Nature Reviews Urology - Table of Contents alert Volume 13 Issue 10

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TABLE OF CONTENTS
October 2016 Volume 13 Number 10
Impact Factor 5.957 *	In this issue Comment Research Highlights News and Views Reviews Also this month  Featured article: Inflammatory mediators in the development and progression of benign prostatic hyperplasia Cosimo De Nunzio, Fabrizio Presicce & Andrea Tubaro
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Comment: Planning for the post-antibiotic era — why we must avoid TRUS-guided biopsy sampling Declan G. Murphy & Jeremy P. Grummet Published online: 20 September 2016 p559 | doi:10.1038/nrurol.2016.176 Health officials are warning that overuse of antibiotics and increasing antibiotic resistance mean that these drugs could soon become useless. Urologists have to take some responsibility as we continue to perform prostate biopsy sampling using a transrectal approach, which increases the possibility of bacterial infection. Full Text | PDF
RESEARCH HIGHLIGHTS Top Testicular cancer: In a spin — disorientated divisions disrupt germ cells Published online: 07 September 2016 p561 | doi:10.1038/nrurol.2016.173 PDF Infection: Sexual transmission of gonorrhoea is facilitated by other bacteria Published online: 17 August 2016 p562 | doi:10.1038/nrurol.2016.158 PDF Prostate cancer: Targeting the ribosome in advanced disease Published online: 23 August 2016 p562 | doi:10.1038/nrurol.2016.162 PDF Prostate cancer: Focal laser ablation improves short-term outcomes Published online: 09 August 2016 p563 | doi:10.1038/nrurol.2016.151 PDF Prostate cancer: Radium-223 safe in combination Published online: 17 August 2016 p563 | doi:10.1038/nrurol.2016.156 PDF Prostate cancer: Promising early outcomes of surgery Published online: 17 August 2016 p563 | doi:10.1038/nrurol.2016.159 PDF Prostate cancer: Fitting to overcome enzalutamide resistance Published online: 23 August 2016 p564 | doi:10.1038/nrurol.2016.160 PDF Sexual dysfunction: Young at heart? ED linked to CVD Published online: 23 August 2016 p564 | doi:10.1038/nrurol.2016.166 PDF Urinary incontinence: Pacing bladder electrical activity Published online: 23 August 2016 p564 | doi:10.1038/nrurol.2016.167 PDF Prostate cancer: Risk SNPs modulate lncRNAs Published online: 31 August 2016 p565 | doi:10.1038/nrurol.2016.171 PDF Sexual dysfunction: Geometry puts curvature on the straight and narrow Published online: 07 September 2016 p566 | doi:10.1038/nrurol.2016.169 PDF IN BRIEF Bladder cancer: Two molecular subtypes identified | Incontinence: Results of the RELAX study extension | Kidney cancer: Sunitinib resistance is futile | Prostate cancer: More cycles of docetaxel improve survival PDF
NEWS AND VIEWS		Top
Urinary incontinence: Making sense of the urinary microbiota in clinical urology Gregor Reid & Jeremy P. Burton Published online: 20 September 2016 p567 | doi:10.1038/nrurol.2016.182 Some urologists might be surprised that the urinary tract is not sterile, and bacteria might have important roles in a number of urological conditions such as urge incontinence. This paradigm shift, which has been further illustrated by data from a recent study, has implications for how urologists diagnose disease and treat patients. Full Text | PDF
Prostate cancer: Birth of a standard: MET-RADS-P for metastatic prostate cancer Baris Turkbey & Peter L. Choyke Published online: 31 August 2016 p568 | doi:10.1038/nrurol.2016.163 METastasis Reporting and Data System for Prostate Cancer (MET-RADS-P) is the first effort to provide the burgeoning field of whole body-MRI (WB-MRI) with minimum standards of image acquisition, interpretation, and reporting; it should act as a catalyst for promoting the use of this promising method. Full Text | PDF
Bladder cancer: Low adherence to guidelines in non-muscle-invasive disease Bas W. G. van Rhijn & Maximilian Burger Published online: 31 August 2016 p570 | doi:10.1038/nrurol.2016.165 The American Urological Association, the Society of Urologic Oncology and the European Association of Urology have recently updated their guidelines for diagnosis and treatment of non-muscle-invasive bladder cancer. Several studies show that adherence to these guidelines is low, especially in North America. Physicians should try to comply with these guidelines to ensure optimal quality of care. Full Text | PDF
REVIEWS		Top
Nocturia: aetiology and treatment in adults Hasan Dani, Ashanda Esdaille & Jeffrey P. Weiss Published online: 26 July 2016 p573 | doi:10.1038/nrurol.2016.134 Nocturia is a very common condition with major sequelae for affected patients. It leads to impaired quality of life and is associated with numerous morbidities including diabetes, coronary artery disease, obstructive sleep apnoea, obesity, metabolic syndrome, and depression. In this Review, the authors discuss the clinical relevance of nocturia and the need for treatment. They describe the various aetiologies of the condition and discuss a contemporary approach to its treatment and management, including methods to tailor treatment strategies to individual patients. Abstract | Full Text | PDF
Epigenetics in male reproduction: effect of paternal diet on sperm quality and offspring health Undraga Schagdarsurengin & Klaus Steger Published online: 31 August 2016 p584 | doi:10.1038/nrurol.2016.157 In this Review, the authors summarize current knowledge of sperm-specific epigenetic signatures and diet-induced epigenetic effects on sperm quality. They also discuss transgenerational effects of the sperm epigenome on offspring health. Abstract | Full Text | PDF
Putative functions of tissue kallikrein-related peptidases in vaginal fluid Carla M. J. Muytjens, Stella K. Vasiliou, Katerina Oikonomopoulou, Ioannis Prassas & Eleftherios P. Diamandis Published online: 07 September 2016 p596 | doi:10.1038/nrurol.2016.161 Proteomic and biochemical studies on cervical-vaginal fluid (CVF) have revealed that it contains several members of the tissue kallikrein-related peptidase (KLK) family. The roles of KLKs in the lower female reproductive system are not fully understood. In this Review, Muytjens and colleagues discuss the putative roles of KLKs in vaginal fluid and how increased understanding of their function could result in new diagnostic and therapeutic modalities. Abstract | Full Text | PDF
Medical expulsive therapy for ureteral stones: where do we go from here? Bhaskar K. Somani, Omar Aboumarzouk, Olivier Traxer, Joyce Baard, Guido Kamphuis & Jean de la Rosette Published online: 02 August 2016 p608 | doi:10.1038/nrurol.2016.146 Medical expulsive therapy (MET) has been widely used for the management of ureteral stones for the past two decades, despite limited evidence on the effectiveness of this approach. In the past year, data from two clinical trials has called the continued use of MET into question. Here, the authors consider the role of MET in the managment of ureteral stones, in light of this improved level of evidence. Abstract | Full Text | PDF
Inflammatory mediators in the development and progression of benign prostatic hyperplasia Cosimo De Nunzio, Fabrizio Presicce & Andrea Tubaro Published online: 30 September 2016 p613 | doi:10.1038/nrurol.2016.168 The prostate is an immune-competent organ and several stimuli have been identified as possible triggers for dysregulation of the prostatic immune system via molecular pathways involving the development of inflammatory infiltrates. From a pathophysiological standpoint, subsequent tissue damage and chronic tissue healing could result in the development of BPH nodules. In this Review, the authors discuss the immunopathology of BPH and consider its links to prostate cancer and other disorders from an immunological viewpoint. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2016. Nature Reviews Urology was previously published as Nature Clinical Practice Urology.

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