The EMBO Journal - Table of Contents alert Volume 32 Issue 11

TABLE OF CONTENTS 29 May 2013 | Volume 32, Issue 11 Commentary Have you seen? Review Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement The EMBO Meeting 2013 — 21-24 September in Amsterdam Keynotes: Kai Simons & Hans Clevers 20 concurrent sessions covering the life sciences Speakers include: Peer Bork, Vishva Dixit, Susan M Gasser, Stephen P Jackson, Timothy Mitchison Abstract submission & early registration: 12 June 2013, 14:00 CEST www.the-embo-meeting.org   Commentary Top Regulation of stem cell therapies under attack in Europe: for whom the bell tolls Stem cell based therapies carry the hope to cure currently untreatable diseases. Leading stem cell researchers argue that rigorous research and regulation must prevail to govern clinical application ahead of a debate in the Italian parliament on legalizing an unproven stem cell treatment. Paolo Bianco, Roger Barker, Oliver Brüstle, Elena Cattaneo, Hans Clevers, George Q Daley, Michele De Luca, Lawrence Goldstein, Olle Lindvall, Christine Mummery, Pamela G Robey, Clara Sattler de Sousa e Brito and Austin Smith The EMBO Journal (2013), 32, 1489 - 1495; 10.1038/emboj.2013.114 Abstract | Full text | PDF Published online: 03 May 2013 Have you seen? Top SUMO wrestling with Drp1 at mitochondria A SUMO protease acting on the mitochondrial fission factor Drp1 regulates cytochrome c release and apoptosis during ischaemia. Caroline A Anderson and Craig Blackstone The EMBO Journal (2013), 32, 1496 - 1498; 10.1038/emboj.2013.103 Abstract | Full text | PDF | Related article Published online: 30 April 2013 Life(span) in balance: oxygen fuels a sophisticated neural network for lifespan homeostasis in C. elegans Oxygen and carbon dioxide regulate lifespan homeostasis in C. elegans via a counterbalanced neuronal network consisting of BAG and URX oxygen-sensing neurons. Susanne Skora and Manuel Zimmer The EMBO Journal (2013), 32, 1499 - 1501; 10.1038/emboj.2013.101 Abstract | Full text | PDF | Related article Published online: 30 April 2013 Review Top Function of oncogenes in cancer development: a changing paradigm This contribution introduces a new perspective on oncogenic transformation: certain oncogenes may act as ‘passengers’ to reprogram tissue-specific stem/progenitor cell into a malignant cancer stem cell state. Carolina Vicente-Dueñas, Isabel Romero-Camarero, Cesar Cobaleda and Isidro Sánchez-García The EMBO Journal (2013), 32, 1502 - 1513; 10.1038/emboj.2013.97 Abstract | Full text | PDF Published online: 30 April 2013 Articles Top SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia  EMBO Open The SUMO-2/3-specific deSUMOylating enzyme SENP3 induces apoptosis by targeting the GTPase Drp1 to mitochondria, causing cytochrome c release. Chun Guo, Keri L Hildick, Jia Luo, Laura Dearden, Kevin A Wilkinson and Jeremy M Henley The EMBO Journal (2013), 32, 1514 - 1528; 10.1038/emboj.2013.65 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 22 March 2013 Counterbalance between BAG and URX neurons via guanylate cyclases controls lifespan homeostasis in C. elegans Neurons that sense low (BAG) and high oxygen (URX) decrease or increase lifespan in C. elegans, respectively, by regulating different guanylate cyclases and independently of pathways previously implicated in ageing. Tiewen Liu and Dongsheng Cai The EMBO Journal (2013), 32, 1529 - 1542; 10.1038/emboj.2013.75 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 April 2013 cAMP/PKA signalling reinforces the LATS–YAP pathway to fully suppress YAP in response to actin cytoskeletal changes Actin cytoskeletal damage triggers inactivation of the oncoprotein YAP through phosphorylation by the LATS kinase downstream of PKA. Indeed, PKA is a Hippo pathway component implicated ubiquitously in LATS–YAP signalling. Minchul Kim, Miju Kim, Seunghee Lee, Shinji Kuninaka, Hideyuki Saya, Ho Lee, Sookyung Lee and Dae-Sik Lim The EMBO Journal (2013), 32, 1543 - 1555; 10.1038/emboj.2013.102 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 03 May 2013 Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation Protein arginine methylation of the recently identified c-Jun coactivator protein RACO-1 establishes PRMT1 as new regulator of c-Jun/AP-1 function. Clare C Davies, Atanu Chakraborty, Markus E Diefenbacher, Mark Skehel and Axel Behrens The EMBO Journal (2013), 32, 1556 - 1567; 10.1038/emboj.2013.98 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 26 April 2013 C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements Targeting of GR to its tissue-specific gene regulatory sites in intact liver is driven by the priming of chromatin through pre-bound C/EBPβ. Lars Grøntved, Sam John, Songjoon Baek, Ying Liu, John R Buckley, Charles Vinson, Greti Aguilera and Gordon L Hager The EMBO Journal (2013), 32, 1568 - 1583; 10.1038/emboj.2013.106 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 10 May 2013 BRCA1 is a negative modulator of the PRC2 complex The tumour-suppressor BRCA1 affects Polycomb complex targeting by disrupting Ezh2 binding to the HOTAIR ncRNA, a mechanism important for ES cell differentiation and for restraining cancer cell invasiveness. Lan Wang, Xianzhuo Zeng, Shuai Chen, Liya Ding, Jian Zhong, Jonathan C Zhao, Liguo Wang, Aaron Sarver, Antonius Koller, Jizu Zhi, Yupo Ma, Jindan Yu, Junjie Chen and Haojie Huang The EMBO Journal (2013), 32, 1584 - 1597; 10.1038/emboj.2013.95 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 26 April 2013 The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation The Polycomb Group (PcG) transcriptional repressor complex interacts with Chd4 to suppress the astrogenic marker GFAP, thereby preventing premature gliogensis during neocortical development. Anke Sparmann, Yunli Xie, Els Verhoeven, Michiel Vermeulen, Cesare Lancini, Gaetano Gargiulo, Danielle Hulsman, Matthias Mann, Juergen A Knoblich and Maarten van Lohuizen The EMBO Journal (2013), 32, 1598 - 1612; 10.1038/emboj.2013.93 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 26 April 2013 The transcription factor Hmx1 and growth factor receptor activities control sympathetic neurons diversification Noradrenergic and cholinergic sympathic neurons are shown to derive from an initially induced hybrid precursor population, with the homeobox protein Hmx1 and tyrosine kinase receptors determining cell lineage fate. Alessandro Furlan, Moritz Lübke, Igor Adameyko, Francois Lallemend and Patrik Ernfors The EMBO Journal (2013), 32, 1613 - 1625; 10.1038/emboj.2013.85 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 16 April 2013 Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity The steroid hormone ecdysone regulates the immune response and defense against bacterial infection in Drosophila by controlling the expression of the microbial sensing receptor PGRP-LC thereby linking developmental and immune signalling systems. Florentina Rus, Thomas Flatt, Mei Tong, Kamna Aggarwal, Kendi Okuda, Anni Kleino, Elisabeth Yates, Marc Tatar and Neal Silverman The EMBO Journal (2013), 32, 1626 - 1638; 10.1038/emboj.2013.100 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 07 May 2013 Real-time observation of the conformational dynamics of mitochondrial Hsp70 by spFRET Time-resolved single molecule data of nucleotide and substrate binding of the Hsp70 chaperone Ssc1 reveals unique nucleotide-binding domain/substrate binding domain interactions and domain dynamics. Martin Sikor, Koyeli Mapa, Lena Voith von Voithenberg, Dejana Mokranjac and Don C Lamb The EMBO Journal (2013), 32, 1639 - 1649; 10.1038/emboj.2013.89 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 26 April 2013 Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. 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