Nature Reviews Neurology - Table of Contents alert Volume 10 Issue 5

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TABLE OF CONTENTS
May 2014 Volume 10 Number 5
Impact Factor 15.518 *	In this issue Research Highlights Editorial News and Views Reviews Perspectives Addendum Also this month  Web focus: Epilepsy
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RESEARCH HIGHLIGHTS Top Alzheimer disease: Advances in imaging of AD biomarkers could aid early diagnosis Published online: 22 April 2014 p239 | doi:10.1038/nrneurol.2014.71 PDF Traumatic brain injury: Blood biomarkers for assessing concussion in professional hockey players Published online: 01 April 2014 p240 | doi:10.1038/nrneurol.2014.65 PDF Epilepsy: Population-based study reinforces the link between autoimmune disease and epilepsy Published online: 22 April 2014 p240 | doi:10.1038/nrneurol.2014.70 PDF Multiple sclerosis: Could simvastatin slow down secondary progressive MS? Published online: 01 April 2014 p241 | doi:10.1038/nrneurol.2014.61 PDF IN BRIEF Neurodevelopmental disorders: Paternal obesity raises risk of autism spectrum disorders | Neuro-oncology: MYCN amplification affects neuroblastoma survival | Parkinson disease: Solid tissue levels of α-synuclein could aid diagnosis of PD | Neurodegenerative disease: Iron deposits in the brain associated with frontotemporal lobar degeneration PDF Neurology JOBS of the week Associate Researcher Icahn School of Medicine at Mount Sinai Postdoctoral Position in Neuroscience at Yale Yale University School of Medicine Associate or Full Professor University of South Florida (USF) More Science jobs from Neurology EVENT Molecular Neurology and Therapeutics 12.07.14 Cambridge, UK More science events from
EDITORIAL		Top
Epilepsy—burning questions and emerging therapies Hemi Malkki Published online: 12 May 2014 p243 | doi:10.1038/nrneurol.2014.63 Full Text | PDF
NEWS AND VIEWS		Top
Epilepsy: Preserving memory in temporal lobectomy—are networks the key? Michael Duchowny & Sanjiv Bhatia Published online: 22 April 2014 p245 | doi:10.1038/nrneurol.2014.67 Dominant mesial temporal lobe resection for pharmacoresistant epilepsy is frequently associated with verbal memory impairment. More-extensive lesioning improves seizure outcome, but further compromises memory. A better understanding of ipsilateral neural structures and networks for verbal memory could improve selectivity of surgical ablation, thereby holding promise for seizure-freedom without memory impairment. Full Text | PDF
Epilepsy: Responsive neurostimulation—modulating the epileptic brain Elinor Ben-Menachem & Gregory L. Krauss Published online: 22 April 2014 p247 | doi:10.1038/nrneurol.2014.69 Responsive neurostimulation (RNS) is an exciting new approach to treating refractory epilepsy. A recent 2 year follow-up study indicates that long-term RNS treatment is safe, and that efficacy improves with time. Although several issues remain to be resolved, RNS is a welcome new arrival in the armamentarium of epilepsy treatments. Full Text | PDF
Focus on: Epilepsy REVIEWS Top The challenges and innovations for therapy in children with epilepsy Jo M. Wilmshurst, Anne T. Berg, Lieven Lagae, Charles R. Newton & J. Helen Cross Published online: 08 April 2014 p249 | doi:10.1038/nrneurol.2014.58 Wilmshurst et al. discuss how appropriate terminology can aid in the diagnosis and treatment of paediatric epilepsies. Furthermore, they give an update on key changes to the organization and terminology of epilepsies by the International League Against Epilepsy and an overview of the challenges in implementing new guidelines to treat paediatric patients particularly in low-income countries. Abstract | Full Text | PDF Electrical brain stimulation for epilepsy Robert S. Fisher & Ana Luisa Velasco Published online: 08 April 2014 p261 | doi:10.1038/nrneurol.2014.59 The use of deep brain stimulation as a treatment for various refractory neurological disorders is increasing—perhaps faster than our understanding of this surgical technique. Electrical neuromodulation has been explored in people with epilepsy since the 1950s, and stimulation sites, parameters and results have varied. In this article, Fisher and Velasco review the use of neurostimulation as a treatment for epilepsy, from early experiments in animal models and humans to recent randomized controlled trials. Abstract | Full Text | PDF Mechanisms of sudden unexpected death in epilepsy: the pathway to prevention Cory A. Massey, Levi P. Sowers, Brian J. Dlouhy & George B. Richerson Published online: 22 April 2014 p271 | doi:10.1038/nrneurol.2014.64 Sudden unexpected death in epilepsy (SUDEP) is cited as the cause of nearly 2,000 deaths per year in the USA alone, and accounts for as many as 15% of epilepsy-related deaths. Controversy prevails over the relative contributions of cardiac failure and respiratory arrest to SUDEP. Here, the authors discuss the mechanisms that cause cardiac, respiratory and arousal abnormalities during the ictal and postictal periods, and highlight possible preventive interventions that might reduce the risk of SUDEP. Abstract | Full Text | PDF The hidden genetics of epilepsy—a clinically important new paradigm Rhys H. Thomas & Samuel F. Berkovic Published online: 15 April 2014 p283 | doi:10.1038/nrneurol.2014.62 The aetiology of most epilepsies used to be regarded as unknown, but in the past few years, massively parallel gene-sequencing techniques and clinical genetic studies have revealed that many forms of epilepsy—including those formerly labelled as idiopathic or acquired—are likely to have a genetic basis. Increased understanding of the genetic architecture of epilepsies has important implications for genetic testing, treatment selection and counselling. Furthermore, understanding the genetic background of epilepsies can guide neurobiological research for novel therapies. Abstract | Full Text | PDF
Focus on: Epilepsy PERSPECTIVES Top OPINION Genetic testing in the epilepsies—developments and dilemmas Annapurna Poduri, Beth Rosen Sheidley, Sara Shostak & Ruth Ottman Published online: 15 April 2014 p293 | doi:10.1038/nrneurol.2014.60 Genetic testing has the potential to revolutionize care for individuals with epilepsy, but its advent is bringing to light important new issues, particularly surrounding the benefits and risks of testing, and the optimal provision of genetic services. Poduri and colleagues describe these challenges, and call for mechanisms to be established to address them. Abstract | Full Text | PDF OPINION Gene therapy in epilepsy—is it time for clinical trials? Dimitri M. Kullmann, Stephanie Schorge, Matthew C. Walker & Robert C. Wykes Published online: 18 March 2014 p300 | doi:10.1038/nrneurol.2014.43 Kullmann et al. discuss the need for gene therapy in epilepsy and the challenges of translating experimental research into the clinic. Furthermore, they outline the potential for gene therapy strategies in pharmacoresistant epilepsy, ways to assess therapeutic efficacy, and the need to evaluate long-term safety data. Abstract | Full Text | PDF
ADDENDUM		Top
Addendum: The worldwide burden of stroke—a blurred photograph Blanca Fuentes & Exuperio Díez Tejedor Published online: 25 March 2014 p241 | doi:10.1038/nrneurol.2014.50 Full Text | PDF
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*Journal Citation Reports, Thomson, 2012. Nature Reviews Neurology was previously published as Nature Clinical Practice Neurology.

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