Nature Reviews Neurology - Table of Contents alert Volume 9 Issue 9

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TABLE OF CONTENTS
September 2013 Volume 9 Number 9
Impact Factor 15.518 *	In this issue Research Highlights News and Views Reviews Perspectives Also this month  Featured article: Treatment trials in progressive MS—current challenges and future directions Marcus W. Koch, Gary Cutter, Peter K. Stys, V. Wee Yong & Luanne M. Metz
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RESEARCH HIGHLIGHTS Top Alzheimer disease: Joining the dots between APOE ε4 and late-onset Alzheimer disease via integrative genomics Published online: 13 August 2013 p483 | doi:10.1038/nrneurol.2013.161 PDF Multiple sclerosis: Regenerative therapies for MS—hope on the horizon Published online: 13 August 2013 p484 | doi:10.1038/nrneurol.2013.158 PDF Dementia: Reduction in the prevalence of dementia in the past 20 years Published online: 13 August 2013 p485 | doi:10.1038/nrneurol.2013.162 PDF Parkinson disease: Long-term levodopa exposure may increase risk of neuropathy in patients with PD Published online: 06 August 2013 p486 | doi:10.1038/nrneurol.2013.155 PDF Multiple sclerosis: Gene-vitamin D interactions likely to influence pathogenesis and risk of relapse in multiple sclerosis Published online: 13 August 2013 p486 | doi:10.1038/nrneurol.2013.160 PDF IN BRIEF Neurodevelopmental disorders: Neonatal infection linked to risk of cerebral palsy | Infectious disease: One step closer to a single-dose vaccine for tick-borne encephalitis | Parkinson disease: Metablomics study reveals novel biomarkers for PD | Epilepsy: Serum brain-derived neurotrophic factor—a marker of seizure severity in patients with epilepsy? | Pain: Prism glasses for limb-specific autonomic dysfunction in complex regional pain syndrome | Dementia: Risk factors associated with dementia with Lewy bodies | Stroke: Routine cardiac event monitoring for detection of atrial fibrillation after ischaemic stroke | White matter disease: Longest follow-up of rituximab for neuromyelitis optica PDF Neurology JOBS of the week The Brain‘s Role in Obesity Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig Postdoctoral Positions in Eye and Brain Development St. Jude Children's Research Hospital, Memphis, Tennessee, USA PhD position at the Interface of Epigenetics and Stroke Research LMU Munich, Dept. Physiological Chemistry Assistant Professor Thomas Jefferson University Tenure-Track Faculty Positions in Neuroscience University of Manitoba More Science jobs from Neurology EVENT Cell Technologies in Obstetrics, Gynecology, Neonatology and Pediatric Neurology 07.11.13 Ukraine More science events from
NEWS AND VIEWS		Top
Dementia: Vascular and neurodegenerative pathways—will they meet? Raj N. Kalaria & Masafumi Ihara Published online: 13 August 2013 p487 | doi:10.1038/nrneurol.2013.164 Vascular and neurodegenerative pathologies are known to co-occur in Alzheimer disease, and were recently proposed to drive progression to dementia through independent pathways. A new study provides evidence in support of this hypothesis, by showing dissociation between the pathologies and regional brain metabolism. But might the two pathways converge? Full Text | PDF
Multiple sclerosis: Month of birth effect in MS—fact or artefact? Rogier Hintzen Published online: 13 August 2013 p489 | doi:10.1038/nrneurol.2013.156 The month of birth effect describes the apparent association between month of birth and future risk of multiple sclerosis, whereby people born in spring months have slightly increased risk. A recent analysis of the available data, however, suggests that this relationship is spurious because studies have not adequately controlled for confounders. Full Text | PDF
Pain: Quantitative sensory testing—a tool for daily practice? Frank Birklein & Claudia Sommer Published online: 06 August 2013 p490 | doi:10.1038/nrneurol.2013.157 Quantitative sensory testing (QST) is being used increasingly in the research environment to measure somatosensory responses, both in patients with pain disorders and in normal individuals. A recent consensus meeting on the use of QST in clinical practice provides recommendations for the implementation of QST in patient diagnosis and monitoring. Full Text | PDF
Stroke: Is thrombolysis safe in anticoagulated ischaemic stroke? Roland Veltkamp & Timolaos Rizos Published online: 06 August 2013 p492 | doi:10.1038/nrneurol.2013.159 Intracerebral haemorrhage is the most serious complication of intravenous thrombolysis in ischaemic stroke, and whether thrombolysis can be performed in patients receiving anticoagulants is an unresolved issue. Data from a large European registry now confirms that thrombolysis in some patients receiving warfarin is as safe as in non-anticoagulated patients. Full Text | PDF
Dementia: Mild cognitive impairment—amyloid and beyond Philip Scheltens Published online: 23 July 2013 p493 | doi:10.1038/nrneurol.2013.147 Recently developed criteria for diagnosis of mild cognitive impairment due to Alzheimer disease make use of clinical and biomarker information. A new study reports that these criteria apply in both community and research settings; however, results from the community-based cohort conflict with a proposed biomarker-based model of disease progression. Full Text | PDF
REVIEWS		Top
Treatment trials in progressive MS—current challenges and future directions Marcus W. Koch, Gary Cutter, Peter K. Stys, V. Wee Yong & Luanne M. Metz Published online: 30 July 2013 p496 | doi:10.1038/nrneurol.2013.148 The majority of patients with multiple sclerosis (MS) will at some point experience the progressive form of the disease, involving relentless functional decline and axonal degeneration. No cure for progressive MS is currently available, and clinical trials in this patient population are problematic. Koch and colleagues describe current limitations of trials in progressive MS, such as lack of suitable outcome measures, and present approaches to address these challenges. Abstract | Full Text | PDF
Defining and scoring response to IFN-β in multiple sclerosis Maria Pia Sormani & Nicola De Stefano Published online: 30 July 2013 p504 | doi:10.1038/nrneurol.2013.146 As the range of therapeutic options for multiple sclerosis (MS) continues to expand, the ability to select the most appropriate treatment for each patient becomes increasingly important. In this Review, Sormani and De Stefano assess the studies that have attempted to classify patients with MS on the basis of their response to IFN-β treatment. The authors also discuss the development and use of scoring systems that combine different clinical and MRI markers to aid definition of an early response to this drug. Abstract | Full Text | PDF
25 years of neuroimaging in amyotrophic lateral sclerosis Bradley R. Foerster, Robert C. Welsh & Eva L. Feldman Published online: 06 August 2013 p513 | doi:10.1038/nrneurol.2013.153 The pathophysiological processes underlying onset and progression of amyotrophic lateral sclerosis (ALS) remain poorly understood. Unlike conventional imaging techniques, which provide information only at a gross structural level, advanced imaging modalities have shed light on the microstructural changes that accompany this disease. Eva Feldman and colleagues describe how advanced neuroimaging studies have delineated key factors, such as white matter tract integrity and brain metabolism, that are altered in ALS, and consider how such insights could aid diagnosis and treatment. Abstract | Full Text | PDF
Outcome predictors for status epilepticus—what really counts Raoul Sutter, Peter W. Kaplan & Stephan Rüegg Published online: 06 August 2013 p525 | doi:10.1038/nrneurol.2013.154 Determination of prognosis in patients with status epilepticus (SE)—a life-threatening state of ongoing or repetitive seizures—is difficult, and current outcome prediction scales do not take into account novel outcome markers, such as EEG and imaging findings. Here, Sutter et al. review the available data on major prognostic determinants of outcome in SE, and propose a novel paradigm for assessment of these predictive factors over the course of the seizure. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION Uhthoff's phenomena in MS—clinical features and pathophysiology Teresa C. Frohman, Scott L. Davis, Shin Beh, Benjamin M. Greenberg, Gina Remington & Elliot M. Frohman Published online: 04 June 2013 p535 | doi:10.1038/nrneurol.2013.98 Uhthoff's phenomena are transient disturbances in neurological functioning that can be triggered by an increase in core body temperature in patients with multiple sclerosis (MS). In this article, Frohman et al. discuss the pathophysiological underpinnings of Uhthoff's phenomena, and highlight the importance of differentiating between these events and true MS exacerbations in the clinic. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2013. Nature Reviews Neurology was previously published as Nature Clinical Practice Neurology.

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