Drug Discovery@nature.com 28 March 2014

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TABLE OF CONTENTS 28 March 2014 News Analysis Research Highlights Research & Reviews Careers Nature Reviews Drug Discovery is on Twitter Advertisement Nature Biotechnology & Nature Immunology  FOCUS ON HIGH-DIMENSIONAL IMMUNE ANALYSIS  Nature Biotechnology and Nature Immunology present a series of specially commissioned articles discussing new technologies and approaches that enable more detailed and comprehensive analysis of the immune system. Listen to the accompanying Webcast: http://bit.ly/1lxqFS2   Produced with support from  Adaptive Biotechnologies    News Top GSK picks six cancer research centers doi:10.1038/nbt0314-206 GlaxoSmithKline (GSK) has launched a collaborative research network with six leading cancer research centers in the USA and Europe. Full Text BMS sells diabetes business doi:10.1038/nbt0314-209 As part of a plan to refocus on specialty care products, Bristol-Myers Squibb has sold its stake in the diabetes business to its former diabetes partner AstraZeneca for up to $4.3 billion. Full Text Straight talk with...Harlan Krumholz doi:10.1038/nm0314-225 The Head of the Yale University Open Data Access (YODA) project explains why greater access to data is a boon for medicine. Full Text Federal red tape ties up marijuana research doi:10.1038/507407a Despite the legalization of marijuana in two US states, biomedical research on the drug faces continued restrictions. Full Text Analysis Top A liver divided doi:10.1038/scibx.2014.302 Three independent teams have directly converted human fibroblasts to liver cells and eliminated a proliferation barrier from stem cell–based protocols. Full Text Systemic lupus erythematosus and lupus nephritis doi:10.1038/nrd4220 The likely market impact of the late-stage pipeline for systemic lupus erythematosus (SLE) and lupus nephritis (LN), which contains biologics and small-molecule drugs for a broad range of targets. Full Text Research Highlights Top Inflammatory disorders: Monocytes derailed by microparticles doi:10.1038/nrd4263 Microparticles that target inflammatory monocytes can dampen inflammation and alleviate symptoms in several mouse models of immune-mediated disease. Full Text Vascular disease: A new way to starve vascular endothelial cells doi:10.1038/nrd4264 Partial inhibition of glycolysis with a small-molecule drug could ameliorate pathological angiogenesis, which occurs in various diseases including cancer. Full Text Neurological disorders: Presynaptic glycine receptors become a startling target doi:10.1038/nrd4265 A cannabinoid derivative that seems to target presynaptic glycine receptors could have therapeutic potential in startle disease. Full Text Research & Reviews Top REV-ERB and ROR nuclear receptors as drug targets doi:10.1038/nrd4100 A Review on the development of ligands to target two classes of nuclear receptors — the REV-ERBs and RORs — and their possible use in treating disorders related to metabolism, immune function and the circadian rhythm. Full Text Drugging the p53 pathway: understanding the route to clinical efficacy doi:10.1038/nrd4236 In this Review, Lane and colleagues provide an overview of the different therapeutic approaches to targeting the p53 pathway in cancer and discuss the state of development of p53 pathway modulators. Full Text Opinion: Targeting tumour-supportive cellular machineries in anticancer drug development doi:10.1038/nrd4201 The advantages and limitations of agents that target tumour-supportive cellular machineries — such as the proteasome, heat shock protein complexes and proteins involved in chromatin modifications — which are emerging as a new wave of anticancer drugs. Full Text Progress: The path of anti-tuberculosis drugs: from blood to lesions to mycobacterial cells doi:10.1038/nrmicro3200 Veronique Dartois describes new methods to quantify and image anti-tuberculosis drug distribution in infected lung tissue and mycobacterial cells, and explores how this technology could be used to design optimized multidrug regimens. Full Text Drug Discovery JOBS of the week Postdoc in Cancer Drug Delivery University of Tartu 4-Year Fully Funded Studentship in "Computation of Allosteric Interactions in Biomolecular Drug Targets�� University of Edinburgh Scientific Officer - Molecular Drug Resistance Team Institute of Cancer Research (ICR) Tenure-Track and Postdoctoral Scientists in Molecular Profiling Research Center for Drug Discovery, AIST National Institute Advanced Industrial Science and Technology (AIST) Postdoctoral Research Fellow in Nanomedicine and Drug Delivery Wayne State University More Science jobs from Drug Discovery EVENT 15th International Conference on Alzheimer�s Drug Discovery 08.09.14 New Jersey, USA More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. Full Text Top Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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