| EDITOR'S CHOICE 2013
Cell Research is proud to present a collection of featured articles from 2013 representing the broad scope of basic molecular and cell biology research. These articles have been chosen by the Editor to illustrate some of the latest advances in topics such as stem cell research, aging, structural biology, viral infections, genome editing, and cell signaling. | | | | | Featured articles include: | | | | | A blueprint for engineering cell fate: current technologies to reprogram cell identity Samantha A Morris and George Q Daley Cell differentiation has long been thought to be a unidirectional process. The early development of all mammals involves a sequence of cell fate decisions along an irreversible pathway of restricted potential and increasing specialization. Development begins with the totipotent zygote, which has the capacity to give rise to all the embryonic and extraembryonic cells of the organism. | | | | | | | Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos Open Nannan Chang, Changhong Sun, Lu Gao, et al. Precise and efficient genome-engineering technologies, including the custom-made zinc-finger nucleases (ZFNs) and transcription activator-like effectors (TALENs), have been successfully applied in a variety of mammalian cells and model organisms, including fruit fly, zebrafish, frog, mouse, rat and pig1. | | | | | | | Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4 Open Nianshuang Wang, Xuanling Shi, Liwei Jiang, et al. A novel coronavirus, recently named the Middle East respiratory syndrome coronavirus (MERS-CoV), was first identified in humans in the Middle East in 2012, and later in several European countries1,2,3. A sizable fraction (> 50%) of the infected patients developed severe respiratory illness and clinical symptoms similar to those seen during outbreak of severe acute respiratory symptom (SARS) caused by the coronavirus SARS-CoV in 20034. | | | | | | | Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system Open Albert W Cheng, Haoyi Wang, Hui Yang, et al. Gene expression is strictly controlled in many biol-ogical processes, such as development and diseases. Transcription factors regulate gene expression by binding to specific DNA sequences at the enhancer and promoter regions of target genes, and modulate transcription through their effector domains1. Based on the same principle, artificial transcription factors (ATFs) have been generated by fusing various functional domains to a DNA binding domain engineered to bind to the genes of interest, thereby modulating their expression2,3. | | | | | | | Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses Open Yan Wu, Yuhai Bi, Christopher J Vavricka, et al. Influenza A virus contains two major surface glycoproteins, hemagglutinin (HA) and neuraminidase (NA). HA initiates viral fusion by binding to sialic acid-containing receptors on the host cell and NA facilitates viral release by hydrolyzing the ketosidic bond of sialic acid. The balance of HA and NA activities is thought to be critical for influenza virus infectivity and transmissibility1. | | | | *2012 Journal Citation Report (Thomson Reuters, 2013) | | | | | Cell Research has a broad scope in basic molecular and cell biology research, including: cell growth and differentiation, signal transduction, apoptosis, stem cells, development, immunology, neuroscience, plant cell biology, chromatin modulation, epigenetics and transcription. With an impact factor of 10.526*, this journal brings the latest in innovative research to an international readership. | | | | | | | | |
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