Nature Reviews Molecular Cell Biology contents January 2016 Volume 17 Number 4 pp 201-262

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This special Focus highlights the unprecedented insights gained into the regulatory mechanisms underlying nuclear reprogramming, pluripotency and cell identity, and looks at the progress and challenges in using embryonic stem (ES) cells and iPSCs for therapeutic applications. Available free online.  Produced with support from: Thermo Fisher Scientific
TABLE OF CONTENTS
April 2016 Volume 17 Number 4
Impact Factor 37.806 *	In this issue Research Highlights Progress Reviews Perspectives Also this month  Featured article: Mitonuclear communication in homeostasis and stress Pedro M. Quirós, Adrienne Mottis & Johan Auwerx
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RESEARCH HIGHLIGHTS Top RNA: Expanding the mRNA epitranscriptome p201 | doi:10.1038/nrm.2016.35 Two new studies report the identification and comprehensive analysis of the m1A mRNA modification, showing that this mark is enriched at the 5' UTRs of mRNAs and might have a functional role in promoting translation of methylated transcripts. PDF Cancer biology: TGFβ and EMT as double agents p202 | doi:10.1038/nrm.2016.26 TGFβ signalling induces EMT and elicits apoptosis by switching SOX4 from acting as a tumour promoter to a tumour suppressor. PDF Gene expression: Buffering newly replicated DNA p202 | doi:10.1038/nrm.2016.34 Acetylation of H3K56 suppresses the transcription of newly replicated DNA during S phase to buffer changes in gene expression. PDF JOURNAL CLUB Eukaryotic antisense ahead of its time p204 | doi:10.1038/nrm.2016.1 Lynne Maquat reminds us that almost 20 years before the discovery of microRNAs, an antisense regulatory RNA was identified in embryonic chick muscle cells. PDF Metabolism: Restoring brown fat commitment p204 | doi:10.1038/nrm.2016.28 The role of DICER1-miR-328-BACE1 signalling in brown adipose tissue differentiation and function. PDF IN BRIEF Cell adhesion: Autophagy consumes integrin junctions | Mechanisms of disease: Benefits of oxygen limitation | Non-coding RNA: 7SK dampens transcription at super-enhancers PDF Molecular Cell Biology JOBS of the week Epigenetic Regulation Of Cell Fate, Cancer And Metabolism University Medical Center Freiburg Post-doctoral Fellowship in Diabetes Boston Children's Hospital and Harvard Medical School More Science jobs from   PROGRESS Top The biogenesis and emerging roles of circular RNAs Ling-Ling Chen p205 | doi:10.1038/nrm.2015.32 Circular RNAs (circRNAs) are produced from precursor RNA back-splicing. Recent findings reveal the complexity of the biogenesis of circRNAs and their cell type-specific expression. They also show that circRNAs can shape eukaryotic transcriptomes by sequestering microRNAs and by regulating transcription and interfering with splicing. Abstract | Full Text | PDF   REVIEWS Top Mitonuclear communication in homeostasis and stress Pedro M. Quirós, Adrienne Mottis & Johan Auwerx p213 | doi:10.1038/nrm.2016.23 As most mitochondrial proteins are encoded in the nucleus, mitochondrial activity requires efficient communication between the nuclear and mitochondrial genomes. This is mediated by nucleus-to-mitochondria (anterograde), mitochondria-to-nucleus (retrograde) and mitonuclear feedback signalling, as well as the integrated stress response and extracellular communication, which regulate homeostasis and, consequently, healthspan and lifespan. Abstract | Full Text | PDF The regulation and functions of the nuclear RNA exosome complex Cornelia Kilchert, Sina Wittmann & Lidia Vasiljeva p227 | doi:10.1038/nrm.2015.15 The versatile RNA-degradation functions of the RNA exosome complex make it crucial for RNA biogenesis. It is now emerging that the nuclear exosome is a specific regulator of gene expression in different physiological processes, and that it has a role in transcription regulation and in maintaining genome stability. Abstract | Full Text | PDF Mechanisms of ephrin-Eph signalling in development, physiology and disease Artur Kania & Rüdiger Klein p240 | doi:10.1038/nrm.2015.16 Ephrin ligands and Eph receptor Tyr kinases are transmembrane proteins that elicit short-distance cell-cell signalling when they interact. As both Eph kinases and ephrins exist in various isoforms and function as receptors or ligands, this signalling evokes versatile responses, which regulate a plethora of morphogenetic and homeostatic processes. Abstract | Full Text | PDF Advertisement Read the latest key research on aging and age-related diseases from npj Aging and Mechanisms of Disease, a new open access journal published in partnership with the Japanese Society of Anti-Aging Medicine (JAAM). Yeast longevity: Living longer with heavy isotopes   Heterochronic microRNAs in temporal specification of neural stem cells: application toward rejuvenation   PERSPECTIVES Top OPINION Do short, frequent DNA sequence motifs mould the epigenome? Timo Quante & Adrian Bird p257 | doi:10.1038/nrm.2015.31 Quante and Bird propose that the epigenome is modulated by the recruitment of cell type-specific DNA-binding proteins to short, abundant sequence motifs. The regulation of gene expression may thus be simplified by tuning gene expression in multigene blocks. Abstract | Full Text | PDF Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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