Nature Reviews Gastroenterology & Hepatology - Table of Contents alert Volume 10 Issue 9

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TABLE OF CONTENTS
September 2013 Volume 10 Number 9
Impact Factor 10.426*	In this issue Research Highlights News and Views Reviews Also this month  Featured article: Autoimmune atrophic gastritis—pathogenesis, pathology and management William L. Neumann, Elizabeth Coss, Massimo Rugge & Robert M. Genta
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RESEARCH HIGHLIGHTS Top Liver disease: Quest to find new mouse models for liver diseases Published online: 13 August 2013 p501 | doi:10.1038/nrgastro.2013.153 PDF Oesophagus: TSLP-basophil axis important in eosinophilic oesophagitis Published online: 30 July 2013 p502 | doi:10.1038/nrgastro.2013.145 PDF Liver disease: Kupffer cells regulate the progression of ALD and NAFLD Published online: 23 July 2013 p503 | doi:10.1038/nrgastro.2013.140 PDF Colorectal cancer: Metabolic signature of CRC revealed by spectroscopic profiling Published online: 30 July 2013 p503 | doi:10.1038/nrgastro.2013.144 PDF Gut microbiota: Selecting Clostridia strains that induce TREG cells from gut microbiota Published online: 23 July 2013 p504 | doi:10.1038/nrgastro.2013.139 PDF Liver: Carbamazepine accelerates liver regeneration in mice after acute injury Published online: 06 August 2013 p504 | doi:10.1038/nrgastro.2013.147 PDF Hepatitis: New route of HCV transmission Published online: 06 August 2013 p504 | doi:10.1038/nrgastro.2013.148 PDF IN BRIEF Liver transplantation: New risk allele for graft steatosis after liver transplantation | Infection: Schistosomiasis mansoni infection is associated with reduced liver function and increased liver fibrosis | Imaging: No success in initial attempt to generate classification criteria for colon adenomas using probe-based CLE | Motility: Efficacy of oral ghrelin agonist in diabetic gastroparesis PDF Gastroenterology & Hepatology JOBS of the week Gastroenterology Opportunity Sanford Health Gastroenterology Faculty University of New Mexico Health Sciences Center Director of Gastroenterology and Staff Gastroenterologist North Shore-LIJ Department of Medicine More Science jobs from Gastroenterology & Hepatology EVENT Asia-Pacific Gastroenterology Cancer Summit 2013 06.12.13 More science events from
NEWS AND VIEWS		Top
Paediatrics: Children need optimal management of chronic hepatitis B Mei-Hwei Chang Published online: 30 July 2013 p505 | doi:10.1038/nrgastro.2013.137 Current therapies for chronic HBV infection are focused on adults. However, the timing of primary infection of HBV often occurs during infancy or childhood, particularly in endemic areas. Children have the potential for a long lifespan and should be treated properly and early before complications develop. Full Text | PDF
Colorectal cancer: Cascade genetic testing in Lynch syndrome: room for improvement Kory Jasperson Published online: 09 July 2013 p506 | doi:10.1038/nrgastro.2013.122 Genetic testing in relatives of individuals with Lynch syndrome is of utmost importance for targeted screening and prevention. A recent systematic review suggests that the uptake of testing in at-risk relatives is inadequate and therefore the cost-effectiveness of Lynch syndrome testing is questionable. The results of this study are discussed here. Full Text | PDF
Viral hepatitis: Cell-culture-derived HCV—a promising vaccine antigen Judith M. Gottwein & Jens Bukh Published online: 30 July 2013 p508 | doi:10.1038/nrgastro.2013.136 With millions of humans infected yearly with HCV, leading to cirrhosis and cancer, a vaccine is urgently needed. Cultured virus particles constitute the antigen in most antiviral vaccines. A study in mice demonstrated induction of neutralizing antibodies by immunization with cell-culture-derived HCV, providing new possibilities for vaccine development. Full Text | PDF
NAFLD: Predictive value of ALT levels for NASH and advanced fibrosis Dawn M. Torres & Stephen A. Harrison Published online: 30 July 2013 p510 | doi:10.1038/nrgastro.2013.138 With expanding waistlines, the prevalence of NAFLD has burgeoned to become the leading cause of chronic liver disease in the USA. A subset of patients with NAFLD meet criteria for NASH with its inherent risk of progression to cirrhosis. Verma et al. addressed the utility of alanine aminotransferase levels for predicting NASH or advanced fibrosis to decide who would benefit from the definitive test of liver biopsy. Full Text | PDF
IBD: Golimumab in ulcerative colitis: a 'menage a trois' of drugs Silvio Danese Published online: 30 July 2013 p511 | doi:10.1038/nrgastro.2013.142 Golimumab, a human anti-TNF antibody, is effective in patients with ulcerative colitis, according to new findings from an international phase III double-blind trial. The addition of this drug makes a menage a trois of available drugs—comprising infliximab, adalimumab and golimumab—for the treatment of ulcerative colitis. Full Text | PDF
REVIEWS		Top
Conservative and surgical treatment of haemorrhoids Donato F. Altomare & Simona Giuratrabocchetta Published online: 11 June 2013 p513 | doi:10.1038/nrgastro.2013.91 Haemorrhoid disease is the most frequent proctologic complaint. The management of haemorrhoids has evolved rapidly during the past few decades. Here, the authors describe the current treatment options for the effective management of patients with grade I-IV haemorrhoids, presenting both conservative and surgical approaches. Abstract | Full Text | PDF
The liver-brain axis in liver failure: neuroinflammation and encephalopathy Roger F. Butterworth Published online: 02 July 2013 p522 | doi:10.1038/nrgastro.2013.99 Hepatic encephalopathy is a severe neuropsychiatric complication of both acute and chronic liver failure. Here, the authors present new evidence that systemic and central proinflammatory mechanisms acting alone or in concert with other toxins have a role in the pathogenesis of hepatic encephalopathy. Novel diagnostic and therapeutic opportunities are also discussed. Abstract | Full Text | PDF
Autoimmune atrophic gastritis—pathogenesis, pathology and management William L. Neumann, Elizabeth Coss, Massimo Rugge & Robert M. Genta Published online: 18 June 2013 p529 | doi:10.1038/nrgastro.2013.101 Autoimmune gastritis is a chronic progressive inflammatory condition that results in the replacement of the parietal cell mass by atrophic and metaplastic mucosa. This Review summarizes the epidemiology, pathogenesis and pathological aspects of autoimmune atrophic gastritis. The authors also provide practical advice for the diagnosis and management of patients with this disease. Abstract | Full Text | PDF
MicroRNAs in liver disease Gyongyi Szabo & Shashi Bala Published online: 21 May 2013 p542 | doi:10.1038/nrgastro.2013.87 This Review summarizes current knowledge on the role of different microRNAs (miRNAs) in liver diseases. The functions of the most relevant miRNAs that have specific roles in liver damage, hepatocyte functions, viral hepatitis, alcoholic and nonalcoholic liver disease, liver fibrosis and hepatocellular carcinoma are highlighted. The emerging utility of miRNAs as potential biomarkers in liver diseases is also discussed. Abstract | Full Text | PDF
Epidemiology and natural history of HCV infection Behzad Hajarizadeh, Jason Grebely & Gregory J. Dore Published online: 02 July 2013 p553 | doi:10.1038/nrgastro.2013.107 Globally, 130-170 million people have HCV infection; however, distribution patterns are highly variable. This Review outlines the latest information on the epidemiology and natural history of HCV infection. The disease burden and mortality of HCV-related diseases, and the potential effect of HCV treatment on disease burden, are also outlined. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2012. Nature Reviews Gastroenterology & Hepatology was previously published as Nature Clinical Practice Gastroenterology & Hepatology.

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