TABLE OF CONTENTS
|  |  |  | Volume 35, Issue 1 (January 2014) |  | In this issue Reviews Original Articles
Also new    AOP
| |  |  | Reviews | Top |  | The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy OPENJose JG Marin, Maria J Monte, Alba G Blazquez, Rocio IR Macias, Maria A Serrano and Oscar Briz Acta Pharmacol Sin 2014 35: 1-10; advance online publication, December 9, 2013; 10.1038/aps.2013.131 Abstract | Full Text |  |  |  | Deorphanizing the human transmembrane genome: A landscape of uncharacterized membrane proteins OPENJoseph J Babcock and Min Li Acta Pharmacol Sin 2014 35: 11-23; advance online publication, November 18, 2013; 10.1038/aps.2013.142 Abstract | Full Text |  | Original Articles | Top |  | Protective effects of the novel adenosine derivative WS0701 in a mouse model of posttraumatic stress disorderZhong-lin Huang, Rui Liu, Xiao-yu Bai, Gang Zhao, Jun-ke Song, Song Wu and Guan-hua Du Acta Pharmacol Sin 2014 35: 24-32; advance online publication, December 16, 2013; 10.1038/aps.2013.143 Abstract | Full Text |  |  |  | Cysteinyl leukotriene receptor 1 mediates LTD4-induced activation of mouse microglial cells in vitroShu-ying Yu, Xia-yan Zhang, Xiao-rong Wang, Dong-min Xu, Lu Chen, Li-hui Zhang, San-hua Fang, Yun-bi Lu, Wei-ping Zhang and Er-qing Wei Acta Pharmacol Sin 2014 35: 33-40; advance online publication, October 21, 2013; 10.1038/aps.2013.130 Abstract | Full Text |  |  |  | Acetazolamide attenuates chemical-stimulated but not thermal-stimulated acute pain in miceYa-jie Sun, Ying Chen, Chong Pang, Ning Wu and Jin Li Acta Pharmacol Sin 2014 35: 41-47; advance online publication, December 16, 2013; 10.1038/aps.2013.149 Abstract | Full Text |  |  |  | (−)Doxazosin is a necessary component for the hypotensive effect of (±)doxazosin during long-term administration in conscious ratsJing Zhao, De-zhi Kong, Qing Li, Ya-qin Zhen, Miao Wang, Yan Zhao, Dong-kai Wang and Lei-ming Ren Acta Pharmacol Sin 2014 35: 48-57; advance online publication, December 16, 2013; 10.1038/aps.2013.154 Abstract | Full Text |  |  |  | Acute exposure of methylglyoxal leads to activation of KATP channels expressed in HEK293 cellsYang Yang, Anuhya S Konduru, Ningren Cui, Lei Yu, Timothy C Trower, Weiwei Shi, Yun Shi and Chun Jiang Acta Pharmacol Sin 2014 35: 58-64; advance online publication, October 14, 2013; 10.1038/aps.2013.122 Abstract | Full Text |  |  |  | Diosgenin relieves goiter via the inhibition of thyrocyte proliferation in a mouse model of Graves' diseaseHu Cai, Zhe Wang, Hai-qing Zhang, Fu-rong Wang, Chun-xiao Yu, Feng-xia Zhang, Ling Gao, Jian Zhang and Jia-jun Zhao Acta Pharmacol Sin 2014 35: 65-73; advance online publication, November 18, 2013; 10.1038/aps.2013.133 Abstract | Full Text |  |  |  | Age-dependent contribution of Rho kinase in carbachol-induced contraction of human detrusor smooth muscle in vitroTimo Kirschstein, Chris Protzel, Katrin Porath, Tina Sellmann, Rüdiger Köhling and Oliver W Hakenberg Acta Pharmacol Sin 2014 35: 74-81; advance online publication, October 14, 2013; 10.1038/aps.2013.126 Abstract | Full Text |  |  |  | P21-activated kinase 5 plays essential roles in the proliferation and tumorigenicity of human hepatocellular carcinomaZhe-ping Fang, Bei-ge Jiang, Xue-feng Gu, Bin Zhao, Rui-liang Ge and Fa-biao Zhang Acta Pharmacol Sin 2014 35: 82-88; advance online publication, May 20, 2013; 10.1038/aps.2013.31 Abstract | Full Text |  |  |  | Yhhu3813 is a novel selective inhibitor of c-Met Kinase that inhibits c-Met-dependent neoplastic phenotypes of human cancer cellsChang-xi He, Jing Ai, Wei-qiang Xing, Yi Chen, Hao-tian Zhang, Min Huang, You-hong Hu, Jian Ding and Mei-yu Geng Acta Pharmacol Sin 2014 35: 89-97; advance online publication, November 18, 2013; 10.1038/aps.2013.125 Abstract | Full Text |  |  |  | CYP3A4 overexpression enhances apoptosis induced by anticancer agent imidazoacridinone C-1311, but does not change the metabolism of C-1311 in CHO cellsMonika PawÅ‚owska, Ewa Augustin and Zofia Mazerska Acta Pharmacol Sin 2014 35: 98-112; advance online publication, December 2, 2013; 10.1038/aps.2013.132 Abstract | Full Text |  |  |  | Bornyl caffeate induces apoptosis in human breast cancer MCF-7 cells via the ROS- and JNK-mediated pathwaysChuan-bin Yang, Wei-jing Pei, Jia Zhao, Yuan-yuan Cheng, Xiao-hui Zheng and Jian-hui Rong Acta Pharmacol Sin 2014 35: 113-123; advance online publication, December 16, 2013; 10.1038/aps.2013.162 Abstract | Full Text |  |  |  | Plumbagin attenuates cancer cell growth and osteoclast formation in the bone microenvironment of miceWei Yan, Ting-yu Wang, Qi-ming Fan, Lin Du, Jia-ke Xu, Zan-jing Zhai, Hao-wei Li and Ting-ting Tang Acta Pharmacol Sin 2014 35: 124-134; 10.1038/aps.2013.152 Abstract | Full Text |  |  |  | Exercise ameliorates the detrimental effect of chloroquine on skeletal muscles in mice via restoring autophagy fluxDan Jiang, Kai Chen, Xuan Lu, Hong-jian Gao, Zheng-hong Qin and Fang Lin Acta Pharmacol Sin 2014 35: 135-142; advance online publication, December 16, 2013; 10.1038/aps.2013.144 Abstract | Full Text |  |  |  | Ginsenoside Rg1 enhances the resistance of hematopoietic stem/progenitor cells to radiation-induced aging in miceCui Chen, Xin-yi Mu, Yue Zhou, Ke Shun, Shan Geng, Jun Liu, Jian-wei Wang, Jie Chen, Tin-yu Li and Ya-ping Wang Acta Pharmacol Sin 2014 35: 143-150; advance online publication, December 16, 2013; 10.1038/aps.2013.136 Abstract | Full Text |  |  |  | 3D-QSAR and 3D-QSSR studies of thieno[2,3-d]pyrimidin-4-yl hydrazone analogues as CDK4 inhibitors by CoMFA analysisBao-qin Cai, Hai-xiao Jin, Xiao-jun Yan, Peng Zhu and Gui-xiang Hu Acta Pharmacol Sin 2014 35: 151-160; advance online publication, October 14, 2013; 10.1038/aps.2013.105 Abstract | Full Text |  |  |  |  |  |  |  |  |  |  | Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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