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August 2016 Volume 13 Number 8 | |||||||||||||||||||||||||||||||||||||
In this issue Research Highlights News and Views Reviews Perspectives
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NEWS AND VIEWS | Top | ||||||||||||||||||||||||||||||||||||
Prostate cancer: Why the prostate arm of the PLCO trial failed and what it has taught us Matthew R. Cooperberg Published online: 12 July 2016 p439 | doi:10.1038/nrurol.2016.116 Given a recent update from the PLCO trial reporting that over 90% of men in the 'usual care' arm underwent some degree of PSA testing, the PLCO can no longer accurately be called a trial of screening versus no screening — nor can it be included as such in meta-analyses or guideline statements. Full Text | PDF | |||||||||||||||||||||||||||||||||||||
Bladder cancer: ASCO endorses EAU muscle-invasive bladder cancer guidelines Seth P. Lerner Published online: 05 July 2016 p440 | doi:10.1038/nrurol.2016.114 A multidisciplinary expert panel from the American Society of Clinical Oncology has endorsed the updated European Association of Urology guidelines for the management of muscle-invasive bladder cancer, with one exception. The panel also provides additional clarification of several recommendations. Full Text | PDF | |||||||||||||||||||||||||||||||||||||
Kidney cancer: Finding a niche for girentuximab in metastatic renal cell carcinoma Sumanta K. Pal & Neeraj Agarwal Published online: 28 June 2016 p442 | doi:10.1038/nrurol.2016.115 For nearly two decades, carbonic anhydrase IX (CAIX) expression has been investigated as a prognostic marker in renal cell carcinoma (RCC). During this time, CAIX-directed treatments have emerged, including 177Lu-labelled girentuximab. A small phase II study highlights modest efficacy and a concerning safety profile associated with this compound in patients with metastatic RCC. Full Text | PDF | |||||||||||||||||||||||||||||||||||||
Kidney cancer: Quality-of-life outcomes in patients with small renal masses Surena F. Matin Published online: 12 July 2016 p443 | doi:10.1038/nrurol.2016.124 Quality-of-life (QoL) outcomes using patient-reported standardized questionnaires are understudied in the field of small renal masses, but are highly relevant for patients who have several treatment options. A recent study has compared QoL outcomes in patients undergoing primary intervention or active surveillance for this malignancy. Full Text | PDF | |||||||||||||||||||||||||||||||||||||
Prostate cancer: Radiotherapy might improve survival, even in the oldest men Stephen T. Ryan & Jesse D. Sammon Published online: 12 July 2016 p444 | doi:10.1038/nrurol.2016.125 In a recent study, men ≥80 years who received external beam radiotherapy (EBRT) for prostate cancer lived longer than those who were observed. Greatest benefits were reported in men with moderate or aggressive disease, and those with few comorbidities. The study also emphasizes the large proportion of men who went untreated after diagnosis. Full Text | PDF | |||||||||||||||||||||||||||||||||||||
REVIEWS | Top | ||||||||||||||||||||||||||||||||||||
Getting out of a tight spot: an overview of ureteroenteric anastomotic strictures Niyati Lobo, Sophie Dupré, Arun Sahai, Ramesh Thurairaja & Muhammad Shamim Khan Published online: 28 June 2016 p447 | doi:10.1038/nrurol.2016.104 Radical cystectomy and urinary diversion is the gold-standard treatment for muscle-invasive and high-risk non-muscle-invasive bladder cancer. Ureteroenteric anastomotic stricture has a reported prevalence of up to 10%, and such strictures have serious consequences that can lead to loss of kidney function and infectious complications. Here, the authors discuss the pathophysiology, diagnosis, risk factors, and management of ureteroenteric anastomotic strictures and describe ways in which stricture risk can be minimized. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
To treat or not to treat: puberty suppression in childhood-onset gender dysphoria Rosalia Costa, Polly Carmichael & Marco Colizzi Published online: 19 July 2016 p456 | doi:10.1038/nrurol.2016.128 Gender dysphoria — distress associated with being assigned to the wrong gender and experiencing oneself as the nonnatal gender — can affect individuals of any age. However, treatment of gender-dysphoric children and adolescents is controversial. In this Review, Costa and colleagues discuss the data supporting hormonal treatment to delay puberty in gender-dysphoric children, and the considerations for managing these patients. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
The endocannabinoid system — a target for the treatment of LUTS? Petter Hedlund & Christian Gratzke Published online: 05 July 2016 p463 | doi:10.1038/nrurol.2016.110 Cannabinoid receptors and their agonists, endocannabinoids, can be detected throughout the urinary tract. However, despite a paucity of well-tolerated agents for patients with lower urinary tract symptoms (LUTS), clinical targeting of this system has remained largely overlooked. In this Review, the authors describe the current evidence for a role of cannabinoids in micturition and as a treatment for LUTS. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
The prognostic role of lymphovascular invasion in urothelial carcinoma of the bladder Romain Mathieu, Ilaria Lucca, Morgan Rouprêt, Alberto Briganti & Shahrokh F. Shariat Published online: 19 July 2016 p471 | doi:10.1038/nrurol.2016.126 Mathieu et al. review current data on the effect of lymphovascular invasion on disease outcomes in patients with bladder cancer and assess its utility in informing clinical decision-making as a prognostic marker or indicator for early intervention. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
PERSPECTIVES | Top | ||||||||||||||||||||||||||||||||||||
OPINION Does central sensitization help explain idiopathic overactive bladder? W. Stuart Reynolds, Roger Dmochowski, Alan Wein & Stephen Bruehl Published online: 01 June 2016 p481 | doi:10.1038/nrurol.2016.95 Central sensitization, resulting in a disproportionately painful response to peripheral signals of a regular intensity has been implicated in a variety of chronic pain syndromes, including interstitial cystitis. In this Perspective, the authors describe a potential role of central sensitization in idiopathic overactive bladder, a condition characterized by altered sensations of urinary urgency with no apparent pathological alterations. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
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*Journal Citation Reports, Thomson, 2016. Nature Reviews Urology was previously published as Nature Clinical Practice Urology. |
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