Nature Reviews Gastroenterology & Hepatology - Table of Contents alert Volume 11 Issue 1

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Changing incidence of inflammatory bowel disease: environmental influences and lessons learnt from the South Asian population (open access) In this review, Alice Foster and Kevan Jacobson discuss the rising incidence of IBD in industrialized countries and the emergence of IBD in countries with traditionally low prevalence, underscoring the importance of environmental influences in the pathobiology of the disease.  Read more high-quality articles from Frontiers in Pediatrics specialty sections.
TABLE OF CONTENTS
January 2014 Volume 11 Number 1
Impact Factor 10.426*	In this issue Research Highlights News and Views Reviews Perspectives Also this month  Featured article: Advances in the treatment of coeliac disease: an immunopathogenic perspective Katri Kaukinen, Katri Lindfors & Markku Müki
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RESEARCH HIGHLIGHTS Top Gut microbiota: Anti-cancer therapies affected by gut microbiota Published online: 10 December 2013 p1 | doi:10.1038/nrgastro.2013.238 PDF Imaging: Advancing dysplasia and neoplasia detection in Barrett oesophagus Published online: 03 December 2013 p2 | doi:10.1038/nrgastro.2013.229 PDF Liver: Potential therapeutic role of osteopontin in alcoholic liver disease Published online: 26 November 2013 p3 | doi:10.1038/nrgastro.2013.228 PDF Hepatocellular carcinoma: New insight into angiogenesis in hepatocellular carcinoma—involvement of microRNA-26a Published online: 03 December 2013 p3 | doi:10.1038/nrgastro.2013.236 PDF Microbiota: Manipulating the microbiota could affect colorectal cancer development Published online: 19 November 2013 p4 | doi:10.1038/nrgastro.2013.225 PDF Liver: Key role for αv integrins in myofibroblasts in liver fibrosis Published online: 26 November 2013 p4 | doi:10.1038/nrgastro.2013.227 PDF Viral hepatitis: Subinfectious HCV exposure Published online: 03 December 2013 p4 | doi:10.1038/nrgastro.2013.235 PDF IN BRIEF Imaging: Reliable optical diagnosis of colonic lesions with endoscopic imaging techniques except autofluorescence imaging | Hepatitis: Sustained virologic response in treatment-experienced patients with HCV genotype 1 is increased by simeprevir | Neurogastroenterology: Role for tumour suppressor retinoblastoma 1 in the enteric nervous system | Liver: Insight gained into how regeneration and fibrosis in the liver are balanced in response to injury PDF Gastroenterology & Hepatology JOBS of the week Faculty Positions in the Gastroenterology Division University of New Mexico Assistant Professor Massachusetts General Hospital & Harvard Medical School Gastroenterologist Mayo Clinic Health System - Franciscan Healthcare Academic Gastroenterologist University of New Mexico More Science jobs from Gastroenterology & Hepatology EVENT 3rd Annual Gastroenterology & Hepatology Symposium 13.02.14 Fort Lauderdale, USA More science events from
NEWS AND VIEWS		Top
Hepatitis: Immunoregulation in pregnancy and perinatal transmission of HCV Giuseppe Indolfi, Chiara Azzari & Massimo Resti Published online: 03 December 2013 p6 | doi:10.1038/nrgastro.2013.230 Perinatal transmission of HCV is the main route of acquisition of HCV infection in children. Few studies have explored the mechanism of perinatal transmission, but a key role in transmission has been attributed to maternal viraemia. A new study now provides insights on the biological basis of this association. Full Text | PDF
Pancreatic cancer: Sorafenib: no effect on efficacy of chemotherapy in pancreatic cancer Muhammad Wasif Saif Published online: 10 December 2013 p8 | doi:10.1038/nrgastro.2013.234 Targeting angiogenesis has not been successful as a treatment for pancreatic cancer. Studies using monoclonal antibodies or small molecule inhibitors of the VEGFR pathway have failed to demonstrate benefit. Now, a phase II study has shown that sorafenib does not improve the efficacy of gemcitabine plus cisplatin chemotherapy in patients with locally advanced or metastatic pancreatic adenocarcinoma. Full Text | PDF
IBD: Measuring what counts—endoscopic assessment in IBD Reena Khanna, Barrett G. Levesque & William J. Sandborn Published online: 03 December 2013 p9 | doi:10.1038/nrgastro.2013.233 Endoscopic assessment in IBD provides direct visualization of the affected bowel mucosa. There is an important need for the meaningful measurement of these endoscopic images at the correct time point for medical decision-making and for clinical trials. European guidelines on endoscopy in IBD have recently been published. Full Text | PDF
REVIEWS		Top
Microscopic imaging in endoscopy: endomicroscopy and endocytoscopy Martin Goetz, Nisar P. Malek & Ralf Kiesslich Published online: 30 July 2013 p11 | doi:10.1038/nrgastro.2013.134 Endomicroscopy and endocytoscopy not only enable prediction of histology, but actual visualization of microscopic tissue details in real time. The authors of this Review discuss these microscopic imaging devices, outlining potential indications for their use and future directions for this technology. Abstract | Full Text | PDF
The '-omics' revolution and oesophageal adenocarcinoma Jamie M. J. Weaver, Caryn S. Ross-Innes & Rebecca C. Fitzgerald Published online: 27 August 2013 p19 | doi:10.1038/nrgastro.2013.150 This Review describes how the latest advances in so-called -omics technologies have helped to provide novel insights into the development and biology of oesophageal adenocarcinoma and its precursor lesion Barrett oesophagus. The authors discuss how these molecular profiles could improve patient management in the future, including early diagnosis and monitoring of response to therapy. Abstract | Full Text | PDF
HCV transmission in industrialized countries and resource-constrained areas Mark Thursz & Arnaud Fontanet Published online: 01 October 2013 p28 | doi:10.1038/nrgastro.2013.179 Understanding HCV transmission routes is essential for designing and implementing control strategies to reduce the prevalence of HCV infection and the burden of hepatitis C. Here, the main routes of HCV transmission in industrialized and resource-constrained countries are presented, along with a global agenda on how the burden of HCV could be reduced. Abstract | Full Text | PDF
Advances in the treatment of coeliac disease: an immunopathogenic perspective Katri Kaukinen, Katri Lindfors & Markku Mäki Published online: 06 August 2013 p36 | doi:10.1038/nrgastro.2013.141 Currently, a gluten-free diet is the only approved therapy for coeliac disease. Advances in the understanding of the disease pathogenesis have enabled researchers to develop new treatment strategies. This Review outlines the search for novel future treatment modes and discusses the potential pitfalls of the new research avenues. Abstract | Full Text | PDF
Chemopreventive strategies in hepatocellular carcinoma Siddharth Singh, Preet Paul Singh, Lewis R. Roberts & William Sanchez Published online: 13 August 2013 p45 | doi:10.1038/nrgastro.2013.143 In light of the high mortality rate associated with hepatocellular carcinoma (HCC), chemopreventive strategies to prevent or delay the development of this disease are attractive. This Review outlines advances in the field of HCC chemoprevention, in particular focusing on the potential of antiviral therapy against HBV and HCV, the cancer-modifying effects of statins, antidiabetic medications and aspirin, as well as dietary strategies. Abstract | Full Text | PDF | Supplementary information
Bile acid receptors as targets for drug development Frank G. Schaap, Michael Trauner & Peter L. M. Jansen Published online: 27 August 2013 p55 | doi:10.1038/nrgastro.2013.151 Bile acids have a crucial role in the digestion of dietary lipids and as signalling molecules in a number of metabolic pathways. Bile acid receptors have become attractive therapeutic targets for liver disease and metabolic disorders. Here, the authors provide an overview of bile acid signalling in humans and highlight the therapeutic potential of compounds that target these pathways. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Chronic hepatitis D at a standstill: where do we go from here? Alessia Ciancio & Mario Rizzetto Published online: 10 September 2013 p68 | doi:10.1038/nrgastro.2013.164 New insights into the virology of hepatitis D are stimulating the search for novel therapeutic approaches, but their clinical return seems far away. Here, Alessia Ciancio and Mario Rizzetto discuss the current epidemiological situation and the development of new therapeutic strategies against hepatitis D virus. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2012. Nature Reviews Gastroenterology & Hepatology was previously published as Nature Clinical Practice Gastroenterology & Hepatology.

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