The EMBO Journal - Table of Contents alert Volume 32 Issue 5

TABLE OF CONTENTS 06 March 2013 | Volume 32, Issue 5 Have you seen? Review Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement The EMBO Journal Editor's choice: RNA Biology FUS participates in microRNA biogenesis M Morlando, Bozzoni and colleagues LncRNA gadd7 regulation of Cdk6 Liu, Zhan and colleagues Wig1 recruits RISC to p21 mRNA Kim, Lee and colleagues   Have you seen? Top Emerging lymphae for the fountain of life Different mechanisms have been proposed for early lymphatic development. Using advanced ultramicroscopy techniques, Kiefer and colleagues now witness the appearance of the earliest lymphatic structures in the mouse embryo and document how they connect to the venous system. Serena Marchiò, Elena Astanina and Federico Bussolino The EMBO Journal (2013), 32, 609 - 611; 10.1038/emboj.2013.13 Abstract | Full text | PDF | Related article Published online: 29 January 2013 A sweet TET-à-tête-synergy of TET proteins and O-GlcNAc transferase in transcription The identification of Tet-proteins as binding partners for O-GlcNAc transferase (OGT) establishes their unexpected role for the assembly of OGT-containing chromatin complexes. Daniel Mariappa, Shalini Pathak and Daan M F van Aalten The EMBO Journal (2013), 32, 612 - 613; 10.1038/emboj.2013.26 Abstract | Full text | PDF | Related article Published online: 12 February 2013 Chromosome segregation: how to open cohesin without cutting the ring? Recent studies show that distinct, reversible entry and exit gates are conserved in yeast, fly and mammalian cohesin complexes. Yasuto Murayama and Frank Uhlmann The EMBO Journal (2013), 32, 614 - 616; 10.1038/emboj.2013.22 Abstract | Full text | PDF | Related article | Related article | Related article Published online: 08 February 2013 Review Top A new genome-driven integrated classification of breast cancer and its implications This review highlights significant advances in the classification of breast cancer that integrate genomic and transcriptomic signatures and might thus enable personalised therapeutic management. Sarah-Jane Dawson, Oscar M Rueda, Samuel Aparicio and Carlos Caldas The EMBO Journal (2013), 32, 617 - 628; 10.1038/emboj.2013.19 Abstract | Full text | PDF Published online: 08 February 2013 Subject Categories: Molecular Biology of Disease | Genomic and Computational Biology Articles Top A novel multistep mechanism for initial lymphangiogenesis in mouse embryos based on ultramicroscopy  EMBO Open Ultramicroscopy of wholemount mouse embryos uncovers the first, previously unknown lymphatic structures in mammals: the dorsal longitudinal lymphatic vessel and the ventral primordial thoracic duct, which eventually connect with the cardinal vein as previously described. René Hägerling, Cathrin Pollmann, Martin Andreas, Christian Schmidt, Harri Nurmi, Ralf H Adams, Kari Alitalo, Volker Andresen, Stefan Schulte-Merker and Friedemann Kiefer The EMBO Journal (2013), 32, 629 - 644; 10.1038/emboj.2012.340 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 08 January 2013 Subject Categories: Development TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS  EMBO Open This paper identifies the N-acetylglucosamine transferase OGT as binding partner for TET2/3 proteins. Their genome-wide chromatin binding and the characterization of the Set1/COMPASS complex as OGT target implies coordinated gene regulation. Rachel Deplus, Benjamin Delatte, Marie K Schwinn, Matthieu Defrance, Jacqui Méndez, Nancy Murphy, Mark A Dawson, Michael Volkmar, Pascale Putmans, Emilie Calonne, Alan H Shih, Ross L Levine, Olivier Bernard, Thomas Mercher, Eric Solary, Marjeta Urh, Danette L Daniels and François Fuks The EMBO Journal (2013), 32, 645 - 655; 10.1038/emboj.2012.357 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 25 January 2013 Subject Categories: Signal Transduction | Chromatin and Transcription Disengaging the Smc3/kleisin interface releases cohesin from Drosophila chromosomes during interphase and mitosis A distinct ring exit gate, recently identified in yeast cohesin, is conserved in flies and relevant for the non-proteolytic prophase cohesin release during metazoan cell division. Christian S Eichinger, Alexander Kurze, Raquel A Oliveira and Kim Nasmyth The EMBO Journal (2013), 32, 656 - 665; 10.1038/emboj.2012.346 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 22 January 2013 Subject Categories: Cell Cycle Prophase pathway-dependent removal of cohesin from human chromosomes requires opening of the Smc3–Scc1 gate Distinct entry and exit gates are conserved in mammalian cohesin rings and involved in non-proteolytic cohesin unloading from chromosome arms. Johannes Buheitel and Olaf Stemmann The EMBO Journal (2013), 32, 666 - 676; 10.1038/emboj.2013.7 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 29 January 2013 Subject Categories: Cell Cycle Structural insights into the regulation of cohesion establishment by Wpl1  EMBO Open The conserved Wapl domain provides the first crystal structure of an associated regulator of the cohesin complex, and new insights into its interaction with cohesin core subunits. Avradip Chatterjee, Silva Zakian, Xiao-Wen Hu and Martin R Singleton The EMBO Journal (2013), 32, 677 - 687; 10.1038/emboj.2013.16 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 08 February 2013 Subject Categories: Cell Cycle | Structural Biology hCAF1/CNOT7 regulates interferon signalling by targeting STAT1 In response to interferon, latent cytoplasmic STAT1 sequestered by the deadenylase hCAF1/CNOT7 is released, leading to activation of STAT1 target genes. hCAF1 also accelerates the decay of STAT1-regulated mRNAs and hCAF1 knockdown cells are resistant to viral infection. Clément Chapat, Chloé Kolytcheff, Muriel Le Romancer, Didier Auboeuf, Pierre De La Grange, Kamel Chettab, Stéphanie Sentis and Laura Corbo The EMBO Journal (2013), 32, 688 - 700; 10.1038/emboj.2013.11 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 05 February 2013 Subject Categories: Signal Transduction | RNA | Immunology Pseudomonas HopU1 modulates plant immune receptor levels by blocking the interaction of their mRNAs with GRP7 The Pseudomonas virulence factor HopU1 mono-ADP-ribosylates the plant RNA-binding protein GRP7 protein to inhibit its binding to immune receptor mRNAs, leading to the suppression of receptor protein synthesis and hence host immunity. Valerie Nicaise, Anna Joe, Byeong-ryool Jeong, Christin Korneli, Freddy Boutrot, Isa Westedt, Dorothee Staiger, James R Alfano and Cyril Zipfel The EMBO Journal (2013), 32, 701 - 712; 10.1038/emboj.2013.15 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 08 February 2013 Subject Categories: Plant Biology | Microbiology and Pathogens Rac and Rab GTPases dual effector Nischarin regulates vesicle maturation to facilitate survival of intracellular bacteria The intracellular survival of Salmonella requires that the vacuoles containing the pathogen are acidified. Vacuolar maturation and acidification is mediated by Nischarin, a cellular effector of the small GTPases Rac1, Rab14 and Rab9 involved in endosomal trafficking. Coenraad Kuijl, Manohar Pilli, Suresh K Alahari, Hans Janssen, Poh-Sim Khoo, Karen E Ervin, Monica Calero, Sobhanaditya Jonnalagadda, Richard H Scheller, Jacques Neefjes and Jagath R Junutula The EMBO Journal (2013), 32, 713 - 727; 10.1038/emboj.2013.10 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 05 February 2013 Subject Categories: Membranes and Transport | Microbiology and Pathogens Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels  EMBO Open The high-resolution crystal structure of a pentameric ligand-gated ion channel reveals that hydroxylated residues and two water pentagon rings form an ion selectivity filter, explaining ion transport across hydrophobic constriction barriers. Ludovic Sauguet, Frédéric Poitevin, Samuel Murail, Catherine Van Renterghem, Gustavo Moraga-Cid, Laurie Malherbe, Andrew W Thompson, Patrice Koehl, Pierre-Jean Corringer, Marc Baaden and Marc Delarue The EMBO Journal (2013), 32, 728 - 741; 10.1038/emboj.2013.17 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 February 2013 Subject Categories: Membranes and Transport Srs2 mediates PCNA-SUMO-dependent inhibition of DNA repair synthesis  EMBO Open An unexpected non-catalytic function of the recombination-attenuating helicase Srs2 further expands the manifold roles of PCNA modifications in ensuring genome stability. Peter Burkovics, Marek Sebesta, Alexandra Sisakova, Nicolas Plault, Valeria Szukacsov, Thomas Robert, Lajos Pinter, Victoria Marini, Peter Kolesar, Lajos Haracska, Serge Gangloff and Lumir Krejci The EMBO Journal (2013), 32, 742 - 755; 10.1038/emboj.2013.9 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 08 February 2013 Subject Categories: Genome Stability and Dynamics Post-translational changes to PrP alter transmissible spongiform encephalopathy strain properties N-linked glycosylation of the endogenous and wild-type prion protein, PrP, alters the infectious properties of prion strains in mice. Enrico Cancellotti, Sukhvir P Mahal, Robert Somerville, Abigail Diack, Deborah Brown, Pedro Piccardo, Charles Weissmann and Jean C Manson The EMBO Journal (2013), 32, 756 - 769; 10.1038/emboj.2013.6 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 08 February 2013 Subject Categories: Proteins | Neuroscience Advertisement Follow EMBO on Facebook for as-it-happens access to news, comments and articles and make it a place to share information with others interested in the field. https://www.facebook.com/EMBO.excellence.in.life.sciences   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. 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