Nature Reviews Nephrology - Table of Contents alert Volume 9 Issue 6

TABLE OF CONTENTS
June 2013 Volume 9 Number 6
Impact Factor 7.092 *	In this issue Research Highlights News and Views Reviews Also this month  Featured article: The role of the podocyte in albumin filtration Paul Thomas Brinkkoetter, Christina Ising & Thomas Benzing
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RESEARCH HIGHLIGHTS Top Acute kidney injury: Perioperative sodium bicarbonate infusion for prevention of acute kidney injury—no benefit and possible harm Published online: 07 May 2013 p307 | doi:10.1038/nrneph.2013.62 PDF End-stage renal disease: A bioengineered kidney with excretory function Published online: 30 April 2013 p308 | doi:10.1038/nrneph.2013.67 PDF Acute kidney injury: High-potency statin therapy and risk of acute kidney injury Published online: 09 April 2013 p309 | doi:10.1038/nrneph.2013.68 PDF Risk factors: Body fat distribution and renal risk Published online: 30 April 2013 p309 | doi:10.1038/nrneph.2013.69 PDF Chronic kidney disease: Renal adenosine in hypertensive CKD Published online: 30 April 2013 p309 | doi:10.1038/nrneph.2013.70 PDF Vasculitis: Epitope specificity responsible for MPO-ANCA pathogenicity Published online: 02 April 2013 p310 | doi:10.1038/nrneph.2013.71 PDF Pre-eclampsia: Podocyturia predicts pre-eclampsia Published online: 16 April 2013 p310 | doi:10.1038/nrneph.2013.72 PDF IN BRIEF Acute kidney injury: Urinary angiotensinogen and adverse outcomes in AKI | Diabetic nephropathy: mTOR and podocyte apoptosis in diabetic nephropathy | Dent disease: Endocytosis and acidification in proximal tubule cells | Diabetic nephropathy: TLR2 involvement in diabetic nephropathy PDF Nephrology JOBS of the week Nephrology Research Northwestern University Feinberg School of Medicine More Science jobs from Nephrology EVENT 12th International Workshop on Developmental Nephrology 23.06.13 Edinburgh More science events from
NEWS AND VIEWS		Top
Renin–angiotensin system: Meta-analyses can misdirect decisions on treatment Piero Ruggenenti & Giuseppe Remuzzi Published online: 30 April 2013 p311 | doi:10.1038/nrneph.2013.82 A recent meta-analysis concluded that the risk-to-benefit ratio of dual (versus single-drug) renin–angiotensin system blockade argues against the use of dual therapy. This conclusion, however, seems inconsistent with the actual data and may convey to physicians a misleading message that could misdirect important decisions on treatment. Full Text | PDF
Diabetic nephropathy: FRMD3 in diabetic nephropathy—guilt by association Nicholette D. Palmer & Barry I. Freedman Published online: 30 April 2013 p313 | doi:10.1038/nrneph.2013.81 Martini and colleagues recently used a novel genomics approach to assess the functional context of a noncoding variant located near to the promoter of the FRMD3 gene, which is associated with diabetic nephropathy. Their findings suggest a mechanistic link between FRMD3 and diabetic nephropathy that involves the bone morphogenetic protein signalling pathway. Full Text | PDF
Chronic kidney disease: How effective and safe are antiplatelet agents in CKD? Jürgen Floege & Georg Schlieper Published online: 30 April 2013 p314 | doi:10.1038/nrneph.2013.83 Aspirin and other antiplatelet agents are widely used in patients with chronic kidney disease. However, their use is often based on data obtained in patients with normal renal function. A recent Cochrane Collaboration systematic review analysed the benefits and risks of these agents in patients with chronic kidney disease. Full Text | PDF
Dialysis: A step towards making online haemodiafiltration a gold standard Francesco Locatelli & Walter H. Hörl Published online: 16 April 2013 p316 | doi:10.1038/nrneph.2013.75 Online haemodiafiltration is the most advanced dialysis treatment currently available, but widespread implementation of this technique has been delayed pending conclusive evidence of its benefits from randomized studies. The results of the randomized, controlled ESHOL study are now available. Will they change practice? Full Text | PDF
Chronic kidney disease: Cystatin-C-based eGFR: what is it telling us? Kristen L. Jablonski & Michel Chonchol Published online: 16 April 2013 p318 | doi:10.1038/nrneph.2013.77 Cystatin C was introduced as a potential alternative or supplement to the estimation of glomerular filtration rate (GFR) using creatinine. Although cystatin C is well supported as a better predictor of outcomes than creatinine, its reflection of actual renal function compared with creatinine is widely debated. A new study by Rule et al. asserts that cystatin-C-based estimated GFR is biased by non-GFR-associated risk factors for chronic kidney disease. Full Text | PDF
REVIEWS		Top
Treatment of IgA nephropathy and Henoch–Schönlein nephritis Jürgen Floege & John Feehally Published online: 02 April 2013 p320 | doi:10.1038/nrneph.2013.59 Treatments administered to patients with primary IgA nephropathy (IgAN) and those with Henoch–Schönlein nephritis are largely based on opinion or weak evidence, and the recent KDIGO Clinical Practice Guidelines for Glomerulonephritis assigned low levels of evidence for the majority of recommendations and suggestions related to these two diseases. In this Review, Floege and Feehally describe an algorithm for structuring the treatment of IgAN depending on the clinical scenario, and discuss ongoing studies to investigate treatments. Abstract | Full Text | PDF
The role of the podocyte in albumin filtration Paul Thomas Brinkkoetter, Christina Ising & Thomas Benzing Published online: 23 April 2013 p328 | doi:10.1038/nrneph.2013.78 Exciting advances in podocyte research over the past decade have provided new insights into the role of podocytes in the function of the glomerular filtration barrier. Here, the authors explain the importance of podocytes for the maintenance of an intact glomerular filtration barrier and prevention of albuminuria. They describe signalling pathways that regulate podocyte structure and function and discuss the potential of live podocyte imaging to further advance our understanding of podocyte biology. Abstract | Full Text | PDF
The effect of vitamin D status on risk factors for cardiovascular disease Sujana S. Gunta, Ravi I. Thadhani & Robert H. Mak Published online: 23 April 2013 p337 | doi:10.1038/nrneph.2013.74 Vitamin D deficiency has been linked to a variety of disorders, including hypertension, type 2 diabetes and chronic kidney disease. A potential role for vitamin D deficiency in cardiovascular morbidity and mortality has also emerged. In this Review, the authors describe the evidence for an association between risk factors for cardiovascular disease and vitamin D status, and discuss the limitations of available data on vitamin D therapy in patients at increased risk of cardiovascular events. Abstract | Full Text | PDF
Vascular access in haemodialysis: strengthening the Achilles' heel Miguel C. Riella & Prabir Roy-Chaudhury Published online: 16 April 2013 p348 | doi:10.1038/nrneph.2013.76 Dialysis vascular access continues to be both a 'lifeline' and an 'Achilles' heel' for patients on haemodialysis. In this Review, the authors address some of the problems associated with vascular access, including dialysis access stenosis and arteriovenous fistula (AVF) maturation failure. They discuss the role of monitoring and surveillance, describe process of care pathways intended to increase AVF rates and decrease catheter use, and discuss novel therapies designed to reduce vascular access dysfunction. Abstract | Full Text | PDF
Chronotherapy improves blood pressure control and reduces vascular risk in CKD Ramón C. Hermida, Diana E. Ayala, Michael H. Smolensky, Artemio Mojón, José R. Fernández, Juan J. Crespo, Ana Moyá, María T. Ríos & Francesco Portaluppi Published online: 23 April 2013 p358 | doi:10.1038/nrneph.2013.79 The prevalence of increased blood pressure during sleep and a blunted sleep-time-relative blood pressure decline is high in patients with chronic kidney disease (CKD) and increases with disease severity. Here, the authors describe 24 h blood pressure variation and discuss data suggesting that bedtime dosing of hypertension medications might improve blood pressure control and reduce cardiovascular risk in hypertensive patients, including those with CKD. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2011. Nature Reviews Nephrology was previously published as Nature Clinical Practice Nephrology.

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