Acta Pharmacologica Sinica - Table of Contents alert Volume 34 Issue 5

Special Feature: Autophagy and Drug Discovery TABLE OF CONTENTS Volume 34, Issue 5 (May 2013) Special Feature: Autophagy and Drug Discovery The word autophagy is derived from the Greek roots "auto"(self) and "phagy" (eating) and broadly refers to the cellular catabolic processes, in which cytoplasmic materials are transported to lysosomes for degradation. Important progress has been achieved in the recent years in defining the role of autophagy in human diseases such as cancers, cardiovascular diseases, metabolism disorders, immune-mediated diseases, and neurodegenerative diseases. In addition, a number of drugs in the clinical trials against cancers, immune diseases, and neurodegenerative diseases affect or act through autophagy. It is conceivable that exploring the molecular mechanisms of autophagy opens an avenue for development of novel drugs to treat these devastating diseases. In order to give a broad picture on recent progress in autophagy research and help deliver a deep insight into autophagy biology and the related disease, Acta Pharmacologica Sinica launched this special issue on "Autophagy and Drug Discovery". As the editors for this special edition, we invited several experts in China and abroad to contribute 13 articles, which cover the important aspects of basic and clinical research on autophagy and reflect on recent developments in this field. In this issue Editorial Perspectives Reviews Original Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Ensure your access If you are unable to access the articles in this alert, your library may not subscribe to this journal. Our online recommendation form is a simple way to make your librarian aware that this journal is valuable to your research. Recommend now.   Editorial Top New horizon in autophagy research Wei-dong Le and Zheng-hong Qin Acta Pharmacol Sin 2013 34: 583-584; 10.1038/aps.2013.53 Full Text | PDF Perspectives Top Coordination of autophagy with other cellular activities Open Yan Wang and Zheng-hong Qin Acta Pharmacol Sin 2013 34: 585-594; advance online publication, March 11, 2013; 10.1038/aps.2012.194 Abstract | Full Text Why should autophagic flux be assessed? Xiao-jie Zhang, Sheng Chen, Kai-xing Huang and Wei-dong Le Acta Pharmacol Sin 2013 34: 595-599; advance online publication, March 11, 2013; 10.1038/aps.2012.184 Abstract | Full Text Therapeutic induction of autophagy to modulate neurodegenerative disease progression Open Warren E Hochfeld, Shirley Lee and David C Rubinsztein Acta Pharmacol Sin 2013 34: 600-604; advance online publication, February 4, 2013; 10.1038/aps.2012.189 Abstract | Full Text Reviews Top Autophagy in ageing and ageing-associated diseases Open Li-qiang He, Jia-hong Lu and Zhen-yu Yue Acta Pharmacol Sin 2013 34: 605-611; advance online publication, February 18, 2013; 10.1038/aps.2012.188 Abstract | Full Text Autophagy modulation as a target for anticancer drug discovery Xin Li, Huai-long Xu, Yong-xi Liu, Na An, Si Zhao and Jin-ku Bao Acta Pharmacol Sin 2013 34: 612-624; advance online publication, April 8, 2013; 10.1038/aps.2013.23 Abstract | Full Text Application and interpretation of current autophagy inhibitors and activators Ya-ping Yang, Li-fang Hu, Hui-fen Zheng, Cheng-jie Mao, Wei-dong Hu, Kang-ping Xiong, Fen Wang and Chun-feng Liu Acta Pharmacol Sin 2013 34: 625-635; advance online publication, March 25, 2013; 10.1038/aps.2013.5 Abstract | Full Text The protective roles of autophagy in ischemic preconditioning Wen-jun Yan, Hai-long Dong and Li-ze Xiong Acta Pharmacol Sin 2013 34: 636-643; advance online publication, April 22, 2013; 10.1038/aps.2013.18 Abstract | Full Text Original Articles Top Establishing a novel C. elegans model to investigate the role of autophagy in amyotrophic lateral sclerosis Open Jia Li, Kai-xing Huang and Wei-dong Le Acta Pharmacol Sin 2013 34: 644-650; advance online publication, March 18, 2013; 10.1038/aps.2012.190 Abstract | Full Text Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62 in vitro Open Liang Zhou, Hong-feng Wang, Hai-gang Ren, Dong Chen, Feng Gao, Qing-song Hu, Chen Fu, Ran-jie Xu, Zheng Ying and Guang-hui Wang Acta Pharmacol Sin 2013 34: 651-656; advance online publication, April 8, 2013; 10.1038/aps.2013.12 Abstract | Full Text The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning Bo Gao, Xiang-yang Zhang, Rong Han, Tong-tong Zhang, Cheng Chen, Zheng-hong Qin and Rui Sheng Acta Pharmacol Sin 2013 34: 657-666; advance online publication, April 22, 2013; 10.1038/aps.2013.34 Abstract | Full Text Adaptive changes in autophagy after UPS impairment in Parkinson's disease Yu-fei Shen, Yu Tang, Xiao-jie Zhang, Kai-xing Huang and Wei-dong Le Acta Pharmacol Sin 2013 34: 667-673; advance online publication, March 18, 2013; 10.1038/aps.2012.203 Abstract | Full Text Crosstalk between the proteasome system and autophagy in the clearance of α-synuclein Fang Yang, Ya-ping Yang, Cheng-jie Mao, Ling Liu, Hui-fen Zheng, Li-fang Hu and Chun-feng Liu Acta Pharmacol Sin 2013 34: 674-680; advance online publication, April 22, 2013; 10.1038/aps.2013.29 Abstract | Full Text NVP-BEZ235, a novel dual PI3K/mTOR inhibitor, enhances the radiosensitivity of human glioma stem cells in vitro Wen-juan Wang, Lin-mei Long, Neng Yang, Qing-qing Zhang, Wen-jun Ji, Jiang-hu Zhao, Zheng-hong Qin, Zhong Wang, Gang Chen and Zhong-qin Liang Acta Pharmacol Sin 2013 34: 681-690; advance online publication, April 22, 2013; 10.1038/aps.2013.22 Abstract | Full Text Functional comparison of the reverse mode of Na+/Ca2+ exchangers NCX1.1 and NCX1.5 expressed in CHO cells Yan Long, Wei-ping Wang, Hui Yuan, Shi-ping Ma, Nan Feng, Ling Wang and Xiao-liang Wang Acta Pharmacol Sin 2013 34: 691-698; advance online publication, April 8, 2013; 10.1038/aps.2013.4 Abstract | Full Text Effect of the HDAC inhibitor vorinostat on the osteogenic differentiation of mesenchymal stem cells in vitro and bone formation in vivo Song Xu, Kim De Veirman, Holly Evans, Gaia Cecilia Santini, Isabelle Vande Broek, Xavier Leleu, Ann De Becker, Ben Van Camp, Peter Croucher, Karin Vanderkerken and Ivan Van Riet Acta Pharmacol Sin 2013 34: 699-709; advance online publication, April 8, 2013; 10.1038/aps.2012.182 Abstract | Full Text Association of single nucleotide polymorphism Rs2236518 in PRDM16 gene with BMI in Chinese males Hua Yue, Jin-wei He, Yao-hua Ke, Hao Zhang, Chun Wang, Wei-wei Hu, Jie-mei Gu, Wen-zhen Fu, Yun-qiu Hu, Miao Li, Yu-juan Liu and Zhen-lin Zhang Acta Pharmacol Sin 2013 34: 710-716; advance online publication, March 25, 2013; 10.1038/aps.2012.201 Abstract | Full Text Advertisement Acta Pharmacologica Sinica (APS) is an international peer-reviewed pharmacology journal that focuses on the latest in pharmacological research being performed around the world. Impact Factor: 1.953* To view articles in the top ten full articles downloads, please visit: www.nature.com/aps/topten/index.html *2011 Journal Citation Reports (Thomson Reuters, June 2012)   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Eye. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.