Molecular Systems Biology - New articles published 16 April 2013

Latest Articles 16th April 2013   Featured Article Research Articles   Web feeds About Open access Advertisement Molecular Systems Biology has a fair and transparent process to rapidly publish your best science. Transparent - No confidential referee remarks - Published referee reports - Detailed decisions Fair - Scooping protection - Pre-decision cross-referee commenting - Fixed bar for revisions - Fast process Submit your paper today!   Featured Article Dissecting specific and global transcriptional regulation of bacterial gene expression An experimental-computational approach is applied to dissect the contribution of specific transcription factor-mediated versus global growth-dependent regulation to bacterial gene expression, and obtain a quantitative understanding of dynamic adaptations in arginine biosynthesis of E. coli. Luca Gerosa, Karl Kochanowski, Matthias Heinemann & Uwe Sauer Molecular Systems Biology 9:658; doi:10.1038/msb.2013.14; published 16 April 2013 Full Text | PDF | Supp. Inf. | Review Process Research Articles Increasing population growth by asymmetric segregation of a limiting resource during cell division When stressed by metal depletion, budding yeast adopt an asymmetric division pattern whereby vacuoles are maintained within dividing mother cells while the vacuoles-deprived daughter cells arrest division. This linear growth mode represents a bet-hedging strategy beneficial at the population level. Nurit Avraham, Ilya Soifer, Miri Carmi & Naama Barkai Molecular Systems Biology 9:656; doi:10.1038/msb.2013.13; published 16 April 2013 Full Text | PDF | Supp. Inf. | Review Process Apoptosis and other immune biomarkers predict influenza vaccine responsiveness A systems analysis of immune biomarkers in 89 young and older adults revealed age-dependent and age-independent features, including markers of apoptosis that correlated with antibody responses to a seasonal influenza vaccine. David Furman, Vladimir Jojic, Brian Kidd, Shai Shen-Orr, Jordan Price, Justin Jarrell, Tiffany Tse, Huang Huang, Peder Lund, Holden T Maecker, Paul J Utz, Cornelia L Dekker, Daphne Koller & Mark M Davis Molecular Systems Biology 9:659; doi:10.1038/msb.2013.15; published 16 April 2013 Full Text | PDF | Supp. Inf. | Review Process Indirect and suboptimal control of gene expression is widespread in bacteria This study shows that, in bacteria grown in the laboratory, there is little correlation between when genes are important for fitness and when they are more highly expressed. Most genes thus appear to be regulated by signals that are not related to their function. Morgan N Price, Adam M Deutschbauer, Jeffrey M Skerker, Kelly M Wetmore, Troy Ruths, Jordan S Mar, Jennifer V Kuehl, Wenjun Shao & Adam P Arkin Molecular Systems Biology 9:660; doi:10.1038/msb.2013.16; published 16 April 2013 Full Text | PDF | Supp. Inf. | Review Process Global remodelling of cellular microenvironment due to loss of collagen VII Loss of collagen VII causes recessive dystrophic epidermolysis bullosa. Quantitative proteomics analysis of the extracellular matrix and secretome of human fibroblasts derived from pathologically altered skin reveals a global remodelling of the cellular microenvironment. Victoria Küttner, Claudia Mack, Kristoffer TG Rigbolt, Johannes S Kern, Oliver Schilling, Hauke Busch, Leena Bruckner-Tuderman & Jörn Dengjel Molecular Systems Biology 9:657; doi:10.1038/msb.2013.17; published 16 April 2013 Full Text | PDF | Supp. Inf. | Review Process

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