Laboratory Investigation - Table of Contents alert Volume 94 Issue 6

If you are unable to see the message below, click here to view.

TABLE OF CONTENTS Volume 94, Issue 6 (June 2014) In this issue Inside the USCAP Journals Research Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Inside the USCAP Journals Top Inside the USCAP Journals 2014 94: 596-597; 10.1038/labinvest.2014.67 Full Text Research Articles Top GENITOURINARY AND REPRODUCTIVE SYSTEMS Dipeptidyl peptidase IV inhibitor protects against renal interstitial fibrosis in a mouse model of ureteral obstruction This paper explores the renoprotective effects of dipeptidyl peptidase IV (DPPIV) inhibition in a mouse model of progressive renal disease. DPPIV activity increases after ureteral obstruction, and DPPIV inhibition protects against renal fibrosis via amelioration of inflammation, oxidative stress and fibrotic process. Hye Sook Min, Jung Eun Kim, Mi Hwa Lee, Hye Kyoung Song, Young Sun Kang, Mi Jin Lee, Ji Eun Lee, Hyun Wook Kim, Jin Joo Cha, Young Yoon Chung, Young Youl Hyun, Jee Young Han and Dae Ryong Cha 2014 94: 598-607; advance online publication, March 31, 2014; 10.1038/labinvest.2014.50 Abstract | Full Text Role of local bioactivation of vitamin D by CYP27A1 and CYP2R1 in the control of cell growth in normal endometrium and endometrial carcinoma Vitamin D deficiency is associated with increased cancer risk. Low serum 25(OH) vitamin D (25(OH)D) reduces intratumoral 25(OH)D conversion to 1α,25-dihydroxyvitaminD (1,25D, the hormonal form of VD), compromising 1,25D-receptor antitumor action. This study shows that vitamin D may protect against EC progression in part through increased intratumoral 25(OH)D production by CYP27A1 and CYP2R1 for autocrine/paracrine enhancement of 1,25D-receptor antiproliferative actions. Laura Bergadà, Judit Pallares, Maria Vittoria Arcidiacono, Anna Cardus, Maria Santacana, Joan Valls, Gonzalo Cao, Elvira Fernàndez, Xavier Dolcet, Adriana S Dusso and Xavier Matias-Guiu 2014 94: 608-622; advance online publication, April 14, 2014; 10.1038/labinvest.2014.57 Abstract | Full Text Genetic modulation of nephrocalcinosis in mouse models of ectopic mineralization: the Abcc6tm1Jfk and Enpp1asj mutant mice This study examines the roles of genetic modulation and diet in nephrocalcinosis, using two mouse models of ectopic mineralization. Each mutant strain, and compound heterozygous mice, show extensive mineralization of the kidneys when placed on an acceleration diet. The synergistic genetic defects in the complex mineralization/anti-mineralization network can profoundly modulate the degree of ectopic mineralization in nephrocalcinosis. Qiaoli Li, David W Chou, Thea P Price, John P Sundberg and Jouni Uitto 2014 94: 623-632; advance online publication, April 14, 2014; 10.1038/labinvest.2014.52 Abstract | Full Text ANGIOGENESIS, CARDIOVASCULAR AND PULMONARY SYSTEMS Vitronectin-binding PAI-1 protects against the development of cardiac fibrosis through interaction with fibroblasts Does the impact of plasminogen activator inhibitor-1 (PAI-1) on angiotensin II (Ang II)-induced cardiac fibrosis occurs through its vitronectin-binding activity or protease inhibitory ability? The authors employed PAI-1 variants that lack either plasminogen activation activity or vitronectin binding ability, and found that vitronectin-binding-PAI-1 provides protective effects against development of Ang II-induced cardiac fibrosis. By binding to vitronectin, PAI-1 blocks integrin αVβ3 action, induces apoptosis, and suppress proliferation, adhesion and migration of cardiac fibroblasts. These results suggest therapeutic utility of this PAI-1 variant. Jianyong Zhong, Hai-Chun Yang, Valentina Kon, Agnes B Fogo, Daniel A Lawrence and Ji Ma 2014 94: 633-644; advance online publication, March 31, 2014; 10.1038/labinvest.2014.51 Abstract | Full Text RNA-sequencing analysis reveals new alterations in cardiomyocyte cytoskeletal genes in patients with heart failure Functional analysis of RNA-sequencing data demonstrates that cytoskeletal processes are altered in human left ventricular tissue samples from heart failure (HF) patients. Two proteins known to be important to left ventricular function, ANKRD1 (part of the stretch sensor system) and RHOU (a regulator cytoskeletal organization), show changes at the gene and protein levels, emphasizing their relevance in HF. These results indicate the role of the cytoskeleton in functional and structural alterations in HF. Isabel Herrer, Esther Roselló-Lletí, Miguel Rivera, María Micaela Molina-Navarro, Estefanía Tarazón, Ana Ortega, Luis Martínez-Dolz, Juan Carlos Triviño, Francisca Lago, José R González-Juanatey, Vicente Bertomeu, José Anastasio Montero and Manuel Portolés 2014 94: 645-653; advance online publication, April 7, 2014; 10.1038/labinvest.2014.54 Abstract | Full Text γ-Secretase inhibitor DAPT attenuates intimal hyperplasia of vein grafts by inhibition of Notch1 signaling Notch signaling is highly activated in vein grafts, promoting development of intimal hyperplasia (IH) and proliferation of vascular smooth muscle cells (vSMCs). The γ-secretase inhibitor DAPT suppresses IH and vSMC proliferation by repressing the activity of the notch1 pathway and stimulating the myocardin pathway, thereby increasing vSMC differentiation marker expression. Yong Guang Xiao, Wei Wang, Dan Gong and Zhi Fu Mao 2014 94: 654-662; advance online publication, April 21, 2014; 10.1038/labinvest.2014.58 Abstract | Full Text Endothelial cells enhance the in vivo bone-forming ability of osteogenic cell sheets Successful production of engineered thick tissue is difficult because of deficient oxygen and nutrient diffusion. Specifically, vascularization remains a major hurdle in bone tissue engineering. This paper demonstrates that combining cell sheet engineering with cultured endothelial cells results in increased formation of osteogenic tissue with improved vascularization. Rogério P Pirraco, Takanori Iwata, Toshiyuki Yoshida, Alexandra P Marques, Masayuki Yamato, Rui L Reis and Teruo Okano 2014 94: 663-673; advance online publication, April 7, 2014; 10.1038/labinvest.2014.55 Abstract | Full Text ENDOCRINE, VISUAL AND AUDITORY SYSTEMS Platelet-derived growth factor (PDGF)-C inhibits neuroretinal apoptosis in a murine model of focal retinal degeneration In a murine model of focal retinal degeneration, intraocular injection of platelet-derived growth factor (PDGF)-C potently ameliorates photoreceptor degeneration via suppression of neuroretinal apoptotic pathways without inducing retinal angiogenesis. The protective effects of PDGF-C suggest a novel treatment for age-related degeneration. Yujuan Wang, Mones S Abu-Asab, Cheng-Rong Yu, Zhongshu Tang, Defen Shen, Jingsheng Tuo, Xuri Li and Chi-Chao Chan 2014 94: 674-682; advance online publication, April 7, 2014; 10.1038/labinvest.2014.60 Abstract | Full Text ORAL, AND GASTROINTESTINAL AND PANCREATIC SYSTEMS Upregulated SMAD3 promotes epithelial–mesenchymal transition and predicts poor prognosis in pancreatic ductal adenocarcinoma This study shows that SMAD3 upregulation in pancreatic ductal adenocarcinoma correlates with malignant characteristics and epithelial-mesenchymal transition (EMT)-like features. SMAD3 knockdown results in EMT-like features suppression, regardless of SMAD4 status. Patients with upregulated SMAD3 experienced unfavorable outcomes after surgery, suggesting SMAD3 as a potential biomarker of poor prognosis. Ken Yamazaki, Yohei Masugi, Kathryn Effendi, Hanako Tsujikawa, Nobuyoshi Hiraoka, Minoru Kitago, Masahiro Shinoda, Osamu Itano, Minoru Tanabe, Yuko Kitagawa and Michiie Sakamoto 2014 94: 683-691; advance online publication, April 7, 2014; 10.1038/labinvest.2014.53 Abstract | Full Text Analysis of MYB oncogene in transformed adenoid cystic carcinomas reveals distinct pathways of tumor progression Adenoid cystic carcinomas can occasionally undergo dedifferentiation or high-grade transformation. Insight into the biology of this pathological phenomenon was sought by means of genetic profiling using microarray comparative genomic hybridization. The authors show that the process of high-grade transformation is not always accompanied by an accumulation of genetic alterations. Ana F Costa, Albina Altemani, Cristina García-Inclán, Florentino Fresno, Carlos Suárez, José L Llorente and Mario Hermsen 2014 94: 692-702; advance online publication, April 14, 2014; 10.1038/labinvest.2014.59 Abstract | Full Text Advertisement Laboratory Investigation Web Focus: Renal Pathology Kidney disease affects over 26 million Americans, resulting in a high demand for elucidating the pathways that lead to renal pathologies and identifying potential therapeutic targets. In this web focus presented by Laboratory Investigation, recent research in the field of renal pathology is highlighted, FREE for a limited time. Visit http://www.nature.com/labinvest/webfocus/index.html to access the full listing of articles in this special web focus FREE for a limited time.   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Laboratory Investigation. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.