Potentiating CD16-Activated ADCC in CAR-NK Cell Therapy

Created for ignoble.experiment@arconati.us |  Web Version This is a paid advertisement.   Sino Biological Featured Products Featured Cytokines CRO Services NK cells recognize cell-bound antibodies via CD16A (FcγRIIIA) to mediate antibody-dependent cellular cytotoxicity (ADCC). Potentiating therapeutic mAb-mediated CD16 activation of NK cells is an emerging area for cancer immunotherapy. CAR-NK cells with multi-specific molecules composed of stabilized CD16 and/or other activating receptors (e.g., NKG2D, DNAM-1/CD226, NKp46/NCR1, NKp44/NCR2, and NKp30/NCR3), scFvs for tumor antigens (e.g., CD19, CD22, ROBO1, and PSMA), and cytokine moieties (e.g., IL-15) are being actively studied to augment ADCC. Genetic modifications of CD16 to abolish the sensitivity to ADAM-17 mediated proteolytic cleavage or enhance its affinity for IgG Fc region has shown promising progress. CAR-NK cells expressing CD16A in recombination with the high-affinity Fc receptor, CD64 (FcγRI), show a more stable and enhanced ADCC response, presenting it as a promising advancement in CAR-NK cell immunotherapy.     Sino Biological has developed a panel of quality proteins and antibodies for CD16 and accompanying molecules to support CAR-NK cell therapy research. Learn More ! Featured Recombinant CD16 and CD64 Proteins   High-Purity HPLC-Verified High-Acitivity Validated by BLI Assay Cited by Researchers   Human CD16a Protein(Cat#: 10389-H08H1) High-Purity: > 95 % as determined by SEC-HPLC Immobilized Human CD16a (V176) can bind human IgG1 (Cat#: 10702-HNAC)   Human CD16b Protein(Cat#: 11046-H08H1) High-Purity: > 90 % as determined by SEC-HPLC BLI assay: Load IgG1 can bind human CD16b (NA1) recombinant protein   Human CD64 Protein(Cat#: 10256-H08H) High-Purity: > 90 % as determined by SEC-HPLC Immobilized Anti-CD20 (Ro) antibody (Cat#: 68055-H005) can bind human CD64 protein More Recombinant CD16 and CD64 Proteins >> Other Related Proteins CD95   TRAIL   TROP-2   CD19   NKG2C   IFN gamma   NKG2A   KLRB1F   NKp80/KLRF1   TIM3   Sino Biological, Inc. (China) order@sinobiological.com Sino Biological US Inc. (U.S.A.) order_us@sinobiologicalus.com Sino Biological Europe GmbH (Europe) order_eu@sinobiologicaleu.com 株式会社日本シノバイオロジカル (Japan) order@sinobiological.co.jp About this email: Future will occasionally send emails from our business partners promoting products and services likely to be of interest to our readers. Unsubscribe  |    Privacy Policy Future US LLC © Full 7th Floor, 130 West 42nd Street, New York, NY, 10036