Nature Reviews Urology - Table of Contents alert Volume 9 Issue 11

TABLE OF CONTENTS
November 2012 Volume 9 Number 11
Impact Factor 4.415*	In this issue Research Highlights News and Views Reviews Also this month  Featured article: Neurotrophins as regulators of urinary bladder function Peter Ochodnicky, Célia D. Cruz, Naoki Yoshimura & Francisco Cruz
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Take a look at this review that recently published in Mucosal Immunology:  Coming of age: reconstruction of heterosexual HIV-1 transmission in human ex vivo organ culture systems P J Southern et al examine heterosexual transmission of human immunodeficiency virus-1. Expanding from the current foundations, they believe that human organ cultures will become increasingly prominent in experimental studies of HIV-1 transmission and continuing efforts to prevent HIV-1 infection at human mucosal surfaces.
RESEARCH HIGHLIGHTS Top Prostate cancer: Following the ethanol TRAIL to prostate cancer destruction Published online: 09 October 2012 p603 | doi:10.1038/nrurol.2012.187 PDF Prostate cancer: Is aspirin a wonder drug in prostate cancer? Published online: 18 September 2012 p604 | doi:10.1038/nrurol.2012.180 PDF Male factor infertility: Testis explantation for spermatogenic failure Published online: 02 October 2012 p604 | doi:10.1038/nrurol.2012.186 PDF Genetics: Schlafen 11 naturally blocks HIV Published online: 09 October 2012 p605 | doi:10.1038/nrurol.2012.188 PDF Male factor infertility: Asymptomatic testicular microlithiasis does not increase antisperm antibody production in infertile men Published online: 18 September 2012 p606 | doi:10.1038/nrurol.2012.179 PDF Prostate cancer: Quality of life factors predict satisfaction with care Published online: 18 September 2012 p606 | doi:10.1038/nrurol.2012.181 PDF Urology JOBS of the week Postdoctoral Fellow Institute of Experimental Medicine - Hungarian Academy of Sciences Postdoctoral Fellow University of Cincinnati More Science jobs from Urology EVENT 2nd International Conference on Gastroenterology & Urology 10.-17.06.13 Chicago, US More science events from
NEWS AND VIEWS		Top
Stones: Do urinary calculi increase risk of bladder pain syndrome? John W. Warren Published online: 09 October 2012 p607 | doi:10.1038/nrurol.2012.184 A Taiwanese study has established an association between bladder pain syndrome (BPS) and prior diagnosis of urinary stones. The study authors suggest that stones initiate a process that results in BPS. An alternative hypothesis is that patients with BPS are more likely to undergo imaging, revealing incidental stones. Full Text | PDF
REVIEWS		Top
Analysing the sperm epigenome: roles in early embryogenesis and assisted reproduction Undraga Schagdarsurengin, Agnieszka Paradowska & Klaus Steger Published online: 09 October 2012 p609 | doi:10.1038/nrurol.2012.183 Aberrant epigenetic mechanisms have been implicated in impaired spermatogenesis, abnormal semen parameters and idiopathic male fertility. This Review covers the unique features of sperm chromatin, the methods used to analyse epigenetics in sperm and the possible roles of the sperm epigenome in early embryo development and assisted reproduction. Abstract | Full Text | PDF
Gender dysphoria associated with disorders of sex development Paulo Sampaio Furtado, Felipe Moraes, Renata Lago, Luciana Oliveira Barros, Maria Betânia Toralles & Ubirajara Barroso Jr Published online: 09 October 2012 p620 | doi:10.1038/nrurol.2012.182 In this Review, Furtado and colleagues evaluate the different treatment approaches available to patients with gender dysphoria secondary to congenital adrenal hyperplasia and other disorders of sex development. Abstract | Full Text | PDF
Neurotrophins as regulators of urinary bladder function Peter Ochodnicky, Célia D. Cruz, Naoki Yoshimura & Francisco Cruz Published online: 09 October 2012 p628 | doi:10.1038/nrurol.2012.178 In this Review, Ochodnicky and colleagues discuss the clinical and experimental evidence that supports a role for neurotrophins in the neural control of bladder function and in the emergence of lower urinary tract symptoms related to overactive bladder (OAB) and bladder pain syndrome/interstitial cystitis. They also consider the potential utility of neurotrophins as urinary biomarkers for improving the accuracy of OAB diagnosis and monitoring therapy efficacy, and review proof-of-principle clinical evidence that confirms nerve growth factor as a potential target in the treatment of bladder disorders. Abstract | Full Text | PDF
Treatment options for intrinsic sphincter deficiency Sovrin M. Shah & Geoffrey S. Gaunay Published online: 02 October 2012 p638 | doi:10.1038/nrurol.2012.177 A consensus definition for urinary intrinsic sphincter deficiency (ISD) is lacking. As a result, studies evaluating the success of any treatment for ISD are difficult to interpret. In this Review, Shah and Gaunay examine surgical and nonsurgical treatments, and the outcomes, for type III stress urinary incontinence caused by ISD. Abstract | Full Text | PDF
The complexity of prostate cancer: genomic alterations and heterogeneity Lara K. Boyd, Xueying Mao & Yong-Jie Lu p652 | doi:10.1038/nrurol.2012.185 In this Review, Boyd and colleagues provide a comprehensive overview of the complex genetic landscape of prostate cancer and the extensive heterogeneity that defines this disease. In addition, they discuss the clinical utility of genomics data. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2011. Nature Reviews Urology was previously published as Nature Clinical Practice Urology.

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