Nature Reviews Gastroenterology & Hepatology - Table of Contents alert Volume 13 Issue 2

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TABLE OF CONTENTS
February 2016 Volume 13 Number 2
Impact Factor 12.610*	In this issue Research Highlights Year in Review Reviews Also this month  Featured article: Lessons learned — resolving the enigma of genetic factors in IBS Maria Gazouli, Mira M. Wouters, Lejla Kapur-Pojskić, May-Bente Bengtson, Eitan Friedman, Gordana Nikčević, Christiana A. Demetriou, Agata Mulak, Javier Santos, & Beate Niesler
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RESEARCH HIGHLIGHTS Top Pancreatitis: KMO inhibitor for multi-organ failure in experimental acute pancreatitis Published online: 21 January 2016 p61 | doi:10.1038/nrgastro.2016.6 PDF Liver: Regulating profibrotic transcription Published online: 23 December 2015 p62 | doi:10.1038/nrgastro.2015.222 PDF Liver: Lipocalin 2 and steatohepatitis Published online: 04 January 2016 p62 | doi:10.1038/nrgastro.2015.225 PDF IBD: Probiotics for IBD: a need for histamine? Published online: 13 January 2016 p62 | doi:10.1038/nrgastro.2016.2 PDF Paediatrics: T cells in necrotizing enterocolitis Published online: 13 January 2016 p63 | doi:10.1038/nrgastro.2016.1 PDF Stem cells: IL-22 activates ISCs for intestinal regeneration Published online: 23 December 2015 p64 | doi:10.1038/nrgastro.2015.221 PDF IN BRIEF Gut microbiota: PPIs alter gut microbiota composition | Viral hepatitis: New entry pathway for HCV | IBS: Risk factors for IBS: data from the US military | Liver: Characteristics of liver-infiltrating MAIT cells PDF Nature Reviews Gastroenterology & Hepatology JOBS of the week Gastroenterology - Inflammatory Bowel Disease (IBD) Gastroenterologist Job Mayo Clinic Group Leader Positions Imagine Institute for Genetic Diseases Academic Hepatologist University of New Mexico More Science jobs from
YEAR IN REVIEW		Top
Regenerative medicine in 2015: Generating and regenerating the digestive system James M. Wells Published online: 13 January 2016 p65 | doi:10.1038/nrgastro.2015.223 Advances into understanding stem and progenitor cells and organoids of the gastrointestinal tract have continued apace. New research published in 2015 identified new cell populations involved in liver regeneration and highlighted the development of pancreatic and gastric organoids. Full Text | PDF
Liver fibrosis in 2015: Crucial steps towards an effective treatment Klaas Poelstra Published online: 13 January 2016 p67 | doi:10.1038/nrgastro.2015.224 In 2015, new tools were developed to modulate fibroblast and macrophage activity to halt liver fibrogenesis and stimulate resolution. Essential factors for resolution were identified and clinical trials yielded potential new antifibrotic drugs. Although innovations were made this year, clinical trials are still hampered by the lack of methods to monitor disease progression. Full Text | PDF
Gut microbiota in 2015: Prevotella in the gut: choose carefully Ruth E. Ley Published online: 01 February 2016 p69 | doi:10.1038/nrgastro.2016.4 Gut microbial communities often contain many Bacteroides or their close relatives, Prevotella, but not both. Prevotella strains are associated with plant-rich diets but are also linked with chronic inflammatory conditions. In 2015, papers probed the genomic diversity of Prevotella strains and interactions of Prevotella copri with its host and other bacteria. Full Text | PDF
HCV in 2015: Advances in hepatitis C research and treatment Barbara Rehermann Published online: 21 January 2016 p70 | doi:10.1038/nrgastro.2015.227 In 2015, new treatment regimens were revealed that achieve >95% cure rates for all HCV genotypes. The HCV polymerase structure was solved in catalytically relevant HCV replication steps and in the context of nucleotide analogue inhibition. Moreover, HCV research taught us new links between innate antiviral responses, lipid metabolism and intracellular membrane formation. Full Text | PDF
Gastrointestinal imaging in 2015: Emerging trends in endoscopic imaging Bishnu P. Joshi & Thomas D. Wang Published online: 04 January 2016 p72 | doi:10.1038/nrgastro.2015.214 Several key papers published in 2015 highlight important emerging trends in endoscopic imaging that promise to improve patient diagnosis and guidance of therapy. These studies reflect the future role for 'smart' contrast agents and fluorescence endoscopes to provide a molecular basis for disease detection, identify precancerous lesions and determine optimal choice of therapy. Full Text | PDF
Pancreatic cancer in 2015: Precision medicine in pancreatic cancer — fact or fiction? Thomas Seufferlein & Julia Mayerle Published online: 13 January 2016 p74 | doi:10.1038/nrgastro.2015.215 Late diagnosis and an inability to personalize treatment are major problems preventing reductions in pancreatic cancer mortality. In 2015, the identification of a highly discriminatory exosomal biomarker, culture systems that recapitulate human disease and new methods of analysing large data sets to identify prognostic markers have improved the future outlook for patients with this cancer. Full Text | PDF
REVIEWS		Top
Lessons learned — resolving the enigma of genetic factors in IBS Maria Gazouli, Mira M. Wouters, Lejla Kapur-Pojskić, May-Bente Bengtson, Eitan Friedman, Gordana Nikčević, Christiana A. Demetriou, Agata Mulak, Javier Santos, & Beate Niesler Published online: 04 January 2016 p77 | doi:10.1038/nrgastro.2015.206 The pathophysiology of IBS is multifactorial with a substantial genetic component. Although a variety of genetic and epigenetic changes have been associated with different IBS subtypes, reproducible validation of these results is still outstanding and pharmacogenetic strategies have yet to be devised. Here, the COST Action BM1106 GENIEUR (epi)genetic working group gives insights into the situation to date, advances and challenges that still need addressing. Abstract | Full Text | PDF | Supplementary information
Immunology in the liver — from homeostasis to disease Felix Heymann & Frank Tacke Published online: 13 January 2016 p88 | doi:10.1038/nrgastro.2015.200 Tremendous progress has been made in understanding the immune responses in the liver. Here, Heymann and Tacke provide a comprehensive overview of liver immunology, from homeostasis to disease. The cellular mediators of immune responses in the liver and triggers of hepatic inflammation are described. Abstract | Full Text | PDF
Consequences of bariatric surgery on oesophageal function in health and disease Rishi D. Naik, Yash A. Choksi & Michael F. Vaezi Published online: 09 December 2015 p111 | doi:10.1038/nrgastro.2015.202 Bariatric surgery is efficient in achieving weight loss in severe obesity, but associated anatomical or mechanical alterations might also affect oesophageal function. Each type of surgery has its own risks and benefits when it comes to pre-existing or the potential development of postoperative oesophageal disorders. Here, the three most common types of bariatric surgery and their respective influences on oesophageal function are discussed. Abstract | Full Text | PDF | Supplementary information
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*Journal Citation Reports, Thomson, 2014. Nature Reviews Gastroenterology & Hepatology was previously published as Nature Clinical Practice Gastroenterology & Hepatology.

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