Laboratory Investigation - Table of Contents alert Volume 92 Issue 11

TABLE OF CONTENTS Volume 92, Issue 11 (November 2012) In this issue Inside LI Research Articles Corrigendum Also new AOP This alert is sponsored by The new NanoZoomer-XR redefines the art of whole-slide imaging with hassle-free, error-free, and blur-free scanning. This high-throughput scanner quickly and automatically scans up to 320 slides. It is extremely easy to use, and offers accurate, error-free scanning and automatic quality checking. These features, coupled with an outstanding optics system and real-time dynamic focus, result in images of top tier quality and clarity. Sign up for e-alerts Recommend to your library Web feed Subscribe The publication of this issue was delayed due to Hurricane Sandy closing our New York offices temporarily. We apologize for any inconvenience caused. Advertisement   Recommended by the Editors of LI:  Multicolored stain-free histopathology with coherent Raman imaging   Inside LI Top Inside Lab Invest 2012 92: 1516-1517; 10.1038/labinvest.2012.149 Full Text Research Articles Top ANGIOGENESIS, CARDIOVASCULAR AND PULMONARY SYSTEMS Pressure overload-induced cardiac remodeling and dysfunction in the absence of interleukin 6 in mice Increased IL-6 levels are associated with pathological changes in congestive heart failure. However, similar left ventricular remodeling and cardiac dysfunction were found in both IL6-null and wild type mice after pressure overload caused by transverse aortic constriction. Thus, limiting IL-6 content alone is not sufficient to attenuate the pathological changes found in heart failure N Chin Lai, Mei Hua Gao, Eric Tang, Ruoying Tang, Tracy Guo, Nancy D Dalton, Aihua Deng and Tong Tang 2012 92: 1518-1526; advance online publication, July 23, 2012; 10.1038/labinvest.2012.97 Abstract | Full Text NHERF1 and CFTR restore tight junction organisation and function in cystic fibrosis airway epithelial cells: role of ezrin and the RhoA/ROCK pathway The abnormal cystic fibrosis (CF) airway epithelial cell tight junctions (TJs) allow excessive neutrophil migration. The role of the multiprotein apical complex CFTR-NHERF1-ezrin-actin in maintaining TJ organization and barrier function implicates the RhoA/ROCK pathway. These findings may help identify novel pathways in the inflammatory reaction in CF. Stefano Castellani, Lorenzo Guerra, Maria Favia, Sante Di Gioia, Valeria Casavola and Massimo Conese 2012 92: 1527-1540; advance online publication, September 10, 2012; 10.1038/labinvest.2012.123 Abstract | Full Text Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteria Heme oxygenase-1, a cytoprotective enzyme, regulates granuloma formation, a critical host defense response in mycobacterial infections. It does this in part by its effects on the expression of monocyte chemoattractant protein-1 as well as the expression of its cognate receptor, CCR2, on mononuclear cells both in the systemic circulation as well as in the lung. Doron Regev, Ranu Surolia, Suman Karki, Jason Zolak, Ana Montes- Worboys, Ocatvio Oliva, Purushotum Guroji, Vikram Saini, Adrie JC Steyn, Anupam Agarwal and Veena B Antony 2012 92: 1541-1552; advance online publication, September 10, 2012; 10.1038/labinvest.2012.125 Abstract | Full Text BLOOD, LYMPHATICS, IMMUNE SYSTEM AND STEM CELLS Angiopoietin-like protein 2 mediates endotoxin-induced acute inflammation in the eye A novel role for angiopoietin-like protein (Angptl) 2 in acute retinal inflammation is revealed using the endotoxin-induced uveitis (EIU) model. Angptl2−/− mice exhibit reduced EIU-associated pathophysiology, which indictes Angptl2 as a new molecular target for the treatment of acute retinal inflammation. Atsuhiro Kanda, Kousuke Noda, Yuichi Oike and Susumu Ishida 2012 92: 1553-1563; advance online publication, August 6, 2012; 10.1038/labinvest.2012.111 Abstract | Full Text Establishment and characterization of a novel cell line derived from human thymoma AB tumor Thymomas are rare epithelial tumors of the thymus gland with diverse pathology. The establishment and characterization of a novel thymoma cell line derived from a patient with type AB thymoma is described that will provide a new tool to investigate the molecular pathology of this malignancy and evaluate novel therapeutics. Yesim Gökmen-Polar, Kerry L Sanders, Chirayu P Goswami, Oscar D Cano, Narjis A Zaheer, Rohit K Jain, Kenneth A Kesler, Robert P Nelson, Jr, Gail H Vance, Danielle Smith, Lang Li, Angelo A Cardoso, Sunil Badve, Patrick J Loehrer, Sr and George W Sledge, Jr 2012 92: 1564-1573; advance online publication, August 27, 2012; 10.1038/labinvest.2012.115 Abstract | Full Text The miR-17-92 microRNA cluster: a novel diagnostic tool in large B-cell malignancies New diagnostic tools are warranted in the clinicopathological management of large B-cell lymphoid malignancies. Profiling of six members of the miR-17-92 cluster (miR-18b, miR-19b, miR-20a, miR-92, miR-93, and miR-106a) can adequately differentiate (germinal center) diffuse large B-cell lymphomas from high-grade follicular lymphomas. Ambrogio Fassina, Filippo Marino, Maayan Siri, Renato Zambello, Laura Ventura, Matteo Fassan, Francesca Simonato and Rocco Cappellesso 2012 92: 1574-1582; advance online publication, September 10, 2012; 10.1038/labinvest.2012.129 Abstract | Full Text GENITOURINARY AND REPRODUCTIVE SYSTEMS Heat shock protein 90 inhibitor attenuates renal fibrosis through degradation of transforming growth factor-β type II receptor An Hsp90 inhibitor prevents development of renal fibrosis induced by TGF-β1 via a mechanism dependent on Smurf2-mediated degradation of the TGF-β type II receptor. The data suggest that a new therapeutic strategy based on Hsp90 inhibition may prove beneficial in chronic kidney diseases. Hyunjin Noh, Hyun J Kim, Mi R Yu, Wan-Young Kim, Jin Kim, Jung H Ryu, Soon H Kwon, Jin S Jeon, Dong C Han and Fuad Ziyadeh 2012 92: 1583-1596; advance online publication, September 10, 2012; 10.1038/labinvest.2012.127 Abstract | Full Text ORAL, HEPATIC AND GASTROINTESTINAL SYSTEMS Stimulation of fat accumulation in hepatocytes by PGE2-dependent repression of hepatic lipolysis, β-oxidation and VLDL-synthesis The prevalence of non-alcoholic fatty liver disease is increasing worldwide. The role of prostanoids in the development of hepatic fat accumulation involves multiple pathways. In obese mice, PGE2-generating capacity is enhanced, which increases incorporation of glucose into hepatic triglycerides synergistically with insulin, due to a complex mechanism involving several enzymes that are all regulated by PGC1α. Janin Henkel, Katja Frede, Nancy Schanze, Heike Vogel, Annette Schürmann, Astrid Spruss, Ina Bergheim and Gerhard P Püschel 2012 92: 1597-1606; advance online publication, September 10, 2012; 10.1038/labinvest.2012.128 Abstract | Full Text Rapid re-expression of CD133 protein in colorectal cancer cell lines in vitro and in vivo This systematic study documents the impressively high plasticity of CD133 protein expression and presentation in various colorectal cancer cell lines in vitro and in vivo, and reveals that in vitro cell surface positivity neither relates to tumorigenic potential, nor does it correlate with response to treatment. Susann Peickert, Julia Waurig, Claudia Dittfeld, Antje Dietrich, Yvette Garbe, Lydia Kabus, Michael Baumann, Marian Grade, Thomas Ried and Leoni A Kunz-Schughart 2012 92: 1607-1622; advance online publication, September 10, 2012; 10.1038/labinvest.2012.124 Abstract | Full Text Blood–brain barrier permeability is positively correlated with cerebral microvascular perfusion in the early fluid percussion-injured brain of the rat Understanding the relationship between changes in cerebral microvascular perfusion and blood-brain barrier (BBB) permeability following traumatic brain injury (TBI) is essential for determining the timeframe of effective treatment. The critical turning point occurs at 4 h post-injury, and an increase BBB in permeability positively correlates with restoration of cerebral capillary perfusion over 24 h. Yong Lin, Yaohua Pan, Mingliang Wang, Xianjian Huang, Yuhua Yin, Yu Wang, Feng Jia, Wenhao Xiong, Nu Zhang and Ji-yao Jiang 2012 92: 1623-1634; advance online publication, September 10, 2012; 10.1038/labinvest.2012.118 Abstract | Full Text MODELS AND TECHNIQUES IPH-926 lobular breast cancer cells harbor a p53 mutant with temperature-sensitive functional activity and allow for profiling of p53-responsive genes A p53 E285K mutant, whose function is reconstituted by temperature shift, was discovered in IPH 926 lobular breast cancer cells. This mutation developed late in the corresponding lobular carcinoma's molecular evolution. p53-responsive genes likely involved in tumor progression could be profiled in IPH 926 because of its unique impairment in p53 function. Matthias Christgen, Monika Noskowicz, Charlotte Heil, Elisa Schipper, Henriette Christgen, Robert Geffers, Hans Kreipe and Ulrich Lehmann 2012 92: 1635-1647; advance online publication, September 3, 2012; 10.1038/labinvest.2012.126 Abstract | Full Text Early-occurring proliferation defects in peripheral tissues of the Ts65Dn mouse model of Down syndrome are associated with patched1 over expression Impairment of proliferation is seen in peripheral tissues of the Ts65Dn mouse model of Down syndrome. This mechanism of this defect is due to inhibition of the sonic hedgehog pathway due to Ptch1 overexpression. The widespread proliferation impairment in trisomic peripheral tissues may explain reduced growth and possibly other manifestations of Down syndrome. Claudia Fuchs, Elisabetta Ciani, Sandra Guidi, Stefania Trazzi and Renata Bartesaghi 2012 92: 1648-1660; advance online publication, August 13, 2012; 10.1038/labinvest.2012.117 Abstract | Full Text Corrigendum Top Multicolored stain-free histopathology with coherent Raman imaging Christian W Freudiger, Rolf Pfannl, Daniel A Orringer, Brian G Saar, Minbiao Ji, Qing Zeng, Linda Ottoboni, Wei Ying, Christian Waeber, John R Sims, Philip L De Jager, Oren Sagher, Martin A Philbert, Xiaoyin Xu, Santosh Kesari, X Sunney Xie and Geoffrey S Young 2012 92: 1661; 10.1038/labinvest.2012.139 Full Text Advertisement Recommended by the Editors of Modern Pathology:  Tumor budding in colorectal carcinoma: time to take notice   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Laboratory Investigation. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2012 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.