Nature Reviews Molecular Cell Biology contents February 2014 Volume 15 Number 2 pp 75-147

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TABLE OF CONTENTS
February 2014 Volume 15 Number 2
Impact Factor 37.162 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Cell death and autophagy  Featured article: Synthetic biology in mammalian cells: next generation research tools and therapeutics Florian Lienert, Jason J. Lohmueller, Abhishek Garg & Pamela A. Silver
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RESEARCH HIGHLIGHTS Top Development: Morphogen gradients revisited p75 | doi:10.1038/nrm3743 Patterning and growth can proceed without an instructive gradient of secreted Wg. PDF DNA damage response: A ligase makes sense of DNA damage p76 | doi:10.1038/nrm3739 This study delineates the previously elusive role of PRP19 in the DDR. PDF RNA decay: Stabilizing stemness through m6A p76 | doi:10.1038/nrm3745 mRNA methylation destabilizes developmental regulators to maintain the properties of mammalian embryonic stem cells. PDF Calcium: An ion channel for cilia p78 | doi:10.1038/nrm3736 Ciliary calcium concentrations are controlled by the PKD1L1–PKD2L1 channel and modulate HH signalling. PDF Gene expression: Methyltransferases 'talk' at histone H3 p78 | doi:10.1038/nrm3746 The histone methyltransferase G9a promotes the recruitment of PRC2 to certain target genes and thus H3K27 methylation. PDF JOURNAL CLUB The lipid trade p79 | doi:10.1038/nrm3740 In 2008, the Bankaitis group suggested that lipid transport proteins can exchange one membrane lipid for another. PDF Stem cells: Moving out of the niche p79 | doi:10.1038/nrm3747 Decaying tracheal branches produce fibroblast growth factor to guide progenitor cells to form new tissue. PDF IN BRIEF Autophagy: Hox times autophagy | Chromosomes: Histone modifications in mitosis | Protein metabolism: N-terminal Met can trigger degradation PDF Molecular Cell Biology JOBS of the week Molecular Cell biology - DNA damage responses NIH / NIEHS Postdoctoral Associate University of Illinois Postdoctoral Associate Baylor College of Medicine Cellular / Molecular Imaging Scientist Western University Epigenetics and Stem Cell Biology Max Planck Institute for Heart and Lung Research More Science jobs from Molecular Cell Biology EVENT More science events from
REVIEWS		Top
Article series: Cell death and autophagy Self-consumption: the interplay of autophagy and apoptosis Guillermo Marino, Mireia Niso-Santano, Eric H. Baehrecke & Guido Kroemer p81 | doi:10.1038/nrm3735 Autophagy and apoptosis control the turnover of organelles and proteins within cells, and of cells within organisms, respectively. It is now clear that these processes often occur sequentially, and that crosstalk between the signalling pathways regulating them generally enables autophagy to block the induction of apoptosis, whereas apoptosis-associated caspase activation shuts off autophagy. Abstract | Full Text | PDF | Supplementary information
Synthetic biology in mammalian cells: next generation research tools and therapeutics Florian Lienert, Jason J. Lohmueller, Abhishek Garg & Pamela A. Silver p95 | doi:10.1038/nrm3738 Engineering of gene circuits, DNA-binding domains and RNA regulators has led to a new generation of synthetic biology research tools, which enable the elucidation of gene function in mammalian cells. The possibility to rebuild complex signalling circuits outside of their normal context is also increasing our understanding of signalling pathways and is leading to innovative therapeutic interventions. Abstract | Full Text | PDF | Supplementary information
A day in the life of the spliceosome A. Gregory Matera & Zefeng Wang p108 | doi:10.1038/nrm3742 The tight regulation of each step of spliceosome assembly from small nuclear RNAs and associated proteins requires coordination between distinct cellular compartments. This in turn dictates where and when alternative splicing occurs and is vital for normal gene expression control. Abstract | Full Text | PDF
Regulated protein turnover: snapshots of the proteasome in action Sucharita Bhattacharyya, Houqing Yu, Carsten Mim & Andreas Matouschek p122 | doi:10.1038/nrm3741 The eukaryotic 26S proteasome degrades regulatory as well as misfolded or damaged proteins. High-resolution structures of the entire 26S proteasome particle in different nucleotide conditions, and with or without substrate, provide insights into its functional mechanism and will guide genetic and biochemical studies of this key regulatory system. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Article series: Cell death and autophagy Regulated necrosis: the expanding network of non-apoptotic cell death pathways Tom Vanden Berghe et al. p135 | doi:10.1038/nrm3737 Cell death research was revitalized by the understanding that necrosis can occur in a regulated and genetically controlled manner. Although necroptosis is the most recognized form of regulated necrosis, other examples of this process have emerged. Understanding how these pathways are interconnected should enable regulated necrosis to be therapeutically targeted. Abstract | Full Text | PDF
Erratum: Biogenesis and homeostasis of chloroplasts and other plastids Paul Jarvis & Enrique López-Juez p147 | doi:10.1038/nrm3744 Full Text | PDF
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