Nature Immunology Contents: May 2013 Volume 14 pp 415 - 522

Advertisement Find out what your cytometer can do for you. You've got the green light to trade in your existing cytometer - regardless of make or model - for more value, discounts, upgrades, and capabilities from BD Biosciences. For a limited time, you can take advantage of exceptional packages with our special trade-in, trade-up program. Learn more today. bdbiosciences.com/go/greenlight TABLE OF CONTENTS May 2013 Volume 14, Issue 5 Editorial Commentary News and Views Research Highlights Review Articles Advertisement The BD FACSJazz™ Cell Sorter with Yellow-Green Laser For perfectly tuned cell sorting using PE and FITC dyes, the BD FACSJazz is now available with yellow-green laser configurations. Built on a proven, dependable platform, it may change the way you'll think of cell sorting, with ease of operation, affordability, and a benchtop fit. bdbiosciences.com/jazz Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement NPG and Frontiers form alliance to further open science Frontiers is at the forefront of building the ultimate Open Science platform and is driving innovations around peer-review, article and author impact metrics and social networking for researchers. NPG and Frontiers will work together to empower researchers to change the way science is communicated. Find out more here   Editorial Top Raising standards   p415 doi:10.1038/ni.2603 Nature journals' updated editorial policies aim to improve transparency and reproducibility Commentary Top The scientist center stage   pp416 - 418 Alex Mermikides doi:10.1038/ni.2592 News and Views Top IL-17-producing B cells combat parasites   pp419 - 421 Beatriz León and Frances E Lund doi:10.1038/ni.2593 Interleukin 17 (IL-17) confers protection against Trypanosoma cruzi. Surprisingly, B cells are the relevant source, producing IL-17 via a unique pathway independent of the transcription factor RORγt, induced by T. cruzi trans-sialidase. See also: Article by Bermejo et al. When metabolism met immunology   pp421 - 422 Marc Y Donath doi:10.1038/ni.2591 Obesity induces metabolic stress and is associated with inflammation. A cellular pathway now links SIRT2, a deacetylase involved in metabolic processes, to cytoskeleton remodelling and activation of the NLRP3 inflammasome. See also: Article by Misawa et al. Slc7a5 helps T cells get with the program   pp422 - 424 Jonathan D Powell doi:10.1038/ni.2594 T cell activation requires an influx of amino acids. Slc7a5, an amino-acid transporter induced by the T cell antigen receptor, facilitates the influx of large neutral amino acids and in doing so promotes metabolic reprogramming necessary for T cell differentiation. See also: Article by Sinclair et al. Immune response: steroids drive dendritic cells   pp424 - 426 David Jarrossay and Marcus Thelen doi:10.1038/ni.2589 The newly identified steroid ligand of the receptor EBI2 (GPCR183), 7α,25-dihydroxycholesterol, is required for the positioning of splenic CD4+ dendritic cells in bridging channels to prime T cells for an efficient antibody response. See also: Article by Gatto et al. Immunology JOBS of the week Postdoctoral Fellow, Cancer Immunology Dana-Farber Cancer Institute / Harvard Medical School Postdoctoral Research in the Immunology of Type 2 Diabetes University Health Network / University of Toronto Bioinformatics of HIV immune response Columbia University - Department of Biochemistry and Molecular Biophysics PhD studentship in the Role of epigenetic regulators in control of immunity and inflammation King’s College London Physician / Scientist in Tumor Immunotherapy Stanford University School of Medicine More Science jobs from Immunology EVENT Immunometabolism: from mechanisms to therapy 9th June - 11th June 2013 Toronto, Canada More science events from Research Highlights Top Putting a block on Foxp3 | HIV turns off the TCR | RLR phosphorylation | Trib1, M2s and the adipose tissue | Dueling interferons | Pu.1 in HSCs Review Top Understanding immunosenescence to improve responses to vaccines   pp428 - 436 Jörg J Goronzy and Cornelia M Weyand doi:10.1038/ni.2588 Articles Top Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment   pp437 - 445 Britta Will, Thomas O Vogler, Boris Bartholdy, Francine Garrett-Bakelman, Jillian Mayer, Laura Barreyro, Ashley Pandolfi, Tihomira I Todorova, Ujunwa C Okoye-Okafor, Robert F Stanley, Tushar D Bhagat, Amit Verma, Maria E Figueroa, Ari Melnick, Michael Roth and Ulrich Steidl doi:10.1038/ni.2572 How hematopoietic stem cells coordinate self-renewal and differentiation remains unclear. Steidl and colleagues show that the transcription factor and chromatin remodeler Satb1 is required for their self-renewal. The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells   pp446 - 453 Dominique Gatto, Katherine Wood, Irina Caminschi, Danielle Murphy-Durland, Peter Schofield, Daniel Christ, Gunasegaran Karupiah and Robert Brink doi:10.1038/ni.2555 Precise lymphoid tissue architecture is needed to generate adaptive immune responses. Brink and colleagues show that CD4+ DCs express the chemotactic receptor EBI2, which is required for their splenic positioning and capture of particulate blood-borne antigens. See also: News and Views by Jarrossay & Thelen Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome   pp454 - 460 Takuma Misawa, Michihiro Takahama, Tatsuya Kozaki, Hanna Lee, Jian Zou, Tatsuya Saitoh and Shizuo Akira doi:10.1038/ni.2550 Much is known about the activation of the NLRP3 inflammasome; however, the control of its physical assembly is less well understood. Akira and colleagues demonstrate that acetylated tubulin drives assembly of the inflammasome at mitochondria. See also: News and Views by Donath Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ   pp461 - 469 Hanh Chi Do-Umehara, Cong Chen, Daniela Urich, Liang Zhou, Ju Qiu, Samuel Jang, Alia Zander, Margaret A Baker, Martin Eilers, Peter H S Sporn, Karen M Ridge, Jacob I Sznajder, G R Scott Budinger, Gökhan M Mutlu, Anning Lin and Jing Liu doi:10.1038/ni.2566 Unchecked inflammation can lead to tissue damage. Liu and colleagues show that the transcription factor Miz1 recruits the histone deacetylase HDAC1 to restore repression of Cebpd transcription, which is necessary for the termination of LPS-induced inflammatory responses. A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation   pp470 - 479 Bill B Chen, Tiffany A Coon, Jennifer R Glasser, Bryan J McVerry, Jing Zhao, Yutong Zhao, Chunbin Zou, Bryon Ellis, Frank C Sciurba, Yingze Zhang and Rama K Mallampalli doi:10.1038/ni.2565 Inflammation needs to be tightly regulated to avoid immunopathology. Mallampalli and colleagues show that a system of F box proteins tunes proinflammatory signaling by degrading TRAF adaptor proteins. Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection   pp480 - 488 Christopher Lupfer, Paul G Thomas, Paras K Anand, Peter Vogel, Sandra Milasta, Jennifer Martinez, Gonghua Huang, Maggie Green, Mondira Kundu, Hongbo Chi, Ramnik J Xavier, Douglas R Green, Mohamed Lamkanfi, Charles A Dinarello, Peter C Doherty and Thirumala-Devi Kanneganti doi:10.1038/ni.2563 Autophagocytic disposal of mitochondria (mitophagy) is important for regulating inflammation. Kanneganti and colleagues show that RIP2 kinase-initiated mitophagy is critical for dampening virally triggered immunopathology. Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity   pp489 - 499 Yoko Kidani, Heidi Elsaesser, M Benjamin Hock, Laurent Vergnes, Kevin J Williams, Joseph P Argus, Beth N Marbois, Evangelia Komisopoulou, Elizabeth B Wilson, Timothy F Osborne, Thomas G Graeber, Karen Reue, David G Brooks and Steven J Bensinger doi:10.1038/ni.2570 T cell division is an intense metabolic process, and meeting its demands requires extensive metabolic reprogramming of the cell. Bensinger and colleagues demonstrate that SREBPs are critical for this reprogramming. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation   pp500 - 508 Linda V Sinclair, Julia Rolf, Elizabeth Emslie, Yun-Bo Shi, Peter M Taylor and Doreen A Cantrell doi:10.1038/ni.2556 T cell activation triggers proliferation and effector-cell differentiation. Cantrell and colleagues show that TCR signaling induces upregulation of amino-acid transporters necessary for metabolic reprogramming via the kinase complex mTORC1 and transcription factor c-Myc. See also: News and Views by Powell Sensing and alarm function of resident memory CD8+ T cells   pp509 - 513 Jason M Schenkel, Kathryn A Fraser, Vaiva Vezys and David Masopust doi:10.1038/ni.2568 Tissue-resident effector memory T cells respond rapidly after reencountering antigen. Masopust and colleagues show that memory CD8+ T cells also induce the release of chemokines, then recruit more memory cells to the site of infection. Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells   pp514 - 522 Daniela A Bermejo, Shaun W Jackson, Melisa Gorosito-Serran, Eva V Acosta-Rodriguez, Maria C Amezcua-Vesely, Blythe D Sather, Akhilesh K Singh, Socheath Khim, Juan Mucci, Denny Liggitt, Oscar Campetella, Mohamed Oukka, Adriana Gruppi and David J Rawlings doi:10.1038/ni.2569 Antibody production is the main effector function of B cells. Rawlings and colleagues show that Trypanosome cruzi induces rapid IL-17 production by B cells that is required for parasite control. See also: News and Views by Leon & Lund Top Advertisement Your clear path to information. Watch the new clinical Nature Reviews video now.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. 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