Nature Reviews Genetics Contents April 2014 Volume 15 Number 4 pp 215-286

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TABLE OF CONTENTS
April 2014 Volume 15 Number 4
Impact Factor 41.063 *	In this issue Research Highlights Ethics Watch Reviews Also this month Article series: Modes of transcriptional regulation Regulatory elements  Featured article: Evolution of transcription factor binding in metazoans — mechanisms and functional implications Diego Villar, Paul Flicek & Duncan T. Odom
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Human Genome Analysis: Genetic Analysis of Multifactorial Diseases (23-29 July 2014) Wellcome Trust Genome Campus, Hinxton, UK This course covers statistical methods used to map disease susceptibility genes, with an emphasis on methods that can analyse family data or a combination of families and individuals. Applications close 11 April (Bursaries available).
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RESEARCH HIGHLIGHTS Top Gene expression: Transcription initiation codes — the tip of the iceberg? p215 | doi:10.1038/nrg3697 PDF Chromosome biology: Genetic reunification p216 | doi:10.1038/nrg3701 PDF Disease genetics: All together now for variant interpretation p216 | doi:10.1038/nrg3702 PDF Evolution: Boom and robust p216 | doi:10.1038/nrg3703 PDF Epigenetics: An epigenetic twist on the missing heritability of complex traits p218 | doi:10.1038/nrg3698 PDF Disease Genetics: Insights into monogenic disease p218 | doi:10.1038/nrg3699 PDF RNA: RiboSNitches reveal heredity in RNA secondary structure p219 | doi:10.1038/nrg3700 PDF IN BRIEF Technology: Sequencing transcriptomes in situ | Chromatin: Chromosome roles for repetitive RNAs | Gene expression: Global analyses of determinants of RNA decay | Evolution: Flu fitness model may inform vaccine selection | Animal models: High-precision gene editing in monkeys is feasible | Disease genetics: Insights into missing heritability | Epigenetics: Mechanisms underlying fragile X syndrome PDF Genetics JOBS of the week Postdoctoral Position in Chromosome Dynamics and Recombination Institut Curie Research Center Postdoc position in stem cells and epigenetics Mount School of Medicine PhD Student in Developmental Epigenetics Institute of Molecular Biology (IMB) Mainz Research Assistant Automated Railway Operations (100%), PhD dissertation intended ETH Zurich Director, Center for Translational Genomic Medicine Nationwide Children's Hospital, Research Institute More Science jobs from Genetics EVENT Drosophila Genetics and Genomics 27.07.14 Cambridge, UK More science events from
ETHICS WATCH		Top
Industry involvement in publicly funded biobanks Timothy Caulfield, Pascal Borry & Herbert Gottweis p220 | doi:10.1038/nrg3704 Increased private funding could add further to the ethical and legal complexities that are associated with biobanks. Full Text | PDF
REVIEWS		Top
Article series: Modes of transcriptional regulation Evolution of transcription factor binding in metazoans — mechanisms and functional implications Diego Villar, Paul Flicek & Duncan T. Odom p221 | doi:10.1038/nrg3481 The rate and mechanisms of evolution of transcription factor binding show striking differences across diverse metazoan phyla. This Review highlights insights gained from sequence-based comparisons of genomes and ChIP-seq studies analysing the evolution of transcription factor binding, as well as their conceptual contribution to models of regulatory evolution and gene expression control. Abstract | Full Text | PDF
Article series: Modes of transcriptional regulation CTCF: an architectural protein bridging genome topology and function Chin-Tong Ong & Victor G. Corces p234 | doi:10.1038/nrg3663 CCCTC-binding factor (CTCF) is a DNA-binding protein that has various, often seemingly contradictory, roles in gene regulation. This Review describes these disparate functions and how the context-dependent looping of DNA regions by CTCF is emerging as a potential unifying mechanism that underpins these diverse roles. Abstract | Full Text | PDF
Cryptic genetic variation: evolution's hidden substrate Annalise B. Paaby & Matthew V. Rockman p247 | doi:10.1038/nrg3688 This Review discusses cryptic genetic variation and focuses particularly on empirical support for widespread cryptic genetic variation in natural populations, its potential role in human diseases and its contribution to evolution. Abstract | Full Text | PDF
Every amino acid matters: essential contributions of histone variants to mammalian development and disease Ian Maze, Kyung-Min Noh, Alexey A. Soshnev & C. David Allis p259 | doi:10.1038/nrg3673 Increasing evidence suggests crucial functions for histone variants in diverse biological processes. This Review examines the roles of histone variants in mammalian germ cell and embryonic development, as well as the consequences of their aberrant regulation in human disease. Abstract | Full Text | PDF
Article series: Regulatory elements Transcriptional enhancers: from properties to genome-wide predictions Daria Shlyueva, Gerald Stampfel & Alexander Stark p272 | doi:10.1038/nrg3682 Enhancers are DNA elements that are key regulators of gene expression, but their complexities and context dependence makes their identification and characterization challenging. This Review discusses how an improved understanding of the varied properties of enhancers is being used in diverse approaches for the systematic prediction of enhancers genome wide. Abstract | Full Text | PDF
Erratum: Metabolically constrained regulatory networks Hannah Stower p286 | doi:10.1038/nrg3696 Full Text | PDF
Erratum: Emerging evidence for functional peptides encoded by short open reading frames Shea J. Andrews & Joseph A. Rothnagel p286 | doi:10.1038/nrg3705 Full Text | PDF
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