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2016/08/01

Nature Reviews Urology - Table of Contents alert Volume 13 Issue 8

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Nature Reviews Urology

 
TABLE OF CONTENTS
 
August 2016 Volume 13 Number 8
Nature Reviews Urology cover
Impact Factor 5.957 *
In this issue
Research Highlights
News and Views
Reviews
Perspectives

Also this month
 Featured article:
Does central sensitization help explain idiopathic overactive bladder?
W. Stuart Reynolds, Roger Dmochowski, Alan Wein & Stephen Bruehl


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RESEARCH HIGHLIGHTS
Top

Prostate cancer: AR-V7 status in CTCs is a treatment-specific biomarker
Published online: 28 June 2016
p433 | doi:10.1038/nrurol.2016.113

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Prostate cancer: Midlife PSA levels predict lethal disease
Published online: 28 June 2016
p434 | doi:10.1038/nrurol.2016.119

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Prostate cancer: Novel subtyping could aid stratification and therapy
Published online: 05 July 2016
p434 | doi:10.1038/nrurol.2016.130

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Prostate cancer: Biomarkers from liquid biopsy
Published online: 19 July 2016
p434 | doi:10.1038/nrurol.2016.133

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Prostate cancer: Hypofractionated radiotherapy confirmed effective and safe
Published online: 05 July 2016
p435 | doi:10.1038/nrurol.2016.129

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Kidney cancer: Power couple: reovirus meets sunitinib
Published online: 14 June 2016
p436 | doi:10.1038/nrurol.2016.111

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Prostate cancer: Inhibiting initiation — targeting BMI1 is effective
Published online: 05 July 2016
p436 | doi:10.1038/nrurol.2016.131

PDF


Prostate cancer: TRIM24 acts as a transcriptional activator
Published online: 14 June 2016
p437 | doi:10.1038/nrurol.2016.112

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Urinary tract obstruction: Stem cells hinder stricture formation
Published online: 28 June 2016
p438 | doi:10.1038/nrurol.2016.117

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Kidney cancer: Cytoreductive nephrectomy improves outcomes in the era of targeted therapy
Published online: 05 July 2016
p438 | doi:10.1038/nrurol.2016.127

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Prostate cancer: Tumour genomes are highly plastic
Published online: 12 July 2016
p438 | doi:10.1038/nrurol.2016.132

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IN BRIEF

Prostate cancer: EBRT + ADT outcomes for node-positive patients | Bladder cancer: Cisplatin response is modulated by AR activity | Biomarkers: Urinary exosome biomarkers of radiation exposure | Paediatrics: Randomized study of the Xiao procedure
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NEWS AND VIEWS
Top
Prostate cancer: Why the prostate arm of the PLCO trial failed and what it has taught us
Matthew R. Cooperberg
Published online: 12 July 2016
p439 | doi:10.1038/nrurol.2016.116
Given a recent update from the PLCO trial reporting that over 90% of men in the 'usual care' arm underwent some degree of PSA testing, the PLCO can no longer accurately be called a trial of screening versus no screening — nor can it be included as such in meta-analyses or guideline statements.
Full Text | PDF

Bladder cancer: ASCO endorses EAU muscle-invasive bladder cancer guidelines
Seth P. Lerner
Published online: 05 July 2016
p440 | doi:10.1038/nrurol.2016.114
A multidisciplinary expert panel from the American Society of Clinical Oncology has endorsed the updated European Association of Urology guidelines for the management of muscle-invasive bladder cancer, with one exception. The panel also provides additional clarification of several recommendations.
Full Text | PDF

Kidney cancer: Finding a niche for girentuximab in metastatic renal cell carcinoma
Sumanta K. Pal & Neeraj Agarwal
Published online: 28 June 2016
p442 | doi:10.1038/nrurol.2016.115
For nearly two decades, carbonic anhydrase IX (CAIX) expression has been investigated as a prognostic marker in renal cell carcinoma (RCC). During this time, CAIX-directed treatments have emerged, including 177Lu-labelled girentuximab. A small phase II study highlights modest efficacy and a concerning safety profile associated with this compound in patients with metastatic RCC.
Full Text | PDF

Kidney cancer: Quality-of-life outcomes in patients with small renal masses
Surena F. Matin
Published online: 12 July 2016
p443 | doi:10.1038/nrurol.2016.124
Quality-of-life (QoL) outcomes using patient-reported standardized questionnaires are understudied in the field of small renal masses, but are highly relevant for patients who have several treatment options. A recent study has compared QoL outcomes in patients undergoing primary intervention or active surveillance for this malignancy.
Full Text | PDF

Prostate cancer: Radiotherapy might improve survival, even in the oldest men
Stephen T. Ryan & Jesse D. Sammon
Published online: 12 July 2016
p444 | doi:10.1038/nrurol.2016.125
In a recent study, men ≥80 years who received external beam radiotherapy (EBRT) for prostate cancer lived longer than those who were observed. Greatest benefits were reported in men with moderate or aggressive disease, and those with few comorbidities. The study also emphasizes the large proportion of men who went untreated after diagnosis.
Full Text | PDF

 
REVIEWS
Top
Getting out of a tight spot: an overview of ureteroenteric anastomotic strictures
Niyati Lobo, Sophie Dupré, Arun Sahai, Ramesh Thurairaja & Muhammad Shamim Khan
Published online: 28 June 2016
p447 | doi:10.1038/nrurol.2016.104
Radical cystectomy and urinary diversion is the gold-standard treatment for muscle-invasive and high-risk non-muscle-invasive bladder cancer. Ureteroenteric anastomotic stricture has a reported prevalence of up to 10%, and such strictures have serious consequences that can lead to loss of kidney function and infectious complications. Here, the authors discuss the pathophysiology, diagnosis, risk factors, and management of ureteroenteric anastomotic strictures and describe ways in which stricture risk can be minimized.
Abstract | Full Text | PDF

To treat or not to treat: puberty suppression in childhood-onset gender dysphoria
Rosalia Costa, Polly Carmichael & Marco Colizzi
Published online: 19 July 2016
p456 | doi:10.1038/nrurol.2016.128
Gender dysphoria — distress associated with being assigned to the wrong gender and experiencing oneself as the nonnatal gender — can affect individuals of any age. However, treatment of gender-dysphoric children and adolescents is controversial. In this Review, Costa and colleagues discuss the data supporting hormonal treatment to delay puberty in gender-dysphoric children, and the considerations for managing these patients.
Abstract | Full Text | PDF

The endocannabinoid system — a target for the treatment of LUTS?
Petter Hedlund & Christian Gratzke
Published online: 05 July 2016
p463 | doi:10.1038/nrurol.2016.110
Cannabinoid receptors and their agonists, endocannabinoids, can be detected throughout the urinary tract. However, despite a paucity of well-tolerated agents for patients with lower urinary tract symptoms (LUTS), clinical targeting of this system has remained largely overlooked. In this Review, the authors describe the current evidence for a role of cannabinoids in micturition and as a treatment for LUTS.
Abstract | Full Text | PDF

The prognostic role of lymphovascular invasion in urothelial carcinoma of the bladder
Romain Mathieu, Ilaria Lucca, Morgan Rouprêt, Alberto Briganti & Shahrokh F. Shariat
Published online: 19 July 2016
p471 | doi:10.1038/nrurol.2016.126
Mathieu et al. review current data on the effect of lymphovascular invasion on disease outcomes in patients with bladder cancer and assess its utility in informing clinical decision-making as a prognostic marker or indicator for early intervention.
Abstract | Full Text | PDF

 
PERSPECTIVES
Top
OPINION
Does central sensitization help explain idiopathic overactive bladder?
W. Stuart Reynolds, Roger Dmochowski, Alan Wein & Stephen Bruehl
Published online: 01 June 2016
p481 | doi:10.1038/nrurol.2016.95
Central sensitization, resulting in a disproportionately painful response to peripheral signals of a regular intensity has been implicated in a variety of chronic pain syndromes, including interstitial cystitis. In this Perspective, the authors describe a potential role of central sensitization in idiopathic overactive bladder, a condition characterized by altered sensations of urinary urgency with no apparent pathological alterations.
Abstract | Full Text | PDF

 
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*Journal Citation Reports, Thomson, 2016. Nature Reviews Urology was previously published as Nature Clinical Practice Urology.

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