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Diabetes drug linked to heart attacks WASHINGTON (UPI) -- The U.S. Senate Finance Committee released a 334-page report Saturday showing a link between the Type 2 diabetes drug Avandia and thousands of heart attacks. The committee's report, which reviewed more than 250,000 pages of documents provided by drug maker GlaxoSmithKline, the U.S. Food and Drug Administration and research institutes, also criticized the FDA for ignoring safety concerns about Avandia (rosiglitazone) brought up by its staff, CNN reported. The Wall Street Journal said confidential studies showed FDA officials recommended Avandia be removed from the market because of a risk of heart attacks and heart failure. The FDA is the federal agency charged with regulating food, tobacco and medications. "Americans have a right to know there are serious health risks associated with Avandia, and GlaxoSmithKline had a responsibility to tell them," committee chairman Sen. Max Baucus, D-Mont., said. "Patients trust drug companies with their health and their lives, and GlaxoSmithKline abused that trust." GlaxoSmithKline Saturday said in a statement the company "rejects the conclusions about the safety of Avandia." "Contrary to the assertions in the (New York Times), and consistent with the FDA-approved labeling, the scientific evidence simply does not establish that Avandia increases ischemic cardiovascular risk or causes myocardical ischemic events." Copyright 2010 by United Press International
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Water replaces fat in chocolate bar BIRMINGHAM, England (UPI) -- British scientists say a new generation of low-fat foods includes a chocolate bar that is nearly two-thirds water yet tastes the same as regular chocolate. Researchers at the University of Birmingham have discovered ways to replace fat particles with calorie-free water, air or gel, The Daily Telegraph reported Saturday. The chocolate bar, which connects water particles to cocoa butter crystals, contains about 60 percent water yet has the taste, smell and texture of regular chocolate, lead researcher Philip Cox said. Cox and his team also are working on a new "super porridge" that would help dieters feel full because it remains in the stomach for up to six hours when liquid changes into a gel after coming into contact with stomach acid. "We are well advanced with the work and are already talking to manufacturers about creating products based on our research," Cox said. Copyright 2010 by United Press International
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Rise of sex predators in energy boomtowns MISSOULA, Mont. (UPI) -- The number of registered sex offenders in energy "boomtowns" was two to three times higher than towns dependent on other industries, U.S. researchers found. Joel Berger of the University of Montana and Jon P. Beckmann of Idaho State University analyzed communities in the Greater Yellowstone Ecosystem in Wyoming. Many towns across the area are dependent on energy extraction, while others are dependent on agriculture and tourism. "In the past few years it has become clear that the development of wide-scale energy projects takes both social and environmental tolls," Berger said in a statement. Through nine local county attorney's offices the authors were able to study the number of registered sexual offenders -- defined as convicted felons who are required by law to register with legal authorities -- across the Greater Yellowstone area. The study, published in Conservation Biology, found that in 2008 there were 300 percent more sexual offenders in the Greater Yellowstone Ecosystem than in 1997 when the Sex Offenders Registry became law. Other symptoms of social change seen in energy boomtowns across the western United States include the use of illicit drugs, domestic violence, wildlife poaching and a general rise in crime, the study said. Copyright 2010 by United Press International
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Low levels of antibiotics cause superbugs BOSTON (UPI) -- Treating bacteria with insufficient levels of antibiotics produces germs that are cross-resistant to a wide range of antibiotics, U.S. researchers say. James J. Collins of Boston University said administered in lethal levels, antibiotics trigger a fatal chain reaction within the bacteria that shreds the cell's DNA. However, when the level of antibiotic is less than lethal the same reaction causes DNA mutations that are not only survivable, but actually protect the bacteria from numerous antibiotics beyond the one to which it was exposed. "In effect, what doesn't kill them makes them stronger," Collins said in a statement. "These findings drive home the need for tighter regulations on the use of antibiotics, especially in agriculture; for doctors to be more disciplined in their prescription of antibiotics; and for patients to be more disciplined in following their prescriptions." Collins with graduate student Michael Kohanski and post-doctoral fellow Mark DePristo showed that when applied in lethal doses, antibiotics stimulate the production of reactive oxygen species molecules, or free radicals that damage DNA, protein and lipids in bacterial cells, contributing to their demise. In the study, the same researchers demonstrated that the free radicals produced by a sub-lethal dose of an antibiotic accelerate mutations that protect against a variety of antibiotics other than the administered drug. Copyright 2010 by United Press International
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