Nature Biotechnology Contents: Volume 31 pp 1055 - 1150

Advertisement Discover Research Partnerships with Boehringer Ingelheim Our research teams know that they can only tackle some of the most important challenges in medicine today if we work together with colleagues outside our organisation. We invite academic institutions, non-profit research centres and external industry partners to help us deliver a better future for patients. Visit http://discoveringtogether.boehringer-ingelheim.com TABLE OF CONTENTS December 2013 Volume 31, Issue 12 Editorial News Bioentrepreneur Opinion and Comment Features News and Views Computational Biology Research Careers and Recruitment Advertisement Microsart AMP Mycoplasma Rapid methods for the detection of mycoplasma contamination, a major risk associated with cell culture derived products, are essential for improving monitoring of the production process of biologicals. Microsart AMP Mycoplasma enables reliable and sensitive detection of mycoplasma DNA in just a few hours. Learn more. Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Frontiers are launching a new collaborative peer review forum We are excited to announce that we will be launching a new collaborative peer-review forum where referees and authors work together to improve the paper until consensus is met. Our new peer-review forum will provide online-tools and increased efficiency to ensure a transparent and fast review process. Follow us for more information! We'll be posting updates about the launch on Twitter and Facebook    Editorial Top The INN crowd   p1055 doi:10.1038/nbt.2760 Moves to give biosimilars nonproprietary names different from brand products are more than a wrangle about words—they could mean biosimilars arrive stillborn to the market. News Top Phase 3 data for PCSK9 inhibitor wows   pp1057 - 1058 Cormac Sheridan doi:10.1038/nbt1213-1057 Appetite for cheaper biologics spreads across the map   pp1059 - 1061 Melanie Senior doi:10.1038/nbt1213-1059 Regado's aptamer lines up against anticoagulants   p1060 Gunjan Sinha doi:10.1038/nbt1213-1060 Mesoblast acquires Osiris' stem cell business   p1061 Emily Waltz doi:10.1038/nbt1213-1061 Italy blocks controversial stem cell therapy   p1062 Anna Meldolesi doi:10.1038/nbt1213-1062a Biocon's first-in-class anti-CD6 mAb reaches the market   pp1062 - 1063 Killugudi Jayaraman doi:10.1038/nbt1213-1062b Monsanto buys Climate Corporation for $1.1 billion   p1064 Jeffrey L Fox doi:10.1038/nbt1213-1064a First-in-class guanylate cyclase stimulator approved for PAH   p1064 Malini Guha doi:10.1038/nbt1213-1064b JDRF teams with VC PureTech to promote startups   p1065 Brian Orelli doi:10.1038/nbt1213-1065a J&J in trio of European deals   p1065 Nuala Moran doi:10.1038/nbt1213-1065b GSK plows ahead with EMA malaria vaccine submission   p1066 Aaron Bouchie doi:10.1038/nbt1213-1066a Corrections   p1066 doi:10.1038/nbt1213-1066b Around the world in a month   p1067 doi:10.1038/nbt1213-1067 News Feature Burning bright   pp1068 - 1071 Brady Huggett doi:10.1038/nbt.2766 How long will the investor exuberance driving public offerings of biotech companies last? Brady Huggett investigates. Bioentrepreneur Top Building a business Do you really want to be a biotech board member?   pp1072 - 1074 Mark Kessel doi:10.1038/nbt.2763 SciCafe Startups on the Menu: Archimedes   p1074 doi:10.1038/nbt.2765 Opinion and Comment Top Correspondence Just the facts, please   pp1075 - 1076 Anne Wojcicki doi:10.1038/nbt.2771 Reply to Just the facts, please   pp1076 - 1077 doi:10.1038/nbt.2772 Science-based risk assessment requires careful evaluation of all studies   pp1077 - 1078 Fern Wickson, Thomas Bohn, Brian Wynne, Angelika Hilbeck and Silvio Funtowicz doi:10.1038/nbt.2761 Reply to Science-based risk assessment requires careful evaluation of all studies   pp1078 - 1080 Jorg Romeis, Morven A McLean and Anthony M Shelton doi:10.1038/nbt.2762 Rational drug repositioning by medical genetics   pp1080 - 1082 Zhong-Yi Wang and Hong-Yu Zhang doi:10.1038/nbt.2758 Reply to Rational drug repositioning by medical genetics   p1082 Philippe Sanseau, Pankaj Agarwal, Michael R Barnes, Tomi Pastinen, J Brent Richards et al. doi:10.1038/nbt.2769 Vaccine delivery with microneedle skin patches in nonhuman primates   pp1082 - 1085 Peter C DeMuth, Adrienne V Li, Peter Abbink, Jinyan Liu, Hualin Li et al. doi:10.1038/nbt.2759 Features Top Patents Transparency tools in gene patenting for informing policy and practice OPEN   pp1086 - 1093 Osmat A Jefferson, Deniz Kollhofer, Thomas H Ehrich and Richard A Jefferson doi:10.1038/nbt.2755 The Supreme Court's decision in Myriad highlights the need for tools enabling nuanced and precise analysis of gene patents at the global level. Recent patent applications in antibody-drug conjugates   p1094 doi:10.1038/nbt.2773 News and Views Top Mining the ultimate phenome repository   pp1095 - 1097 Nigam H Shah doi:10.1038/nbt.2757 Combining genotyping and the data locked in medical records yields a large number of known genotype-phenotype associations. See also: Computational Biology by Denny et al. Epigenome editing   pp1097 - 1099 Philipp Voigt and Danny Reinberg doi:10.1038/nbt.2756 Technologies developed for genome editing are repurposed to study functions of chromatin modifications. See also: Research by Mendenhall et al. | Research by Maeder et al. Genome assembly and haplotyping with Hi-C   pp1099 - 1101 Jan O Korbel and Charles Lee doi:10.1038/nbt.2764 Genome sequencing is improved by information on long-range chromatin interactions. See also: Research by Selvaraj et al. | Research by Burton et al. | Research by Kaplan & Dekker Research Highlights   p1101 doi:10.1038/nbt.2770 Biotechnology JOBS of the week Postdoctoral Fellow, Computational Biology University of Minnesota Postdoctoral Appointee – Advanced Materials Sciences Sandia National Laboratories Postdoctoral Position in Yeast Genetics and Biochemistry Max Planck Institute of Immunobiology and Epigenetics Bioinformatician (Bioinformatics Operations Manager) University of Edinburgh Postdoctoral Fellow (Bioinformatics) National University of Singapore (NUS) More Science jobs from Biotechnology EVENT 3rd Biotechnology World Congress February 10-12, 2014 Dubai More science events from Computational Biology Top Analysis Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data   pp1102 - 1111 Joshua C Denny, Lisa Bastarache, Marylyn D Ritchie, Robert J Carroll, Raquel Zink et al. doi:10.1038/nbt.2749 When applied in large scale to electronic medical record data, the PheWAS approach replicates GWAS associations and reveals potentially new pleiotropic associations. See also: News and Views by Shah Research Top Articles Whole-genome haplotype reconstruction using proximity-ligation and shotgun sequencing   pp1111 - 1118 Siddarth Selvaraj, Jesse R Dixon, Vikas Bansal and Bing Ren doi:10.1038/nbt.2728 Genetic variants are grouped into chromosome-spanning haplotypes with the help of chromatin-interaction data. See also: News and Views by Korbel & Lee Chromosome-scale scaffolding of de novo genome assemblies based on chromatin interactions   pp1119 - 1125 Joshua N Burton, Andrew Adey, Rupali P Patwardhan, Ruolan Qiu, Jacob O Kitzman et al. doi:10.1038/nbt.2727 Short sequencing reads are scaffolded into chromosome-scale sequences with the help of chromatin-interaction data. See also: News and Views by Korbel & Lee Massively parallel polymerase cloning and genome sequencing of single cells using nanoliter microwells   pp1126 - 1132 Jeff Gole, Athurva Gore, Andrew Richards, Yu-Jui Chiu, Ho-Lim Fung et al. doi:10.1038/nbt.2720 Arrays of nanoliter wells reduce bias in single-cell genome sequencing, allowing copy number changes in one cell to be detected at unprecedented resolution. Letters Locus-specific editing of histone modifications at endogenous enhancers   pp1133 - 1136 Eric M Mendenhall, Kaylyn E Williamson, Deepak Reyon, James Y Zou, Oren Ram et al. doi:10.1038/nbt.2701 The function of specific enhancers is studied using TAL effectors fused to a histone demethylase. See also: News and Views by Voigt & Reinberg Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins   pp1137 - 1142 Morgan L Maeder, James F Angstman, Marcy E Richardson, Samantha J Linder, Vincent M Cascio et al. doi:10.1038/nbt.2726 A fusion protein comprising a TALE DNA-targeting domain and the 5-methylcytosine hydroxylase TET1 enables investigation of the function of specific DNA methylation events. See also: News and Views by Voigt & Reinberg High-throughput genome scaffolding from in vivo DNA interaction frequency   pp1143 - 1147 Noam Kaplan and Job Dekker doi:10.1038/nbt.2768 Kaplan and Dekker use genome-wide chromatin interaction data to place 65 previously unplaced contigs onto the human reference genome. See also: News and Views by Korbel & Lee Errata Erratum: Public Biotech 2012—the numbers   p1148 Brady Huggett doi:10.1038/nbt1213-1148a Erratum: How safe does transgenic food need to be?   p1148 Laura DeFrancesco doi:10.1038/nbt1213-1148b Erratum: What is the point of large-scale collections of human induced pluripotent stem cells?   p1148 Ruth McKernan and Fiona M Watt doi:10.1038/nbt1213-1148c Erratum: Differences that matter in cancer genomics   p1148 Li Ding and Michael C Wendl doi:10.1038/nbt1213-1148d Corrigendum Corrigendum: Updating benchtop sequencing performance comparison   p1148 Sebastian Junemann, Fritz Joachim Sedlazeck, Karola Prior, Andreas Albersmeier, Uwe John et al. doi:10.1038/nbt1213-1148e Careers and Recruitment Top Fixing the broken graduate education experience   p1149 Nathan L Vanderford doi:10.1038/nbt.2767 The current academic culture needs to change its mission, which is narrowly focused on training PhDs to be the next generation of academic tenure-track scientists. People People   p1150 doi:10.1038/nbt.2774 Advertisement nature.com webcasts Macmillan Science Communication presents a custom webcast: Pioneering advances in the next generation sequencing clinical research workflow. Wednesday December 18th at 8am PST / 11am EST / 4pm GMT / 5pm CET  Register for the free webcast followed by our live Q & A session  Sponsored by: Agilent    Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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