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December 2013 Volume 14 Number 12 | |||||||||||||||||||||||||||||||||||||
In this issue Research Highlights Reviews Correspondence
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REVIEWS | Top | ||||||||||||||||||||||||||||||||||||
Genome dynamics during experimental evolution Jeffrey E. Barrick & Richard E. Lenski p827 | doi:10.1038/nrg3564 This Review describes how whole-genome sequencing of experimental populations of microorganisms and other species is yielding new insights into evolutionary processes. These details include variation in mutation rates, diverse genetic routes to adaptation and dynamic interactions within and between populations. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
Evolution of crop species: genetics of domestication and diversification Rachel S. Meyer & Michael D. Purugganan p840 | doi:10.1038/nrg3605 The recent improvement in technologies to identify genetic variants linked with quantitative traits has allowed the identification of variants that are associated with crop domestication. This Review considers these approaches and their application to the study of crop domestication. Abstract | Full Text | PDF | Supplementary information | |||||||||||||||||||||||||||||||||||||
A new world of Polycombs: unexpected partnerships and emerging functions Yuri B. Schwartz & Vincenzo Pirrotta p853 | doi:10.1038/nrg3603 Polycomb group (PcG) proteins have long been known to have repressive functions. Recently, novel complexes of PcG proteins have been identified and have been shown to have novel molecular and biological functions, which are discussed in this Review. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
High-resolution network biology: connecting sequence with function Colm J. Ryan, Peter Cimermancic, Zachary A. Szpiech, Andrej Sali, Ryan D. Hernandez & Nevan J. Krogan p865 | doi:10.1038/nrg3574 Network analyses of protein-protein, genetic and drug-gene interactions have typically been limited to analyses at the whole-protein and whole-gene levels. This Review discusses how high-resolution network analyses at the domain and residue levels are providing valuable insights into diverse research fields that range from structural biology to human disease. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
Article series: Non-coding RNA Gene regulation by antisense transcription Vicent Pelechano & Lars M. Steinmetz p880 | doi:10.1038/nrg3594 Antisense transcription is increasingly being recognized as an important regulator of gene expression across all kingdoms of life and through a range of regulatory modes. Antisense transcripts are also emerging as facilitators of rapid evolution of gene regulation. Abstract | Full Text | PDF | |||||||||||||||||||||||||||||||||||||
CORRESPONDENCE | Top | ||||||||||||||||||||||||||||||||||||
Correspondence: A commentary on Pitfalls of predicting complex traits from SNPs Gustavo de los Campos & Daniel A. Sorensen p894 | doi:10.1038/nrg3457-c1 Full Text | PDF | |||||||||||||||||||||||||||||||||||||
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Reply: Author reply to A commentary on Pitfalls of predicting complex traits from SNPs Naomi R. Wray, Jian Yang, Ben J. Hayes, Alkes L. Price, Michael E. Goddard & Peter M. Visscher p894 | doi:10.1038/nrg3457-c2 Full Text | PDF | |||||||||||||||||||||||||||||||||||||
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*2012 Journal Citation Report (Thomson Reuters, 2013) |
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