries operated at higher temperatures. 11 February 2016 | doi: 10.1038/ncomms10683 Chemical Sciences  Materials science  Physical chemistry  Structural complexity of simple Fe2O3 at high pressures and temperatures OPEN E. Bykova, L. Dubrovinsky, N. Dubrovinskaia, M. Bykov, C. McCammon, S. V. Ovsyannikov, H. -P. Liermann, I. Kupenko, A. I. Chumakov, R. Rüffer, M. Hanfland and V. Prakapenka Fe2O3 is known to undergo a series of structural, electronic and magnetic transformations at high pressures and temperatures but these are poorly understood due to a lack of structural data. Here, the authors perform experiments to elucidate the transformations and relationships between them. 11 February 2016 | doi: 10.1038/ncomms10661 Earth Sciences  Geology and geophysics  Materials science  Physical chemistry  Multimodal stimulus coding by a gustatory sensory neuron in Drosophila larvae OPEN Lena van Giesen, Luis Hernandez-Nunez, Sophie Delasoie-Baranek, Martino Colombo, Philippe Renaud, Rémy Bruggmann, Richard Benton, Aravinthan D. T. Samuel and Simon G. Sprecher While gustatory systems have been extensively studied in adult Drosophila, not much is known about taste coding at the larval stage. Here, the authors investigate gustatory receptor neurons in larvae and find single neurons are capable of responding to more than one taste modality. 11 February 2016 | doi: 10.1038/ncomms10687 Biological Sciences  Neuroscience  Microbially assisted recording of the Earth’s magnetic field in sediment OPEN Xiangyu Zhao, Ramon Egli, Stuart A. Gilder and Sebastian Müller Sediments record variations of the Earth’s magnetic field via the alignment of magnetic grains during and after deposition, yet the role of post-depositional processes remains unclear. Here, the authors present experiments showing how microbially-induced bioturbation controls the alignment process. 11 February 2016 | doi: 10.1038/ncomms10673 Earth Sciences  Geology and geophysics  Microbiology  A dilation-driven vortex flow in sheared granular materials explains a rheometric anomaly OPEN K. P. Krishnaraj and Prabhu R. Nott Flowing granular materials exhibit fluid-like features, but not all of them can be described by extending fluid mechanics. Here, the authors show vortex flow in a granular layer sheared between coaxial cylinders, and attribute it to the effect that the material moves away from the sheared region. 11 February 2016 | doi: 10.1038/ncomms10630 Physical Sciences  Condensed matter  Fluids and plasma physics  Materials science  Giant conductivity switching of LaAlO3/SrTiO3 heterointerfaces governed by surface protonation OPEN Keith A. Brown, Shu He, Daniel J. Eichelsdoerfer, Mengchen Huang, Ishan Levy, Hyungwoo Lee, Sangwoo Ryu, Patrick Irvin, Jose Mendez-Arroyo, Chang-Beom Eom, Chad A. Mirkin and Jeremy Levy The interface between two oxide materials can play host to numerous exotic phenomenon. Here, the authors observe a four order of magnitude change in the conductance at a lanthanum-aluminate–strontium-titanate interface controlled by surface protonation, which can be reversed by exposure to light. 10 February 2016 | doi: 10.1038/ncomms10681 Physical Sciences  Condensed matter  Materials science  Pure and stable metallic phase molybdenum disulfide nanosheets for hydrogen evolution reaction OPEN Xiumei Geng, Weiwei Sun, Wei Wu, Benjamin Chen, Alaa Al-Hilo, Mourad Benamara, Hongli Zhu, Fumiya Watanabe, Jingbiao Cui and Tar-pin Chen Metallic molybdenum disulfide is a metastable phase of the material. Here, the authors synthesize two-dimensional metallic molybdenum disulfide nanosheets, stabilized by adsorbed aqueous monolayers, and evaluate their catalytic hydrogen evolution activity. 10 February 2016 | doi: 10.1038/ncomms10672 Chemical Sciences  Catalysis  Materials science  Nanotechnology  Nanocaged enzymes with enhanced catalytic activity and increased stability against protease digestion OPEN Zhao Zhao, Jinglin Fu, Soma Dhakal, Alexander Johnson-Buck, Minghui Liu, Ting Zhang, Neal W. Woodbury, Yan Liu, Nils G. Walter and Hao Yan Cells compartmentalize enzymes for enhanced efficiency of their metabolic pathways. Here, the authors describe a self-assembly approach to construct DNA nanocaged enzymes for enhancing catalytic activity and stability, and observe an inversed correlation between the protein size and the activity enhancement. 10 February 2016 | doi: 10.1038/ncomms10619 Chemical Sciences  Biotechnology  Nanotechnology  Achromatic vector vortex beams from a glass cone OPEN N. Radwell, R. D. Hawley, J. B. Götte and S. Franke-Arnold Under total internal reflection light acquires a phase shift that depends on its polarisation. Here, the authors show that this effect can be harnessed to generate so-called vector vortex beams—light with polarization and phase singularities—when white light is back-reflected from a glass cone 10 February 2016 | doi: 10.1038/ncomms10564 Physical Sciences  Optical physics  Atomically isolated nickel species anchored on graphitized carbon for efficient hydrogen evolution electrocatalysis OPEN Lili Fan, Peng Fei Liu, Xuecheng Yan, Lin Gu, Zhen Zhong Yang, Hua Gui Yang, Shilun Qiu and Xiangdong Yao There is tremendous ongoing effort in the development of electrocatalysts for hydrogen evolution. Here, the authors report that single nickel atoms dispersed on graphitic supports are formed by carbonization of metal-organic frameworks and that they are highly active hydrogen evolution catalysts. 10 February 2016 | doi: 10.1038/ncomms10667 Chemical Sciences  Catalysis  Inorganic chemistry  Materials science  NLRC5 shields T lymphocytes from NK-cell-mediated elimination under inflammatory conditions OPEN Kristina Ludigs, Camilla Jandus, Daniel T. Utzschneider, Francesco Staehli, Stéphanie Bessoles, Anh Thu Dang, Giorgia Rota, Wilson Castro, Dietmar Zehn, Eric Vivier, Werner Held, Pedro Romero and Greta Guarda NK cell tolerance to self-MHCI levels is calibrated during their development. Here the authors show that this tolerance is overcome by an inflammatory environment and that NLRC5 protects T cells from NK cell-mediated elimination by maintaining high MHCI expression. 10 February 2016 | doi: 10.1038/ncomms10554 Biological Sciences  Immunology  Picosecond metrology of laser-driven proton bursts OPEN B. Dromey, M. Coughlan, L. Senje, M. Taylor, S. Kuschel, B. Villagomez-Bernabe, R. Stefanuik, G. Nersisyan, L. Stella, J. Kohanoff, M. Borghesi, F. Currell, D. Riley, D. Jung, C.-G. Wahlström, C.L.S. Lewis and M. Zepf Experimental investigations of the response of matter to ionization would require extremely fast ion pump pulses. Here, the authors explore a different approach observing ionisation dynamics in SiO2 glass by generating synchronized proton pulses from the interaction of high-power lasers on a solid target. 10 February 2016 | doi: 10.1038/ncomms10642 Physical Sciences  Fluids and plasma physics  Optical physics  Maternal plasma folate impacts differential DNA methylation in an epigenome-wide meta-analysis of newborns OPEN Bonnie R. Joubert, Herman T. den Dekker, Janine F. Felix, Jon Bohlin, Symen Ligthart, Emma Beckett, Henning Tiemeier, Joyce B. van Meurs, Andre G. Uitterlinden, Albert Hofman, Siri E. Håberg, Sarah E. Reese, Marjolein J. Peters, Bettina Kulle Andreassen, Eric A. P. Steegers, Roy M. Nilsen, Stein E. Vollset, Øivind Midttun, Per M. Ueland, Oscar H. Franco et al. Folic acid is routinely recommended for women trying to conceive to ensure proper fetal development. Here, the authors perform a large epigenomics study to examine which fetal epigenetic changes are associated with varied maternal plasma folate levels. 10 February 2016 | doi: 10.1038/ncomms10577 Biological Sciences  Developmental biology  Genetics    Nature Communications JOBS of the week Postdoctoral Research Scientist The Pirbright Institute Postdoctoral Associate Rutgers University - New Brunswick Investigator Scientist (MBU2534) Medical Research Council Postdoctoral Research Associate Grade 7 University of Liverpool Advanced Research Assistant Wellcome Trust Sanger Institute Research Group Leader Inserm Postdoctoral Research Assistant University of Dundee Post-doctoral fellowship Lund University Postdoctoral Fellowship: Linköping University (LiU) Postdoctoral Research Fellow Memorial Sloan Kettering Cancer Center (MSKCC) More Science jobs from Nature Communications EVENT AACR'S Ninth Annual Cancer and Biomedical Research Career Fair 10.02.16 New Orleans, USA More science events from       Latest Corrigenda     Corrigendum: Modulating protein activity using tethered ligands with mutually exclusive binding sites OPEN Alberto Schena, Rudolf Griss and Kai Johnsson 15 February 2016 | doi: 10.1038/ncomms10758 Biological Sciences  Biochemistry  Chemical biology      Corrigendum: EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques OPEN Hye Yun Kim, Hyunjin Vincent Kim, Seonmi Jo, C. Justin Lee, Seon Young Choi, Dong Jin Kim and YoungSoo Kim 15 February 2016 | doi: 10.1038/ncomms10755 Biological Sciences  Cell biology  Neuroscience      Corrigendum: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations OPEN M. Geoffrey Hayes, Margrit Urbanek, David A. Ehrmann, Loren L. Armstrong, Ji Young Lee, Ryan Sisk, Tugce Karaderi, Thomas M. Barber, Mark I. McCarthy, Stephen Franks, Cecilia M. Lindgren, Corrine K. Welt, Evanthia Diamanti-Kandarakis, Dimitrios Panidis, Mark O. Goodarzi, Ricardo Azziz, Yi Zhang, Roland G. James, Michael Olivier, Ahmed H. Kissebah et al. 12 February 2016 | doi: 10.1038/ncomms10762 Biological Sciences  Genetics      Corrigendum: A draft network of ligand-receptor-mediated multicellular signalling in human OPEN Jordan A. Ramilowski, Tatyana Goldberg, Jayson Harshbarger, Edda Kloppmann, Marina Lizio, Venkata P. Satagopam, Masayoshi Itoh, Hideya Kawaji, Piero Carninci, Burkhard Rost and Alistair R. R. Forrest 10 February 2016 | doi: 10.1038/ncomms10706 Biological Sciences  Bioinformatics  Cell biology      Corrigendum: A fluorescent hormone biosensor reveals the dynamics of jasmonate signalling in plants OPEN Antoine Larrieu, Antony Champion, Jonathan Legrand, Julien Lavenus, David Mast, Géraldine Brunoud, Jaesung Oh, Soazig Guyomarc′h, Maxime Pizot, Edward E. Farmer, Colin Turnbull, Teva Vernoux, Malcolm J. Bennett and Laurent Laplaze 10 February 2016 | doi: 10.1038/ncomms10704 Biological Sciences  Plant sciences        Latest Erratum     Erratum: Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection OPEN Teng Zuo, Jianfeng Sun, Guiqin Wang, Liwei Jiang, Yanan Zuo, Danyang Li, Xuanling Shi, Xi Liu, Shilong Fan, Huanhuan Ren, Hongxing Hu, Lina Sun, Boping Zhou, Mifang Liang, Paul Zhou, Xinquan Wang and Linqi Zhang 15 February 2016 | doi: 10.1038/ncomms10757 Biological Sciences  Immunology  Virology      Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. 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