Nature Reviews Neurology - Table of Contents alert Volume 10 Issue 1

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Does chronic idiopathic dizziness reflect an impairment of sensory predictions of self-motion?  In this article, Jörn K. Pomper and colleagues discuss how most patients suffering from chronic idiopathic dizziness do not present signs of vestibular dysfunction or organic failures of other kinds. Hence, this kind of dizziness is commonly seen as psychogenic in nature, sharing commonalities with specific phobias, panic disorder, and anxiety.  Read more high-quality articles from Frontiers in Neurology
TABLE OF CONTENTS
January 2014 Volume 10 Number 1
Impact Factor 15.518 *	In this issue Research Highlights News and Views Reviews Also this month  Featured article: The emerging agenda of stratified medicine in neurology Paul M. Matthews, Paul Edison, Olivia C. Geraghty & Michael R. Johnson
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In 2013, the ACNP established the "Neuropsychopharmacology Editors' Award for a Transformative Original Report" (also known as the NEATOR Award). This award is intended to recognize and honour the best original paper published in Neuropsychopharmacology during the previous calendar year. Read the winning article by Dr Baumann and his colleagues here.  Submit your research to Neuropsychopharmacology and get the recognition your research deserves!
RESEARCH HIGHLIGHTS Top Stroke: Improving the management of patients at risk of haemorrhagic stroke Published online: 10 December 2013 p1 | doi:10.1038/nrneurol.2013.257 PDF Prion disease: A newly identified mutation in prion protein is associated with diarrhoea and autonomic neuropathy Published online: 03 December 2013 p2 | doi:10.1038/nrneurol.2013.249 PDF Neurometabolic disease: Treating mitochondrial diseases with mTOR inhibitors—a potential treatment for Leigh syndrome? Published online: 03 December 2013 p2 | doi:10.1038/nrneurol.2013.251 PDF Traumatic brain injury: PET imaging detects amyloid deposits after TBI Published online: 03 December 2013 p3 | doi:10.1038/nrneurol.2013.250 PDF Alzheimer disease: Effects of the APOE ε4 allele on brain development Published online: 10 December 2013 p4 | doi:10.1038/nrneurol.2013.258 PDF IN BRIEF Neuroinflammation: Thrombin activity—an early biomarker for neuroinflammatory disease? | Genetics: TBC1D24 mutations are implicated in DOORS syndrome | Neural repair and rehabilitation: Body art meets neuroprosthetics | Dementia: Brain-derived neurotrophic factor might protect against dementia in selected population subgroups | Headache: Norwegian study identifies headache as a risk factor for vascular dementia | Neurodegenerative disease: Histone deacetylase 4 promotes cytoplasmic huntingtin aggregation in mouse models of Huntington disease | Alzheimer disease: Primate study deals a fresh blow to the peripheral sink hypothesis PDF Neurology JOBS of the week Fully-funded PhD Studentship: Neurology Swansea University Postdoctoral Research Fellow - Brain Tumor Research Massachusetts General Hospital & Harvard Medical School Director of MRI Research at Columbia University Columbia University More Science jobs from Neurology EVENT The 8th World Congress on Controversies in Neurology (CONy) 08.05.14 Berlin, Germany More science events from
NEWS AND VIEWS		Top
Neuro-oncology: Stability of medulloblastoma subgroups at tumour recurrence Jacques Grill & Christelle Dufour Published online: 10 December 2013 p5 | doi:10.1038/nrneurol.2013.256 Medulloblastomas can be categorized into four molecular subgroups. A new report shows, for the first time, that these tumours remain in the same subgroup at relapse, and the molecular subgroup influences the pattern of relapse. These findings indicate that this developmentally defined classification is robust, although its relationship to prognosis remains uncertain. Full Text | PDF
Movement disorders: Tourette syndrome—beyond swearing and sex? Mary May Robertson Published online: 03 December 2013 p6 | doi:10.1038/nrneurol.2013.248 Gilles de la Tourette syndrome (GTS) is often perceived as the 'swearing disease', yet coprolalia affects only 10-15% of individuals with this condition. As highlighted in a new study, GTS has many phenotypes, some of which are sex-related. Could gender—that is, culturally established roles—also affect the phenotype? Full Text | PDF | Supplementary information
Parkinson disease: Low vitamin D and Parkinson disease—a causal conundrum Marian L. Evatt Published online: 03 December 2013 p8 | doi:10.1038/nrneurol.2013.252 Increasing evidence suggests that Parkinson disease (PD) should be included on the growing list of diseases associated with vitamin D insufficiency. A recent study reconfirms this association and supports the monitoring of vitamin D concentrations in patients with PD. The conundrum of causality regarding this association, however, remains unanswered. Full Text | PDF
Migraine: Differential effects of placebos in migraine clinical trials Peer C. Tfelt-Hansen & Anders Hougaard Published online: 10 December 2013 p10 | doi:10.1038/nrneurol.2013.255 According to a new systematic review, placebo treatment in clinical trials of migraine prophylaxis results in responder rates ranging from 0-56%, probably owing to variable combinations of spontaneous improvement and genuine placebo effects. Clinicians who treat patients with migraine should be aware of the potential nonspecific effects of any treatment modality. Full Text | PDF
Epilepsy: Effects of exposure to antiepileptic drugs during development Frank Vajda Published online: 10 December 2013 p11 | doi:10.1038/nrneurol.2013.254 A population-based study of babies who were exposed to antiepileptic drugs (AEDs) in utero revealed impairment of fine motor and social skills as early as 6 months of age. Such neurocognitive changes were independent of breastfeeding status at 18 months, suggesting that breastfeeding can be recommended in women receiving AEDs. Full Text | PDF
Neurodegenerative disease: Mapping the natural history of Huntington disease Roger A. Barker & Sarah L. Mason Published online: 10 December 2013 p12 | doi:10.1038/nrneurol.2013.253 A key challenge to improving the design of clinical trials in Huntington disease (HD) has been the limited data on the natural history of HD. A recent prospective longitudinal study has provided important information in this regard, which could be useful for future translation of disease-modifying therapies for early-stage HD. Full Text | PDF
REVIEWS		Top
The emerging agenda of stratified medicine in neurology Paul M. Matthews, Paul Edison, Olivia C. Geraghty & Michael R. Johnson Published online: 10 December 2013 p15 | doi:10.1038/nrneurol.2013.245 In this Review, Paul Matthews and colleagues outline the potential benefits of a stratified approach to health-care delivery in neurology, including reduced risk of adverse events from medicines, and lower treatment costs. They provide examples of neurological diseases in which stratified medicine is already improving treatment, and consider challenges to implementation of these approaches. Abstract | Full Text | PDF
Primary cilia in neurodevelopmental disorders Enza Maria Valente, Rasim O. Rosti, Elizabeth Gibbs & Joseph G. Gleeson Published online: 03 December 2013 p27 | doi:10.1038/nrneurol.2013.247 Primary cilia are hair-like, non-motile sensory organelles that are found on the surface of almost all cells in vertebrates. Defects in these organelles can lead to a wide array of disorders known as ciliopathies. In this Review, Valente et al. focus on ciliopathies with major neurological involvement, describing their clinical features and known pathogenetic mechanisms, and discussing the possible aetiologies of associated brain malformations. Abstract | Full Text | PDF
Bringing rigour to translational medicine David W. Howells, Emily S. Sena & Malcolm R. Macleod Published online: 19 November 2013 p37 | doi:10.1038/nrneurol.2013.232 Effective treatments are lacking for most neurological disorders, and progress in developing new therapeutic agents has been frustratingly slow. Howells and colleagues explore the barriers to the development of treatments for these conditions, focusing predominantly on the stroke field. They highlight the current deficiencies and conflicts of interest in preclinical and clinical research, and suggest ways in which scientific rigour might be improved. Abstract | Full Text | PDF
Delayed neurological deterioration after subarachnoid haemorrhage R. Loch Macdonald Published online: 10 December 2013 p44 | doi:10.1038/nrneurol.2013.246 Subarachnoid haemorrhage (SAH) has a high case fatality. In addition to neurological injury occurring at the time of haemorrhage, delayed neurological deterioration can occur days later owing to processes such as cerebral vasospasm and microthrombosis, which culminate in delayed cerebral ischaemia. R. Loch Macdonald reviews the pathophysiology of these delayed complications of SAH, and outlines existing treatments and drugs in development for this indication. Abstract | Full Text | PDF | Supplementary information
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