Nature Reviews Neurology - Table of Contents alert Volume 12 Issue 4

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TABLE OF CONTENTS
April 2016 Volume 12 Number 4
Impact Factor 15.358 *	In this issue Research Highlights News and Views Reviews Also this month Article series: Rare diseases Article series: Infections of the CNS  Featured article: HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment Deanna Saylor, Alex M. Dickens, Ned Sacktor, Norman Haughey, Barbara Slusher, Mikhail Pletnikov, Joseph L. Mankowski, Amanda Brown, David J. Volsky & Justin C. McArthur
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RESEARCH HIGHLIGHTS Top CNS infections: Zika virus infection could trigger Guillain-Barré syndrome Published online: 18 March 2016 p187 | doi:10.1038/nrneurol.2016.30 PDF Dementia: Cerebellar atrophy has disease-specific patterns Published online: 11 March 2016 p188 | doi:10.1038/nrneurol.2016.28 PDF Motor neuron disease: Loss of MHCI exposes motor neurons to astrocyte-mediated toxicity Published online: 18 March 2016 p188 | doi:10.1038/nrneurol.2016.34 PDF Alzheimer disease: Meta-analysis finds high reversion rate from MCI to normal cognition Published online: 11 March 2016 p189 | doi:10.1038/nrneurol.2016.29 PDF Trial Watch: Glioblastoma vaccine therapy disappointment in Phase III trial Published online: 29 March 2016 p190 | doi:10.1038/nrneurol.2016.38 PDF Alzheimer disease: Antibody-secreting implant reduces AD pathology in mice Published online: 29 March 2016 p190 | doi:10.1038/nrneurol.2016.39 PDF IN BRIEF Epilepsy: Metabolic syndrome in young adults with epilepsy | Demyelinating disease: Novel markers for disease severity in neuromyelitis optica | Neuro-oncology: Long-term outcomes in childhood low-grade glioma | Multiple sclerosis: Does low vitamin D level during pregnancy increase the risk of MS? PDF Nature Reviews Neurology EVENT World Congress On Neurology And Brain Disorders - 2016 22.08.16 London, UK
NEWS AND VIEWS		Top
Multiple sclerosis: Repurposing dopaminergic drugs for MS — the evidence mounts Franca Marino & Marco Cosentino Published online: 29 March 2016 p191 | doi:10.1038/nrneurol.2016.33 A new study has shown that both in patients with multiple sclerosis (MS) and in healthy controls, dopamine inhibits production of IL-17 and IFN-γ by peripheral blood mononuclear cells. The finding adds to previous evidence for the potential benefit of dopaminergic drugs in MS. Full Text | PDF
Intracerebral haemorrhage: Prognostic scales versus clinical judgment in ICH Daniel F. Hanley, Jr Published online: 12 February 2016 p192 | doi:10.1038/nrneurol.2016.11 Prognostic scoring systems are widely used as objective outcome predictors in neurocritical care, for example, after haemorrhagic stroke. A new study, however, has unexpectedly shown that clinicians can predict outcome after intracerebral haemorrhage more accurately than do formal scoring scales. Full Text | PDF
REVIEWS		Top
Article series: Rare diseases Rare neurological channelopathies — networks to study patients, pathogenesis and treatment Joanna C. Jen, Tetsuo Ashizawa, Robert C. Griggs & Michael F. Waters Published online: 04 March 2016 p195 | doi:10.1038/nrneurol.2016.18 Rare neurological diseases require widely distributed networks of centres, investigators and patients to foster multidisciplinary investigations and recruit sufficient numbers of patients for research studies and clinical trials. In this article, Jen and colleagues highlight the role of two networks, the Consortium for Clinical Investigations of Neurological Channelopathies (CINCH) and the Clinical Research Consortium for Studies of Cerebellar Ataxias (CRC-SCA), in bringing together the various stakeholders in patient-oriented research into rare neurological channelopathies. Abstract | Full Text | PDF
Seizures and gliomas — towards a single therapeutic approach Gilles Huberfeld & Charles J. Vecht Published online: 11 March 2016 p204 | doi:10.1038/nrneurol.2016.26 Epilepsy develops in many patients with glioma, and the two presentations are currently treated with independent therapies. In this Review, Huberfeld and Vecht provide an overview of the evidence that epilepsy and gliomas share pathogenic mechanisms that could be targeted to simultaneously manage seizures and target tumours. They consider the benefits and risks of using antiepileptic drugs to treat gliomas, and antitumour drugs to control epilepsy. Abstract | Full Text | PDF
Disease-modifying therapies and infectious risks in multiple sclerosis Alexander Winkelmann, Micha Loebermann, Emil C. Reisinger, Hans-Peter Hartung & Uwe K. Zettl Published online: 04 March 2016 p217 | doi:10.1038/nrneurol.2016.21 The range of immunomodulatory therapies to treat multiple sclerosis (MS) has widened markedly in recent years, and MS treatments have become more efficient. This improvement in efficacy has been accompanied by an increased risk of treatment-associated infections. In this Review, Winkelman et al. discuss the modes of action of the currently available MS therapies and detail the specific infections associated with each treatment. They consider how this information can influence the daily clinical use of MS therapies, so as to minimize the associated infectious risk. Abstract | Full Text | PDF
Article series: Infections of the CNS HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment Deanna Saylor, Alex M. Dickens, Ned Sacktor, Norman Haughey, Barbara Slusher, Mikhail Pletnikov, Joseph L. Mankowski, Amanda Brown, David J. Volsky & Justin C. McArthur Published online: 11 March 2016 p234 | doi:10.1038/nrneurol.2016.27 Despite highly effective combination antiretroviral therapies, the prevalence of HIV-associated neurocognitive disorder (HAND) has not reduced. To date, clinical trials of HAND therapies have been unsuccessful, calling for better understanding of HAND pathogenesis to develop more-effective treatment strategies. In this Review, Justin McArthur and colleagues discuss recent proceedings in understanding the immunopathogenesis of HAND, drawing from human studies and animal models. Abstract | Full Text | PDF
Erratum: Clearance systems in the brain—implications for Alzheimer diseaser Jenna M. Tarasoff-Conway, Roxana O. Carare, Ricardo S. Osorio, Lidia Glodzik, Tracy Butler, Els Fieremans, Leon Axel, Henry Rusinek, Charles Nicholson, Berislav V. Zlokovic, Blas Frangione, Kaj Blennow, Joël Ménard, Henrik Zetterberg, Thomas Wisniewski and Mony J. de Leon Published online: 29 March 2016 p248 | doi:10.1038/nrneurol.2016.36 Full Text | PDF
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*Journal Citation Reports, Thomson, 2015. Nature Reviews Neurology was previously published as Nature Clinical Practice Neurology.

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