Nature Reviews Immunology Contents April 2016 Volume 16 Number 4 pp 203-271

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Animation: Immunology of the rheumatoid joint This animation guides us through the immune pathways involved in rheumatoid arthritis, from the first signs of self-reactive immune cells to joint damage and other symptoms, and highlights opportunities for new treatments. Watch now. Produced with support from: Janssen Pharmaceutical Companies of Johnson & Johnson
TABLE OF CONTENTS
April 2016 Volume 16 Number 4
Impact Factor 30.458 *	In this issue Research Highlights Reviews Correspondence Also this month  Featured article: T cell receptor signalling in the control of regulatory T cell differentiation and function Ming O. Li & Alexander Y. Rudensky
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nature.com webcasts Nature Publishing Group presents a custom webcast on: Analyzing immune cell communities on a massive scale with single-cell RNA-Seq Speaker: Cole Trapnell, Assistant Professor, University of Washington Thursday April 21, 2016 11AM PDT, 2PM EDT Register for the webcast and live Q&A session Sponsored by: 10x Genomics
RESEARCH HIGHLIGHTS Top T cell responses: Autophagy maintains metabolic order p203 | doi:10.1038/nri.2016.37 Autophagy regulates survival and lineage stability in peripheral regulatory T cells. PDF Regulatory T cells: Ageing muscles lose T Reg-eneration p204 | doi:10.1038/nri.2016.30 Ageing muscles fail to accumulate regeneration-promoting regulatory T cells after injury. PDF Autoimmunity: Nanoparticles engineered for antigen-specific immunotherapy p204 | doi:10.1038/nri.2016.39 PDF Neuroimmunology: IL-17A mediates a path to autism p205 | doi:10.1038/nri.2016.35 Maternal immune activation can lead to autism-like behaviour in offspring, and in mice this depends on maternal interleukin-17A production. PDF JOURNAL CLUB A metabolic bridge between microbiota and humans p206 | doi:10.1038/nri.2016.18 Kiyoshi Takeda describes a 2009 paper by Maslowski et al. that provides the first evidence of a link between microbiota-derived metabolites and human health. PDF Inflammasome: Anti-inflammatory effect of mitophagy p206 | doi:10.1038/nri.2016.33 Nuclear factor-kB signalling induces p62-dependent autophagy of damaged mitochondria to limit NLRP3 inflammasome activation. PDF Immunology JOBS of the week Postdoctoral Fellow - Cancer Biology / Immunology Baylor College of Medicine (BCM) Post Doctoral Scholar in Immunology: Mechanisms of Tolerance Induction Boston Children's Hospital; Harvard Medical School Post-doctoral fellow in Immunology at MGH and Harvard Medical School Ragon Institute of MGH, MIT and Harvard MicroSurgeon Position in Transplant Immunology Cleveland Clinic Faculty Positions for Physician-Scientists in Immuno-Oncology Memorial Sloan-Kettering (MSK) More Science jobs from Immunology EVENT AAI Advanced Course in Immunology 31.07.16 Boston, USA More science events from
REVIEWS		Top
Immune responses to endogenous retroelements: taking the bad with the good George Kassiotis & Jonathan P. Stoye p207 | doi:10.1038/nri.2016.27 A substantial proportion of our genome is composed of endogenous retroelements of viral origin. Such elements can retain viral characteristics and drive activation of the immune system; this can contribute to both undesirable outcomes, such as autoimmune disease, as well as beneficial responses, such as increased immune reactivity to tumours. In this Review, the authors describe the pros and the cons of these 'enemies within'. Abstract | Full Text | PDF
T cell receptor signalling in the control of regulatory T cell differentiation and function Ming O. Li & Alexander Y. Rudensky p220 | doi:10.1038/nri.2016.26 In this Review, the authors discuss the emerging role of T cell receptor (TCR) specificity and signalling in the differentiation, maintenance and function of regulatory T (TReg) cells. Understanding how TCR signalling regulates TReg cells has important therapeutic implications in the regulation of immune tolerance and inflammation. Abstract | Full Text | PDF
Human RAG mutations: biochemistry and clinical implications Luigi D. Notarangelo, Min-Sung Kim, Jolan E. Walter & Yu Nee Lee p234 | doi:10.1038/nri.2016.28 The wide diversity of clinical and immunological phenotypes of patients with RAG deficiency, combined with structural characterization of the RAG protein complex, have provided new mechanistic insights into RAG protein function. Abstract | Full Text | PDF | Supplementary information
AIRE expands: new roles in immune tolerance and beyond Mark S. Anderson & Maureen A. Su p247 | doi:10.1038/nri.2016.9 Autoimmune regulator (AIRE) is best known for its role in immune tolerance. In this Review, the authors summarize the recent advances in our understanding of the diverse functions of AIRE, including its role in selection of regulatory T cells and modulation of non-autoimmune diseases. Abstract | Full Text | PDF
Paediatric HIV infection: the potential for cure Philip J. Goulder, Sharon R. Lewin & Ellen M. Leitman p259 | doi:10.1038/nri.2016.19 Anecdotal reports of HIV-infected children who have continued to control viral replication after discontinuing antiretroviral therapy have led to the hope that unique factors associated with paediatric infection might offer greater potential for HIV cure in children than in adults. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Maintenance of memory T cells in the bone marrow: survival or homeostatic proliferation? Francesca Di Rosa p271 | doi:10.1038/nri.2016.31 Full Text | PDF
The lifestyle of memory CD8+ T cells Özen Sercan Alp & Andreas Radbruch p271 | doi:10.1038/nri.2016.32 Full Text | PDF
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