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August 2016 Volume 13 Number 8 | |||||||||||||||||||||||||||||||||||||||
In this issue Research Highlights News and Views Reviews
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NEWS AND VIEWS | Top | ||||||||||||||||||||||||||||||||||||||
Liver: Phenotypic and genetic variance: a systems approach to the liver Adil Mardinoglu & Mathias Uhlén Published online: 22 June 2016 p439 | doi:10.1038/nrgastro.2016.93 Elucidating the entire complexity of biological functions in the liver is vital to understand its key role in the progression of complex diseases. A new mouse study integrates complementary '-omics' data across various environmental states using the liver as a platform for multiomics analysis and identifies new mechanisms in hepatic mitochondrial function. Full Text | PDF | |||||||||||||||||||||||||||||||||||||||
Nutrition: How will the next 'Decade of Nutrition' be different from the past one? Zulfiqar A. Bhutta Published online: 29 June 2016 p441 | doi:10.1038/nrgastro.2016.102 The global burden of malnutrition (undernutrition, micronutrient deficiencies or obesity) is considerable and associated with risk of excess mortality and long-term adverse outcomes. Concerted action to achieve agreed global nutrition targets is proposed for the next decade, which must be coupled with the political will to address the root causes of malnutrition and implement evidence-based strategies. Full Text | PDF | |||||||||||||||||||||||||||||||||||||||
Obesity: Metabolically healthy obesity and NAFLD Giovanni Targher & Christopher D. Byrne Published online: 29 June 2016 p442 | doi:10.1038/nrgastro.2016.104 Obesity is a risk factor for several noncommunicable diseases, but some individuals with obesity remain metabolically healthy throughout life; whether these individuals are at risk of developing NAFLD is uncertain. In a new study, Chang et al. showed a statistically significant, graded relationship between BMI and NAFLD in metabolically healthy individuals. Full Text | PDF | |||||||||||||||||||||||||||||||||||||||
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REVIEWS | Top | ||||||||||||||||||||||||||||||||||||||
Respiratory disease and the oesophagus: reflux, reflexes and microaspiration Lesley A. Houghton et al. Published online: 06 July 2016 p445 | doi:10.1038/nrgastro.2016.91 This Review comprehensively examines the possible mechanisms that might link pulmonary disease and oesophageal reflux, highlighting the gaps in current knowledge and limitations of previous research, and helping to shed light on the frequent failure of antireflux treatments in pulmonary disease. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||||
Current management of the gastrointestinal complications of systemic sclerosis Anton Emmanuel Published online: 06 July 2016 p461 | doi:10.1038/nrgastro.2016.99 Gastrointestinal dysfunction is very common in patients with systemic sclerosis, and often severely reduces quality of life. In this Review, Emmanuel discusses optimal strategies to identify and manage gastrointestinal complications in patients with systemic sclerosis, and outlines potential new therapies. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||||
Article series: Cell & developmental biology in the digestive system Liver regeneration — mechanisms and models to clinical application Stuart J. Forbes & Philip N. Newsome Published online: 29 June 2016 p473 | doi:10.1038/nrgastro.2016.97 Liver regeneration is important in both the context of homeostasis and in recovery from disease or injury. In this Review, Forbes and Newsome describe the mechanisms underlying liver regeneration and the experimental models used to study this process, as well as discussing how liver regeneration is clinically relevant. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||||
Endoscopic mucosal resection and endoscopic submucosal dissection of large colonic polyps Brian P. Saunders & Zacharias P. Tsiamoulos Published online: 29 June 2016 p486 | doi:10.1038/nrgastro.2016.96 Most colorectal polyps can now be resected endoscopically using either mucosal resection or submucosal dissection. Although the former is an established technique, the latter has seen slow adoption in the West. In this Review, the authors summarize the indications for both procedures and discuss new advances in endoscopic polyp surgery. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||||
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*Journal Citation Reports, Thomson, 2015. Nature Reviews Gastroenterology & Hepatology was previously published as Nature Clinical Practice Gastroenterology & Hepatology. |
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