Nature Reviews Rheumatology - Table of Contents alert Volume 8 Issue 11

TABLE OF CONTENTS
November 2012 Volume 8 Number 11
Impact Factor 8.388 *	In this issue Research Highlights News and Views Reviews Perspectives Also this month  Web focus: Bone research
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RESEARCH HIGHLIGHTS Top Osteoarthritis: Surgical options for hip OA: digging beneath the surface of implant survival Published online: 16 October 2012 p631 | doi:10.1038/nrrheum.2012.186 PDF Therapy: Response to T-cell-dependent vaccine thwarted by TNF blockade Published online: 25 September 2012 p632 | doi:10.1038/nrrheum.2012.169 PDF Genetics: GWAS identifies STAT4 as a susceptibility locus for Behçet disease in Han Chinese people Published online: 09 October 2012 p632 | doi:10.1038/nrrheum.2012.179 PDF Bone research: Autophagy is central to joint destruction in arthritis Published online: 02 October 2012 p633 | doi:10.1038/nrrheum.2012.171 PDF Experimental arthritis: GM-CSF mediates pain and disease in a mouse model of osteoarthritis Published online: 16 October 2012 p634 | doi:10.1038/nrrheum.2012.180 PDF Crystal arthritis: Gout attack prevention with a cherry on top Published online: 16 October 2012 p634 | doi:10.1038/nrrheum.2012.187 PDF IN BRIEF Rheumatoid arthritis: GO-MONOtherapy with golimumab for RA | Rheumatoid arthritis: Safety profile of tocilizumab confirmed | Osteoarthritis: No association between mtDNA variants and osteoarthritis | Therapy: NSAID use early in pregnancy does not increase risk of congenital malformations PDF Rheumatology JOBS of the week Post-doctoral Fellow (S Nath) - Genetic epidemiology of Systemic Lupus Erythematosus (SLE) - Arthritis and Clinical Immunology Oklahoma Medical Research Foundation (OMRF) Postdoctoral Fellow University of Cincinnati Postdoctoral Associate Baylor College of Medicine More Science jobs from Rheumatology EVENT 2nd International Conference & Exhibition on Orthopedics and Rheumatology 19.-21.08.13 Las Vegas, US More science events from
NEWS AND VIEWS		Top
Osteoarthritis: Is viscosupplementation really so unsafe for knee OA? Timothy E. McAlindon & Raveendhara R. Bannuru Published online: 11 September 2012 p635 | doi:10.1038/nrrheum.2012.152 The latest in a series of meta-analyses of trials assessing viscosupplementation for knee osteoarthritis is the first to raise concerns about its safety. Questions remain, however, regarding the methodological rigour with which the serious adverse events were analyzed, and the biological plausibility of the events reported. Full Text | PDF
Immunology: Zoster vaccine and biologic agents: time to question a paradigm? Tim Bongartz & Robert Orenstein Published online: 02 October 2012 p636 | doi:10.1038/nrrheum.2012.168 Vaccination for the prevention of herpes zoster with the attenuated live vaccine is currently not recommended for patients with rheumatic diseases while they are receiving biologic agents, but new evidence calls the validity of this guidance into question. Is it time to rethink the use of the herpes zoster vaccine in these patients? Full Text | PDF
Paediatric rheumatic disease: Defining clinically inactive disease in juvenile dermatomyositis Nadia J. Luca & Brian M. Feldman Published online: 02 October 2012 p638 | doi:10.1038/nrrheum.2012.165 Achievement of a state of inactive disease has become a realistic goal in juvenile dermatomyositis. The development of a standardized definition of inactive disease in this disorder is a critical step in measuring outcomes, and might now be a step closer. Full Text | PDF
Diagnosis: Screening for arthritis in patients with psoriasis Oliver FitzGerald Published online: 16 October 2012 p640 | doi:10.1038/nrrheum.2012.177 Early diagnosis of psoriatic arthritis will prevent joint damage and improve long-term patient outcome. For dermatologists and general practitioners, early recognition of the diverse musculoskeletal manifestations can prove problematic. Screening tools and biomarkers offer great promise—the recent description and initial validation of the EARP tool is an encouraging development. Full Text | PDF
Rheumatoid arthritis: Obesity impairs efficacy of anti-TNF therapy in patients with RA Miguel A. González-Gay & Carlos González-Juanatey Published online: 25 September 2012 p641 | doi:10.1038/nrrheum.2012.158 Insulin resistance is closely associated with an increased risk of subclinical atherosclerosis in patients with rheumatoid arthritis (RA). Anti-TNF therapy reduces insulin resistance and improves insulin sensitivity in patients with severe RA. New findings have shown, however, that the efficacy of these agents in this regard is impaired by obesity. Full Text | PDF
Imaging: Use of MRI as an outcome measure in clinical trials in RA Annette H. M. van der Helm-van Mil Published online: 16 October 2012 p643 | doi:10.1038/nrrheum.2012.182 Following a decade of substantial improvements in sensitivity and usability, MRI is increasingly used to assess primary outcomes of therapeutic trials in rheumatoid arthritis (RA). In the wake of an MRI-based evaluation of treatment efficacy, what lessons are emerging about the clinical value of this technique for patients with RA? Full Text | PDF
Focus on: Bone research REVIEWS Top The multiple facets of glucocorticoid action in rheumatoid arthritis Ulrike Baschant, Nancy E. Lane & Jan Tuckermann Published online: 09 October 2012 p645 | doi:10.1038/nrrheum.2012.166 Despite their association with loss of bone mass and increased fracture risk, glucocorticoids have been an important component of rheumatoid arthritis therapy for more than 60 years. In this article, Ulrike Baschant and colleagues describe the tissue-specific, molecular and cellular mechanisms of glucocorticoid action, and suggest new criteria for selective glucocorticoid receptor agonists, which could have similar anti-inflammatory efficacy to traditional glucocorticoids without the adverse effects. Abstract | Full Text | PDF Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment Georg Schett & Ellen Gravallese Published online: 25 September 2012 p656 | doi:10.1038/nrrheum.2012.153 In this Review, the authors summarize the substantial progress that has been made in understanding the pathophysiology of bone erosions and discuss the improvements in the diagnosis, monitoring and treatment of such lesions. Abstract | Full Text | PDF Bone remodelling in osteoarthritis David B. Burr & Maxime A. Gallant Published online: 07 August 2012 p665 | doi:10.1038/nrrheum.2012.130 Subchondral bone remodelling in osteoarthritis (OA) is biphasic and spatially variable. Early-stage disease is associated with bone loss owing to increased bone remodelling. As disease progresses, the remodelling rate slows down leading to densification of the subchondral plate and complete loss of cartilage. In this article, Burr and Gallant review the current knowledge on OA and discuss the role of subchondral bone in the initiation and progression of disease. They also present a hypothetical model of OA pathogenesis. Abstract | Full Text | PDF The skeleton as an endocrine organ Douglas J. DiGirolamo, Thomas L. Clemens & Stavroula Kousteni Published online: 09 October 2012 p674 | doi:10.1038/nrrheum.2012.157 Increasing evidence points towards the skeleton as having an endocrine role in humans. In this Review, DiGirolamo and colleagues introduce the concept of the skeleton as an endocrine organ, summarizing the evolution of skeletal endocrine networks and the role of the skeleton in phosphate and glucose homeostasis. Abstract | Full Text | PDF
Focus on: Bone research PERSPECTIVES Top OPINION New developments in osteoimmunology Hiroshi Takayanagi Published online: 16 October 2012 p684 | doi:10.1038/nrrheum.2012.167 Crosstalk between the skeletal and immune systems—especially immunomodulation of bone turnover, but increasingly also regulation of immune functions by bone cells—was recognized during research into arthritis and has evolved into the discipline of osteoimmunology. Hiroshi Takayanagi presents an update of advances in this area, focusing on the influences of T cells on bone remodelling, and relationships between osteoblasts and haematopoiesis. Abstract | Full Text | PDF | Supplementary information
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*Journal Citation Reports, Thomson, 2011. Nature Reviews Rheumatology was previously published as Nature Clinical Practice Rheumatology.

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