Nature Reviews Immunology Contents February 2014 Volume 14 Number 2 pp 61-131

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Regulatory B cells and tolerance in transplantation: from animal models to human (open access) In this review, Sophie Brouard and colleagues summarize the different studies in animals and humans that suggest a B-cell regulatory role in the transplant tolerance mechanisms.  Read many more high-quality articles from Frontiers in Immunology
TABLE OF CONTENTS
February 2014 Volume 14 Number 2
Impact Factor 33.129 *	In this issue Research Highlights Reviews Also this month  Featured article: Alveolar macrophages: plasticity in a tissue-specific context Tracy Hussell & Thomas J. Bell
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Nature Immunology & Nature Biotechnology  FOCUS ON HIGH-DIMENSIONAL IMMUNE ANALYSIS  Nature Biotechnology and Nature Immunology present a series of specially commissioned articles discussing new technologies and approaches that enable more detailed and comprehensive analysis of the immune system.
RESEARCH HIGHLIGHTS Top Innate immunity: The inside story on complement activation p61 | doi:10.1038/nri3603 Intracellular production of C3a in human CD4+ T cells mediated by cathepsin L is required for T cell survival and effector function. PDF Immune evasion: Mycobacteria hide from TLRs p62 | doi:10.1038/nri3604 Pathogenic mycobacteria use membrane lipids to evade detection by TLRs and killing by microbicidal macrophages. PDF T cells: Skin oils trigger T cell responses p62 | doi:10.1038/nri3611 Natural skin oils activate CD1a-restricted T cells for barrier immunity. PDF Regulatory T cells: Muscling in on repair p63 | doi:10.1038/nri3602 A unique population of TReg cells accumulates in injured muscles and promotes muscle repair. PDF T cells: Spotting the troublemakers p64 | doi:10.1038/nri3610 MDR1 expression distinguishes pathogenic from non-pathogenic TH17 cells in humans. PDF Asthma and allergy: Diet and airway inflammation p64 | doi:10.1038/nri3612 A high-fat diet promotes airway inflammation through IL-17A+ innate lymphoid cells, whereas a high-fibre diet reduces airway inflammation through effects on dendritic cells. PDF Immunogenetics: Ethnic differences in sensitivity to H7N9 virus p65 | doi:10.1038/nri3614 The prevalence of MHC class I molecules that present conserved immunogenic influenza A virus peptides varies among ethnicities. PDF Autoimmunity: A new clue to sleepiness p66 | doi:10.1038/nri3609 The identification of CD4+ T cells that are specific for the wake-promoting hormone orexin confirms narcolepsy as an autoimmune disease. PDF Mucosal immunology: Innate control of IgA p66 | doi:10.1038/nri3613 Soluble lymphotoxin and membrane-bound lymphotoxin produced by innate lymphoid cells control the generation of IgA in the gut. PDF IN BRIEF Immunotherapy: Glucocorticoids shift response in macrophages | Neutrophils: Oxygen depletion puts out the flames | Reproductive immunology: Fetal intervention rouses maternal T cells | Dendritic cells: IFN-dependent DC maturation | Tumour immunology: Next-generation antibody overcomes resistance | Autoimmunity: A link between autoimmunity and cancer? PDF Immunology JOBS of the week Postdoc fellow Medical University of South Carolina Postdoctoral Positions Icahn School of Medicine at Mount Sinai Bioinformatics Programmer Drexel University Group Leader Positions Imagine Institute of Genetic Diseases More Science jobs from Immunology EVENT Ita Askonas: Sixty Years in Immunology 07.04.14 London, UK More science events from
REVIEWS		Top
Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling Marcus R. Clark, Malay Mandal, Kyoko Ochiai & Harinder Singh p69 | doi:10.1038/nri3570 Developing B cells that have successfully expressed a pre-B cell receptor (pre-BCR) undergo clonal expansion, but must exit the cell cycle before rearranging their immunoglobulin light chain loci. The authors discuss how signalling through the interleukin-7 receptor and BCR is coordinated in a mutually exclusive manner to ensure the production of mature B cells without risking leukaemic transformation. Abstract | Full Text | PDF
Alveolar macrophages: plasticity in a tissue-specific context Tracy Hussell & Thomas J. Bell p81 | doi:10.1038/nri3600 In this Review, the authors describe the unique molecular and functional features of alveolar macrophages that distinguish these cells from other macrophage populations. They discuss how alveolar macrophages are able to shape both pro-inflammatory and tolerogenic immune responses in the lung in order to maintain health at this site. Abstract | Full Text | PDF
The function of Fcγ receptors in dendritic cells and macrophages Martin Guilliams, Pierre Bruhns, Yvan Saeys, Hamida Hammad & Bart N. Lambrecht p94 | doi:10.1038/nri3582 Here, the authors review the expression patterns and function of Fc receptors for IgG (FcγRs) on conventional dendritic cells (DCs), monocyte-derived DCs, plasmacytoid DCs and macrophages in the steady state and at sites of inflammation. They also discuss emerging concepts and areas that require further investigation. Abstract | Full Text | PDF | Supplementary information
Innate immunity to Toxoplasma gondii infection Felix Yarovinsky p109 | doi:10.1038/nri3598 Much research into Toxoplasma gondii infection has concentrated on adaptive T helper 1 cell responses. More recently, scientists have focused on the innate immune pathways that enable control of T. gondii infection. This Review compares the innate immune response to T. gondii in mice and humans, with a particular focus on Toll-like receptor-dependent pathways. Abstract | Full Text | PDF
The roles of Pellino E3 ubiquitin ligases in immunity Paul N. Moynagh p122 | doi:10.1038/nri3599 Ubiquitylation is an important regulatory process that controls numerous signalling pathways, including those that drive immune responses. As described in this Review, Pellino proteins are E3 ubiquitin ligases that regulate both innate and adaptive immune signalling pathways. Abstract | Full Text | PDF
Corrigendum: NOD proteins: regulators of inflammation in health and disease Dana J. Philpott, Matthew T. Sorbara, Susan J. Robertson, Kenneth Croitoru & Stephen E. Girardin p131 | doi:10.1038/nri3601 Full Text | PDF
Erratum: Concepts of tissue injury and cell death in inflammation: a historical perspective David Wallach, Tae-Bong Kang & Andrew Kovalenko p131 | doi:10.1038/nri3606 Full Text | PDF
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