Nature Reviews Nephrology - Table of Contents alert Volume 10 Issue 3

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TABLE OF CONTENTS
March 2014 Volume 10 Number 3
Impact Factor 7.943 *	In this issue Research Highlights News and Views Correction Reviews Perspectives Correspondence Also this month  Featured article: Risk of chronic kidney disease after cancer nephrectomy Lin Li, Wei Ling Lau, Connie M. Rhee, Kevin Harley, Csaba P. Kovesdy, John J. Sim, Steve Jacobsen, Anthony Chang, Jaime Landman & Kamyar Kalantar-Zadeh
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RESEARCH HIGHLIGHTS Top Basic Research: The long and the short of it—the temporal effects of renal lithium exposure are beginning to be unravelled Published online: 28 January 2014 p123 | doi:10.1038/nrneph.2014.10 PDF Acute kidney injury: SOCS-3 expression detrimental in AKI Published online: 28 January 2014 p124 | doi:10.1038/nrneph.2014.11 PDF Hypertension: Understanding baroreflex dysfunction in chronic kidney disease Published online: 21 January 2014 p124 | doi:10.1038/nrneph.2014.4 PDF Transplantation: Immunoadsorption combined with membrane filtration might enhance desensitization Published online: 21 January 2014 p125 | doi:10.1038/nrneph.2014.5 PDF Tubular disease: Mistargeted protein disrupts mitochondrial metabolism in inherited Fanconi syndrome Published online: 21 January 2014 p125 | doi:10.1038/nrneph.2014.6 PDF Glomerular disease: Increased complexity of the glomerular extracellular matrix Published online: 04 February 2014 p126 | doi:10.1038/nrneph.2014.16 PDF IN BRIEF Dialysis: Loss of mobility associated with mortality in elderly patients | Genetics: Genotypes and phenotypes in WT1-associated nephropathy | Acute kidney injury: Proximal tubular cells transiently acquire STC phenotype PDF
NEWS AND VIEWS		Top
Chronic kidney disease: Chronic kidney disease and the ageing population Marcello Tonelli & Miguel C. Riella Published online: 14 January 2014 p127 | doi:10.1038/nrneph.2013.279 'Chronic kidney disease (CKD) in older people' is the focus of World Kidney Day 2014. In this article, we discuss the key links between kidney function, age, health and illness, as well as the implications of the ageing population for the care of people with CKD. Full Text | PDF
Proteinuria: Abate or applaud abatacept in proteinuric kidney disease? Jochen Reiser & Nada Alachkar Published online: 24 December 2013 p128 | doi:10.1038/nrneph.2013.276 T-lymphocyte activation antigen CD80 is a B-cell costimulator and podocyte injury marker originally described in lupus nephritis; CD80 blockade with abatacept disappointed in a lupus nephritis trial. A study now suggests abatacept efficacy in focal and segmental glomerulosclerosis. Small patient numbers and concurrent treatment regimens call for more definitive studies regarding this therapeutic strategy. Full Text | PDF
Transplantation: Increased ESRD and mortality risk for kidney donors? Arthur J. Matas Published online: 21 January 2014 p130 | doi:10.1038/nrneph.2014.2 For most patients with end-stage renal disease (ESRD), a kidney transplant is the best treatment option. Compared with dialysis, a successful kidney transplant is associated with increased life expectancy and improved quality of life; a living donor transplant is associated with better long-term results than a deceased donor transplant. Full Text | PDF
Chronic kidney disease: Haemodialysis catheter care in practice Sunil V. Badve & David W. Johnson Published online: 21 January 2014 p131 | doi:10.1038/nrneph.2014.3 A new haemodialysis catheter-care procedure has been reported, including exit-site disinfection with chlorhexidine gluconate that results in a sustained reduction in bacteraemia rates, new intravenous antibiotic starts and sepsis-associated and access-associated hospitalization rates compared with standard care. These findings have potential implications for the prevention of haemodialysis catheter-associated infections. Full Text | PDF
Acute kidney injury: Late-onset acute kidney injury—subacute or more of the same? Zoltán H. Endre & John W. Pickering Published online: 28 January 2014 p133 | doi:10.1038/nrneph.2014.9 Fujii and colleagues define 'subacute' kidney injury (s-AKI) as AKI that takes >7 days to develop, timed from admission or lowest creatinine measurement after admission. Although s-AKI is unlikely to be a distinct syndrome from AKI, the association with increased mortality highlights the need to monitor patient creatinine levels. Full Text | PDF
CORRECTION		Top
Nephrology in Africa—not yet uhuru Charles R. Swanepoel, Nicola Wearne & Ikechi G. Okpechi Published online: 14 January 2014 p124 | doi:10.1038/nrneph.2014.7 Full Text | PDF
REVIEWS		Top
Risk of chronic kidney disease after cancer nephrectomy Lin Li, Wei Ling Lau, Connie M. Rhee, Kevin Harley, Csaba P. Kovesdy, John J. Sim, Steve Jacobsen, Anthony Chang, Jaime Landman & Kamyar Kalantar-Zadeh Published online: 14 January 2014 p135 | doi:10.1038/nrneph.2013.273 In this Review, the authors describe the potential benefits of partial versus radical nephrectomy for small renal cell carcinomas. They also discuss the risk of de novo kidney disease or progression of pre-existing chronic kidney disease after nephrectomy, the potential factors that might influence patient prognosis after this surgery, and the need for further research in this field. Abstract | Full Text | PDF
Blood pressure and amiloride-sensitive sodium channels in vascular and renal cells David G. Warnock, Kristina Kusche-Vihrog, Antoine Tarjus, Shaohu Sheng, Hans Oberleithner, Thomas R. Kleyman & Frederic Jaisser Published online: 14 January 2014 p146 | doi:10.1038/nrneph.2013.275 Blood pressure control is influenced by amiloride-sensitive sodium channels in the vascular and epithelial homeostatic systems in the kidney. Here, the authors describe the expression and regulation of sodium channels, and they outline the emerging evidence that differences between sodium channel complexes expressed in the epithelia and endothelia might permit novel therapeutic approaches to lower systemic blood pressure without the adverse effects associated with the sodium channel blockers that are currently available. Abstract | Full Text | PDF
The emergence of the glomerular parietal epithelial cell Stuart J. Shankland, Bart Smeets, Jeffrey W. Pippin & Marcus J. Moeller Published online: 28 January 2014 p158 | doi:10.1038/nrneph.2014.1 The glomerular parietal epithelial cell (PEC)—a resident glomerular cell type—has been under active study in recent years, improving the understanding and definition of how these cells behave normally and in glomerular disease. Here, the authors discuss model systems to study PECs, how PECs might contribute to glomerulosclerosis, crescent and pseudocrescent formation and how PECs handle filtered albumin. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Cardiovascular complications in atypical haemolytic uraemic syndrome Marina Noris & Giuseppe Remuzzi Published online: 14 January 2014 p174 | doi:10.1038/nrneph.2013.280 Haemolytic uraemic syndrome (HUS) leads to anaemia, thrombocytopenia and, ultimately, acute renal failure. Some patients are also at risk of cardiovascular complications owing to mutations in the complement pathway, which result in microangiopathic injury of the coronary vasculature. This Perspectives article highlights the cardiovascular complications arising in patients with HUS and the implications for treatment of this rare disease. Abstract | Full Text | PDF
CORRESPONDENCE		Top
Albuminuria is controlled primarily by proximal tubules Wayne D. Comper Published online: 28 January 2014 p180 | doi:10.1038/nrneph.2013.58-c1 Full Text | PDF
Reply: Podocytes are key—although albumin never reaches the slit diaphragm Marcus J. Moeller & George A. Tanner Published online: 28 January 2014 p180 | doi:10.1038/nrneph.2013.58-c2 Full Text | PDF
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*Journal Citation Reports, Thomson, 2012. Nature Reviews Nephrology was previously published as Nature Clinical Practice Nephrology.

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