Cell Death and Disease - Table of Contents alert Volume 5, May 2014

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Special Issue on "Systems Biology approach to investigate cell death pathways in diseases" Disturbances in cell death pathways result in pathogenesis of various disorders. Thus, too much cell death is associated with neurological and immunological diseases and too little cell death is associated with development of malignancies. There are many pathological situations when cross-talk between different cell death subroutines plays significant role and treatment of all of these disorders is based on the attempts either to suppress, or induce cell death. To understand the mechanism of complex cross-talks, especially, in multifactorial disorders, an integrated systems biology approach is essential. A unified "language" model) helps to define the proper functioning of the biological system. Systemic understanding of cell death pathways is crucial to refine the molecular diagnosis of diseases, associated with dysfunction of cell death. It is helpful in optimizing the calculation of prognostic and predictive parameters of guiding new strategies of existing treatments and identification of novel targets for therapies based on modulation of cell death pathways. This issue of Cell Death & Disease includes several reviews focusing on different angles of system biology requirement for cell death research and medical applications and will be interesting for cell biologists, bioinformaticians, and physicians. Please see articles marked TABLE OF CONTENTS Volume 5, May 2014 In this issue Retraction Corrigendum Editorial Reviews Original Articles Correspondence Sign up for e-alerts Web feed Retraction Top Retraction to: High-mobility group A1 protein inhibits p53-mediated intrinsic apoptosis by interacting with Bcl-2 at mitochondria F Esposito, M Tornincasa, A Federico, G Chiappetta, G M Pierantoni and A Fusco Cell Death Dis 2014 5: e1206; 10.1038/cddis.2014.163 Full Text Corrigendum Top HSP70 inhibition by 2-phenylethynesulfonamide induces lysosomal cathepsin D release and immunogenic cell death in primary effusion lymphoma M Granato, V Lacconi, M Peddis, L V Lotti, L Di Renzo, R Gonnella, R Santarelli, P Trivedi, L Frati, G D'Orazi, A Faggioni and M Cirone Cell Death Dis 2014 5: e1254; 10.1038/cddis.2014.238 Full Text Editorial Top Systems biology: a way to make complex problems more understandable  I N Lavrik and B Zhivotovsky Cell Death Dis 2014 5: e1256; 10.1038/cddis.2014.195 Full Text | PDF Reviews Top Systems biology of cisplatin resistance: past, present and future   L Galluzzi, I Vitale, J Michels, C Brenner, G Szabadkai, A Harel-Bellan, M Castedo and G Kroemer Cell Death Dis 2014 5: e1257; 10.1038/cddis.2013.428 Abstract | Full Text Systems biology of death receptor networks: live and let die   I N Lavrik Cell Death Dis 2014 5: e1259; 10.1038/cddis.2014.160 Abstract | Full Text The pleiotropic roles of sphingolipid signaling in autophagy Y Li, S Li, X Qin, W Hou, H Dong, L Yao and L Xiong Cell Death Dis 2014 5: e1245; 10.1038/cddis.2014.215 Abstract | Full Text Understanding the roadmaps to induced pluripotency K Liu, Y Song, H Yu and T Zhao Cell Death Dis 2014 5: e1232; 10.1038/cddis.2014.205 Abstract | Full Text Bioactive lipids and the control of Bax pro-apoptotic activity V Mignard, L Lalier, F Paris and F M Vallette Cell Death Dis 2014 5: e1266; 10.1038/cddis.2014.226 Abstract | Full Text Systems biology approaches to develop innovative strategies for lung cancer therapy  K Viktorsson, R Lewensohn and B Zhivotovsky Cell Death Dis 2014 5: e1260; 10.1038/cddis.2014.28 Abstract | Full Text From computational modelling of the intrinsic apoptosis pathway to a systems-based analysis of chemotherapy resistance: achievements, perspectives and challenges in systems medicine  M L Würstle, E Zink, J H M Prehn and M Rehm Cell Death Dis 2014 5: e1258; 10.1038/cddis.2014.36 Abstract | Full Text Cell-to-cell variability in cell death: can systems biology help us make sense of it all?  X Xia, M S Owen, R E C Lee and S Gaudet Cell Death Dis 2014 5: e1261; 10.1038/cddis.2014.199 Abstract | Full Text Original Articles Top Celastrol targets proteostasis and acts synergistically with a heat-shock protein 90 inhibitor to kill human glioblastoma cells S Boridy, P U Le, K Petrecca and D Maysinger Cell Death Dis 2014 5: e1216; 10.1038/cddis.2014.182 Abstract | Full Text Cab45S inhibits the ER stress-induced IRE1-JNK pathway and apoptosis via GRP78/BiP L Chen, S Xu, L Liu, X Wen, Y Xu, J Chen and J Teng Cell Death Dis 2014 5: e1219; 10.1038/cddis.2014.193 Abstract | Full Text Interconnections between autophagy and the coagulation cascade in hepatocellular carcinoma K-D Chen, C-C Wang, M-C Tsai, C-H Wu, H-J Yang, L-Y Chen, T Nakano, S Goto, K-T Huang, T-H Hu, C-L Chen and C-C Lin Cell Death Dis 2014 5: e1244; 10.1038/cddis.2014.212 Abstract | Full Text Tip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expression F Chen, A Li, S Gao, D Hollern, M Williams, F Liu, E A VanSickle, E Andrechek, C Zhang, C Yang, R Luo and H Xiao Cell Death Dis 2014 5: e1242; 10.1038/cddis.2014.224 Abstract | Full Text The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer C-H Chuang, W-J Wang, C-F Li, C-Y Ko, Y-H Chou, C-P Chuu, T-L Cheng and J-M Wang Cell Death Dis 2014 5: e1220; 10.1038/cddis.2014.106 Abstract | Full Text The cockayne syndrome B protein is essential for neuronal differentiation and neuritogenesis F Ciaffardini, S Nicolai, M Caputo, G Canu, E Paccosi, M Costantino, M Frontini, A S Balajee and L Proietti-De-Santis Cell Death Dis 2014 5: e1268; 10.1038/cddis.2014.228 Abstract | Full Text Role of alpha-synuclein in autophagy modulation of primary human T lymphocytes T Colasanti, M Vomero, C Alessandri, C Barbati, A Maselli, C Camperio, F Conti, A Tinari, C Carlo-Stella, L Tuosto, D Benincasa, G Valesini, W Malorni, M Pierdominici and E Ortona Cell Death Dis 2014 5: e1265; 10.1038/cddis.2014.211 Abstract | Full Text Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage N Dashzeveg, N Taira, Z-G Lu, J Kimura and K Yoshida Cell Death Dis 2014 5: e1221; 10.1038/cddis.2014.176 Abstract | Full Text Chaetocin-induced ROS-mediated apoptosis involves ATM–YAP1 axis and JNK-dependent inhibition of glucose metabolism D Dixit, R Ghildiyal, N P Anto and E Sen Cell Death Dis 2014 5: e1212; 10.1038/cddis.2014.179 Abstract | Full Text Fas-associated factor (Faf1) is a novel CD40 interactor that regulates CD40-induced NF-κB activation via a negative feedback loop T Elmetwali, L S Young and D H Palmer Cell Death Dis 2014 5: e1213; 10.1038/cddis.2014.172 Abstract | Full Text Reversion of apoptotic resistance of TP53-mutated Burkitt lymphoma B-cells to spindle poisons by exogenous activation of JNK and p38 MAP kinases M Farhat, A Poissonnier, A Hamze, C Ouk-Martin, J-D Brion, M Alami, J Feuillard and C Jayat-Vignoles Cell Death Dis 2014 5: e1201; 10.1038/cddis.2014.150 Abstract | Full Text Degradation of mutant p53H175 protein by Zn(II) through autophagy A Garufi, D Pucci, V D’Orazi, M Cirone, G Bossi, M L Avantaggiati and G D’Orazi Cell Death Dis 2014 5: e1271; 10.1038/cddis.2014.217 Abstract | Full Text Ex vivo culture of intestinal crypt organoids as a model system for assessing cell death induction in intestinal epithelial cells and enteropathy T Grabinger, L Luks, F Kostadinova, C Zimberlin, J P Medema, M Leist and T Brunner Cell Death Dis 2014 5: e1228; 10.1038/cddis.2014.183 Abstract | Full Text IRE1a constitutes a negative feedback loop with BMP2 and acts as a novel mediator in modulating osteogenic differentiation F-J Guo, R Jiang, Z Xiong, F Xia, M Li, L Chen and C-J Liu Cell Death Dis 2014 5: e1239; 10.1038/cddis.2014.194 Abstract | Full Text Macropinocytosis and TAK1 mediate anti-inflammatory to pro-inflammatory macrophage differentiation by HIV-1 Nef M Hashimoto, H Nasser, T Chihara and S Suzu Cell Death Dis 2014 5: e1267; 10.1038/cddis.2014.233 Abstract | Full Text Prognostic significance of low DICER expression regulated by miR-130a in cervical cancer L He, H-Y Wang, L Zhang, L Huang, J-D Li, Y Xiong, M-Y Zhang, W-H Jia, J-P Yun, R-Z Luo and M Zheng Cell Death Dis 2014 5: e1205; 10.1038/cddis.2014.127 Abstract | Full Text Involvement of p38 in signal switching from autophagy to apoptosis via the PERK/eIF2α/ATF4 axis in selenite-treated NB4 cells Q Jiang, F Li, K Shi, P Wu, J An, Y Yang and C Xu Cell Death Dis 2014 5: e1270; 10.1038/cddis.2014.200 Abstract | Full Text Death-associated protein kinase 1 has a critical role in aberrant tau protein regulation and function B M Kim, M-H You, C-H Chen, S Lee, Y Hong, Y Hong, A Kimchi, X Z Zhou and T H Lee Cell Death Dis 2014 5: e1237; 10.1038/cddis.2014.216 Abstract | Full Text ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS J C Koch, L Tönges, E Barski, U Michel, M Bähr and P Lingor Cell Death Dis 2014 5: e1225; 10.1038/cddis.2014.191 Abstract | Full Text HKH40A downregulates GRP78/BiP expression in cancer cells T Kosakowska-Cholody, J Lin, S M Srideshikan, L Scheffer, N I Tarasova and J K Acharya Cell Death Dis 2014 5: e1240; 10.1038/cddis.2014.203 Abstract | Full Text Transcriptional and metabolic adaptation of human neurons to the mitochondrial toxicant MPP+ A K Krug, S Gutbier, L Zhao, D Pöltl, C Kullmann, V Ivanova, S Förster, S Jagtap, J Meiser, G Leparc, S Schildknecht, M Adam, K Hiller, H Farhan, T Brunner, T Hartung, A Sachinidis and M Leist Cell Death Dis 2014 5: e1222; 10.1038/cddis.2014.166 Abstract | Full Text The CT20 peptide causes detachment and death of metastatic breast cancer cells by promoting mitochondrial aggregation and cytoskeletal disruption M W Lee, R Bassiouni, N A Sparrow, A Iketani, R J Boohaker, C Moskowitz, P Vishnubhotla, A S Khaled, J Oyer, A Copik, C Fernandez-Valle, J M Perez and A R Khaled Cell Death Dis 2014 5: e1249; 10.1038/cddis.2014.225 Abstract | Full Text Rapamycin reverses insulin resistance (IR) in high-glucose medium without causing IR in normoglycemic medium O V Leontieva, Z N Demidenko and M V Blagosklonny Cell Death Dis 2014 5: e1214; 10.1038/cddis.2014.178 Abstract | Full Text HSCARG downregulates NF-κB signaling by interacting with USP7 and inhibiting NEMO ubiquitination T Li, J Guan, S Li, X Zhang and X Zheng Cell Death Dis 2014 5: e1229; 10.1038/cddis.2014.197 Abstract | Full Text Upregulation and nuclear translocation of testicular ghrelin protects differentiating spermatogonia from ionizing radiation injury W Li, Y Zeng, J Zhao, C-J Zhu, W-G Hou and S Zhang Cell Death Dis 2014 5: e1248; 10.1038/cddis.2014.223 Abstract | Full Text Integrated analyses identify the involvement of microRNA-26a in epithelial–mesenchymal transition during idiopathic pulmonary fibrosis H Liang, Y Gu, T Li, Y Zhang, L Huangfu, M Hu, D Zhao, Y Chen, S Liu, Y Dong, X Li, Y Lu, B Yang and H Shan Cell Death Dis 2014 5: e1238; 10.1038/cddis.2014.207 Abstract | Full Text Serum-dependent processing of late apoptotic cells for enhanced efferocytosis Y Y Liang, T Arnold, A Michlmayr, D Rainprecht, B Perticevic, A Spittler and R Oehler Cell Death Dis 2014 5: e1264; 10.1038/cddis.2014.210 Abstract | Full Text Radiation induces senescence and a bystander effect through metabolic alterations E-C Liao, Y-T Hsu, Q-Y Chuah, Y-J Lee, J-Y Hu, T-C Huang, P-M Yang and S-J Chiu Cell Death Dis 2014 5: e1255; 10.1038/cddis.2014.220 Abstract | Full Text Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/PKA signaling D Liu, Y Huang, D Bu, A D Liu, L Holmberg, Y Jia, C Tang, J Du and H Jin Cell Death Dis 2014 5: e1251; 10.1038/cddis.2014.229 Abstract | Full Text Senescence induced by RECQL4 dysfunction contributes to Rothmund–Thomson syndrome features in mice H Lu, E F Fang, P Sykora, T Kulikowicz, Y Zhang, K G Becker, D L Croteau and V A Bohr Cell Death Dis 2014 5: e1226; 10.1038/cddis.2014.168 Abstract | Full Text Mammalian STE20-like kinase 2, not kinase 1, mediates photoreceptor cell death during retinal detachment H Matsumoto, Y Murakami, K Kataoka, H Lin, K M Connor, J W Miller, D Zhou, J Avruch and D G Vavvas Cell Death Dis 2014 5: e1269; 10.1038/cddis.2014.218 Abstract | Full Text Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner K Mnich, L A Carleton, E T Kavanagh, K M Doyle, A Samali and A M Gorman Cell Death Dis 2014 5: e1202; 10.1038/cddis.2014.173 Abstract | Full Text Simultaneous loss of phospholipase Cδ1 and phospholipase Cδ3 causes cardiomyocyte apoptosis and cardiomyopathy Y Nakamura, K Kanemaru, R Kojima, Y Hashimoto, T Marunouchi, N Oka, T Ogura, K Tanonaka and K Fukami Cell Death Dis 2014 5: e1215; 10.1038/cddis.2014.181 Abstract | Full Text Pigment epithelium-derived factor expression prolongs survival and enhances the cytotoxicity of low-dose chemotherapy in castration-refractory prostate cancer T Nelius, D Martinez-Marin, J Hirsch, B Miller, K Rinard, J Lopez, W de Riese and S Filleur Cell Death Dis 2014 5: e1210; 10.1038/cddis.2014.180 Abstract | Full Text Quantitative multi-parametric evaluation of centrosome declustering drugs: centrosome amplification, mitotic phenotype, cell cycle and death A Ogden, A Cheng, P C G Rida, V Pannu, R Osan, R Clewley and R Aneja Cell Death Dis 2014 5: e1204; 10.1038/cddis.2014.164 Abstract | Full Text The heat-shock response co-inducer arimoclomol protects against retinal degeneration in rhodopsin retinitis pigmentosa D A Parfitt, M Aguila, C H McCulley, D Bevilacqua, H F Mendes, D Athanasiou, S S Novoselov, N Kanuga, P M Munro, P J Coffey, B Kalmar, L Greensmith and M E Cheetham Cell Death Dis 2014 5: e1236; 10.1038/cddis.2014.214 Abstract | Full Text β-Lapachone induces programmed necrosis through the RIP1-PARP-AIF-dependent pathway in human hepatocellular carcinoma SK-Hep1 cells E J Park, K-j Min, T-J Lee, Y H Yoo, Y-S Kim and T K Kwon Cell Death Dis 2014 5: e1230; 10.1038/cddis.2014.202 Abstract | Full Text Osteopontin deficiency aggravates hepatic injury induced by ischemia–reperfusion in mice S Patouraux, D Rousseau, A Rubio, S Bonnafous, V J Lavallard, J Lauron, M-C Saint-Paul, B Bailly-Maitre, A Tran, D Crenesse and P Gual Cell Death Dis 2014 5: e1208; 10.1038/cddis.2014.174 Abstract | Full Text Sec-containing TrxR1 is essential for self-sufficiency of cells by control of glucose-derived H2O2 X Peng, P K Mandal, V O Kaminskyy, A Lindqvist, M Conrad and E S J Arnér Cell Death Dis 2014 5: e1235; 10.1038/cddis.2014.209 Abstract | Full Text Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation B I Pérez-Revuelta, M M Hettich, A Ciociaro, C Rotermund, P J Kahle, S Krauss and D A Di Monte Cell Death Dis 2014 5: e1209; 10.1038/cddis.2014.175 Abstract | Full Text Wnt inhibitory factor 1 suppresses cancer stemness and induces cellular senescence I Ramachandran, V Ganapathy, E Gillies, I Fonseca, S M Sureban, C W Houchen, A Reis and L Queimado Cell Death Dis 2014 5: e1246; 10.1038/cddis.2014.219 Abstract | Full Text High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy M Rossi, B Rotblat, K Ansell, I Amelio, M Caraglia, G Misso, F Bernassola, C N Cavasotto, R A Knight, A Ciechanover and G Melino Cell Death Dis 2014 5: e1203; 10.1038/cddis.2014.113 Abstract | Full Text Knockout of PARG110 confers resistance to cGMP-induced toxicity in mammalian photoreceptors A Sahaboglu, N Tanimoto, S Bolz, M G Garrido, M Ueffing, M W Seeliger, H Löwenheim, P Ekström and F Paquet-Durand Cell Death Dis 2014 5: e1234; 10.1038/cddis.2014.208 Abstract | Full Text Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo M Signore, F Pelacchi, S di Martino, D Runci, M Biffoni, S Giannetti, L Morgante, M De Majo, E F Petricoin, L Stancato, L M Larocca, R De Maria, R Pallini and L Ricci-Vitiani Cell Death Dis 2014 5: e1223; 10.1038/cddis.2014.188 Abstract | Full Text Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells Y Sun, X Gu, E Zhang, M-A Park, A M Pereira, S Wang, T Morrison, C Li, J Blenis, V H Gerbaudo, E P Henske and J J Yu Cell Death Dis 2014 5: e1231; 10.1038/cddis.2014.204 Abstract | Full Text Interferon consensus sequence-binding protein (ICSBP) promotes epithelial-to-mesenchymal transition (EMT)-like phenomena, cell-motility, and invasion via TGF-β signaling in U2OS cells J Y Sung, S-Y Park, J H Kim, H G Kang, J H Yoon, Y S Na, Y-N Kim and B-K Park Cell Death Dis 2014 5: e1224; 10.1038/cddis.2014.189 Abstract | Full Text EphrinB3 blocks EphB3 dependence receptor functions to prevent cell death following traumatic brain injury M H Theus, J Ricard, S J Glass, L G Travieso and D J Liebl Cell Death Dis 2014 5: e1207; 10.1038/cddis.2014.165 Abstract | Full Text Axl-altered microRNAs regulate tumorigenicity and gefitinib resistance in lung cancer Y Wang, H Xia, Z Zhuang, L Miao, X Chen and H Cai Cell Death Dis 2014 5: e1227; 10.1038/cddis.2014.186 Abstract | Full Text FoxO mediates APP-induced AICD-dependent cell death X Wang, Z Wang, Y Chen, X Huang, Y Hu, R Zhang, M S Ho and L Xue Cell Death Dis 2014 5: e1233; 10.1038/cddis.2014.196 Abstract | Full Text Elf3 drives β-catenin transactivation and associates with poor prognosis in colorectal cancer J-L Wang, Z-F Chen, H-M Chen, M-Y Wang, X Kong, Y-C Wang, T-T Sun, J Hong, W Zou, J Xu and J-Y Fang Cell Death Dis 2014 5: e1263; 10.1038/cddis.2014.206 Abstract | Full Text Non-viral FoxM1 gene delivery to hepatocytes enhances liver repopulation D Xiang, C-C Liu, M-J Wang, J-X Li, F Chen, H Yao, B Yu, L Lu, U Borjigin, Y-X Chen, L Zhong, K J Wangensteen, Z-Y He, X Wang and Y-P Hu Cell Death Dis 2014 5: e1252; 10.1038/cddis.2014.230 Abstract | Full Text Rasfonin, a novel 2-pyrone derivative, induces ras-mutated Panc-1 pancreatic tumor cell death in nude mice Z Xiao, L Li, Y Li, W Zhou, J Cheng, F Liu, P Zheng, Y Zhang and Y Che Cell Death Dis 2014 5: e1241; 10.1038/cddis.2014.213 Abstract | Full Text Mitochondrial dysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells and motor coordination deficits in diabetic rat model S Yang, C Xia, S Li, L Du, L Zhang and Y Hu Cell Death Dis 2014 5: e1217; 10.1038/cddis.2014.184 Abstract | Full Text Identification of prolidase as a high affinity ligand of the ErbB2 receptor and its regulation of ErbB2 signaling and cell growth L Yang, Y Li and Y Zhang Cell Death Dis 2014 5: e1211; 10.1038/cddis.2014.187 Abstract | Full Text SPAG5 upregulation predicts poor prognosis in cervical cancer patients and alters sensitivity to taxol treatment via the mTOR signaling pathway L-J Yuan, J-D Li, L Zhang, J-H Wang, T Wan, Y Zhou, H Tu, J-P Yun, R-Z Luo, W-H Jia and M Zheng Cell Death Dis 2014 5: e1247; 10.1038/cddis.2014.222 Abstract | Full Text Altered expression of Alzheimer’s disease-related genes in the cerebellum of autistic patients: a model for disrupted brain connectome and therapy F Zeidán-Chuliá, B-HN de Oliveira, A B Salmina, M F Casanova, D P Gelain, M Noda, A Verkhratsky and J CF Moreira Cell Death Dis 2014 5: e1250; 10.1038/cddis.2014.227 Abstract | Full Text P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression E-b Zhang, D-d Yin, M Sun, R Kong, X-h Liu, L-h You, L Han, R Xia, K-m Wang, J-s Yang, W De, Y-q Shu and Z-x Wang Cell Death Dis 2014 5: e1243; 10.1038/cddis.2014.201 Abstract | Full Text Receptor-interacting protein kinases modulate noise-induced sensory hair cell death H-W Zheng, J Chen and S-H Sha Cell Death Dis 2014 5: e1262; 10.1038/cddis.2014.177 Abstract | Full Text Zeaxanthin induces Nrf2-mediated phase II enzymes in protection of cell death X Zou, J Gao, Y Zheng, X Wang, C Chen, K Cao, J Xu, Y Li, W Lu, J Liu and Z Feng Cell Death Dis 2014 5: e1218; 10.1038/cddis.2014.190 Abstract | Full Text DNA replication stress in CHK1-depleted tumour cells triggers premature (S-phase) mitosis through inappropriate activation of Aurora kinase B P Zuazua-Villar, R Rodriguez, M E Gagou, P A Eyers and M Meuth Cell Death Dis 2014 5: e1253; 10.1038/cddis.2014.231 Abstract | Full Text Correspondence Top CREAM: a database for chemotherapy resistance-associated miRSNP E Dai, Y Lv, F Meng, X Yu, Y Zhang, S Wang, X Liu, D Liu, J Wang, X Li and W Jiang Cell Death Dis 2014 5: e1272; 10.1038/cddis.2014.236 Full Text Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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