Nature Reviews Rheumatology - Table of Contents alert Volume 8 Issue 12

TABLE OF CONTENTS
December 2012 Volume 8 Number 12
Impact Factor 8.388 *	In this issue Research Highlights News and Views Reviews Perspectives Correspondence Also this month  Featured article: MicroRNAs—novel regulators of systemic lupus erythematosus pathogenesis Nan Shen, Dong Liang, YuanJia Tang, Niek de Vries & Paul-Peter Tak
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RESEARCH HIGHLIGHTS Top Pathology: Autophagy defect traps mutant TNF receptor in TRAPS Published online: 20 November 2012 p691 | doi:10.1038/nrrheum.2012.207 PDF Connective tissue diseases: NET loss implicates Nox2 in SLE Published online: 13 November 2012 p692 | doi:10.1038/nrrheum.2012.201 PDF Paediatric rheumatology: RCT of adalimumab supports anti-TNF therapy for juvenile-onset ankylosing spondylitis Published online: 13 November 2012 p693 | doi:10.1038/nrrheum.2012.202 PDF Osteoarthritis: Evaluating strontium ranelate treatment for knee OA Published online: 20 November 2012 p693 | doi:10.1038/nrrheum.2012.206 PDF Rheumatoid arthritis: Genetic variants in DKK1 linked to severity of joint damage in RA Published online: 23 October 2012 p694 | doi:10.1038/nrrheum.2012.189 PDF Bone: Bare bones of glucocorticoid effects on metabolism Published online: 13 November 2012 p694 | doi:10.1038/nrrheum.2012.203 PDF IN BRIEF Rheumatoid arthritis: Methotrexate therapy confers survival advantage | Inflammation: Rilonacept for familial Mediterranean fever? | Spondyloarthritis: Arterial stiffness unchanged by anti-TNF therapy | Therapy: Rapid infusion of rituximab seems to be safe and well-tolerated PDF Rheumatology JOBS of the week PostDoc in Bioinformatics, Rheumatology Research Group Rheumatology Research Group Chief of the Division of Rheumatology University of California at Los Angeles Chief of the Division of Rheumatology University of California, Los Angeles (UCLA) Chief of the Division of Rheumatology at the David Geffen School of Medicine at UCLA University of California, Los Angeles (UCLA) More Science jobs from Rheumatology EVENT 2nd International Conference & Exhibition on Orthopedics and Rheumatology 19.-21.08.13 Las Vegas, US More science events from
NEWS AND VIEWS		Top
Connective tissue diseases: SLE-associated arthropathy: truly a benign entity? Grainne Murphy & David A. Isenberg Published online: 13 November 2012 p695 | doi:10.1038/nrrheum.2012.200 Arthropathy is a common manifestation of systemic lupus erythematosus (SLE), but remains poorly understood. Recent ultrasonographic evidence demonstrating high levels of joint and tendon pathology in SLE challenges our previous concepts of arthritis subtypes in this multisystem disease. Full Text | PDF
Lupus nephritis: Transatlantic management recommendations compared Falk Hiepe Published online: 13 November 2012 p697 | doi:10.1038/nrrheum.2012.192 In the wake of publication of clinical data for new drugs in the management of lupus nephritis, European rheumatology and renal societies have issued new recommendations for management of this condition. Coming hot on the heels of American guidelines, how does this latest advice compare? Full Text | PDF
Spondyloarthritis: A conundrum: classifying patients with SpA in daily practice Filip Van den Bosch & Dirk Elewaut Published online: 20 November 2012 p699 | doi:10.1038/nrrheum.2012.204 The emphasis placed on HLA-B27 positivity in classification criteria for axial spondyloarthritis has generated some concern over potential misclassification of patients with chronic back pain. The results of a recent study suggest that these worries could have some foundation, at least in regions with high HLA-B27 prevalence. Full Text | PDF
REVIEWS		Top
MicroRNAs—novel regulators of systemic lupus erythematosus pathogenesis Nan Shen, Dong Liang, Yuanjia Tang, Niek de Vries & Paul-Peter Tak Published online: 16 October 2012 p701 | doi:10.1038/nrrheum.2012.142 Aberrant expression of microRNAs is associated with the pathogenesis of systemic lupus erythematosus (SLE). In this Review, Shen and colleagues discuss the potential of microRNAs to act as biomarkers for the diagnosis and assessment of patients with SLE, as well as the future therapeutic potential of targeting miRNAs in the management of patients with SLE. Abstract | Full Text | PDF | Supplementary information
Management of pregnancy in systemic lupus erythematosus Aisha Lateef & Michelle Petri Published online: 21 August 2012 p710 | doi:10.1038/nrrheum.2012.133 Pregnancy in women with systemic lupus erythematosus (SLE) is increasingly common, as patients' survival and quality of life improve. However, these pregnancies are associated with substantially higher risk of maternal and fetal morbidity and mortality than those in healthy women. Especially in the presence of anti-Ro, anti-La and antiphospholipid antibodies, increased fetal loss, premature births and neonatal syndromes including congenital heart block are major issues. Although success rates of pregnancies have increased considerably, pregnancy management in women with SLE is not optimal. This Review discusses the risk factors and outcomes and proposes a pregnancy planning strategy for women with SLE. Abstract | Full Text | PDF
Emerging optical and nuclear medicine imaging methods in rheumatoid arthritis James M. Mountz, Abass Alavi & John D. Mountz Published online: 25 September 2012 p719 | doi:10.1038/nrrheum.2012.148 Noninvasive biomolecular imaging techniques, such as thermography, near-infrared imaging, PET and single photon emission CT (SPECT), can be used to detect the earliest biological and physiological changes that are associated with rheumatoid arthritis (RA). The authors describe these new imaging approaches, which could enable targeted intervention in early RA before the occurrence of irreversible joint damage. Abstract | Full Text | PDF
Metabolic syndrome meets osteoarthritis Qi Zhuo, Wei Yang, Jiying Chen & Yan Wang Published online: 21 August 2012 p729 | doi:10.1038/nrrheum.2012.135 Metabolic osteoarthritis (OA) is increasingly recognized as a subtype of OA, and its aetiology has much in common with that of metabolic syndrome (MetS). Indeed, as the authors explain in this Review, mounting evidence suggests that metabolic OA could be considered as the fifth component of MetS. The prospects for treating OA by tackling underlying metabolic disease are also discussed. Abstract | Full Text | PDF
Coagulation and the fibrin network in rheumatic disease: a role beyond haemostasis Berthold Hoppe & Thomas Dörner Published online: 13 November 2012 p738 | doi:10.1038/nrrheum.2012.184 The association between coagulation and the immune system has been increasingly recognised to have a role in the development of inflammatory rheumatic diseases. The fact that the risk of venous thromboembolism is increased in patients with rheumatoid arthritis (RA) and citrullinated fibrinogen is an early autoantigen in RA indicates an adaptive immune response to coagulation factors in inflammatory rheumatic diseases. In this article, Hoppe and Dorner describes the pathophysiology of an induced procoagulatory state in inflammatory rheumatic diseases, discussing the roles of endothelial cell and platelet activation, and coagulation and fibrinolytic systems, and providing insights into future research for innovative therapeutic interventions. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Long-term effects of sport: preventing and managing OA in the athlete Kim Bennell, David J. Hunter & Bill Vicenzino Published online: 31 July 2012 p747 | doi:10.1038/nrrheum.2012.119 Alongside great sporting achievements, unfortunately, are inadvertent unwanted effects, as intense physical training in elite athletes can lead to long-term musculoskeletal issues. Here, Bennell and colleagues provide insights into the long-term consequences of sporting activity on the joint, in particular osteoarthritis, and describe how best to prevent and manage this damage in athletes. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Punctal occlusion in Sjögren's syndrome needs clarification Eduardo M. Rocha, Jayter S. Paula & Peter S. Reinach Published online: 23 October 2012 p752 | doi:10.1038/nrrheum.2012.53-c1 Full Text | PDF
REPLY		Top
Punctal occlusion in Sjögren's syndrome needs clarification Manuel Ramos-Casals, P. Brito-Zerón, A. Sisó-Almirall, X. Bosch & Athanasios G. Tzioufas Published online: 23 October 2012 p752 | doi:10.1038/nrrheum.2012.53-c2 Full Text | PDF
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*Journal Citation Reports, Thomson, 2011. Nature Reviews Rheumatology was previously published as Nature Clinical Practice Rheumatology.

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