Nature Communications - 29 June 2016

Weekly Content Alert Nature Communications is now fully open access. Read more. 29 June 2016  Featured image: Gissibl et al. demonstrate the capability of femtosecond three-dimensional printing in fabricating optical components with sub-micrometre accuracy. Latest content: Articles Corrigenda Journal homepage Recommend to library Web feed   Advertisement Nature Publishing Group offers a free open access funding support service to enable authors to discover and apply for article processing charge funding available to them. Visit our website for further advice on the funding options available, and guidance in approaching funders and institutions, or email openaccess@nature.com for more information.         Nature Communications - now fully open access All new submissions, if accepted, will be published open access and an article processing charge (APC) will apply. For more information visit the website. Visit our open access funding page or contact openaccess@nature.com to learn more about APC funding.       Latest Articles View all Articles     Social inheritance can explain the structure of animal social networks OPEN Amiyaal Ilany and Erol Akçay Social networks have important implications to a variety of ecological and evolutionary processes. Here, Ilany and Akçay develop a social network model and show that inheritance of social contacts leads to networks with properties observed in species such as sleepy lizards and spotted hyenas. 28 June 2016 | doi: 10.1038/ncomms12084 Biological Sciences  Ecology  Evolution  A rhesus macaque model of Asian-lineage Zika virus infection OPEN Dawn M. Dudley, Matthew T. Aliota, Emma L. Mohr, Andrea M. Weiler, Gabrielle Lehrer-Brey, Kim L. Weisgrau, Mariel S. Mohns, Meghan E. Breitbach, Mustafa N. Rasheed, Christina M. Newman, Dane D. Gellerup, Louise H. Moncla, Jennifer Post, Nancy Schultz-Darken, Michele L. Schotzko, Jennifer M. Hayes, Josh A. Eudailey, M. Anthony Moody, Sallie R. Permar, Shelby L. O’Connor et al. Animal models of infection with Zika virus (ZIKV) are urgently needed for a better understanding of pathogenesis and for testing potential therapies. Here, the authors describe infection of rhesus macaques with an Asian-lineage ZIKV strain as a relevant animal model for studying ZIKV pathogenesis. 28 June 2016 | doi: 10.1038/ncomms12204 Biological Sciences  Immunology  Microbiology  Virology  Mummified precocial bird wings in mid-Cretaceous Burmese amber OPEN Lida Xing, Ryan C. McKellar, Min Wang, Ming Bai, Jingmai K. O’Connor, Michael J. Benton, Jianping Zhang, Yan Wang, Kuowei Tseng, Martin G. Lockley, Gang Li, Weiwei Zhang and Xing Xu The plumage of Cretaceous birds has previously been described only from compression fossils and isolated feathers in amber. Here, Xing et al. describe two 99 million year old bird wings found preserved in amber, enabling new insight into the evolution of feather arrangement, pigmentation, and structure. 28 June 2016 | doi: 10.1038/ncomms12089 Biological Sciences  Evolution  Palaeontology  A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries OPEN Aman P. Mann, Pablo Scodeller, Sazid Hussain, Jinmyoung Joo, Ester Kwon, Gary B. Braun, Tarmo Mölder, Zhi-Gang She, Venkata Ramana Kotamraju, Barbara Ranscht, Stan Krajewski, Tambet Teesalu, Sangeeta Bhatia, Michael J. Sailor and Erkki Ruoslahti Accurate treatment of traumatic brain injuries, a leading cause of neurological disability and death in young people, is hampered by poor accumulation of drugs in the brain. Here, the authors describe a tetrapeptide that can efficiently target brain injuries and deliver therapeutic or diagnostic payload. 28 June 2016 | doi: 10.1038/ncomms11980 Biological Sciences  Medical research  Nanotechnology  Neuroscience  Alterations of the human gut microbiome in multiple sclerosis OPEN Sushrut Jangi, Roopali Gandhi, Laura M. Cox, Ning Li, Felipe von Glehn, Raymond Yan, Bonny Patel, Maria Antonietta Mazzola, Shirong Liu, Bonnie L. Glanz, Sandra Cook, Stephanie Tankou, Fiona Stuart, Kirsy Melo, Parham Nejad, Kathleen Smith, Begüm D. Topçuolu, James Holden, Pia Kivisäkk, Tanuja Chitnis et al. The gut microbiome has been implicated in several autoimmune disorders. Here, the authors study the gut microbiome of patients with multiple sclerosis, and find correlations between altered abundance of certain gut microorganisms and changes in expression of immune defence genes. 28 June 2016 | doi: 10.1038/ncomms12015 Biological Sciences  Immunology  Medical research  Microbiology  miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy OPEN Shawn S. Badal, Yin Wang, Jianyin Long, David L. Corcoran, Benny H. Chang, Luan D. Truong, Yashpal S. Kanwar, Paul A. Overbeek and Farhad R. Danesh Podocyte injury is central to kidney dysfunction in diabetic nephropathy. Here the authors show that Msk2 is a target of miR-93 and this interaction mediates pathogenic chromatin remodelling in diabetic nephropathy. 28 June 2016 | doi: 10.1038/ncomms12076 Biological Sciences  Medical research  Sub-kBT micro-electromechanical irreversible logic gate OPEN M. López-Suárez, I. Neri and L. Gammaitoni In computers, computation is performed by assemblies of logic gates, most of which are logically irreversible. Here, the authors explore the connection between logical and physical irreversibility through an OR gate made by a micro-electromechanical cantilever that can be operated with extremely little energy. 28 June 2016 | doi: 10.1038/ncomms12068 Physical Sciences  Applied physics  Comprehensive identification of internal structure and alternative splicing events in circular RNAs OPEN Yuan Gao, Jinfeng Wang, Yi Zheng, Jinyang Zhang, Shuai Chen and Fangqing Zhao Circular RNAs are increasingly understood to have important biological roles and have several subclasses. Here, the authors develop CIRI-AS to analyse sequencing data, identifying the prevalence of alternative splicing and circular RNA isoforms. 28 June 2016 | doi: 10.1038/ncomms12060 Biological Sciences  Bioinformatics  Molecular biology  Industrial-scale separation of high-purity single-chirality single-wall carbon nanotubes for biological imaging OPEN Yohei Yomogida, Takeshi Tanaka, Minfang Zhang, Masako Yudasaka, Xiaojun Wei and Hiromichi Kataura Single-chirality, single-wall carbon nanotubes are attractive for bioimaging applications, however large-scale separation remains a challenge. Here, the authors utilize mixed surfactants for high-resolution single-chirality separation of (9,4) SWCNTs, demonstrating their improved performance for bioimaging. 28 June 2016 | doi: 10.1038/ncomms12056 Chemical Sciences  Materials science  Nanotechnology  Optical physics  Structural lubricity under ambient conditions OPEN Ebru Cihan, Semran İpek, Engin Durgun and Mehmet Z. Baykara Structural lubricity—referring to ultralow levels of friction between atomically flat, incommensurate surfaces—has previously been observed under ultrahigh vacuum. Here, the authors report structural lubricity at gold-graphite interfaces under ambient conditions and on mesoscopic scales. 28 June 2016 | doi: 10.1038/ncomms12055 Chemical Sciences  Applied physics  Materials science  Nanotechnology  Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles OPEN Linling He, Natalia de Val, Charles D. Morris, Nemil Vora, Therese C. Thinnes, Leopold Kong, Parisa Azadnia, Devin Sok, Bin Zhou, Dennis R. Burton, Ian A Wilson, David Nemazee, Andrew B. Ward and Jiang Zhu The development of native-like envelope trimers has been a major focus in the efforts to produce HIV vaccines. Here the authors demonstrate the production and characterization of virus-like nanoparticles displaying trimeric HIV-1 antigens with the potential to elicit broadly neutralizing antibodies. 28 June 2016 | doi: 10.1038/ncomms12041 Biological Sciences  Bioengineering  Medical research  Virology  Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability OPEN Leopold Kong, Linling He, Natalia de Val, Nemil Vora, Charles D. Morris, Parisa Azadnia, Devin Sok, Bin Zhou, Dennis R. Burton, Andrew B. Ward, Ian A. Wilson and Jiang Zhu A major goal of HIV-1 vaccine development is to produce antigens that can induce broadly neutralizing antibodies. Here the authors examine the underlying causes of HIV-1 envelope metastability and design uncleaved, prefusion-optimized gp140 trimers with potential for use as HIV-1 vaccine antigens. 28 June 2016 | doi: 10.1038/ncomms12040 Biological Sciences  Biophysics  Virology  Memory of cell shape biases stochastic fate decision-making despite mitotic rounding OPEN Takashi Akanuma, Cong Chen, Tetsuo Sato, Roeland M. H. Merks and Thomas N. Sato Cell shape influences function but during mitotic cell rounding the original shape is lost. Here the authors show that the cellular eccentricity of progenitor cell biases stochastic fate-decisions using a combination of quantitative live imaging, genetic manipulations and computational simulations. 28 June 2016 | doi: 10.1038/ncomms11963 Biological Sciences  Cell biology  Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury OPEN Jiyun Peng, Nan Gu, Lijun Zhou, Ukpong B Eyo, Madhuvika Murugan, Wen-Biao Gan and Long-Jun Wu Microglia and monocytes contribute to neuropathic pain states, but the precise role of the two cell types is not clear. Here Peng et al. use temporally controlled ablation of monocytes and microglia in mice to show that these cells work together to initiate neuropathic-pain like behaviour, but are less important in the maintenance phase. 28 June 2016 | doi: 10.1038/ncomms12029 Biological Sciences  Neuroscience  Enhancing digestibility and ethanol yield of Populus wood via expression of an engineered monolignol 4-O-methyltransferase OPEN Yuanheng Cai, Kewei Zhang, Hoon Kim, Guichuan Hou, Xuebin Zhang, Huijun Yang, Huan Feng, Lisa Miller, John Ralph and Chang-Jun Liu The efficiency of cellulosic biofuel production from woody biomass is limited by the presence of lignin that impedes efficient processing. Here the authors show that transgenic modification of aspen to depress lignin polymerization can increase ethanol yield without affecting tree growth. 28 June 2016 | doi: 10.1038/ncomms11989 Biological Sciences  Biotechnology  Plant sciences  Mapping polaronic states and lithiation gradients in individual V2O5 nanowires OPEN Luis R. De Jesus, Gregory A. Horrocks, Yufeng Liang, Abhishek Parija, Cherno Jaye, Linda Wangoh, Jian Wang, Daniel A. Fischer, Louis F. J. Piper, David Prendergast and Sarbajit Banerjee Rapid insertion and extraction of lithium ions from a cathode material is imperative for lithium-ion battery function. Here, the authors present evidence of inhomogeneities in charge localization, local structural distortions and polaron formation induced upon lithiation using scanning transmission X-ray microscopy. 28 June 2016 | doi: 10.1038/ncomms12022 Physical Sciences  Applied physics  Materials science  Sudden restoration of the band ordering associated with the ferromagnetic phase transition in a semiconductor OPEN Iriya Muneta, Shinobu Ohya, Hiroshi Terada and Masaaki Tanaka As semiconductors are doped with impurities, their useful electrical transport properties are degraded as their band structures are increasingly modified. Here, the authors demonstrate that the band ordering is restored in Mn-doped GaAs above a ferromagnetic transition at a critical concentration. 28 June 2016 | doi: 10.1038/ncomms12013 Physical Sciences  Condensed matter  Materials science  Targeted proteomics identifies liquid-biopsy signatures for extracapsular prostate cancer OPEN Yunee Kim, Jouhyun Jeon, Salvador Mejia, Cindy Q Yao, Vladimir Ignatchenko, Julius O Nyalwidhe, Anthony O Gramolini, Raymond S Lance, Dean A Troyer, Richard R Drake, Paul C Boutros, O. John Semmes and Thomas Kislinger Proteomic technologies are capable of identifying thousands of proteins in biological samples, but biomarker applications are lagging. Here the authors use Multiple Reaction Monitoring Mass Spectrometry to delineate peptide signatures that accurately distinguish between defined prostate cancer patient risk groups. 28 June 2016 | doi: 10.1038/ncomms11906 Biological Sciences  Cancer  Medical research  Systems biology  Information recovery from low coverage whole-genome bisulfite sequencing OPEN Emanuele Libertini, Simon C. Heath, Rifat A. Hamoudi, Marta Gut, Michael J. Ziller, Agata Czyz, Victor Ruotti, Hendrik G. Stunnenberg, Mattia Frontini, Willem H. Ouwehand, Alexander Meissner, Ivo G. Gut and Stephan Beck Here, Libertini and colleagues devise a computation tool that can analyze whole-genome bisulfite sequencing (WGBS) data to recover of ∼30% of the lost differential methylation position information. They use COMETgazer and COMETvintage to analyze 13 diffferent methylome data to demonstrate their performance. 27 June 2016 | doi: 10.1038/ncomms11306 Biological Sciences  Bioinformatics  Genetics  Pharmacological chaperone reshapes the energy landscape for folding and aggregation of the prion protein OPEN Amar Nath Gupta, Krishna Neupane, Negar Rezajooei, Leonardo M. Cortez, Valerie L. Sim and Michael T. Woodside Small-molecule chaperones that can prevent protein misfolding have potential applications for treating diseases such as Alzheimer’s and ALS. Here the authors use high-resolution force spectroscopy to gain insight into the mechanism of action of an iron-tetrapyrrole with anti-prion properties. 27 June 2016 | doi: 10.1038/ncomms12058 Biological Sciences  Biophysics  Skin-inspired hydrogel–elastomer hybrids with robust interfaces and functional microstructures OPEN Hyunwoo Yuk, Teng Zhang, German Alberto Parada, Xinyue Liu and Xuanhe Zhao Soft hybrids that integrate hydrogels and elastomers can be used in applications, such as stretchable electronics and soft robotics, but usually have shortcomings. Here, Zhao and co-workers show a simple method of assembling hydrogel/elastomer hybrids with robust interfaces and functional microstructures. 27 June 2016 | doi: 10.1038/ncomms12028 Physical Sciences  Bioengineering  Materials science  A global reanalysis of storm surges and extreme sea levels OPEN Sanne Muis, Martin Verlaan, Hessel C. Winsemius, Jeroen C. J. H. Aerts and Philip J. Ward Protection of coastlines from devastating flooding associated with sea-level extremes is impeded by a lack of continuous records. Here, the authors apply a hydrodynamic modelling approach and present the first reanalysis of tides, surges and extreme sea levels for the entire world's coastline. 27 June 2016 | doi: 10.1038/ncomms11969 Earth Sciences  Climate science  Oceanography  Characterization of the targeting signal in mitochondrial β-barrel proteins OPEN Tobias Jores, Anna Klinger, Lucia E. Groß, Shin Kawano, Nadine Flinner, Elke Duchardt-Ferner, Jens Wöhnert, Hubert Kalbacher, Toshiya Endo, Enrico Schleiff and Doron Rapaport Mitochondrial β-barrel proteins are synthesized in the cytosol before being targeted to the organelle. Here, Jores et al. show that a specialized hydrophobic β-hairpin motif is the previously undefined targeting sequence and is recognized by the mitochondrial outer membrane translocase. 27 June 2016 | doi: 10.1038/ncomms12036 Biological Sciences  Biochemistry  Cell biology  Chromatin accessibility maps of chronic lymphocytic leukaemia identify subtype-specific epigenome signatures and transcription regulatory networks OPEN André F. Rendeiro, Christian Schmidl, Jonathan C. Strefford, Renata Walewska, Zadie Davis, Matthias Farlik, David Oscier and Christoph Bock Chronic lymphocytic leukemia (CLL) is characterized by substantial clinical heterogeneity. Here, the authors report the genome-wide chromatin accessibility maps for 88 CLL samples from 55 patients using ATAC-seq, and 10 matched RNA-seq datasets, providing a resource for studying epigenome deregulation in CLL. 27 June 2016 | doi: 10.1038/ncomms11938 Biological Sciences  Cancer  Molecular biology  Radiocarbon evidence for enhanced respired carbon storage in the Atlantic at the Last Glacial Maximum OPEN E. Freeman, L. C. Skinner, C. Waelbroeck and D. Hodell The Atlantic Ocean overturning circulation and its impact on respired carbon storage during glacial periods remains a mystery. Here, the authors combine radiocarbon and stable carbon isotope data from the Brazil and Iberian Margins to investigate ocean circulation and carbon storage at the Last Glacial Maximum. 27 June 2016 | doi: 10.1038/ncomms11998 Earth Sciences  Climate science  Oceanography  p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming OPEN Tetsuya Saito, Yoshinobu Ichimura, Keiko Taguchi, Takafumi Suzuki, Tsunehiro Mizushima, Kenji Takagi, Yuki Hirose, Masayuki Nagahashi, Tetsuro Iso, Toshiaki Fukutomi, Maki Ohishi, Keiko Endo, Takefumi Uemura, Yasumasa Nishito, Shujiro Okuda, Miki Obata, Tsuguka Kouno, Riyo Imamura, Yukio Tada, Rika Obata et al. Dysregulation of p62 has been implicated in tumorigenesis. Here, the authors show that p62 promotes hepatocellular carcinoma by reprogramming glucose and glutamine metabolism through Nrf2 and present a novel compound that can inhibit p62 action thus sensitizing cancer cells to chemotherapy. 27 June 2016 | doi: 10.1038/ncomms12030 Biological Sciences  Biochemistry  Cancer  Cell biology  PACAP suppresses dry eye signs by stimulating tear secretion OPEN Tomoya Nakamachi, Hirokazu Ohtaki, Tamotsu Seki, Sachiko Yofu, Nobuyuki Kagami, Hitoshi Hashimoto, Norihito Shintani, Akemichi Baba, Laszlo Mark, Ingela Lanekoff, Peter Kiss, Jozsef Farkas, Dora Reglodi and Seiji Shioda Dry eye disease is a complex condition with limited treatments. Here the authors show that mice lacking a multi-functional peptide PACAP develop dry eye-like signs that can be topically treated with PACAP peptide that stimulates tearing in mice, suggesting a possible therapy in humans with dry eyes. 27 June 2016 | doi: 10.1038/ncomms12034 Biological Sciences  Medical research  Dual nature of magnetic dopants and competing trends in topological insulators OPEN Paolo Sessi, Rudro R. Biswas, Thomas Bathon, Oliver Storz, Stefan Wilfert, Alessandro Barla, Konstantin A. Kokh, Oleg E. Tereshchenko, Kai Fauth, Matthias Bode and Alexander V. Balatsky Magnetic impurities break time reversal symmetry in topological insulators, but there has been disagreement between theory and experiment. Here, the authors study the response of topological states to magnetic dopants at the atomic level and show that, contrary to what generally believed, magnetic order and gapless states can coexist. 27 June 2016 | doi: 10.1038/ncomms12027 Physical Sciences  Condensed matter  Materials science  Stimulus-responsive light-harvesting complexes based on the pillararene-induced co-assembly of β-carotene and chlorophyll OPEN Yan Sun, Fang Guo, Tongfei Zuo, Jingjing Hua and Guowang Diao Carotenoids are photoactive organic pigments found in many plants. Here, the authors report the self-assembly of carotenoid suprastructures by forming a pillararene host-guest complex, and show that these structures display functionalities including stimuli responsiveness and photocatalytic activity. 27 June 2016 | doi: 10.1038/ncomms12042 Chemical Sciences  Catalysis  Materials science  Nanotechnology  Structure–function analysis of the extracellular domain of the pneumococcal cell division site positioning protein MapZ OPEN Sylvie Manuse, Nicolas L. Jean, Mégane Guinot, Jean-Pierre Lavergne, Cédric Laguri, Catherine M. Bougault, Michael S. VanNieuwenhze, Christophe Grangeasse and Jean-Pierre Simorre Placement of the bacterial division site is crucial for the creation of identical daughter cells. Here, the authors solve the structure of the MapZ protein, which helps to position the cell division protein FtsZ at the cell centre, and further analyse the function of the protein in vivo. 27 June 2016 | doi: 10.1038/ncomms12071 Biological Sciences  Biochemistry  Biophysics  Molecular biology  Observation of a topologically non-trivial surface state in half-Heusler PtLuSb (001) thin films OPEN J. A. Logan, S. J. Patel, S. D. Harrington, C. M. Polley, B. D. Schultz, T. Balasubramanian, A. Janotti, A. Mikkelsen and C. J. Palmstrøm Half-Heusler compounds are predicted to bear topological properties, which is yet to be experimentally evidenced. Here, Logan et al. report experimental evidence of a topological surface state in epitaxially grown thin films of the half-Heusler compound PtLuSb, providing a candidate for new spintronic devices. 27 June 2016 | doi: 10.1038/ncomms11993 Physical Sciences  Condensed matter  Mechanisms of increased Trichodesmium fitness under iron and phosphorus co-limitation in the present and future ocean OPEN Nathan G. Walworth, Fei-Xue Fu, Eric A. Webb, Mak A. Saito, Dawn Moran, Matthew R. Mcllvin, Michael D. Lee and David A. Hutchins Cyanobacterial nitrogen fixation supplies bioavailable nitrogen to marine ecosystems, but the mechanisms governing iron and phosphorus co-limitation in elevated CO2 remain unknown. Here, the authors show a complex cellular response to co-limitation characterized by changes in growth, cell size, and the proteome. 27 June 2016 | doi: 10.1038/ncomms12081 Earth Sciences  Biogeochemistry  Ecology  Oceanography  Direct measurement of proximity-induced magnetism at the interface between a topological insulator and a ferromagnet OPEN Changmin Lee, Ferhat Katmis, Pablo Jarillo-Herrero, Jagadeesh S. Moodera and Nuh Gedik Emergent phenomena at the interface between a topological insulator and a ferromanget reflect broken symmetry of topological state. Here, Lee et al. report direct measurement of induced magnetism at the Bi2Se3-EnS interface, paving the way to understand emergent orders in topological material with broken time reversal symmetry. 27 June 2016 | doi: 10.1038/ncomms12014 Physical Sciences  Condensed matter  Materials science  Ecological responses to experimental glacier-runoff reduction in alpine rivers OPEN Sophie Cauvy-Fraunié, Patricio Andino, Rodrigo Espinosa, Roger Calvez, Dean Jacobsen and Olivier Dangles Glacier retreat due to climate change can affect the biodiversity and ecosystem function. Here, Cauvy-Fraunié and colleagues manipulated the flow of tropical glacier-fed stream in the Ecuadorian Andes, and show that benthic fauna community composition requires several months before it can recover to the pre-blockade conditions. 24 June 2016 | doi: 10.1038/ncomms12025 Biological Sciences  Climate science  Ecology  Sub-micrometre accurate free-form optics by three-dimensional printing on single-mode fibres OPEN Timo Gissibl, Simon Thiele, Alois Herkommer and Harald Giessen Combining freeform optics with micro- and nano-optics can permit wavefront shaping, phase engineering, k-space and polarization control. Here, Gissibl et al. use femtosecond 3D printing to manufacture free-form optical elements, giving sub-micrometre accuracy so that direct manufacturing on single-mode fibres is possible. 24 June 2016 | doi: 10.1038/ncomms11763 Physical Sciences  Applied physics  Optical physics  A key genetic factor for fucosyllactose utilization affects infant gut microbiota development OPEN Takahiro Matsuki, Kana Yahagi, Hiroshi Mori, Hoshitaka Matsumoto, Taeko Hara, Saya Tajima, Eishin Ogawa, Hiroko Kodama, Kazuya Yamamoto, Takuji Yamada, Satoshi Matsumoto and Ken Kurokawa The factors shaping the development of infants' gut microbiota are poorly understood. Here, the authors show that alterations in gut microbiota development in infants are associated with the presence of bifidobacteria having a gene for utilisation of human milk oligosaccharides. 24 June 2016 | doi: 10.1038/ncomms11939 Biological Sciences  Microbiology  Mapping RNA–RNA interactome and RNA structure in vivo by MARIO OPEN Tri C. Nguyen, Xiaoyi Cao, Pengfei Yu, Shu Xiao, Jia Lu, Fernando H. Biase, Bharat Sridhar, Norman Huang, Kang Zhang and Sheng Zhong Current methods for mapping RNA-RNA interactions have to rely on an ‘anchor’ protein or RNA. Here, the authors report the MARIO (Mapping RNA interactome in vivo) technology that can massively reveal RNA-RNA interactions and RNA structure from unperturbed cells. 24 June 2016 | doi: 10.1038/ncomms12023 Biological Sciences  Bioinformatics  Molecular biology  MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation OPEN Anton Shostak, Bianca Ruppert, Nati Ha, Philipp Bruns, Umut H. Toprak, ICGC MMML-Seq Project, Chris Lawerenz, Peter Lichter, Bernhard Radlwimmer, Jürgen Eils, Benedikt Brors, Sylwester Radomski, Ingrid Scholz, Gesine Richter, Reiner Siebert, Susanne Wagner, Andrea Haake, Julia Richter, Sietse Aukema, Ole Ammerpohl et al. The circadian clock and the cell cycle systems coordinate global physiology. Here the authors show that MYC represses the clock genes, together with MIZ1, and induces proliferation, suggesting that MYC inversely modulates cell cycle and circadian clock genes. 24 June 2016 | doi: 10.1038/ncomms11807 Biological Sciences  Cell biology  Unveiling the complexity of the maize transcriptome by single-molecule long-read sequencing OPEN Bo Wang, Elizabeth Tseng, Michael Regulski, Tyson A Clark, Ting Hon, Yinping Jiao, Zhenyuan Lu, Andrew Olson, Joshua C. Stein and Doreen Ware Zea mays is an important crop species and genetic model but uncertainties remain regarding the structure of the transcriptome. Here Wang et al. use single-molecule sequencing and size-fractionated libraries to identify novel transcripts and isoforms illustrating the complexity of maize mRNA. 24 June 2016 | doi: 10.1038/ncomms11708 Biological Sciences  Plant sciences  Glacial legacies on interglacial vegetation at the Pliocene-Pleistocene transition in NE Asia OPEN Ulrike Herzschuh, H. John B. Birks, Thomas Laepple, Andrei Andreev, Martin Melles and Julie Brigham-Grette Climate is broadly assumed to control vegetation, with vegetation lags thought to last no more than a few centuries. Here, based on the analysis of Lake El’gygytgyn pollen record, the authors show that vegetation-climate disequilibrium persisted for several millennia during the Plio-Pleistocene transition. 24 June 2016 | doi: 10.1038/ncomms11967 Earth Sciences  Climate science  Ecology  Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability OPEN Solene M. Evrard, Laura Lecce, Katherine C. Michelis, Aya Nomura-Kitabayashi, Gaurav Pandey, K-Raman Purushothaman, Valentina d’Escamard, Jennifer R. Li, Lahouaria Hadri, Kenji Fujitani, Pedro R. Moreno, Ludovic Benard, Pauline Rimmele, Ariella Cohain, Brigham Mecham, Gwendalyn J. Randolph, Elizabeth G. Nabel, Roger Hajjar, Valentin Fuster, Manfred Boehm et al. Endothelial to mesenchymal transition (EndMT) is a crucial developmental process that also plays a role in the pathogenesis of some diseases. Here the authors show that EndMT contributes to the development of atherosclerosis in mice and humans, and is associated with complex human plaques that may be prone to rupture. 24 June 2016 | doi: 10.1038/ncomms11853 Biological Sciences  Cell biology  Medical research  Multimetallic catalysed radical oxidative C(sp3)–H/C(sp)–H cross-coupling between unactivated alkanes and terminal alkynes OPEN Shan Tang, Pan Wang, Haoran Li and Aiwen Lei Cross coupling via the activation of two carbon-hydrogen bonds avoids the need for organometallic coupling partners and associated waste. Here, the authors report a radical process that allows selective coupling between alkynes and non-activated C(sp3)-H groups via a multimetallic catalytic system. 24 June 2016 | doi: 10.1038/ncomms11676 Chemical Sciences  Catalysis  Organic chemistry  Photon-efficient imaging with a single-photon camera OPEN Dongeek Shin, Feihu Xu, Dheera Venkatraman, Rudi Lussana, Federica Villa, Franco Zappa, Vivek K. Goyal, Franco N. C. Wong and Jeffrey H. Shapiro Active optical imaging systems use their own light sources to recover scene information but typically operate with large number of photon detections. Here, the authors present a 3D imaging system that acquires depth and reflectivity information with a single photon camera operating in low-light conditions. 24 June 2016 | doi: 10.1038/ncomms12046 Physical Sciences  Applied physics  Optical physics  A survey of the sorghum transcriptome using single-molecule long reads OPEN Salah E. Abdel-Ghany, Michael Hamilton, Jennifer L. Jacobi, Peter Ngam, Nicholas Devitt, Faye Schilkey, Asa Ben-Hur and Anireddy S. N. Reddy Alternative splicing and alternative polyadenylation (APA) contribute to mRNA diversity but are difficult to assess using short read RNA-seq data. Here, the authors use single molecule long-read isoform sequencing and develop a computational pipeline to identify full-length splice isoforms and APA sites in sorghum. 24 June 2016 | doi: 10.1038/ncomms11706 Biological Sciences  Plant sciences  Circadian regulation of human cortical excitability OPEN Julien Q. M. Ly, Giulia Gaggioni, Sarah L. Chellappa, Soterios Papachilleos, Alexandre Brzozowski, Chloé Borsu, Mario Rosanova, Simone Sarasso, Benita Middleton, André Luxen, Simon N. Archer, Christophe Phillips, Derk-Jan Dijk, Pierre Maquet, Marcello Massimini and Gilles Vandewalle Cognitive performance is impaired after prolonged wakefulness, yet the contribution of circadian rhythms for proper brain function remains unclear. Here the authors show that cortical excitability measured using TMS exhibits robust circadian dynamics which is correlated with cognitive performance. 24 June 2016 | doi: 10.1038/ncomms11828 Biological Sciences  Neuroscience  Gelation process visualized by aggregation-induced emission fluorogens OPEN Zhengke Wang, Jingyi Nie, Wei Qin, Qiaoling Hu and Ben Zhong Tang Chitosan hydrogel materials have unique properties, but understanding the gelation process these materials undergo has been problematic. Here, Wang and co-workers have visualised the entire gelation process of a chitosan LiOH-urea aqueous system by aggregation induced emission fluorescent imaging. 23 June 2016 | doi: 10.1038/ncomms12033 Physical Sciences  Analytical chemistry  Materials science  Alix-mediated assembly of the actomyosin–tight junction polarity complex preserves epithelial polarity and epithelial barrier OPEN Yvan Campos, Xiaohui Qiu, Elida Gomero, Randall Wakefield, Linda Horner, Wojciech Brutkowski, Young-Goo Han, David Solecki, Sharon Frase, Antonella Bongiovanni and Alessandra d’Azzo Correct assembly of intercellular junctions is required to maintain epithelial polarity and barrier function. Here Campos et al. show that the scaffold protein Alix interacts with F-actin, the Par complex and ZO-1 to ensure the formation and maintenance of the actomyosin tight junction complex in choroid plexus epithelium. 23 June 2016 | doi: 10.1038/ncomms11876 Biological Sciences  Cell biology  MAIT cells are activated during human viral infections OPEN Bonnie van Wilgenburg, Iris Scherwitzl, Edward C. Hutchinson, Tianqi Leng, Ayako Kurioka, Corinna Kulicke, Catherine de Lara, Suzanne Cole, Sirijitt Vasanawathana, Wannee Limpitikul, Prida Malasit, Duncan Young, Laura Denney, STOP-HCV consortium, Eleanor Barnes, Jonathan Ball, Gary Burgess, Graham Cooke, John Dillon, Charles Gore et al. Mucosal Associated Invariant T cells have been implicated in response to bacterial pathogens. Here the authors show that in human viral infections, these cells are activated by IL-18 in cooperation with other pro-inflammatory cytokines, producing interferon gamma and granzyme B. 23 June 2016 | doi: 10.1038/ncomms11653 Biological Sciences  Immunology  Medical research  Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism OPEN Catherine Marquer, Huasong Tian, Julie Yi, Jayson Bastien, Claudia Dall'Armi, YoungJoo Yang-Klingler, Bowen Zhou, Robin Barry Chan and Gilbert Di Paolo The small GTPase Arf6 regulates intracellular transport, phosphoinositide signalling and cholesterol homeostasis. Here, Marquer et al. show that loss of Arf6 causes cholesterol accumulation in endosomes due to defects in phosphoinositide-dependent retromer-mediated trafficking of CI-M6PR and NPC2. 23 June 2016 | doi: 10.1038/ncomms11919 Biological Sciences  Cell biology  Cardiac sodium channel palmitoylation regulates channel availability and myocyte excitability with implications for arrhythmia generation OPEN Zifan Pei, Yucheng Xiao, Jingwei Meng, Andy Hudmon and Theodore R. Cummins Cardiac voltage-gated sodium channels (Nav1.5) are crucial regulators of heart electric activity. Here the authors show that palmitoylation, a process of lipid modification of cysteine residues, modulates Nav1.5 function and affects cardiomyocyte excitability, representing a potential target in treating cardiac diseases. 23 June 2016 | doi: 10.1038/ncomms12035 Biological Sciences  Cell biology  Medical research  Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes OPEN Rachel Barrow-McGee, Naoki Kishi, Carine Joffre, Ludovic Ménard, Alexia Hervieu, Bakhouche A. Bakhouche, Alejandro J. Noval, Anja Mai, Camilo Guzmán, Luisa Robert-Masson, Xavier Iturrioz, James Hulit, Caroline H. Brennan, Ian R. Hart, Peter J. Parker, Johanna Ivaska and Stéphanie Kermorgant Cooperative signalling between receptor tyrosine kinases (RTKs) and integrins is thought to occur at the cell surface. Here the authors show that β1 integrin influences signalling of an RTK, c-Met, from a novel intracellular compartment they call autophagy-related endomembranes. 23 June 2016 | doi: 10.1038/ncomms11942 Biological Sciences  Cell biology  Programming a topologically constrained DNA nanostructure into a sensor OPEN Meng Liu, Qiang Zhang, Zhongping Li, Jimmy Gu, John D. Brennan and Yingfu Li DNA nanostructures with interlocked topologies will tend to display different behaviour to the linear counterparts. Here, the authors show a DNA catenane that is inactive for rolling circle amplification but is activated upon cleavage of one ring, and exploit this for the development of a biosensing system. 23 June 2016 | doi: 10.1038/ncomms12074 Chemical Sciences  Analytical chemistry  Chemical biology  Nanotechnology  Modularity and stability in ecological communities OPEN Jacopo Grilli, Tim Rogers and Stefano Allesina Modularity in food webs can be caused by spatial and temporal mismatches in interactions. Here, Jacopo Grilli, Tim Rogers and Stefano Allesina show that modularity, contrary to expectations, does not generally help stabilizing ecological communities. 23 June 2016 | doi: 10.1038/ncomms12031 Biological Sciences  Ecology  Reconfigurable optical assembly of nanostructures OPEN Yunuen Montelongo, Ali K. Yetisen, Haider Butt and Seok-Hyun Yun Reconfigurable materials are of interest for many photonic applications. Here, Montelongo et al. demonstrate optical elements such as Bragg diffraction gratings, volumetric photonic crystals, lenses, and holograms in a composite with dispersed nanoparticles which can be recorded and erased. 23 June 2016 | doi: 10.1038/ncomms12002 Physical Sciences  Applied physics  Optical physics  Spontaneous incorporation of gold in palladium-based ternary nanoparticles makes durable electrocatalysts for oxygen reduction reaction OPEN Deli Wang, Sufen Liu, Jie Wang, Ruoqian Lin, Masahiro Kawasaki, Eric Rus, Katharine E. Silberstein, Michael A. Lowe, Feng Lin, Dennis Nordlund, Hongfang Liu, David A. Muller, Huolin L. Xin and Héctor D. Abruña Replacement of platinum is important for lowering the cost of fuel-cell electrocatalysts, but less precious alternatives such as palladium are hindered by lower durability. Here, the authors show that incorporation of trace amounts of gold improves the durability of palladium based oxygen reduction catalysts. 23 June 2016 | doi: 10.1038/ncomms11941 Chemical Sciences  Materials science  Nanotechnology  Physical chemistry  Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases OPEN Louise J. Walport, Richard J. Hopkinson, Rasheduzzaman Chowdhury, Rachel Schiller, Wei Ge, Akane Kawamura and Christopher J. Schofield While reversal of lysine methylation on histone tails is a well-established mechanism to tune gene expression, the existence of a similar arginine demethylation process is controversial. Here, the authors show that some jumonji enzymes possess both lysine and arginine demethylase activity in vitro. 23 June 2016 | doi: 10.1038/ncomms11974 Biological Sciences  Biochemistry  Chemical biology  Molecular biology  MicroRNA-125b-5p mimic inhibits acute liver failure OPEN Dakai Yang, Qinggong Yuan, Asha Balakrishnan, Heike Bantel, Jan-Henning Klusmann, Michael P. Manns, Michael Ott, Tobias Cantz and Amar Deep Sharma miR125b-5p has been associated with acute liver failure. Here the authors show that this miRNA targets Keap1 and activates Nrf2 to inhibit liver cell death after APAP or FAS toxicity, plus they show that a miR125b-5p mimic can inhibit ALF in mice. 23 June 2016 | doi: 10.1038/ncomms11916 Biological Sciences  Medical research  Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation OPEN Carina Soares-Cunha, Barbara Coimbra, Ana David-Pereira, Sonia Borges, Luisa Pinto, Patricio Costa, Nuno Sousa and Ana J. Rodrigues Striatal D1 and D2-receptor expressing neurons have been shown to have opposing effects on reward-related behaviours. Here the authors reveal that specific activation of both D1 and D2 neurons in the nucleus accumbens leads to increase in motivational drive in rodents. 23 June 2016 | doi: 10.1038/ncomms11829 Biological Sciences  Neuroscience  Electrically driven optical metamaterials OPEN Quynh Le-Van, Xavier Le Roux, Abdelhanin Aassime and Aloyse Degiron Active metamaterials are largely controlled by light, preventing integration in electronic systems. Here, the authors introduce electroluminescent metamaterials based on metal nano-inclusions hybridized with colloidal quantum dots and use this approach to weave intricate light-emitting surfaces. 22 June 2016 | doi: 10.1038/ncomms12017 Physical Sciences  Applied physics  Materials science  Optical physics  Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer OPEN Peter Ulz, Jelena Belic, Ricarda Graf, Martina Auer, Ingrid Lafer, Katja Fischereder, Gerald Webersinke, Karl Pummer, Herbert Augustin, Martin Pichler, Gerald Hoefler, Thomas Bauernhofer, Jochen B. Geigl, Ellen Heitzer and Michael R. Speicher The genomic features of metastatic prostate cancer are beginning to be understood. Here, the authors performed whole genome sequencing of plasma samples from these patients and found a high plasticity of the cancer genomes with newly occurring focal amplifications as a driving force in progression. 22 June 2016 | doi: 10.1038/ncomms12008 Biological Sciences  Cancer  Genetics  The role of MscL amphipathic N terminus indicates a blueprint for bilayer-mediated gating of mechanosensitive channels OPEN Navid Bavi, D. Marien Cortes, Charles D. Cox, Paul R. Rohde, Weihong Liu, Joachim W. Deitmer, Omid Bavi, Pavel Strop, Adam P. Hill, Douglas Rees, Ben Corry, Eduardo Perozo and Boris Martinac The activation of bacterial mechanosensitive channels is still not fully understood. Here, Bavi et al. show that the N-terminal helix of MscL dynamically couples membrane tension to channel gating, suggesting a conserved mechanism underlying the mechanosensitivity of ion channels of higher organisms. 22 June 2016 | doi: 10.1038/ncomms11984 Biological Sciences  Biochemistry  Biophysics  Demographic routes to variability and regulation in bird populations OPEN Bernt-Erik Sæther, Vidar Grøtan, Steinar Engen, Tim Coulson, Peter R. Grant, Marcel E. Visser, Jon E. Brommer, B. Rosemary Grant, Lars Gustafsson, Ben J. Hatchwell, Kurt Jerstad, Patrik Karell, Hannu Pietiäinen, Alexandre Roulin, Ole W. Røstad and Henri Weimerskirch Why does population variability differ? Sæther et al. show that the magnitude of temporal variation of avian population fluctuations is mainly determined by environmental fluctuations affecting recruitment, whereas regulation of mean population size occurs through density-dependent mortality. 22 June 2016 | doi: 10.1038/ncomms12001 Biological Sciences  Ecology  The biogeography of red snow microbiomes and their role in melting arctic glaciers OPEN Stefanie Lutz, Alexandre M. Anesio, Rob Raiswell, Arwyn Edwards, Rob J. Newton, Fiona Gill and Liane G. Benning The Arctic is melting at an unprecedented rate and key drivers are changes in snow and ice albedo. Here, the authors show that red pigmented snow algae play a crucial role in decreasing surface albedo and their patterns for diversity, pigmentation, and consequently albedo, are ubiquitous across the Arctic. 22 June 2016 | doi: 10.1038/ncomms11968 Earth Sciences  Biogeochemistry  Climate science  Integrated genetic and pharmacologic interrogation of rare cancers OPEN Andrew L. Hong, Yuen-Yi Tseng, Glenn S. Cowley, Oliver Jonas, Jaime H. Cheah, Bryan D. Kynnap, Mihir B. Doshi, Coyin Oh, Stephanie C. Meyer, Alanna J. Church, Shubhroz Gill, Craig M. Bielski, Paula Keskula, Alma Imamovic, Sara Howell, Gregory V. Kryukov, Paul A. Clemons, Aviad Tsherniak, Francisca Vazquez, Brian D. Crompton et al. Identifying therapeutic targets in rare cancers is challenging due to the lack of relevant pre-clinical models. Here, the authors generate a cancer cell line from a paediatric patient with a rare undifferentiated sarcoma and through functional genomics and chemical screens identified CDK4 and XPO1 as potential therapeutic targets in this cancer. 22 June 2016 | doi: 10.1038/ncomms11987 Biological Sciences  Cancer  Cell biology  Correlation and anti-correlation of the East Asian summer and winter monsoons during the last 21,000 years OPEN Xinyu Wen, Zhengyu Liu, Shaowu Wang, Jun Cheng and Jiang Zhu Future projection of changes in the East Asia Summer and Winter Monsoon are hindered by a lack of understanding of past variability. Here, using longterm transient simulations, the authors show that the monsoons respond in phase to precessional forcing, yet out of phase millennial-scale North Atlantic forcing. 22 June 2016 | doi: 10.1038/ncomms11999 Earth Sciences  Climate science  Influence of orbital symmetry on diffraction imaging with rescattering electron wave packets OPEN M. G. Pullen, B. Wolter, A. -T. Le, M. Baudisch, M. Sclafani, H. Pires, C. D. Schröter, J. Ullrich, R. Moshammer, T. Pfeifer, C. D. Lin and J. Biegert Laser-induced electron diffraction possesses sufficient resolution to resolve nuclear dynamics in molecules, but imaging was thought to depend on the orbital symmetries for the backscattering electrons. Here, the authors image the structure of randomly oriented O2 and C2H2 molecules and prove the contrary. 22 June 2016 | doi: 10.1038/ncomms11922 Physical Sciences  Atomic and molecular physics  Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling OPEN Fatemeh Mirzamohammadi, Garyfallia Papaioannou, Jennifer B. Inloes, Erinn B. Rankin, Huafeng Xie, Ernestina Schipani, Stuart H. Orkin and Tatsuya Kobayashi Eed is a polycomb repressive complex 2 component involved in stem cell lineage determination, but little is known about its role in lineage committed cells. Here the authors show that chondrocyte-specific Eed KO mice have skeletal growth defects related to induction of Wnt and TGF-β signalling. 22 June 2016 | doi: 10.1038/ncomms12047 Biological Sciences  Medical research  Structural basis of suppression of host translation termination by Moloney Murine Leukemia Virus OPEN Xuhua Tang, Yiping Zhu, Stacey L. Baker, Matthew W. Bowler, Benjamin Jieming Chen, Chen Chen, J. Robert Hogg, Stephen P. Goff and Haiwei Song Retroviral reverse transcriptase from Moloney Murine Leukemia Virus (MoMLV) requires interaction with peptidyl release factor 1. Here, the authors report the crystal structure of this complex, and provide insights into how MoMLV uses the host translation machinery to synthesize its own proteins. 22 June 2016 | doi: 10.1038/ncomms12070 Biological Sciences  Biochemistry  Biophysics  Virology  ASC filament formation serves as a signal amplification mechanism for inflammasomes OPEN Mathias S. Dick, Lorenzo Sborgi, Sebastian Rühl, Sebastian Hiller and Petr Broz Inflammasomes regulate IL-1β family maturation and pyroptosis. Here the authors show that ASC oligomerization and the formation of ASC specks are needed for IL-1β processing, but are not required for pyroptosis, indicating distinct inflammasome regulatory pathways. 22 June 2016 | doi: 10.1038/ncomms11929 Biological Sciences  Cell biology  Immunology  Strain-engineered diffusive atomic switching in two-dimensional crystals OPEN Janne Kalikka, Xilin Zhou, Eric Dilcher, Simon Wall, Ju Li and Robert E. Simpson Strain engineering allows design of materials with tailored properties. Here, the authors show that strain can be used to control atomic diffusion in Sb2Te3-GeTe superlattices, and they propose general design rules to enable atomic switching functionalities in van der Waals heterostructures. 22 June 2016 | doi: 10.1038/ncomms11983 Physical Sciences  Condensed matter  Materials science  Nanotechnology  Experimental demonstration of the microscopic origin of circular dichroism in two-dimensional metamaterials OPEN A. B. Khanikaev, N. Arju, Z. Fan, D. Purtseladze, F. Lu, J. Lee, P. Sarriugarte, M. Schnell, R. Hillenbrand, M. A. Belkin and G. Shvets The effect of Ohmic dissipation in two-dimensional chiral materials has never been experimentally verified. Here, Khanikaev et al. demonstrate that the circular dichroism in a nanostructured metasurface occurs due to handedness-dependent Ohmic heating. 22 June 2016 | doi: 10.1038/ncomms12045 Physical Sciences  Materials science  Optical physics  Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer OPEN Daniel Chubb, Peter Broderick, Sara E. Dobbins, Matthew Frampton, Ben Kinnersley, Steven Penegar, Amy Price, Yussanne P. Ma, Amy L. Sherborne, Claire Palles, Maria N. Timofeeva, D. Timothy Bishop, Malcolm G. Dunlop, Ian Tomlinson and Richard S. Houlston The genetic factors that predispose individuals to familial colorectal cancer are poorly understood. In this study, the authors use whole exome sequencing of 1,006 patients and 1,609 healthy controls and show it is unlikely that further major high-penetrance susceptibility genes exist. 22 June 2016 | doi: 10.1038/ncomms11883 Biological Sciences  Cancer  Genetics  Genome-wide analysis of chromosomal import patterns after natural transformation of Helicobacter pylori OPEN Sebastian Bubendorfer, Juliane Krebes, Ines Yang, Elias Hage, Thomas F. Schulz, Christelle Bahlawane, Xavier Didelot and Sebastian Suerbaum Uptake and integration of exogenous DNA into the bacterial genome play an important role in the evolution of the pathogen Helicobacter pylori. Here, the authors describe a bimodal pattern of chromosomal integration and show how restriction-modification systems limit the import of heterologous DNA. 22 June 2016 | doi: 10.1038/ncomms11995 Biological Sciences  Evolution  Genetics  Microbiology    Nature Communications JOBS of the week Research Scientist NHS The Royal Marsden NHS Foundation Trust Postdoctoral Position University Hospital of Munster Two Postdoctoral Positions University of Pittsburgh Medical Center (UPMC) Research Fellow The University of Warwick Senior Research Scientist NHS National Services Scotland Junior Group Leader Candiolo Cancer Institute - IRCCS, Candiolo (To) - Italy Postdoctoral Position University Children's Hospital Zurich 2 Postdoctoral Research Associates University of Liverpool 11 Tenure-Track Positions Norwegian University of Science and Technology (NTNU) Post-doctoral Fellow University of California - San Francisco More Science jobs from Nature Communications EVENT World Congress on Cancer Research & Therapy 21.11.16 Miami, USA More science events from       Latest Corrigenda     Corrigendum: Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3 OPEN Yasuhito Yahara, Hiroshi Takemori, Minoru Okada, Azuma Kosai, Akihiro Yamashita, Tomohito Kobayashi, Kaori Fujita, Yumi Itoh, Masahiro Nakamura, Hiroyuki Fuchino, Nobuo Kawahara, Naoshi Fukui, Akira Watanabe, Tomoatsu Kimura and Noriyuki Tsumaki 27 June 2016 | doi: 10.1038/ncomms12117 Biological Sciences  Medical research      Corrigendum: Mechanical slowing-down of cytoplasmic diffusion allows in vivo counting of proteins in individual cells OPEN Burak Okumus, Dirk Landgraf, Ghee Chuan Lai, Somenath Bakshi, Juan Carlos Arias-Castro, Sadik Yildiz, Dann Huh, Raul Fernandez-Lopez, Celeste N. Peterson, Erdal Toprak, Meriem El Karoui and Johan Paulsson 24 June 2016 | doi: 10.1038/ncomms12130 Biological Sciences  Biophysics  Cell biology      Corrigendum: The child brain computes and utilizes internalized maternal choices OPEN Seung-Lark Lim, J. Bradley C Cherry, Ann M. Davis, S. N. Balakrishnan, Oh-Ryeong Ha, Jared M. Bruce and Amanda S. Bruce 23 June 2016 | doi: 10.1038/ncomms12127 Biological Sciences  Neuroscience      Corrigendum: Mutations in CDCA7 and HELLS cause immunodeficiency–centromeric instability–facial anomalies syndrome OPEN Peter E. Thijssen, Yuya Ito, Giacomo Grillo, Jun Wang, Guillaume Velasco, Hirohisa Nitta, Motoko Unoki, Minako Yoshihara, Mikita Suyama, Yu Sun, Richard J. L. F. Lemmers, Jessica C. de Greef, Andrew Gennery, Paolo Picco, Barbara Kloeckener-Gruissem, Tayfun Güngör, Ismail Reisli, Capucine Picard, Kamila Kebaili, Bertrand Roquelaure et al. 22 June 2016 | doi: 10.1038/ncomms12003 Biological Sciences  Genetics      Advertisement Nature Focus and Animation: Innate lymphoid cells Nature Immunology presents this Focus on the evolution, development, functional diversity and immunotherapeutic potential of innate lymphoid cells (ILCs). Access the Focus free online Watch the accompanying animation showing the complexity of ILC biology in the gut here Produced with support from MedImmune     Advertisement Open for Submissions  Online-only and open access, npj Primary Care Respiratory Medicine is the only fully-indexed scientific journal devoted to the management of respiratory diseases in primary care. 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